OpenCravat.bsky.social
@opencravat.bsky.social
Developed at Johns Hopkins, a platform to annotate and prioritize variants and genes in cancer and germline sequencing projects!
https://opencravat.org
https://opencravat.org
Pinned
OpenCRAVAT Community Contributor Interest Form
Help shape the future of genomic variant annotation! We’re looking for members of the genomics, bioinformatics, and clinical variant interpretation community to help improve OpenCRAVAT. As a…
forms.gle
Help shape the future of genomic variant annotation! We’re looking for community contributors to support OpenCRAVAT — from testing new features to improving documentation and outreach.
📝 Sign up here: forms.gle/v5t2ErBxYzqn...
#Genomics #Bioinformatics #OpenScience #Annotation
📝 Sign up here: forms.gle/v5t2ErBxYzqn...
#Genomics #Bioinformatics #OpenScience #Annotation
Discover the latest updates and project status of OpenCRAVAT by exploring the roadmap available on GitHub. Stay informed about the progress and developments by visiting this link: [OpenCRAVAT Roadmap](github.com/orgs/Karchin...). #annotator #opencravat #bioinformatics #opensource #genomics 🧬 🧪 🖥️
OpenCRAVAT Roadmap • KarchinLab
This is the roadmap for the OpenCRAVAT Project.
github.com
October 16, 2025 at 10:01 PM
Discover the latest updates and project status of OpenCRAVAT by exploring the roadmap available on GitHub. Stay informed about the progress and developments by visiting this link: [OpenCRAVAT Roadmap](github.com/orgs/Karchin...). #annotator #opencravat #bioinformatics #opensource #genomics 🧬 🧪 🖥️
Stuck with a three-month VCF backlog? Try these five rapid changes to cut turnaround time in half. (1) prioritize with calibrated predictors; (2) use OpenCRAVAT modular annotators to remove tool fragmentation#annotator #opencravat #bioinformatics #opensource #genomics🧬 🖥️ 🧪
September 19, 2025 at 3:35 PM
Stuck with a three-month VCF backlog? Try these five rapid changes to cut turnaround time in half. (1) prioritize with calibrated predictors; (2) use OpenCRAVAT modular annotators to remove tool fragmentation#annotator #opencravat #bioinformatics #opensource #genomics🧬 🖥️ 🧪
We are planning to launch a new collection of Jupyter notebooks and would love to know if you're interested. If so, please share topics or features you'd like included. Your feedback will help us tailor these notebooks to your needs and preferences.#annotator #opencravat #opensource 🧬 🧪 🖥️
August 23, 2025 at 2:30 PM
We are planning to launch a new collection of Jupyter notebooks and would love to know if you're interested. If so, please share topics or features you'd like included. Your feedback will help us tailor these notebooks to your needs and preferences.#annotator #opencravat #opensource 🧬 🧪 🖥️
Introducing our latest offering: the Calibrated Classification Package for clinical interpretation of variant effect predictor scores. This innovative package aids users in applying ACMG/AMP variant interpretation guidelines.#annotator #opencravat #bioinformatics #opensource #genomics 🧬 🧪 🖥️
August 22, 2025 at 8:51 PM
Introducing our latest offering: the Calibrated Classification Package for clinical interpretation of variant effect predictor scores. This innovative package aids users in applying ACMG/AMP variant interpretation guidelines.#annotator #opencravat #bioinformatics #opensource #genomics 🧬 🧪 🖥️
@moezdawood.bsky.social created the AllofUs 250k annotator for OpenCRAVAT to improve genomic research by integrating diverse data, including ancestry-specific allele frequencies. You can read more about Moez's experience developing the annotator here: www.opencravat.org/bringing-gen...
#opensource
#opensource
Bringing Genetic Diversity to the Forefront: Moez Dawood on the AllofUs 250k Annotator for OpenCRAVAT
Moez Dawood, an MD/PhD student at Baylor College of Medicine, has recently developed the AllofUs 250k annotator for OpenCRAVAT, a genomic annotation platform designed to handle both single variant…
www.opencravat.org
August 15, 2025 at 4:14 PM
@moezdawood.bsky.social created the AllofUs 250k annotator for OpenCRAVAT to improve genomic research by integrating diverse data, including ancestry-specific allele frequencies. You can read more about Moez's experience developing the annotator here: www.opencravat.org/bringing-gen...
#opensource
#opensource
Help shape the future of genomic variant annotation! We’re looking for community contributors to support OpenCRAVAT — from testing new features to improving documentation and outreach.
📝 Sign up here: forms.gle/v5t2ErBxYzqn...
#Genomics #Bioinformatics #OpenScience #Annotation
📝 Sign up here: forms.gle/v5t2ErBxYzqn...
#Genomics #Bioinformatics #OpenScience #Annotation
OpenCRAVAT Community Contributor Interest Form
Help shape the future of genomic variant annotation! We’re looking for members of the genomics, bioinformatics, and clinical variant interpretation community to help improve OpenCRAVAT. As a…
forms.gle
August 15, 2025 at 3:43 PM
Help shape the future of genomic variant annotation! We’re looking for community contributors to support OpenCRAVAT — from testing new features to improving documentation and outreach.
📝 Sign up here: forms.gle/v5t2ErBxYzqn...
#Genomics #Bioinformatics #OpenScience #Annotation
📝 Sign up here: forms.gle/v5t2ErBxYzqn...
#Genomics #Bioinformatics #OpenScience #Annotation
We are seeking community members interested in taking part in OpenCRAVAT's future.
Let us know if you might contribute in any of these areas:
Would you be interested in contributing code, bug fixes, or performance improvements?
Are there features or issues you’d like to help implement or debug?🧬🖥️
Let us know if you might contribute in any of these areas:
Would you be interested in contributing code, bug fixes, or performance improvements?
Are there features or issues you’d like to help implement or debug?🧬🖥️
July 7, 2025 at 7:01 PM
We are seeking community members interested in taking part in OpenCRAVAT's future.
Let us know if you might contribute in any of these areas:
Would you be interested in contributing code, bug fixes, or performance improvements?
Are there features or issues you’d like to help implement or debug?🧬🖥️
Let us know if you might contribute in any of these areas:
Would you be interested in contributing code, bug fixes, or performance improvements?
Are there features or issues you’d like to help implement or debug?🧬🖥️
🧪 🧬 Want to explore your own genome?
Join our free webinar on how to use OpenCRAVAT to annotate & interpret your personal variants.
📅 July 10 | 🕐 1 PM EDT
🎙️ With Jasmine Baker, PhD & Rachel Karchin, PhD
🔗 tinyurl.com/3ur6vv35
#Genomics #Bioinformatics #OpenSource #OpenCRAVAT🖥️
Join our free webinar on how to use OpenCRAVAT to annotate & interpret your personal variants.
📅 July 10 | 🕐 1 PM EDT
🎙️ With Jasmine Baker, PhD & Rachel Karchin, PhD
🔗 tinyurl.com/3ur6vv35
#Genomics #Bioinformatics #OpenSource #OpenCRAVAT🖥️
Welcome! You are invited to join a webinar: Exploring Personal Genomes with OpenCRAVAT. After registering, you will receive a confirmation email about joining the webinar.
One-hour webinar teaching how to utilize OpenCRAVAT as an annotation tool for personal genomic data.
tinyurl.com
July 1, 2025 at 12:42 PM
🧪 🧬 Want to explore your own genome?
Join our free webinar on how to use OpenCRAVAT to annotate & interpret your personal variants.
📅 July 10 | 🕐 1 PM EDT
🎙️ With Jasmine Baker, PhD & Rachel Karchin, PhD
🔗 tinyurl.com/3ur6vv35
#Genomics #Bioinformatics #OpenSource #OpenCRAVAT🖥️
Join our free webinar on how to use OpenCRAVAT to annotate & interpret your personal variants.
📅 July 10 | 🕐 1 PM EDT
🎙️ With Jasmine Baker, PhD & Rachel Karchin, PhD
🔗 tinyurl.com/3ur6vv35
#Genomics #Bioinformatics #OpenSource #OpenCRAVAT🖥️
🧬 Curious about your genome?
Join our free webinar on OpenCRAVAT to explore and annotate your own data!
📅 July 10 – 1 PM EDT
🎙️ Baker & Karchin (JHU)
🔗 tinyurl.com/3ur6vv35
#Genomics #Bioinformatics #OpenScience
#annotator #opencravat #bioinformatics #opensource #webinar #genomes 🖥🧪
Join our free webinar on OpenCRAVAT to explore and annotate your own data!
📅 July 10 – 1 PM EDT
🎙️ Baker & Karchin (JHU)
🔗 tinyurl.com/3ur6vv35
#Genomics #Bioinformatics #OpenScience
#annotator #opencravat #bioinformatics #opensource #webinar #genomes 🖥🧪
June 16, 2025 at 1:31 PM
🧬 Curious about your genome?
Join our free webinar on OpenCRAVAT to explore and annotate your own data!
📅 July 10 – 1 PM EDT
🎙️ Baker & Karchin (JHU)
🔗 tinyurl.com/3ur6vv35
#Genomics #Bioinformatics #OpenScience
#annotator #opencravat #bioinformatics #opensource #webinar #genomes 🖥🧪
Join our free webinar on OpenCRAVAT to explore and annotate your own data!
📅 July 10 – 1 PM EDT
🎙️ Baker & Karchin (JHU)
🔗 tinyurl.com/3ur6vv35
#Genomics #Bioinformatics #OpenScience
#annotator #opencravat #bioinformatics #opensource #webinar #genomes 🖥🧪
Ever wonder what secrets your personal genome might hold? 🧬
Join us live on July 10 to explore how OpenCRAVAT helps annotate your data & turn it into meaningful insight.
Perfect for researchers & curious minds alike.
🔬 Registration link coming soon!🖥
Join us live on July 10 to explore how OpenCRAVAT helps annotate your data & turn it into meaningful insight.
Perfect for researchers & curious minds alike.
🔬 Registration link coming soon!🖥
June 10, 2025 at 12:14 PM
Ever wonder what secrets your personal genome might hold? 🧬
Join us live on July 10 to explore how OpenCRAVAT helps annotate your data & turn it into meaningful insight.
Perfect for researchers & curious minds alike.
🔬 Registration link coming soon!🖥
Join us live on July 10 to explore how OpenCRAVAT helps annotate your data & turn it into meaningful insight.
Perfect for researchers & curious minds alike.
🔬 Registration link coming soon!🖥
Discover the power of OpenCRAVAT's cutting-edge annotation features that ensure seamless collaboration among users. Its intuitive design makes it easy for everyone to navigate, while enhancing productivity across the board.#annotator #opencravat #bioinformatics #opensource #genomics 🖥️ 🧬
June 6, 2025 at 11:17 PM
Discover the power of OpenCRAVAT's cutting-edge annotation features that ensure seamless collaboration among users. Its intuitive design makes it easy for everyone to navigate, while enhancing productivity across the board.#annotator #opencravat #bioinformatics #opensource #genomics 🖥️ 🧬
Discover the power of the All of Us annotator with Open Cravat! This tool uses allele frequency data from the All of Us Research Program to explore genetic variations in diverse populations, enhancing precision medicine. Let's innovate healthcare together! #PrecisionMedicine #Genomics #AllOfUs🖥️ 🧬
May 31, 2025 at 11:07 PM
Discover the power of the All of Us annotator with Open Cravat! This tool uses allele frequency data from the All of Us Research Program to explore genetic variations in diverse populations, enhancing precision medicine. Let's innovate healthcare together! #PrecisionMedicine #Genomics #AllOfUs🖥️ 🧬
Introducing the Regeneron Million Exome Annotator curated by Regeneron Genetics Center. Developed with major biobanks and health systems, it provides valuable genetic insights for research. We encourage its use in your research toolkit. #annotator #bioinformatics #opensource #genomics 🧪 🖥️🧬
May 31, 2025 at 11:02 PM
Introducing the Regeneron Million Exome Annotator curated by Regeneron Genetics Center. Developed with major biobanks and health systems, it provides valuable genetic insights for research. We encourage its use in your research toolkit. #annotator #bioinformatics #opensource #genomics 🧪 🖥️🧬
Need variant annotation fast? OpenCRAVAT makes it easy—whether you're analyzing one variant or thousands. Free, flexible, and built for discovery. Try it today at opencravat.org 🧪🖥🧬
OpenCRAVAT
mouse
www.opencravat.org
April 18, 2025 at 3:14 AM
Need variant annotation fast? OpenCRAVAT makes it easy—whether you're analyzing one variant or thousands. Free, flexible, and built for discovery. Try it today at opencravat.org 🧪🖥🧬
🧬 🖥OpenCRAVAT will integrate the All of Us dataset. That's BILLIONS of gene variation annotations for better understanding our DNA.
Check out the blog: www.opencravat.org/opencravat-i...
Preprint coming soon from @moezdawood.bsky.social
Check out the blog: www.opencravat.org/opencravat-i...
Preprint coming soon from @moezdawood.bsky.social
OpenCRAVAT Integrates All of Us Dataset for Variant Annotation
At ACMG 2025, Dr. Moez Dawood announced a groundbreaking initiative: the global democratization of deidentified allele count and frequency data from the first ~250,000 short-read Whole Genome…
www.opencravat.org
March 28, 2025 at 3:09 AM
🧬 🖥OpenCRAVAT will integrate the All of Us dataset. That's BILLIONS of gene variation annotations for better understanding our DNA.
Check out the blog: www.opencravat.org/opencravat-i...
Preprint coming soon from @moezdawood.bsky.social
Check out the blog: www.opencravat.org/opencravat-i...
Preprint coming soon from @moezdawood.bsky.social
The cat is out of the bag! We are excited to be a part of this collaboration. Global democratization of deidentified allele count + frequency data with population breakdown from the first ~250k short-read WGS in All of Us designed to plug straight into clinical workflows.🖥️🧪🧬
🚨 Big news at #ACMG2025! 🚨
Today we’re announcing global democratization of deidentified allele count + frequency data with population breakdown from the first ~250k short-read WGS in All of Us designed to plug straight into clinical workflows. It is ~1.1 billion unique variants! 🧬💡
🧵 (1/4)
Today we’re announcing global democratization of deidentified allele count + frequency data with population breakdown from the first ~250k short-read WGS in All of Us designed to plug straight into clinical workflows. It is ~1.1 billion unique variants! 🧬💡
🧵 (1/4)
March 21, 2025 at 5:05 PM
The cat is out of the bag! We are excited to be a part of this collaboration. Global democratization of deidentified allele count + frequency data with population breakdown from the first ~250k short-read WGS in All of Us designed to plug straight into clinical workflows.🖥️🧪🧬
🖥️ New to OpenCRAVAT? Explore our Vignettes—tutorials designed for easy genomic variant analysis! 🧬
📖 Learn to:
✅ Annotate variants
✅ Interpret results for clinical & research
✅ Utilize powerful analysis tools
Start here: karchinlab.github.io/oc_vignettes/
#Genomics #VariantAnnotation #OpenSource
📖 Learn to:
✅ Annotate variants
✅ Interpret results for clinical & research
✅ Utilize powerful analysis tools
Start here: karchinlab.github.io/oc_vignettes/
#Genomics #VariantAnnotation #OpenSource
March 11, 2025 at 10:37 PM
🖥️ New to OpenCRAVAT? Explore our Vignettes—tutorials designed for easy genomic variant analysis! 🧬
📖 Learn to:
✅ Annotate variants
✅ Interpret results for clinical & research
✅ Utilize powerful analysis tools
Start here: karchinlab.github.io/oc_vignettes/
#Genomics #VariantAnnotation #OpenSource
📖 Learn to:
✅ Annotate variants
✅ Interpret results for clinical & research
✅ Utilize powerful analysis tools
Start here: karchinlab.github.io/oc_vignettes/
#Genomics #VariantAnnotation #OpenSource
🧬 We Want Your Feedback! 🧬\
Do you use variant annotation software? We’re gathering insights from the genomics community to improve OpenCRAVAT and understand what features matter most to you.💡 Take this quick survey (it takes less than 2 minutes!): https://shorturl.at/iOvMt
Do you use variant annotation software? We’re gathering insights from the genomics community to improve OpenCRAVAT and understand what features matter most to you.💡 Take this quick survey (it takes less than 2 minutes!): https://shorturl.at/iOvMt
February 22, 2025 at 10:53 PM
🧬 We Want Your Feedback! 🧬\
Do you use variant annotation software? We’re gathering insights from the genomics community to improve OpenCRAVAT and understand what features matter most to you.💡 Take this quick survey (it takes less than 2 minutes!): https://shorturl.at/iOvMt
Do you use variant annotation software? We’re gathering insights from the genomics community to improve OpenCRAVAT and understand what features matter most to you.💡 Take this quick survey (it takes less than 2 minutes!): https://shorturl.at/iOvMt
Have you seen our updated website? Head over to opencravat.org and check it out! 🖥🧪
OpenCRAVAT
mouse
buff.ly
January 19, 2025 at 10:14 PM
Have you seen our updated website? Head over to opencravat.org and check it out! 🖥🧪
Do you have research goals for 2025!? We'd love to hear them! #annotation #OpenCRAVAT #2025 🧪🖥
January 14, 2025 at 2:04 AM
Do you have research goals for 2025!? We'd love to hear them! #annotation #OpenCRAVAT #2025 🧪🖥
All OpenCRAVAT systems are back up!
January 6, 2025 at 4:29 PM
All OpenCRAVAT systems are back up!
❗We are experiencing a power outage at our data center due to the polar vortex. All OpenCRAVAT systems are currently down. We will update as systems come back online.
January 6, 2025 at 2:37 PM
❗We are experiencing a power outage at our data center due to the polar vortex. All OpenCRAVAT systems are currently down. We will update as systems come back online.
Day 12: 🎉 A Genomic Variant Community
Our community is at the heart of everything we do. From researchers to clinicians, your feedback shapes OpenCRAVAT's future. Join us in celebrating our shared journey in variant annotation. 💬 Connect with us: https://buff.ly/3ZQ1MZT 🖥️ 🧬 #Community #Genomics
Our community is at the heart of everything we do. From researchers to clinicians, your feedback shapes OpenCRAVAT's future. Join us in celebrating our shared journey in variant annotation. 💬 Connect with us: https://buff.ly/3ZQ1MZT 🖥️ 🧬 #Community #Genomics
December 12, 2024 at 2:00 PM
Day 12: 🎉 A Genomic Variant Community
Our community is at the heart of everything we do. From researchers to clinicians, your feedback shapes OpenCRAVAT's future. Join us in celebrating our shared journey in variant annotation. 💬 Connect with us: https://buff.ly/3ZQ1MZT 🖥️ 🧬 #Community #Genomics
Our community is at the heart of everything we do. From researchers to clinicians, your feedback shapes OpenCRAVAT's future. Join us in celebrating our shared journey in variant annotation. 💬 Connect with us: https://buff.ly/3ZQ1MZT 🖥️ 🧬 #Community #Genomics
⚙️ Day 11: Widgets That Work for You! Customization is 🔑! OpenCRAVAT’s widgets allow you to visualize variant data in a way that makes sense for your workflow.
🌐 Explore widgets: https://buff.ly/3DbcEbK
What’s your favorite widget?
#12DaysOfOpenCRAVAT #GenomicTools #Visualization🖥️ 🧬
🌐 Explore widgets: https://buff.ly/3DbcEbK
What’s your favorite widget?
#12DaysOfOpenCRAVAT #GenomicTools #Visualization🖥️ 🧬
December 11, 2024 at 11:00 PM
⚙️ Day 11: Widgets That Work for You! Customization is 🔑! OpenCRAVAT’s widgets allow you to visualize variant data in a way that makes sense for your workflow.
🌐 Explore widgets: https://buff.ly/3DbcEbK
What’s your favorite widget?
#12DaysOfOpenCRAVAT #GenomicTools #Visualization🖥️ 🧬
🌐 Explore widgets: https://buff.ly/3DbcEbK
What’s your favorite widget?
#12DaysOfOpenCRAVAT #GenomicTools #Visualization🖥️ 🧬
🧬 New Blog by Dr. Rachel Karchin!
Dr. Karchin shares how OpenCRAVAT and CIViC are addressing transparency and interpretability in variant effect predictors. Discover how calibrated predictors are transforming clinical variant classification. 🖥️ 🔗 Read the full post:
Dr. Karchin shares how OpenCRAVAT and CIViC are addressing transparency and interpretability in variant effect predictors. Discover how calibrated predictors are transforming clinical variant classification. 🖥️ 🔗 Read the full post:
Variant effect predictors in the clinic: Working with calibrated predictors in OpenCRAVAT
Computational methods for predicting the effects of genetic variants are used by clinicians for interpreting genetic test results and by researchers for scientific exploration. However, their utility…
buff.ly
December 10, 2024 at 12:46 PM
🧬 New Blog by Dr. Rachel Karchin!
Dr. Karchin shares how OpenCRAVAT and CIViC are addressing transparency and interpretability in variant effect predictors. Discover how calibrated predictors are transforming clinical variant classification. 🖥️ 🔗 Read the full post:
Dr. Karchin shares how OpenCRAVAT and CIViC are addressing transparency and interpretability in variant effect predictors. Discover how calibrated predictors are transforming clinical variant classification. 🖥️ 🔗 Read the full post: