A Michigan resident died of rabies after receiving a transplanted organ in Ohio, county health officials say.

Introduction Tree bacterial diseases are a threat in forestry due to their increasing incidence and severity. Understanding tree defence mechanisms requires evaluating metabolic changes arising during...

Antimicrobial resistance is still a problem today, with increasingly limited therapeutic options. St

Nature - Proteasomal degradation of cellular proteins generate defence peptides constitutively and in response to bacterial infection. Such peptides might provide a source of natural antibiotics...

Examination of immunological changes in transgender individuals undergoing gender-affirming testosterone treatment reveals sex hormone-regulated pathways in humans and explains sex-divergent responses...

A dire need exists for novel drugs to treat Mycobacterium tuberculosis infection. In an effort to build on our early efforts targeting the MenG enzyme within the menaquinone biosynthetic pathway, we have pursued the optimization of diaryl amide JSF-2911 to address its poor metabolic stability and modest in vitro potency. A hit evolution campaign focused on modification of the amine substructure within this hit compound, resulting in a range of analogues that have been profiled extensively. Among these derivatives, JSF-4536 and JSF-4898 demonstrated significantly improved biological profiles, notably offering submicromolar MIC values versus M. tuberculosis and promising values characterizing the mouse liver microsome stability, aqueous solubility, and mouse pharmacokinetic profile. JSF-4898 enhanced the efficacy of rifampicin in a subacute model of M. tuberculosis infection in mice. The findings suggest a rationale for the further optimization of MenG inhibitors to provide a novel therapeutic strategy to address M. tuberculosis infection.

Confidence in all types of vaccination has taken a hit. The question is why, and what can be done about it?

Kazachstania pintolopesii is a highly prevalent fungal symbiont that can trigger type 2 immunity and influence the composition of the gut mycobiome, as well as immune and disease phenotypes.

Scientific Reports - Regional variations in serum IL-35 levels and association with systemic lupus erythematosus: a systematic review and meta-analysis

Abstract. Entamoeba histolytica is considered the primary species causing the parasitic gastrointestinal infection amebiasis. A cluster of amebiasis infect

Scientific Reports - Regional variations in serum IL-35 levels and association with systemic lupus erythematosus: a systematic review and meta-analysis

Class A PBPs (aPBPs) play a key role in the biosynthesis and remodeling of peptidoglycan, the main c

Monocyte research reveals “doppelgänger” populations that resemble classical monocytes but differ in origin, function, or migration.

You will contribute to a range of research, teaching and administration. In addition you will be expected to demonstrate academic citizenship, developing and maintaining generous, mutually respectful ...

AbstractBackground. Evidence is limited about the comparative safety of antibiotic regimens for treatment of community-acquired pneumonia (CAP). We compare

With antibiotic resistance rapidly spreading, multidrug-resistant (MDR) Gram-negative bacteria (GNB) have become a major public health concern, threatening our ability to effectively treat bacterial i...