@nipagh.bsky.social
Ph.d. in immunolgy. T cells, tetramers, DNA barcodes, Espresso Martini, and the Tank/Healer in my local DnD group. 🇩🇰🏳️🌈.
Reposted
Our new paper is out in Nature - online today!
Huge congrats to shared first authors Sofía Ibáñez-Molero & Johanna Veldman, the whole team & all collaborators.
📄 Open-access paper: www.nature.com/articles/s41...
Huge congrats to shared first authors Sofía Ibáñez-Molero & Johanna Veldman, the whole team & all collaborators.
📄 Open-access paper: www.nature.com/articles/s41...
Tumour-reactive heterotypic CD8 T cell clusters from clinical samples - Nature
Tumour-reactive CD8+ T cells are enriched in functional clusters with tumour cells and/or antigen-presenting cells and can be isolated and expanded from clinical samples.
www.nature.com
November 19, 2025 at 9:00 PM
Our new paper is out in Nature - online today!
Huge congrats to shared first authors Sofía Ibáñez-Molero & Johanna Veldman, the whole team & all collaborators.
📄 Open-access paper: www.nature.com/articles/s41...
Huge congrats to shared first authors Sofía Ibáñez-Molero & Johanna Veldman, the whole team & all collaborators.
📄 Open-access paper: www.nature.com/articles/s41...
Sunday reading. I aspire to write something like this for T cells one day. www.cell.com/immunity/ful...
A roadmap for defining “extrafollicular” B cell responses
The term “extrafollicular” is now being used expansively to describe a variety of
B cell processes beyond the original use of the term, potentially obscuring important
distinct immunological processes...
www.cell.com
November 16, 2025 at 8:53 AM
Sunday reading. I aspire to write something like this for T cells one day. www.cell.com/immunity/ful...
Reposted
Epstein-Barr virus–mediated B cell reprogramming may initiate systemic lupus erythematosus
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/... @stanfordmedicine.bsky.social @shady-myounis.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/... @stanfordmedicine.bsky.social @shady-myounis.bsky.social
November 12, 2025 at 11:21 PM
Epstein-Barr virus–mediated B cell reprogramming may initiate systemic lupus erythematosus
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/... @stanfordmedicine.bsky.social @shady-myounis.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/... @stanfordmedicine.bsky.social @shady-myounis.bsky.social
Reposted
Dear single-cell bluesky community: We’re running Cell Ranger (5’ scRNA-seq) on sorted human CD8+ T cells with a custom library. Custom seqs (27–133 bp) appear in FASTQs + BAM but aren’t mapped. They are filtered out by STAR for being too short—any way to lower the length limit or workaround?
November 3, 2025 at 10:16 AM
Dear single-cell bluesky community: We’re running Cell Ranger (5’ scRNA-seq) on sorted human CD8+ T cells with a custom library. Custom seqs (27–133 bp) appear in FASTQs + BAM but aren’t mapped. They are filtered out by STAR for being too short—any way to lower the length limit or workaround?
Me as a PhD student:"I hate how useful this is".
Me as a Postdoc: "I LOVE HOW USEFUL THIS IS".
Me as a Postdoc: "I LOVE HOW USEFUL THIS IS".
October 30, 2025 at 11:34 AM
Me as a PhD student:"I hate how useful this is".
Me as a Postdoc: "I LOVE HOW USEFUL THIS IS".
Me as a Postdoc: "I LOVE HOW USEFUL THIS IS".
Reposted
Mapping of CD8 T-cell recognition to latent EBV infection and neuroantigens reveals HLA-specific depletion of T-cell responses in multiple sclerosis https://www.biorxiv.org/content/10.1101/2025.10.23.682742v1
October 24, 2025 at 1:15 PM
Mapping of CD8 T-cell recognition to latent EBV infection and neuroantigens reveals HLA-specific depletion of T-cell responses in multiple sclerosis https://www.biorxiv.org/content/10.1101/2025.10.23.682742v1
Reposted
If the immune system is an army...
...
would you rather rely on one “super warrior” — or on a diverse team of fighters, even if none of them is the single strongest?
I’d go with the team.
Why? Check out our new study, just published in Science Immunology: www.science.org/doi/10.1126/...
...
would you rather rely on one “super warrior” — or on a diverse team of fighters, even if none of them is the single strongest?
I’d go with the team.
Why? Check out our new study, just published in Science Immunology: www.science.org/doi/10.1126/...
October 3, 2025 at 6:07 PM
If the immune system is an army...
...
would you rather rely on one “super warrior” — or on a diverse team of fighters, even if none of them is the single strongest?
I’d go with the team.
Why? Check out our new study, just published in Science Immunology: www.science.org/doi/10.1126/...
...
would you rather rely on one “super warrior” — or on a diverse team of fighters, even if none of them is the single strongest?
I’d go with the team.
Why? Check out our new study, just published in Science Immunology: www.science.org/doi/10.1126/...
Reposted
When a T cell carries both its natural TCR and an engineered CAR, do these two receptors cooperate - or compete?
Our new preprint on bioRxiv shows that TCR activation can enhance CAR-T activation but impairs CAR-mediated killing when targets are on separate cells.
www.biorxiv.org/content/10.1...
Our new preprint on bioRxiv shows that TCR activation can enhance CAR-T activation but impairs CAR-mediated killing when targets are on separate cells.
www.biorxiv.org/content/10.1...
TCR activation impairs CAR-T cytotoxicity against separate target cells
Chimeric antigen receptor T cells (CAR-T) are effective therapeutics against cancer and autoimmunity, but whether the endogenous T cell receptor (TCR) is beneficial, detrimental or irrelevant for CAR ...
www.biorxiv.org
October 8, 2025 at 6:06 AM
When a T cell carries both its natural TCR and an engineered CAR, do these two receptors cooperate - or compete?
Our new preprint on bioRxiv shows that TCR activation can enhance CAR-T activation but impairs CAR-mediated killing when targets are on separate cells.
www.biorxiv.org/content/10.1...
Our new preprint on bioRxiv shows that TCR activation can enhance CAR-T activation but impairs CAR-mediated killing when targets are on separate cells.
www.biorxiv.org/content/10.1...
Reposted
Sometimes, knocking out a gene isn't a good way to figure out the function of that gene ...
In our new @jcellsci.bsky.social paper, we report potent transcriptional adaptation by cytotoxic T lymphocytes (CTLs) in response to CRISPR/Cas9-mediated deletion of the important polarity protein CDC42 🧵⬇️
In our new @jcellsci.bsky.social paper, we report potent transcriptional adaptation by cytotoxic T lymphocytes (CTLs) in response to CRISPR/Cas9-mediated deletion of the important polarity protein CDC42 🧵⬇️
August 4, 2025 at 7:31 PM
Sometimes, knocking out a gene isn't a good way to figure out the function of that gene ...
In our new @jcellsci.bsky.social paper, we report potent transcriptional adaptation by cytotoxic T lymphocytes (CTLs) in response to CRISPR/Cas9-mediated deletion of the important polarity protein CDC42 🧵⬇️
In our new @jcellsci.bsky.social paper, we report potent transcriptional adaptation by cytotoxic T lymphocytes (CTLs) in response to CRISPR/Cas9-mediated deletion of the important polarity protein CDC42 🧵⬇️
Reposted
De novo identification of the specificities of recurrent human T cell receptors https://www.biorxiv.org/content/10.1101/2025.08.03.668342v1
August 5, 2025 at 4:22 AM
De novo identification of the specificities of recurrent human T cell receptors https://www.biorxiv.org/content/10.1101/2025.08.03.668342v1
Reposted
Writing a technical blog improves your writing, forces you to learn new things, helps others and yourself, and helps your career. In this essay: (1) why blog, (2) what to blog about, (3) how to get started, and (4) using AI. https://doi.org/10.59350/bqnfd-7p249 🧪
Technical blogging for growth and learning
Writing a technical blog improves your writing, forces you to learn new things, helps others and yourself, and helps your career. This post: why blog, what to blog about, how to start, and using AI.
doi.org
January 25, 2025 at 4:00 PM
Writing a technical blog improves your writing, forces you to learn new things, helps others and yourself, and helps your career. In this essay: (1) why blog, (2) what to blog about, (3) how to get started, and (4) using AI. https://doi.org/10.59350/bqnfd-7p249 🧪
Double negative T cells can act as professional APCs capable of tolerance induction? How fascinating - I'm picturing a western stand-off between two T cells (both equipped with granzymes btw) unwilling to let go of the other!
Intestinal CD4−CD8αβ−TCRαβ+ T cells function as tolerogenic antigen presenting cells in mice
@natcomms.nature.com
www.nature.com/articles/s41...
@natcomms.nature.com
www.nature.com/articles/s41...
August 2, 2025 at 7:28 AM
Double negative T cells can act as professional APCs capable of tolerance induction? How fascinating - I'm picturing a western stand-off between two T cells (both equipped with granzymes btw) unwilling to let go of the other!
Reposted
Intestinal CD4−CD8αβ−TCRαβ+ T cells function as tolerogenic antigen presenting cells in mice
@natcomms.nature.com
www.nature.com/articles/s41...
@natcomms.nature.com
www.nature.com/articles/s41...
August 2, 2025 at 3:27 AM
Intestinal CD4−CD8αβ−TCRαβ+ T cells function as tolerogenic antigen presenting cells in mice
@natcomms.nature.com
www.nature.com/articles/s41...
@natcomms.nature.com
www.nature.com/articles/s41...
Reposted
Autoantibodies against cytokines, growth factors, immunoreceptors, & tumor surface proteins robustly modulate immune checkpoint inhibition therapy response @aaronmring.bsky.social @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
July 23, 2025 at 5:47 PM
Autoantibodies against cytokines, growth factors, immunoreceptors, & tumor surface proteins robustly modulate immune checkpoint inhibition therapy response @aaronmring.bsky.social @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted
Excited to share a new preprint from the lab with @ryandhindsa.bsky.social ! www.biorxiv.org/content/10.1...
Led by @sherrynyeo.bsky.social, @erinmayc.bsky.social, and friends, we continue our journey to find viral DNA in our favorite place-- the overlooked and discarded reads in existing data! 1/
Led by @sherrynyeo.bsky.social, @erinmayc.bsky.social, and friends, we continue our journey to find viral DNA in our favorite place-- the overlooked and discarded reads in existing data! 1/
July 22, 2025 at 9:59 PM
Excited to share a new preprint from the lab with @ryandhindsa.bsky.social ! www.biorxiv.org/content/10.1...
Led by @sherrynyeo.bsky.social, @erinmayc.bsky.social, and friends, we continue our journey to find viral DNA in our favorite place-- the overlooked and discarded reads in existing data! 1/
Led by @sherrynyeo.bsky.social, @erinmayc.bsky.social, and friends, we continue our journey to find viral DNA in our favorite place-- the overlooked and discarded reads in existing data! 1/
My last history lesson in school was in 2012. Today I realized that my memory is blank on certain events outside biology, many probably. Fx. I had no idea the EU includes illegal activities in calculating GDP. The amount of colorful assumptions as to how much this contributes to GDP must be wild!
July 21, 2025 at 2:37 PM
My last history lesson in school was in 2012. Today I realized that my memory is blank on certain events outside biology, many probably. Fx. I had no idea the EU includes illegal activities in calculating GDP. The amount of colorful assumptions as to how much this contributes to GDP must be wild!
Reposted
Early identification of individuals at risk for multiple sclerosis by quantification of EBNA-1381-452-specific antibody titers @natcomms.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
July 14, 2025 at 2:40 PM
Early identification of individuals at risk for multiple sclerosis by quantification of EBNA-1381-452-specific antibody titers @natcomms.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted
Wow, when lower IFN in aging is a good thing! Congratulations Chaz L and team. #ImmuneProfiling
#Aging Epigenetic attenuation of interferon signaling is associated with aging-related improvements in systemic lupus erythematosus | Science Translational Medicine www.science.org/doi/10.1126/...
#Aging Epigenetic attenuation of interferon signaling is associated with aging-related improvements in systemic lupus erythematosus | Science Translational Medicine www.science.org/doi/10.1126/...
Epigenetic attenuation of interferon signaling is associated with aging-related improvements in systemic lupus erythematosus
Patients with systemic lupus erythematosus exhibit aging-related decreases in interferon signaling that correlate with improved disease activity.
www.science.org
June 27, 2025 at 3:19 PM
Wow, when lower IFN in aging is a good thing! Congratulations Chaz L and team. #ImmuneProfiling
#Aging Epigenetic attenuation of interferon signaling is associated with aging-related improvements in systemic lupus erythematosus | Science Translational Medicine www.science.org/doi/10.1126/...
#Aging Epigenetic attenuation of interferon signaling is associated with aging-related improvements in systemic lupus erythematosus | Science Translational Medicine www.science.org/doi/10.1126/...
Reposted
#ToStressOrNotToStress! @christinviral.bsky.social @cadwelllab.bsky.social show @naturemicrobiol.nature.com that stress drives #interferon stimulated genes to protect against an enteric virus! After immune suppression by stress-induced glucorticoids, CD8 T cells get activated protecting the host!
Environmental stress drives clearance of a persistent enteric virus in mice - Nature Microbiology
Cage change of mice with persistent murine astrovirus infection triggers stress responses marked by corticosterone fluctuation, which is followed by CD8 T cell activation and induction of epithelial a...
www.nature.com
June 26, 2025 at 11:50 AM
#ToStressOrNotToStress! @christinviral.bsky.social @cadwelllab.bsky.social show @naturemicrobiol.nature.com that stress drives #interferon stimulated genes to protect against an enteric virus! After immune suppression by stress-induced glucorticoids, CD8 T cells get activated protecting the host!
Outright banning ChatGPT? Like a commenter said, chess robots have been instrumental in teaching chess, so why can't AI be a way to teach better scientific writing? "ChatGPT is fun, but not an author" | Science www.science.org/doi/10.1126/...
ChatGPT is fun, but not an author
In less than 2 months, the artificial intelligence (AI) program ChatGPT has become a cultural sensation. It is freely accessible through a web portal created by the tool’s developer, OpenAI. The progr...
www.science.org
June 22, 2025 at 2:49 PM
Outright banning ChatGPT? Like a commenter said, chess robots have been instrumental in teaching chess, so why can't AI be a way to teach better scientific writing? "ChatGPT is fun, but not an author" | Science www.science.org/doi/10.1126/...
A perfect date in Erlangen for me really is June 19th. Summer, green parks, a long weekend ahead, and nobody in sight!
June 19, 2025 at 7:31 AM
A perfect date in Erlangen for me really is June 19th. Summer, green parks, a long weekend ahead, and nobody in sight!
Absolutely fascinating work.
""In this vein, we contend that future incorporation of physiological microbial exposure into animal models may offer translational value to the study of brain health and disease.""
(most? any? some?) Infections create a T cell memory in the brain.
""In this vein, we contend that future incorporation of physiological microbial exposure into animal models may offer translational value to the study of brain health and disease.""
(most? any? some?) Infections create a T cell memory in the brain.
Physiological microbial exposure normalizes memory T cell surveillance of the brain and modifies host seizure outcomes @natimmunol.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
June 13, 2025 at 2:46 PM
Absolutely fascinating work.
""In this vein, we contend that future incorporation of physiological microbial exposure into animal models may offer translational value to the study of brain health and disease.""
(most? any? some?) Infections create a T cell memory in the brain.
""In this vein, we contend that future incorporation of physiological microbial exposure into animal models may offer translational value to the study of brain health and disease.""
(most? any? some?) Infections create a T cell memory in the brain.
Reposted
Physiological microbial exposure normalizes memory T cell surveillance of the brain and modifies host seizure outcomes @natimmunol.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
June 13, 2025 at 2:29 PM
Physiological microbial exposure normalizes memory T cell surveillance of the brain and modifies host seizure outcomes @natimmunol.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted
Really interesting new study on CD8+ T cells in MS from @ali-syedaliraza.bsky.social and Danny Reich
Maintenance of chronic neuroinflammation in multiple sclerosis via interferon signaling and CD8 T cell-mediated cytotoxicity https://www.biorxiv.org/content/10.1101/2025.06.09.658729v1
June 11, 2025 at 2:55 PM
Really interesting new study on CD8+ T cells in MS from @ali-syedaliraza.bsky.social and Danny Reich
Reposted
CSF single-cell RNA sequencing reveals clonally expanded CD4+ stem cell-like memory T cells in GAD65-antibody associated neurological syndromes https://www.biorxiv.org/content/10.1101/2025.05.18.654720v1
May 23, 2025 at 7:16 AM
CSF single-cell RNA sequencing reveals clonally expanded CD4+ stem cell-like memory T cells in GAD65-antibody associated neurological syndromes https://www.biorxiv.org/content/10.1101/2025.05.18.654720v1