Nicky McGranahan
@nickymcgranahan.bsky.social
Professor of Cancer Evolution. UCL Cancer Institute. Interested in cancer genomics, bioinformatics, and somatic evolution.
https://www.ucl.ac.uk/medical-sciences/divisions/cancer/our-research/cancer-genome-evolution
https://www.ucl.ac.uk/medical-sciences/divisions/cancer/our-research/cancer-genome-evolution
Reposted by Nicky McGranahan
Paul Nurse describing the main job of a PI
(From ‘The Thinking Game’, 2024)
(From ‘The Thinking Game’, 2024)
October 31, 2025 at 8:45 AM
Paul Nurse describing the main job of a PI
(From ‘The Thinking Game’, 2024)
(From ‘The Thinking Game’, 2024)
I wanted my first @bsky.app post to be witty, thoughtful & somewhat self-depreciating. I wanted to make sure I could highlight all the exciting computational cancer evolution research my lab does, without sounding too arrogant. But, instead I posted this. (At least it's within the character limit.)
October 13, 2025 at 10:13 AM
I wanted my first @bsky.app post to be witty, thoughtful & somewhat self-depreciating. I wanted to make sure I could highlight all the exciting computational cancer evolution research my lab does, without sounding too arrogant. But, instead I posted this. (At least it's within the character limit.)
Reposted by Nicky McGranahan
An excellent systematic analysis of RBPs by @quaidmorris.bsky.social and colleagues (with a tiny contribution from us) #RNAsky #RNAbiology
New in @natbiotech.nature.com: a team led by scientists at MSK and University of Toronto have developed a new platform to facilitate the study of RNA-biding proteins (RBPs) across hundreds of species of plants, insects, and animals.
A resource of RNA-binding protein motifs across eukaryotes reveals evolutionary dynamics and gene-regulatory function - Nature Biotechnology
RNA-binding motifs in eukaryotic proteins are presented in a comprehensive resource.
www.nature.com
July 29, 2025 at 1:41 AM
An excellent systematic analysis of RBPs by @quaidmorris.bsky.social and colleagues (with a tiny contribution from us) #RNAsky #RNAbiology
Reposted by Nicky McGranahan
Studying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...
Fluctuating DNA methylation tracks cancer evolution at clinical scale - Nature
Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.
www.nature.com
September 10, 2025 at 3:21 PM
Studying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...
Reposted by Nicky McGranahan
Very excited to share our new paper on the influence of biological sex and smoking in the clonal landscape of normal human bladder, just published in Nature.
A big thank you and congrats to all the authors, specially to @raquelbmi.bsky.social for all the shared efforts in this journey!
⬇️More info⬇️
A big thank you and congrats to all the authors, specially to @raquelbmi.bsky.social for all the shared efforts in this journey!
⬇️More info⬇️
🚨 New paper alert!
Sex and smoking bias in the selection of somatic mutations in human bladder
www.nature.com/articles/s41...
by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)
Sex and smoking bias in the selection of somatic mutations in human bladder
www.nature.com/articles/s41...
by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)
Sex and smoking bias in the selection of somatic mutations in human bladder - Nature
Sex bias and association with smoking history identified in the landscape of driver mutations and clonal expansions in normal human bladder tissue may explain the higher bladder cancer risk in men and smokers.
www.nature.com
October 8, 2025 at 6:04 PM
Very excited to share our new paper on the influence of biological sex and smoking in the clonal landscape of normal human bladder, just published in Nature.
A big thank you and congrats to all the authors, specially to @raquelbmi.bsky.social for all the shared efforts in this journey!
⬇️More info⬇️
A big thank you and congrats to all the authors, specially to @raquelbmi.bsky.social for all the shared efforts in this journey!
⬇️More info⬇️
Reposted by Nicky McGranahan
Clone copy number diversity is linked to survival in lung cancer @nature.com @zaccasimo.bsky.social @nickymcgranahan.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 13, 2025 at 6:23 PM
Clone copy number diversity is linked to survival in lung cancer @nature.com @zaccasimo.bsky.social @nickymcgranahan.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...