Nicole Hoitsma
@nhoitsma.bsky.social
Reposted by Nicole Hoitsma
Thrilled to share our lab’s latest work in JBC! 🎉 We uncovered a critical role for APE1 Asn174 in stabilizing AP-sites using mutagenesis, enzymology, crystallography, and MD-simulations. Congrats to Kaitlin Dehart and all the co-authors! Check it out: www.jbc.org/article/S002...
APE1 active site residue Asn174 stabilizes the AP-site and is essential for catalysis
Apurinic/Apyrimidinic (AP)-sites are common and highly mutagenic DNA lesions that
can arise spontaneously or as intermediates during Base Excision Repair (BER). The
enzyme apurinic/apyrimidinic endonu...
www.jbc.org
September 5, 2025 at 4:44 PM
Thrilled to share our lab’s latest work in JBC! 🎉 We uncovered a critical role for APE1 Asn174 in stabilizing AP-sites using mutagenesis, enzymology, crystallography, and MD-simulations. Congrats to Kaitlin Dehart and all the co-authors! Check it out: www.jbc.org/article/S002...
Reposted by Nicole Hoitsma
My lab is looking to hire a Postdoc to study mechanisms of DNA repair in chromatin using biochemical, biophysical, and structural biology approaches! Feel free to share with anyone you think may be interested.
jobs.virginia.edu/us/en/job/R0...
jobs.virginia.edu/us/en/job/R0...
Postdoctoral Research Associate in Biochemistry and Molecular Genetics – Weaver Lab in Charlottesville, Virginia, United States of America | Research at University of Virginia
Apply for Postdoctoral Research Associate in Biochemistry and Molecular Genetics – Weaver Lab job with University of Virginia in Charlottesville, Virginia, United States of America. Research at Univer...
jobs.virginia.edu
January 16, 2025 at 8:35 PM
My lab is looking to hire a Postdoc to study mechanisms of DNA repair in chromatin using biochemical, biophysical, and structural biology approaches! Feel free to share with anyone you think may be interested.
jobs.virginia.edu/us/en/job/R0...
jobs.virginia.edu/us/en/job/R0...
Reposted by Nicole Hoitsma
Our paper on the strange ATP-dependent chromatin remodeler Smarcad1 paper is out and freely accessible. Differential regulation of its many activities by phosphorylation. Congrats to Briana and @nhoitsma.bsky.social 🧪https://www.sciencedirect.com/science/article/pii/S0021925824023950?via%3Dihub
Phosphorylation regulates the chromatin remodeler SMARCAD1 in nucleosome binding, ATP hydrolysis, and histone exchange
Maintaining the dynamic structure of chromatin is critical for regulating the cellular processes that require access to the DNA template, such as DNA …
www.sciencedirect.com
November 18, 2024 at 8:48 PM
Our paper on the strange ATP-dependent chromatin remodeler Smarcad1 paper is out and freely accessible. Differential regulation of its many activities by phosphorylation. Congrats to Briana and @nhoitsma.bsky.social 🧪https://www.sciencedirect.com/science/article/pii/S0021925824023950?via%3Dihub
Reposted by Nicole Hoitsma
Not to take anything away from the fantastic scientists who were recognized this year, and unreservedly applauding the choices.... but i guess we are back to all guys now for the STEM Nobels. Just an observation..... 🧪👩🔬
October 9, 2024 at 10:31 AM
Not to take anything away from the fantastic scientists who were recognized this year, and unreservedly applauding the choices.... but i guess we are back to all guys now for the STEM Nobels. Just an observation..... 🧪👩🔬