Natalie Krahmer
@nataliekrahmer.bsky.social
Group leader at Helmholtz Diabetes Center Munich. ❤️lipid droplets/ organelles/ proteomics/ metabolism/ running
Reposted by Natalie Krahmer
Our paper on ovarian cancer #LGSC is out in @Cancer_Cell. Using deep visual proteomics #DVP and spatial transcriptomics, we mapped how non-invasive tumors become deadly ovarian disease, and found a promising new treatment combination.
www.cell.com/cancer-cell/...
www.cell.com/cancer-cell/...
Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression
Schweizer et al. profile the tumor progression from non-invasive serous borderline
tumors of the ovary to metastatic low-grade serous ovarian cancer. By integrating
cell-type resolved Deep Visual Prot...
www.cell.com
June 26, 2025 at 3:20 PM
Our paper on ovarian cancer #LGSC is out in @Cancer_Cell. Using deep visual proteomics #DVP and spatial transcriptomics, we mapped how non-invasive tumors become deadly ovarian disease, and found a promising new treatment combination.
www.cell.com/cancer-cell/...
www.cell.com/cancer-cell/...
Reposted by Natalie Krahmer
Thrilled to share that our manuscript mapping proteomic & phosphoproteomic signatures of NGT, T2D, males & females — before and after hyperinsulinemic-euglycemic clamp — is now accepted in Cell.
@annakrook.bsky.social @juleenrzierath.bsky.social
@cbmr.science
doi.org/10.1016/j.ce...
@annakrook.bsky.social @juleenrzierath.bsky.social
@cbmr.science
doi.org/10.1016/j.ce...
Redirecting
doi.org
May 27, 2025 at 7:15 PM
Thrilled to share that our manuscript mapping proteomic & phosphoproteomic signatures of NGT, T2D, males & females — before and after hyperinsulinemic-euglycemic clamp — is now accepted in Cell.
@annakrook.bsky.social @juleenrzierath.bsky.social
@cbmr.science
doi.org/10.1016/j.ce...
@annakrook.bsky.social @juleenrzierath.bsky.social
@cbmr.science
doi.org/10.1016/j.ce...
Reposted by Natalie Krahmer
There a lot of use of NAD+ supplements out there, without evidence of anti-aging effects in people. Here's some new data that detracts from NAD's role in modulating the aging process
www.cell.com/cell-metabol...
www.cell.com/cell-metabol...
NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging
NAD depletion in skeletal muscle does not impair tissue integrity and function or
accelerate aging, as shown in a mouse model with an 85% decrease in muscle NAD+ levels.
Muscle structure, metabolism, ...
www.cell.com
April 30, 2025 at 7:00 PM
There a lot of use of NAD+ supplements out there, without evidence of anti-aging effects in people. Here's some new data that detracts from NAD's role in modulating the aging process
www.cell.com/cell-metabol...
www.cell.com/cell-metabol...
Reposted by Natalie Krahmer
April 28, 2025 at 2:03 PM
Reposted by Natalie Krahmer
My story about @kevinh-phd.bsky.social, nutrition and metabolism scientist at N.I.H., who felt compelled to take early retirement after experiencing censorship of his work under the new administration. www.nytimes.com/2025/04/16/w...
Leading Nutrition Scientist Departs N.I.H., Citing Censorship (Gift Article)
Kevin Hall said his work on ultraprocessed foods has been “hobbled” under the Trump administration. Scientists have been raising such concerns for months.
www.nytimes.com
April 16, 2025 at 10:27 PM
My story about @kevinh-phd.bsky.social, nutrition and metabolism scientist at N.I.H., who felt compelled to take early retirement after experiencing censorship of his work under the new administration. www.nytimes.com/2025/04/16/w...
Reposted by Natalie Krahmer
After 21 years at my dream job, I’m very sad to announce my early retirement from the National Institutes of Health. My life’s work has been to scientifically study how our food environment affects what we eat, and how what we eat affects our physiology.
April 16, 2025 at 9:00 PM
After 21 years at my dream job, I’m very sad to announce my early retirement from the National Institutes of Health. My life’s work has been to scientifically study how our food environment affects what we eat, and how what we eat affects our physiology.
Reposted by Natalie Krahmer
Our paper is out in Nature today! We use Deep Visual Proteomics (DVP) to dissect α1-antitrypsin deficiency (AATD) in human liver at single-cell resolution.
Let us take a tour through proteotoxic stress in intact human tissue — one hepatocyte at a time.
www.nature.com/articles/s41...
Let us take a tour through proteotoxic stress in intact human tissue — one hepatocyte at a time.
www.nature.com/articles/s41...
Deep Visual Proteomics maps proteotoxicity in a genetic liver disease - Nature
High-resolution spatial proteomics were used to map molecular events during hepatocyte stress in pseudotime across all fibrosis stages, recapitulating known disease progression markers and revealing e...
www.nature.com
April 16, 2025 at 3:16 PM
Our paper is out in Nature today! We use Deep Visual Proteomics (DVP) to dissect α1-antitrypsin deficiency (AATD) in human liver at single-cell resolution.
Let us take a tour through proteotoxic stress in intact human tissue — one hepatocyte at a time.
www.nature.com/articles/s41...
Let us take a tour through proteotoxic stress in intact human tissue — one hepatocyte at a time.
www.nature.com/articles/s41...
Reposted by Natalie Krahmer
I am a professor at Columbia University. All of the student NIH training grants have been canceled and now there are reports that ALL funding will be frozen. Why are Universities not banding together and speaking out publicly and forcibly about governmental attacks on biomedical research?
April 11, 2025 at 4:53 PM
I am a professor at Columbia University. All of the student NIH training grants have been canceled and now there are reports that ALL funding will be frozen. Why are Universities not banding together and speaking out publicly and forcibly about governmental attacks on biomedical research?
Reposted by Natalie Krahmer
😢 this is not normal. And we should not turn away from this illegal BS!
This, about a dedicated young researcher who found joy in her science, gutted me.
“She does not even complain much about life in detention. If she had access to a laptop, and could analyze data from her laboratory at Harvard, “it would be good enough,” she said.”
www.nytimes.com/2025/04/11/s...
“She does not even complain much about life in detention. If she had access to a laptop, and could analyze data from her laboratory at Harvard, “it would be good enough,” she said.”
www.nytimes.com/2025/04/11/s...
She Worked in a Harvard Lab to Reverse Aging, Until ICE Jailed Her (Gift Article)
President Trump’s immigration crackdown ensnared Kseniia Petrova, a scientist who fled Russia after protesting its invasion of Ukraine. She fears arrest if she is deported there.
www.nytimes.com
April 13, 2025 at 2:15 PM
😢 this is not normal. And we should not turn away from this illegal BS!
Reposted by Natalie Krahmer
“It is up to all of us to fix this. It’s not going to be because somebody comes and saves you.” - President Obama yesterday
We must organize the pro-democracy majority to reclaim its power. Join an event near you for tomorrow’s nationwide day of action: handsoff2025.com?SQF_SOURCE=i...
We must organize the pro-democracy majority to reclaim its power. Join an event near you for tomorrow’s nationwide day of action: handsoff2025.com?SQF_SOURCE=i...
April 5, 2025 at 12:20 AM
“It is up to all of us to fix this. It’s not going to be because somebody comes and saves you.” - President Obama yesterday
We must organize the pro-democracy majority to reclaim its power. Join an event near you for tomorrow’s nationwide day of action: handsoff2025.com?SQF_SOURCE=i...
We must organize the pro-democracy majority to reclaim its power. Join an event near you for tomorrow’s nationwide day of action: handsoff2025.com?SQF_SOURCE=i...
Reposted by Natalie Krahmer
Eine freie Wissenschaft gehört zum Kern liberaler, demokratischer Gesellschaften.
Es ist in höchstem Maße besorgniserregend, dass die Freiheit der Wissenschaft in verschiedenen Regionen der Welt zunehmend unter Druck gerät.
Es ist in höchstem Maße besorgniserregend, dass die Freiheit der Wissenschaft in verschiedenen Regionen der Welt zunehmend unter Druck gerät.
March 26, 2025 at 4:44 PM
Eine freie Wissenschaft gehört zum Kern liberaler, demokratischer Gesellschaften.
Es ist in höchstem Maße besorgniserregend, dass die Freiheit der Wissenschaft in verschiedenen Regionen der Welt zunehmend unter Druck gerät.
Es ist in höchstem Maße besorgniserregend, dass die Freiheit der Wissenschaft in verschiedenen Regionen der Welt zunehmend unter Druck gerät.
Reposted by Natalie Krahmer
With everything happening in the US right now, how safe are scientific conferences for foreign participants in the US? I think this is something we have to discuss as a scientific community. I am hesitating to register for US meetings due to the unpredictable situation. Others who feel the same?
March 19, 2025 at 8:03 AM
With everything happening in the US right now, how safe are scientific conferences for foreign participants in the US? I think this is something we have to discuss as a scientific community. I am hesitating to register for US meetings due to the unpredictable situation. Others who feel the same?
Reposted by Natalie Krahmer
Beautiful, powerful letter
I have been asked by Harvard colleagues if they should keep quiet so as not put the larger Harvard community at risk with their words
Took me a while to ruminate
My response:
Harvard is its people and their voices
If we are silent then there is no Harvard to save
I have been asked by Harvard colleagues if they should keep quiet so as not put the larger Harvard community at risk with their words
Took me a while to ruminate
My response:
Harvard is its people and their voices
If we are silent then there is no Harvard to save
Agreed. We are speaking up where we can.
docs.google.com/document/d/1...
docs.google.com/document/d/1...
A Statement by Teachers College, Columbia University Faculty
A Statement by Teachers College, Columbia University Faculty The Attack on American Education, from our Perspective as Teachers College Faculty March 19, 2025 We are a group of Teachers College facult...
docs.google.com
March 20, 2025 at 1:01 AM
Beautiful, powerful letter
I have been asked by Harvard colleagues if they should keep quiet so as not put the larger Harvard community at risk with their words
Took me a while to ruminate
My response:
Harvard is its people and their voices
If we are silent then there is no Harvard to save
I have been asked by Harvard colleagues if they should keep quiet so as not put the larger Harvard community at risk with their words
Took me a while to ruminate
My response:
Harvard is its people and their voices
If we are silent then there is no Harvard to save
Reposted by Natalie Krahmer
While, in a nice collaboration with the Carvalho lab and @joanavferreira.bsky.social, PhD student Yara Ahmed used MD simulations to characterize the binding mechanism of the Dysferlin domain of Pex30 to phosphatidic acid. Anyone interested in a novel PA-sensor? (2/2)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Pex30-dependent membrane contacts sites maintain ER lipid homeostasis
In eukaryotic cells, communication between organelles and the coordination of their activities depend on membrane contact sites (MCS). How MCS are regulated under the dynamic cellular environment rema...
www.biorxiv.org
March 19, 2025 at 3:34 PM
While, in a nice collaboration with the Carvalho lab and @joanavferreira.bsky.social, PhD student Yara Ahmed used MD simulations to characterize the binding mechanism of the Dysferlin domain of Pex30 to phosphatidic acid. Anyone interested in a novel PA-sensor? (2/2)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Natalie Krahmer
It is important at this pivotal moment to @standupforscience.bsky.social. Looking forward to sharing my thoughts on why this should be a national priority at tomorrow’s rally in SF:
March 5, 2025 at 4:54 PM
It is important at this pivotal moment to @standupforscience.bsky.social. Looking forward to sharing my thoughts on why this should be a national priority at tomorrow’s rally in SF:
Reposted by Natalie Krahmer
Time to fight !
Trump 2.0: an assault on science anywhere is an assault on science everywhere
US President Donald Trump is taking a wrecking ball to science and to international institutions. The global research community must take a stand against these attacks.
www.nature.com
March 5, 2025 at 6:03 PM
Time to fight !
Reposted by Natalie Krahmer
@moiradonegan.bsky.social: „Now, the Democrats seem less like a resistance than an acquiescence. They are not mounting any meaningful opposition to Trump’s aggressive, sadistic mission. Instead they’re rolling over, like a submissive dog showing its belly, …“ www.theguardian.com/commentisfre...
Why are the Democrats so spineless? | Moira Donegan
No wonder the American public thinks of Democrats as out of touch, opportunistic and cowardly. That is because they are
www.theguardian.com
March 5, 2025 at 4:57 PM
@moiradonegan.bsky.social: „Now, the Democrats seem less like a resistance than an acquiescence. They are not mounting any meaningful opposition to Trump’s aggressive, sadistic mission. Instead they’re rolling over, like a submissive dog showing its belly, …“ www.theguardian.com/commentisfre...
Reposted by Natalie Krahmer
One week left to register! Registration possible until the 28th of February. Do not miss this chance! 🔥
We would like to welcome you to our second International Conference on Brown and Beige Fat
March 31st - April 02nd 2025
Top-class speakers, cutting edge research and respected experts will come together in beautiful Bonn.
Registration is open!
www.trr333.uni-bonn.de/batenergy-sy...
February 21, 2025 at 5:01 PM
One week left to register! Registration possible until the 28th of February. Do not miss this chance! 🔥
Reposted by Natalie Krahmer
The self censorship and appeasement by *National Academies of science* is really disturbing.
How do you stand for science and freedom of academic research when you self censor terms such as “health equity”?
It really takes you back to dark, dark days…
How do you stand for science and freedom of academic research when you self censor terms such as “health equity”?
It really takes you back to dark, dark days…
National Academies is altering pending reports to appease Trump administration, some members say
Words such as “health equity” are being replacing with vaguer terms, and 100 members sent a letter of protest to NASEM leaders.
www.statnews.com
February 21, 2025 at 6:07 PM
The self censorship and appeasement by *National Academies of science* is really disturbing.
How do you stand for science and freedom of academic research when you self censor terms such as “health equity”?
It really takes you back to dark, dark days…
How do you stand for science and freedom of academic research when you self censor terms such as “health equity”?
It really takes you back to dark, dark days…
Our new fashion collection for future mass spectrometrists 🤩 designed by Eva Trautmann
February 21, 2025 at 6:02 PM
Our new fashion collection for future mass spectrometrists 🤩 designed by Eva Trautmann
A great resource for the field of adipose tissue biology! Check it out
#Adiposetissue.org: New Knowledge Portal Enhances Obesity and Metabolism Research
👉 Discover more about the platform in our news: t1p.de/cogg2
@ki.se #HelmholtzMunich
#ObesityResearch #Metabolism #Bioinformatics #AdiposeTissue #Obesity #Diabetes #HI_MAGLeipzig #metabolism
👉 Discover more about the platform in our news: t1p.de/cogg2
@ki.se #HelmholtzMunich
#ObesityResearch #Metabolism #Bioinformatics #AdiposeTissue #Obesity #Diabetes #HI_MAGLeipzig #metabolism
February 20, 2025 at 4:38 PM
A great resource for the field of adipose tissue biology! Check it out
Reposted by Natalie Krahmer
#Adiposetissue.org: New Knowledge Portal Enhances Obesity and Metabolism Research
👉 Discover more about the platform in our news: t1p.de/cogg2
@ki.se #HelmholtzMunich
#ObesityResearch #Metabolism #Bioinformatics #AdiposeTissue #Obesity #Diabetes #HI_MAGLeipzig #metabolism
👉 Discover more about the platform in our news: t1p.de/cogg2
@ki.se #HelmholtzMunich
#ObesityResearch #Metabolism #Bioinformatics #AdiposeTissue #Obesity #Diabetes #HI_MAGLeipzig #metabolism
February 20, 2025 at 4:06 PM
#Adiposetissue.org: New Knowledge Portal Enhances Obesity and Metabolism Research
👉 Discover more about the platform in our news: t1p.de/cogg2
@ki.se #HelmholtzMunich
#ObesityResearch #Metabolism #Bioinformatics #AdiposeTissue #Obesity #Diabetes #HI_MAGLeipzig #metabolism
👉 Discover more about the platform in our news: t1p.de/cogg2
@ki.se #HelmholtzMunich
#ObesityResearch #Metabolism #Bioinformatics #AdiposeTissue #Obesity #Diabetes #HI_MAGLeipzig #metabolism
Reposted by Natalie Krahmer
I am wondering, is civil society in America fine with all of this?
February 14, 2025 at 5:53 PM
I am wondering, is civil society in America fine with all of this?
Exciting times for lipid cell biology! I am happy to share this viewpoint together with other colleagues on the challenges and exciting questions in lipid biology
rdcu.be/d8K8P
@saranowinski.bsky.social
@fedorovalab.bsky.social
rdcu.be/d8K8P
@saranowinski.bsky.social
@fedorovalab.bsky.social
Time for lipid cell biology
Nature Cell Biology - It is an exciting time for lipid metabolism and membrane cell biologists as technological progress has increased our ability to study lipids in cells. We asked leaders...
rdcu.be
February 5, 2025 at 6:55 PM
Exciting times for lipid cell biology! I am happy to share this viewpoint together with other colleagues on the challenges and exciting questions in lipid biology
rdcu.be/d8K8P
@saranowinski.bsky.social
@fedorovalab.bsky.social
rdcu.be/d8K8P
@saranowinski.bsky.social
@fedorovalab.bsky.social