Nael Nadif Kasri
@naelnadifkasri-lab.bsky.social
Neurobiologist interested in synaptic communication, neuronal networks, neurodevelopmental disorders, stem cell models and much more | Professor Group leader Radboudumc | http://www.nadifkasri-lab.com/Home.html
Reposted by Nael Nadif Kasri
Long-read genome sequencing is new first-tier generic test in diagnostics of rare diseases
So satisfying to see a long journey end in best-possible diagnostic test for patients with rare diseases @radboudumc.bsky.social.
www.radboudumc.nl/en/news-item...
(1/n)
So satisfying to see a long journey end in best-possible diagnostic test for patients with rare diseases @radboudumc.bsky.social.
www.radboudumc.nl/en/news-item...
(1/n)
World first: Radboudumc pioneers new genetic test in clinical practice - New test is faster, more efficient, and provides more diagnoses for rare diseases
17 November 2025
www.radboudumc.nl
November 17, 2025 at 8:29 AM
Long-read genome sequencing is new first-tier generic test in diagnostics of rare diseases
So satisfying to see a long journey end in best-possible diagnostic test for patients with rare diseases @radboudumc.bsky.social.
www.radboudumc.nl/en/news-item...
(1/n)
So satisfying to see a long journey end in best-possible diagnostic test for patients with rare diseases @radboudumc.bsky.social.
www.radboudumc.nl/en/news-item...
(1/n)
Reposted by Nael Nadif Kasri
Our new manuscript, led by Emily Corrigan, examines inhibitory neuron diversity across approximately 160 million years of evolutionary divergence, as part of BRAIN Initiative Cell Atlas Network (BICAN) developing brain atlas package: www.nature.com/articles/s41...
Conservation and alteration of mammalian striatal interneurons - Nature
An analysis of cell-type diversity in brain samples from a variety of mammalian species, both during development and in adult animals, reveals that the TAC3 initial class of striatal interneurons is c...
www.nature.com
November 7, 2025 at 6:06 PM
Our new manuscript, led by Emily Corrigan, examines inhibitory neuron diversity across approximately 160 million years of evolutionary divergence, as part of BRAIN Initiative Cell Atlas Network (BICAN) developing brain atlas package: www.nature.com/articles/s41...
Reposted by Nael Nadif Kasri
James Watson, Co-Discoverer of the Structure of DNA, Is Dead at 97 www.nytimes.com/2025/11/07/s...
James Watson, Co-Discoverer of the Structure of DNA, Is Dead at 97
www.nytimes.com
November 7, 2025 at 7:29 PM
James Watson, Co-Discoverer of the Structure of DNA, Is Dead at 97 www.nytimes.com/2025/11/07/s...
Third time in a row authors “forget” to cite a very relevant paper with almost identical conclusions. With rushed reviews, it feels like they’re banking on reviewers missing it. Please cite the work you build on. This pattern is exhausting.
October 27, 2025 at 12:39 PM
Third time in a row authors “forget” to cite a very relevant paper with almost identical conclusions. With rushed reviews, it feels like they’re banking on reviewers missing it. Please cite the work you build on. This pattern is exhausting.
Reposted by Nael Nadif Kasri
No, Tylenol does not cause autism. And there is no compelling evidence that leucovorin reduces symptoms. A consensus summary is found here - www.coalitionofautismscientists.org
Coalition of Autism Scientists | "autism scientists"
The Coalition of Autism Scientists formed in 2025 and is comprised of the leading autism researchers across the United States. The website includes statements made by researchers and science-based edu...
www.coalitionofautismscientists.org
September 23, 2025 at 9:37 AM
No, Tylenol does not cause autism. And there is no compelling evidence that leucovorin reduces symptoms. A consensus summary is found here - www.coalitionofautismscientists.org
Reposted by Nael Nadif Kasri
Very interesting pre-print by @moritz-negwer.mstdn.science.ap.brid.gy and @naelnadifkasri-lab.bsky.social using a new clearing technology to capture the abundance of specific neuron populations in a mouse model of ASD. #autism #neurodevelopment #Kleefstra
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Whole-brain clearing reveals region- and cell type-specific imbalances in inhibitory neurons in a mouse model for Kleefstra Syndrome
GABAergic inhibition is essential for balanced brain function and is frequently disrupted in neurodevelopmental disorders such as autism spectrum disorder (ASD). The inhibition is generated by a diver...
www.biorxiv.org
September 17, 2025 at 12:47 PM
Very interesting pre-print by @moritz-negwer.mstdn.science.ap.brid.gy and @naelnadifkasri-lab.bsky.social using a new clearing technology to capture the abundance of specific neuron populations in a mouse model of ASD. #autism #neurodevelopment #Kleefstra
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
New #cilia preprint alert
Our latest manuscript is now live on bioRxiv:
"The Neuronal Primary Cilium is a Key Regulator of Homeostatic Plasticity"
We hope you enjoy reading it!
www.biorxiv.org/content/10.1...
Our latest manuscript is now live on bioRxiv:
"The Neuronal Primary Cilium is a Key Regulator of Homeostatic Plasticity"
We hope you enjoy reading it!
www.biorxiv.org/content/10.1...
The Neuronal Primary Cilium is a Key Regulator of Homeostatic Plasticity
The capacity of neurons to maintain stable activity levels through homeostatic plasticity is essential for proper brain function. Primary cilia, which are non-motile, antenna-like organelles projectin...
www.biorxiv.org
September 1, 2025 at 10:12 PM
New #cilia preprint alert
Our latest manuscript is now live on bioRxiv:
"The Neuronal Primary Cilium is a Key Regulator of Homeostatic Plasticity"
We hope you enjoy reading it!
www.biorxiv.org/content/10.1...
Our latest manuscript is now live on bioRxiv:
"The Neuronal Primary Cilium is a Key Regulator of Homeostatic Plasticity"
We hope you enjoy reading it!
www.biorxiv.org/content/10.1...
New preprint alert!
Excited to share our latest study, now live on bioRxiv:
"The NSL Complex Promotes Neural Development by Preventing R-Loop Induced Replication Stress"
www.biorxiv.org/content/10.1...
Excited to share our latest study, now live on bioRxiv:
"The NSL Complex Promotes Neural Development by Preventing R-Loop Induced Replication Stress"
www.biorxiv.org/content/10.1...
THE NSL COMPLEX PROMOTES NEURAL DEVELOPMENT BY PREVENTING R-LOOP INDUCED REPLICATION STRESS
Early neuronal development relies on the proliferation of neural progenitor cells, making this developmental stage particularly vulnerable to DNA replication impediments. Here, we identify a non-canon...
www.biorxiv.org
August 30, 2025 at 7:37 AM
New preprint alert!
Excited to share our latest study, now live on bioRxiv:
"The NSL Complex Promotes Neural Development by Preventing R-Loop Induced Replication Stress"
www.biorxiv.org/content/10.1...
Excited to share our latest study, now live on bioRxiv:
"The NSL Complex Promotes Neural Development by Preventing R-Loop Induced Replication Stress"
www.biorxiv.org/content/10.1...
Reposted by Nael Nadif Kasri
Detailed characterization of the recurrent, independent evolution of a medically relevant locus across humans and great apes — the 17q21.31 locus
By @psudmant.bsky.social and colleagues
🧪🧬
www.biorxiv.org/content/10.1...
By @psudmant.bsky.social and colleagues
🧪🧬
www.biorxiv.org/content/10.1...
Rapid turnover and recurrent structural variation at the 17q21.31 locus in modern and ancient human genomes, and primates
The 17q21.31 locus in humans harbors several complex structural haplotypes including a ~970kb inversion. Different inversion haplotypes have been associated with susceptibility to microdeletions causi...
www.biorxiv.org
August 16, 2025 at 7:28 AM
Detailed characterization of the recurrent, independent evolution of a medically relevant locus across humans and great apes — the 17q21.31 locus
By @psudmant.bsky.social and colleagues
🧪🧬
www.biorxiv.org/content/10.1...
By @psudmant.bsky.social and colleagues
🧪🧬
www.biorxiv.org/content/10.1...
🧠 Join us in Rotterdam for a one-day meeting focused on iPSC-Driven Therapeutic Innovation for Brain Disorders!
We’re thrilled to announce our keynote speaker @sergiuppasca.bsky.social
📅 Event date: September 19, 2025
📍 Location: Erasmus MC Rotterdam
🔗 Register now: www.neurodevdisorders.org
We’re thrilled to announce our keynote speaker @sergiuppasca.bsky.social
📅 Event date: September 19, 2025
📍 Location: Erasmus MC Rotterdam
🔗 Register now: www.neurodevdisorders.org
PSIDER NETWORKING MEETING: IPSC-DRIVEN THERAPEUTIC INNOVATION FOR BRAIN DISORDERS
Joint meeting of the ZonMW PSIDER consortia This year we organize a joint meeting of the ZonMW PSIDER consortia TAILORED and BRAINmodel, two large scientific consortia supported by ZonMW. We...
www.neurodevdisorders.org
July 17, 2025 at 1:42 PM
🧠 Join us in Rotterdam for a one-day meeting focused on iPSC-Driven Therapeutic Innovation for Brain Disorders!
We’re thrilled to announce our keynote speaker @sergiuppasca.bsky.social
📅 Event date: September 19, 2025
📍 Location: Erasmus MC Rotterdam
🔗 Register now: www.neurodevdisorders.org
We’re thrilled to announce our keynote speaker @sergiuppasca.bsky.social
📅 Event date: September 19, 2025
📍 Location: Erasmus MC Rotterdam
🔗 Register now: www.neurodevdisorders.org
It was a pleasure of having @cedricboeckx.bsky.social visiting us on his way to the Max Planck in Nijmegen. He even wanted to help @ellylewerissa.bsky.social in the lab. Look at her reaction.
July 2, 2025 at 4:59 PM
It was a pleasure of having @cedricboeckx.bsky.social visiting us on his way to the Max Planck in Nijmegen. He even wanted to help @ellylewerissa.bsky.social in the lab. Look at her reaction.
Reposted by Nael Nadif Kasri
What an incredible week at the GRC on Excitatory Synapses! Thrilled for the chance to share our work on building an all-human co-culture of excitatory and inhibitory neurons, astrocytes and microglia to better capture synapse biology in health and disease. A huge team effort driving this forward!
June 10, 2025 at 6:17 PM
What an incredible week at the GRC on Excitatory Synapses! Thrilled for the chance to share our work on building an all-human co-culture of excitatory and inhibitory neurons, astrocytes and microglia to better capture synapse biology in health and disease. A huge team effort driving this forward!
If you are at the GRC on excitatory synapses @nickyscheefhals.bsky.social will be presenting on Wednesday.
What an incredible week at the GRC on Excitatory Synapses! Thrilled for the chance to share our work on building an all-human co-culture of excitatory and inhibitory neurons, astrocytes and microglia to better capture synapse biology in health and disease. A huge team effort driving this forward!
June 10, 2025 at 6:24 PM
If you are at the GRC on excitatory synapses @nickyscheefhals.bsky.social will be presenting on Wednesday.
Reposted by Nael Nadif Kasri
🎥 MAP2 (green), PSD95 (magenta), inhibitory neuron (blue) @naelnadifkasri-lab.bsky.social lab
June 10, 2025 at 6:17 PM
🎥 MAP2 (green), PSD95 (magenta), inhibitory neuron (blue) @naelnadifkasri-lab.bsky.social lab
New paper alert! How many neurodevelopment disorders would be amenable for ASO treatment? Fabulous PhD student @Kim Wijnant, did the analysis.
genomemedicine.biomedcentral.com/articles/10....
genomemedicine.biomedcentral.com/articles/10....
Systematic analysis of genetic and phenotypic characteristics reveals antisense oligonucleotide therapy potential for one-third of neurodevelopmental disorders - Genome Medicine
Background Neurodevelopmental disorders (NDDs) are a challenging group of disorders to treat, but promising therapeutic interventions in the form of antisense oligonucleotides (AONs) have emerged in r...
genomemedicine.biomedcentral.com
May 29, 2025 at 6:47 PM
New paper alert! How many neurodevelopment disorders would be amenable for ASO treatment? Fabulous PhD student @Kim Wijnant, did the analysis.
genomemedicine.biomedcentral.com/articles/10....
genomemedicine.biomedcentral.com/articles/10....
Reposted by Nael Nadif Kasri
Bart De Strooper giving The EMBO Keynote Lecture - From correlation to mechanisms: how genetics determine your risk of Alzheimer’s disease
at #neurogen25
@nereokalebic.bsky.social @harschnitz.bsky.social @humantechnopole.bsky.social
@r3rt0.bsky.social
at #neurogen25
@nereokalebic.bsky.social @harschnitz.bsky.social @humantechnopole.bsky.social
@r3rt0.bsky.social
May 20, 2025 at 9:15 AM
Bart De Strooper giving The EMBO Keynote Lecture - From correlation to mechanisms: how genetics determine your risk of Alzheimer’s disease
at #neurogen25
@nereokalebic.bsky.social @harschnitz.bsky.social @humantechnopole.bsky.social
@r3rt0.bsky.social
at #neurogen25
@nereokalebic.bsky.social @harschnitz.bsky.social @humantechnopole.bsky.social
@r3rt0.bsky.social
Reposted by Nael Nadif Kasri
Nael Nadif Kasri @naelnadifkasri-lab.bsky.social exploring the role of the primary cilium in neuronal plasticity and development: How the quiet organelle claims center stage!
at #neurogen25
@nereokalebic.bsky.social @harschnitz.bsky.social
@humantechnopole.bsky.social
@r3rt0.bsky.social
at #neurogen25
@nereokalebic.bsky.social @harschnitz.bsky.social
@humantechnopole.bsky.social
@r3rt0.bsky.social
May 19, 2025 at 12:30 PM
Nael Nadif Kasri @naelnadifkasri-lab.bsky.social exploring the role of the primary cilium in neuronal plasticity and development: How the quiet organelle claims center stage!
at #neurogen25
@nereokalebic.bsky.social @harschnitz.bsky.social
@humantechnopole.bsky.social
@r3rt0.bsky.social
at #neurogen25
@nereokalebic.bsky.social @harschnitz.bsky.social
@humantechnopole.bsky.social
@r3rt0.bsky.social
RIP #JanTerlouw. Zijn boeken leerden me lezen, dromen en denken. Dank je wel, Jan.
May 16, 2025 at 9:21 AM
RIP #JanTerlouw. Zijn boeken leerden me lezen, dromen en denken. Dank je wel, Jan.
Reposted by Nael Nadif Kasri
Bonus result: the lysosome/autophagy pathway surfaced as an important dimension of maturational tempo, in line with our recent work with @naelnadifkasri-lab.bsky.social (study led by @olivieroleonardi.bsky.social & @ellylewerissa.bsky.social)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
CHD2 Dosage Ties Autolysosomal Pathway to Cortical Maturation in Disease and Evolution
The relatively slow pace of cortical development in humans has long been a topic of investigation. Studies seeking to understand the underlying mechanisms have mostly focused on neurogenetic compariso...
www.biorxiv.org
May 2, 2025 at 6:51 AM
Bonus result: the lysosome/autophagy pathway surfaced as an important dimension of maturational tempo, in line with our recent work with @naelnadifkasri-lab.bsky.social (study led by @olivieroleonardi.bsky.social & @ellylewerissa.bsky.social)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
New paper alert!
We performed a systematic analysis of genetic and phenotypic characteristics to identify potential candidate neurodevelopmental disorders amenable for antisense
oligonucleotide therapy.
Kudos to PhD student Kim Wijnant
www.biorxiv.org/content/10.1...
We performed a systematic analysis of genetic and phenotypic characteristics to identify potential candidate neurodevelopmental disorders amenable for antisense
oligonucleotide therapy.
Kudos to PhD student Kim Wijnant
www.biorxiv.org/content/10.1...
March 21, 2025 at 7:21 PM
New paper alert!
We performed a systematic analysis of genetic and phenotypic characteristics to identify potential candidate neurodevelopmental disorders amenable for antisense
oligonucleotide therapy.
Kudos to PhD student Kim Wijnant
www.biorxiv.org/content/10.1...
We performed a systematic analysis of genetic and phenotypic characteristics to identify potential candidate neurodevelopmental disorders amenable for antisense
oligonucleotide therapy.
Kudos to PhD student Kim Wijnant
www.biorxiv.org/content/10.1...
Reposted by Nael Nadif Kasri
🚨New preprint from @bonevlab.bsky.social 🚨: What are the key epigenetic mechanisms that drive species-specific gene regulation during primate neurogenesis - and how do they contribute to the evolution of the human neocortex?
Here’s what we discovered 👇
www.biorxiv.org/content/10.1...
Here’s what we discovered 👇
www.biorxiv.org/content/10.1...
3D Epigenome Evolution Underlies Divergent Gene Regulatory Programs in Primate Neural Development
The expansion of the neocortex is a hallmark of human evolution and is closely linked to neural stem cell biology. Yet, the epigenetic mechanisms driving divergent gene regulation during primate neuro...
www.biorxiv.org
March 13, 2025 at 9:59 AM
🚨New preprint from @bonevlab.bsky.social 🚨: What are the key epigenetic mechanisms that drive species-specific gene regulation during primate neurogenesis - and how do they contribute to the evolution of the human neocortex?
Here’s what we discovered 👇
www.biorxiv.org/content/10.1...
Here’s what we discovered 👇
www.biorxiv.org/content/10.1...
New paper alert on Inter-individual variation in fusion transcript expression representing an overlooked source of
genetic diversity #evolution #disease
www.biorxiv.org/content/10.1...
genetic diversity #evolution #disease
www.biorxiv.org/content/10.1...
www.biorxiv.org
March 18, 2025 at 12:28 AM
New paper alert on Inter-individual variation in fusion transcript expression representing an overlooked source of
genetic diversity #evolution #disease
www.biorxiv.org/content/10.1...
genetic diversity #evolution #disease
www.biorxiv.org/content/10.1...
Interested in disease modelling, stem cell models metabolism and novel on-chip technology? Then this might be an exciting project for you.
PhD position in now open
www.radboudumc.nl/en/vacancies...
PhD position in now open
www.radboudumc.nl/en/vacancies...
Vacancy - PhD candidate | Junior researcher 'Spatiotemporal properties of neuronal metabolofunction using novel on-chip technology'
We are seeking a PhD candidate / junior researcher to develop and apply an innovative on-chip technology platform for integrated neuronal ...
www.radboudumc.nl
March 18, 2025 at 12:03 AM
Interested in disease modelling, stem cell models metabolism and novel on-chip technology? Then this might be an exciting project for you.
PhD position in now open
www.radboudumc.nl/en/vacancies...
PhD position in now open
www.radboudumc.nl/en/vacancies...
Reposted by Nael Nadif Kasri
💫 New preprint from the lab: Comparing great ape cerebral organoids, we found that human-specific morphoregulatory signatures in basal radial glia characterise neocortex evolution. Fantastic work from super-talented PhD student Theresa Schütze!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
March 13, 2025 at 10:11 AM
💫 New preprint from the lab: Comparing great ape cerebral organoids, we found that human-specific morphoregulatory signatures in basal radial glia characterise neocortex evolution. Fantastic work from super-talented PhD student Theresa Schütze!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Nael Nadif Kasri
Registration for the 10th edition of our Summerschool on 'Neural circuit development and plasticity' is open! July 7-11 in Utrecht for MSc and PhD students, and others who are interested. Spread the news! @umcutrecht.bsky.social @utrechtuniversity.bsky.social
March 13, 2025 at 3:51 PM
Registration for the 10th edition of our Summerschool on 'Neural circuit development and plasticity' is open! July 7-11 in Utrecht for MSc and PhD students, and others who are interested. Spread the news! @umcutrecht.bsky.social @utrechtuniversity.bsky.social