Mychael Lourenco
@mvlourenco.bsky.social
Neuroscientist studying molecular mechanisms of Alzheimer’s disease and related disorders. Assistant Professor at UFRJ, Brazil.
www.lourencolab.org
www.lourencolab.org
Pinned
Sex differences in mitochondrial free-carnitine levels in subjects at-risk and with Alzheimer’s disease in two independent study cohorts - Molecular Psychiatry
Molecular Psychiatry - Sex differences in mitochondrial free-carnitine levels in subjects at-risk and with Alzheimer’s disease in two independent study cohorts
www.nature.com
Happy to share this study led by Betty Bigio, Carla Nasca (NYU) and our team @ufrjoficial.bsky.social just published in Molecular Psychiatry. Here, using two cohorts, we show that plasma carnitine levels are reduced in women with cognitive impairment and dementia.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Mychael Lourenco
Check out our latest review @cp-trendspharma.bsky.social, outlining emerging pharmacological interventions for #autism and #fragileXsyndrome. A nice collaboration with Amedeo D'Agiulli, Vivian Lee and @salmasolab.bsky.social! #neuroskyence:
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Emerging autism and Fragile X syndrome treatments
The limitations of current symptom-focused treatments drive the urgent need for effective therapies for autism and Fragile X syndrome (FXS). Currently…
www.sciencedirect.com
March 17, 2025 at 4:30 PM
Check out our latest review @cp-trendspharma.bsky.social, outlining emerging pharmacological interventions for #autism and #fragileXsyndrome. A nice collaboration with Amedeo D'Agiulli, Vivian Lee and @salmasolab.bsky.social! #neuroskyence:
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Mychael Lourenco
Women twice as likely to develop Alzheimer’s disease as men — but scientists do not know why
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Women twice as likely to develop Alzheimer’s disease as men — but scientists do not know why - Nature Medicine
Changes to the female brain during menopause, together with social and cultural factors, might affect disease risk.
www.nature.com
March 15, 2025 at 6:45 PM
Women twice as likely to develop Alzheimer’s disease as men — but scientists do not know why
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Mychael Lourenco
Aging activates escape of the silent X chromosome in the female mouse hippocampus
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Aging activates escape of the silent X chromosome in the female mouse hippocampus
Aging activates the silent X chromosome, increasing escape expression, and potentially cognitive resilience, in the female mouse.
www.science.org
March 5, 2025 at 8:15 PM
Aging activates escape of the silent X chromosome in the female mouse hippocampus
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Mychael Lourenco
Don’t miss the chance to present your work at the #AAICSatellite Symposium in Lima, Peru & strengthen the future of the dementia science community in Latin America. Abstracts are due Feb. 24: alz.org/satellite-symposium
AAIC Satellite Symposium | Alzheimer’s Association
Join leading research experts at the 2025 AAIC Satellite Symposium in Lima, Peru, and online to network & explore emerging dementia research.
alz.org
February 5, 2025 at 10:38 PM
Don’t miss the chance to present your work at the #AAICSatellite Symposium in Lima, Peru & strengthen the future of the dementia science community in Latin America. Abstracts are due Feb. 24: alz.org/satellite-symposium
Reposted by Mychael Lourenco
Join us one week from today for the second virtual roundtable in our Dementia in Latin America and the Caribbean series. Leading dementia experts will dive deep into brain health and social determinants of health. Learn more: bit.ly/40PzSwd
Virtual dialogue: brain health | World Dementia Council
bit.ly
February 7, 2025 at 3:57 PM
Join us one week from today for the second virtual roundtable in our Dementia in Latin America and the Caribbean series. Leading dementia experts will dive deep into brain health and social determinants of health. Learn more: bit.ly/40PzSwd
Our comment on a very interesting @elife.bsky.social
paper showing how S1PR signaling may underlie pain-associated memory impairment is now out! Check it out!
elifesciences.org/articles/105...
paper showing how S1PR signaling may underlie pain-associated memory impairment is now out! Check it out!
elifesciences.org/articles/105...
Pain-Related Memory Impairment: How does chronic pain lead to memory loss?
A dysfunctional signaling pathway in the hippocampus has been linked to chronic pain-related memory impairment in mice.
elifesciences.org
January 27, 2025 at 8:44 PM
Our comment on a very interesting @elife.bsky.social
paper showing how S1PR signaling may underlie pain-associated memory impairment is now out! Check it out!
elifesciences.org/articles/105...
paper showing how S1PR signaling may underlie pain-associated memory impairment is now out! Check it out!
elifesciences.org/articles/105...
Reposted by Mychael Lourenco
Happy to share this study led by Betty Bigio, Carla Nasca (NYU) and our team @ufrjoficial.bsky.social just published in Molecular Psychiatry. Here, using two cohorts, we show that plasma carnitine levels are reduced in women with cognitive impairment and dementia.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Sex differences in mitochondrial free-carnitine levels in subjects at-risk and with Alzheimer’s disease in two independent study cohorts - Molecular Psychiatry
Molecular Psychiatry - Sex differences in mitochondrial free-carnitine levels in subjects at-risk and with Alzheimer’s disease in two independent study cohorts
www.nature.com
January 9, 2025 at 5:06 PM
Happy to share this study led by Betty Bigio, Carla Nasca (NYU) and our team @ufrjoficial.bsky.social just published in Molecular Psychiatry. Here, using two cohorts, we show that plasma carnitine levels are reduced in women with cognitive impairment and dementia.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Happy to share this study led by Betty Bigio, Carla Nasca (NYU) and our team @ufrjoficial.bsky.social just published in Molecular Psychiatry. Here, using two cohorts, we show that plasma carnitine levels are reduced in women with cognitive impairment and dementia.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Sex differences in mitochondrial free-carnitine levels in subjects at-risk and with Alzheimer’s disease in two independent study cohorts - Molecular Psychiatry
Molecular Psychiatry - Sex differences in mitochondrial free-carnitine levels in subjects at-risk and with Alzheimer’s disease in two independent study cohorts
www.nature.com
January 9, 2025 at 5:06 PM
Happy to share this study led by Betty Bigio, Carla Nasca (NYU) and our team @ufrjoficial.bsky.social just published in Molecular Psychiatry. Here, using two cohorts, we show that plasma carnitine levels are reduced in women with cognitive impairment and dementia.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Mychael Lourenco
Male-Female comparisons are powerful in Biomedical Research. More on this and what is a "Pink Box Warning"?? From @ctmurphy1.bsky.social @bbparis1984.bsky.social Yousin Suh and me in the latest issue of Neuron www.sciencedirect.com/science/arti...
Biological sex matters in brain aging
Every cell in the body has a biological sex. The expansion of aging research to investigate female- and male-specific biology heralds a major advance …
www.sciencedirect.com
January 8, 2025 at 4:38 PM
Male-Female comparisons are powerful in Biomedical Research. More on this and what is a "Pink Box Warning"?? From @ctmurphy1.bsky.social @bbparis1984.bsky.social Yousin Suh and me in the latest issue of Neuron www.sciencedirect.com/science/arti...
Reposted by Mychael Lourenco
Monocyte-derived macrophages act as reinforcements when microglia fall short in Alzheimer’s disease
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Monocyte-derived macrophages act as reinforcements when microglia fall short in Alzheimer’s disease - Nature Neuroscience
This article discusses a puzzling issue in brain pathology: why brain-resident microglia are insufficient for protection, and why myeloid cells are needed from the periphery. Several strategies are pr...
www.nature.com
January 7, 2025 at 3:50 AM
Monocyte-derived macrophages act as reinforcements when microglia fall short in Alzheimer’s disease
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Mychael Lourenco
A recent study by Kelly Jin, Zizhen Yao, Cindy van Velthoven, et al. @alleninstitute.bsky.social "provides detailed single-cell transcriptomic map of brain aging & has uncovered cell-type-specific & region-specific molecular changes linked to aging."
@nature.com
www.nature.com/articles/s41...
@nature.com
www.nature.com/articles/s41...
Brain-wide cell-type-specific transcriptomic signatures of healthy ageing in mice - Nature
A comprehensive single-cell RNA sequencing study delineates cell-type-specific transcriptomic changes in the brain associated with normal ageing that will inform the investigation into functional chan...
www.nature.com
January 6, 2025 at 6:24 PM
A recent study by Kelly Jin, Zizhen Yao, Cindy van Velthoven, et al. @alleninstitute.bsky.social "provides detailed single-cell transcriptomic map of brain aging & has uncovered cell-type-specific & region-specific molecular changes linked to aging."
@nature.com
www.nature.com/articles/s41...
@nature.com
www.nature.com/articles/s41...
Reposted by Mychael Lourenco
Our spotlight on @cp-trendsneuro.bsky.social, commenting on this great article by the Herfert Group 👇
‘Assessing brain-wide outcomes of dopamine system activation in the living rodent brain’
TINS ‘Spotlight’ by @limberger-chris.bsky.social & @erzimmer.bsky.social
www.cell.com/trends/neuro...
discussing Haas, Bravo, et al., 2024, Kristina Herfert group
www.science.org/doi/10.1126/...
TINS ‘Spotlight’ by @limberger-chris.bsky.social & @erzimmer.bsky.social
www.cell.com/trends/neuro...
discussing Haas, Bravo, et al., 2024, Kristina Herfert group
www.science.org/doi/10.1126/...
Assessing brain-wide outcomes of dopamine system activation in the living rodent brain
In a recent study, Haas, Bravo, and colleagues integrated optogenetic stimulation with simultaneous functional in vivo positron emission tomography (PET)/magnetic resonance imaging (MRI) measurements in rats. By activating the nigrostriatal pathway in the substantia nigra pars compacta (SNc), they observed concurrent metabolic and hemodynamic fluctuations associated with the dopaminergic pathway in living animals at the whole-brain level.
www.cell.com
January 7, 2025 at 12:41 AM
Our spotlight on @cp-trendsneuro.bsky.social, commenting on this great article by the Herfert Group 👇
Happy 2025 to all my colleagues and friends here!
January 1, 2025 at 10:02 PM
Happy 2025 to all my colleagues and friends here!
Happy Christmas to all those who celebrate! I hope you all have a great season.
a cartoon cat looking at a christmas tree in a pink room
ALT: a cartoon cat looking at a christmas tree in a pink room
media.tenor.com
December 24, 2024 at 6:47 PM
Happy Christmas to all those who celebrate! I hope you all have a great season.
Reposted by Mychael Lourenco
new preprint!
www.biorxiv.org/content/10.1...
a characterization of APOE effects on the lipid droplet-ome (turns out you see a lot of "AD-related" proteins!)
first authors Cassi Friday & Isaiah Stephens + great collaborators Scott Gordon, @cohenlaboratory.bsky.social @morganti.bsky.social
www.biorxiv.org/content/10.1...
a characterization of APOE effects on the lipid droplet-ome (turns out you see a lot of "AD-related" proteins!)
first authors Cassi Friday & Isaiah Stephens + great collaborators Scott Gordon, @cohenlaboratory.bsky.social @morganti.bsky.social
December 21, 2024 at 3:17 PM
new preprint!
www.biorxiv.org/content/10.1...
a characterization of APOE effects on the lipid droplet-ome (turns out you see a lot of "AD-related" proteins!)
first authors Cassi Friday & Isaiah Stephens + great collaborators Scott Gordon, @cohenlaboratory.bsky.social @morganti.bsky.social
www.biorxiv.org/content/10.1...
a characterization of APOE effects on the lipid droplet-ome (turns out you see a lot of "AD-related" proteins!)
first authors Cassi Friday & Isaiah Stephens + great collaborators Scott Gordon, @cohenlaboratory.bsky.social @morganti.bsky.social
Reposted by Mychael Lourenco
Too many authors to list here, but very happy to have contributed to this review led by Michael Heneka on #neuroinflammation in #Alzheimer‘s disease, now out in @natrevimmunol.bsky.social. @dzne.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Neuroinflammation in Alzheimer disease - Nature Reviews Immunology
This Review provides an in-depth examination of how inflammation contributes to neurodegeneration in Alzheimer disease. The authors explore the impact of extrinsic factors, such as brain trauma, diet ...
www.nature.com
December 9, 2024 at 10:29 PM
Too many authors to list here, but very happy to have contributed to this review led by Michael Heneka on #neuroinflammation in #Alzheimer‘s disease, now out in @natrevimmunol.bsky.social. @dzne.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Mychael Lourenco
Dysregulated calcium signaling in the aged macaque entorhinal cortex associated with tau hyperphosphorylation. https://www.biorxiv.org/content/10.1101/2024.12.05.626721v1
December 9, 2024 at 10:15 PM
Dysregulated calcium signaling in the aged macaque entorhinal cortex associated with tau hyperphosphorylation. https://www.biorxiv.org/content/10.1101/2024.12.05.626721v1
Important findings from the investigational AL-002 trial. These results, though disappointing in terms of clinical outcomes, may substantially inform future approaches and help us better understand Alzheimer's pathophysiology.
investors.alector.com/news-release...
investors.alector.com/news-release...
Alector Announces Results from AL002 INVOKE-2 Phase 2 Trial in Individuals with Early Alzheimer’s Disease and Provides Business Update | Alector
SOUTH SAN FRANCISCO, Calif. , Nov. 25, 2024 (GLOBE NEWSWIRE) -- Alector, Inc. (Nasdaq: ALEC), a clinical-stage biotechnology company pioneering novel, genetically validated therapies for the treatment...
investors.alector.com
December 2, 2024 at 3:59 PM
Important findings from the investigational AL-002 trial. These results, though disappointing in terms of clinical outcomes, may substantially inform future approaches and help us better understand Alzheimer's pathophysiology.
investors.alector.com/news-release...
investors.alector.com/news-release...