Maren Salla
@ms-maren.bsky.social
PhD Student studying human brain tissue using and expanding single-cell genomic methologies. Berlin, Germany
Reposted by Maren Salla
🚨 New preprints from our lab!
First, we introduce Cryo-mtscATAC-seq, led by Maren (@ms-maren.bsky.social ), enabling high-throughput clonal tracing from frozen human samples by isolating nuclei with their mitochondria (“CryoCells”).
👉 www.biorxiv.org/content/10.1...
Cryo-mtscATAC-seq for single-cell mitochondrial DNA genotyping and clonal tracing in archived human tissues
High-throughput clonal tracing of primary human samples relies on naturally occurring barcodes, such as somatic mitochondrial DNA (mtDNA) mutations detected via single-cell ATAC-seq (mtscATAC-seq). Fr...
www.biorxiv.org
September 24, 2025 at 12:39 PM
🚨 New preprints from our lab!
First, we introduce Cryo-mtscATAC-seq, led by Maren (@ms-maren.bsky.social ), enabling high-throughput clonal tracing from frozen human samples by isolating nuclei with their mitochondria (“CryoCells”).
👉 www.biorxiv.org/content/10.1...
Exciting new method to decellularize human brain tissue - opening up ways to study stem cell differentiation or how the ECM shapes immune responses. Great work by Roemel Jeusep Bueno and team!
www.frontiersin.org/journals/bio...
www.frontiersin.org/journals/bio...
Frontiers | Generation of decellularized human brain tissue for investigating cell-matrix interactions: a proof-of-concept study
The brain extracellular matrix (ECM) regulates myelin repair and regeneration following a demyelinating event by interacting with neuronal progenitors and im...
www.frontiersin.org
June 7, 2025 at 7:11 PM
Exciting new method to decellularize human brain tissue - opening up ways to study stem cell differentiation or how the ECM shapes immune responses. Great work by Roemel Jeusep Bueno and team!
www.frontiersin.org/journals/bio...
www.frontiersin.org/journals/bio...
Reposted by Maren Salla
We had two great 'Night Science' workshops on the creative scientific process in Heidelberg yesterday (at EMBL and at the EMBO PhD Course). Here are the slides if you're interested in running something like this at your place! docs.google.com/presentation...
May 20, 2025 at 10:24 PM
We had two great 'Night Science' workshops on the creative scientific process in Heidelberg yesterday (at EMBL and at the EMBO PhD Course). Here are the slides if you're interested in running something like this at your place! docs.google.com/presentation...
Reposted by Maren Salla
Check out our CRISPR/Cas9 methods paper, online on arxiv! 🚀🧬
Long in the making but our protocol for gene editing is online! FAB CRISPR is super easy and allows the generation of N and C terminal fusions with TurboID, SNAP, Halo and mStayGold. A single cloninf step to generate HDR templates! arxiv.org/abs/2502.12675 1/n
Fast Antibiotic resistance-Based gene editing of mammalian cells with CRISPR-Cas9 (FAB-CRISPR)
Protein tagging with CRISPR-Cas9 enables the investigation of protein function in its native environment but is limited by low homology-directed repair (HDR) efficiency causing low knock-in rates. We ...
arxiv.org
February 19, 2025 at 9:04 AM
Check out our CRISPR/Cas9 methods paper, online on arxiv! 🚀🧬
Reposted by Maren Salla
Interested in 'Mitochondrial single cell-multi-omics for lineage tracing and genetics'? Apply for our free workshop in Berlin following our #ISCO2025 conference!
www.isco-conference.eu
www.mdc-berlin.de/news/events/...
www.isco-conference.eu
www.mdc-berlin.de/news/events/...
Mitochondrial single cell-multi-omics for lineage tracing and genetics
www.mdc-berlin.de
January 31, 2025 at 10:36 AM
Interested in 'Mitochondrial single cell-multi-omics for lineage tracing and genetics'? Apply for our free workshop in Berlin following our #ISCO2025 conference!
www.isco-conference.eu
www.mdc-berlin.de/news/events/...
www.isco-conference.eu
www.mdc-berlin.de/news/events/...
Reposted by Maren Salla
Join us to connect with the vibrant #singlecell community.
📢Register for the #ISCO'25 Conference "Innovations in #SingleCell #OMICS" in Berlin!
🗓️ 12-13 May 2025
🎤 Fantastic Keynote and Invited Speakers
🫵🏿 Many slots for talks: submit your abstract
🔗http://isco-conference.eu
Please spread the word!
📢Register for the #ISCO'25 Conference "Innovations in #SingleCell #OMICS" in Berlin!
🗓️ 12-13 May 2025
🎤 Fantastic Keynote and Invited Speakers
🫵🏿 Many slots for talks: submit your abstract
🔗http://isco-conference.eu
Please spread the word!
January 31, 2025 at 10:29 AM
Join us to connect with the vibrant #singlecell community.
📢Register for the #ISCO'25 Conference "Innovations in #SingleCell #OMICS" in Berlin!
🗓️ 12-13 May 2025
🎤 Fantastic Keynote and Invited Speakers
🫵🏿 Many slots for talks: submit your abstract
🔗http://isco-conference.eu
Please spread the word!
📢Register for the #ISCO'25 Conference "Innovations in #SingleCell #OMICS" in Berlin!
🗓️ 12-13 May 2025
🎤 Fantastic Keynote and Invited Speakers
🫵🏿 Many slots for talks: submit your abstract
🔗http://isco-conference.eu
Please spread the word!
Reposted by Maren Salla
Spatial multi-omics has just gone to the next level!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
—Integration of 5 omic modalities w/ spatial resolution at 20 -50 μm
—"a new era for characterizing tissue & cellular heterogeneity that single-modality studies alone could not reveal"
www.nature.com/articles/s41...
www.nature.com/articles/s41...
—Integration of 5 omic modalities w/ spatial resolution at 20 -50 μm
—"a new era for characterizing tissue & cellular heterogeneity that single-modality studies alone could not reveal"
January 27, 2025 at 11:26 PM
Spatial multi-omics has just gone to the next level!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
—Integration of 5 omic modalities w/ spatial resolution at 20 -50 μm
—"a new era for characterizing tissue & cellular heterogeneity that single-modality studies alone could not reveal"
www.nature.com/articles/s41...
www.nature.com/articles/s41...
—Integration of 5 omic modalities w/ spatial resolution at 20 -50 μm
—"a new era for characterizing tissue & cellular heterogeneity that single-modality studies alone could not reveal"
December 19, 2024 at 10:05 AM
Reposted by Maren Salla
A Review in Nature Reviews Genetics discusses how biobanks facilitate genetics research towards advancing precision medicine and overviews potential solutions to their current limitations. https://go.nature.com/3OLSnw1 🔒
December 9, 2024 at 1:43 PM
A Review in Nature Reviews Genetics discusses how biobanks facilitate genetics research towards advancing precision medicine and overviews potential solutions to their current limitations. https://go.nature.com/3OLSnw1 🔒
Reposted by Maren Salla
The December issue of Nature Neuroscience is now live, featuring our Focus on Single-Cell Genomics! We hope that these consensus reviews from experts in the field will serve as a useful guide for neuroscientists regarding best practices for these approaches.
www.nature.com/neuro/volume...
www.nature.com/neuro/volume...
Nature Neuroscience - Focus on single-cell genomics in neuroscience
Single-cell and single-nucleus genomics pave the way for a comprehensive understanding of the nervous system and its diverse cell populations. Realizing this...
www.nature.com
December 3, 2024 at 7:49 PM
The December issue of Nature Neuroscience is now live, featuring our Focus on Single-Cell Genomics! We hope that these consensus reviews from experts in the field will serve as a useful guide for neuroscientists regarding best practices for these approaches.
www.nature.com/neuro/volume...
www.nature.com/neuro/volume...