The ecological and evolutionary outcomes of plant–fungal interactions are strongly influenced by genome size and ploidy, yet the ploidy level of both partners is rarely assessed simultaneously. Epichl...

Members of Scytalidium are primarily saprotrophic and are known for their ability to colonize a variety of substrates, including soil, decaying plant material, and wood. During an investigation of soi...

In the course of biochemical prospection of Laburnicola nematophila isolated from eggs of the plant-parasitic cyst nematode Heterodera filipjevi, eight 2-pyridone alkaloids were isolated from its solid-state BRFT cultures and identified as six previously undescribed, cordypyridones E–J (1–6), and two known congeners, cordypyridones C (7) and D (8). The structures and absolute configurations of all isolated compounds were elucidated through HR-ESI–MS, 1D/2D NMR spectroscopy, and TDDFT–ECD calculations. Compound 4, bearing a rare N-hydroxy-2-pyridone moiety structurally related to that of PF1140, exhibited broad-spectrum bioactivity in cytotoxicity and antimicrobial assays. Compounds 5 and 6 demonstrated potent antibiofilm activities against Staphylococcus aureus, reducing its biofilm formation by almost 50% at 0.25 and 7.8 μg/mL, respectively.

Discover the final programme of ChemBioChem and ChemPhysChem 25th Anniversary Symposium on Advances in Structural Analysis of Biomolecules! Join us for 1,5 days of exciting science showcasing:  >> 14...

The genus Scleroderma (Sclerodermataceae) contains gasteroid ectomycorrhizal fungi and is distributed worldwide in temperate and tropical regions. Fresh specimens were collected in Thailand and report...

Health authorities race to contain fungus that survives routine disinfection.

RNA helicases are conserved enzymes found in both prokaryotes and eukaryotes. They function in all aspects of RNA metabolism and are known to influence various cellular and metabolic processes. In add...

Lichens are specialized complex ecosystems formed by algae/fungi living in interspecific symbiosis, which produce secondary metabolites that function as a defense against pathogens/competitors and/or external abiotic factors acting as antibiotics, antifeedants, UV protectants, etc., but also as a tool for taxonomy of lichen-forming fungi. However, the lichen substance content of crustose lichens of the genus Graphis from Colombian tropical dry forests has been poorly explored. In this work, the chemical composition of total extracts from three lichens belonging to the genus Graphis collected in the tropical dry forests of northern Colombia was determined by TLC/HPLC–DAD/MS (ESI); and from one of them, two depsidones were isolated/structurally characterized (LC-HRMS, 1H-13C (DEPT135, HSQC)-NMR). Consequently, the main findings were as follows: (i) stictic (1)/constictic (2), norstictic (5), and protocetraric (13) acids were the representative depsidones for G. dendrogramma (Tubará), G. dendrogramma (Piojó), and G. supracola, respectively; and (ii) the isolated depsidones from G. dendrogramma (Tubará) were stictic ( −)-(1) and constictic ( +)-(2) acids. These results provided key insights into the chemical diversity and taxonomic biomarkers of these species, and therefore, it could be concluded that (i) there was chemical variability between G. dendrogramma collected in different places, although all contained stictic acid–derived depsidones; (ii) for the first time, extrolites other than protocetraric acid (13) were identified for G. supracola, as well as norstictic acid (5) as major lichen substance for G. dendrogramma; (iii) the main chemical biomarker [stictic acid (1)] reported in the scientific literature for one of G. dendrogramma sample (Tubará) was confirmed (by LC–MS and NMR analysis); and (iv) for the first time, the specific optical rotation related to the chirality of the two isolated depsidones was determined [( −)-(1), ( +)-(2)].

Populus euphratica is a key deciduous and tall arbour capable of forming forests in arid and desert environments, exhibiting notable tolerance to drought, salinity and bacterial resistance. This study...

The Onygenales represent a versatile group of fungi that primarily inhabit soils, degrading cellulose and/or keratin. While some are known human pathogens, others are osmotolerant or colonize chitin s...

High planting density boosts crop yields but also heightens pest and pathogen risks. How plants adapt their defenses under these conditions remains unclear. In this study, we reveal that maize enhance...

Wie kommt es zu Resistenzen? Was genau passiert da in der Bakterienzelle? Und welche Alternativen gibt es zu klassischen Antibiotika? Darum geht es in der neuen Folge.