Miguel Ramalho-Santos
@mrsantos.bsky.social
Scientist and Professor in Developmental Epigenetics.
Lunenfeld-Tanenbaum Research Institute
Dpt Molecular Genetics, University of Toronto, Canada
Lab: mrsantoslab.org
Coimbra, Portugal -> Cambridge, MA, USA -> S. Francisco, CA, USA -> Toronto, ON, Canada
Lunenfeld-Tanenbaum Research Institute
Dpt Molecular Genetics, University of Toronto, Canada
Lab: mrsantoslab.org
Coimbra, Portugal -> Cambridge, MA, USA -> S. Francisco, CA, USA -> Toronto, ON, Canada
Trick or Treat! 👻🎃
November 10, 2025 at 7:23 PM
Trick or Treat! 👻🎃
Discussed @mrsantos.bsky.social lit review: Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells. www.biorxiv.org/content/10.1...
Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells
Acquisition of specific cell shapes and morphologies is a central component of cell fate transitions. Although signaling circuits and gene regulatory networks that regulate pluripotent stem cell diffe...
www.biorxiv.org
October 22, 2025 at 2:06 PM
Discussed @mrsantos.bsky.social lit review: Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells. www.biorxiv.org/content/10.1...
Discussed @mrsantos.bsky.social lit review: Preventing CpG hypermethylation in oocytes safeguards mouse development. www.cell.com/developmenta...
Preventing CpG hypermethylation in oocytes safeguards mouse development
Kawamura et al. show that H3K36me2 removal by the KDM2A and KDM2B histone demethylases
restricts DNMT3A in establishing global DNA methylation in oocytes. Maternal Kdm2a/Kdm2b
knockout embryos die dur...
www.cell.com
October 15, 2025 at 2:23 PM
Discussed @mrsantos.bsky.social lit review: Preventing CpG hypermethylation in oocytes safeguards mouse development. www.cell.com/developmenta...
(1/4) New Pre-print! 🌟
Embryonic development is usually seen as a continuous process, yet some embryos can pause their development to survive harsh conditions, a phenomenon known as diapause. How this pausing is actively maintained has remained a mystery.
Embryonic development is usually seen as a continuous process, yet some embryos can pause their development to survive harsh conditions, a phenomenon known as diapause. How this pausing is actively maintained has remained a mystery.
October 9, 2025 at 8:08 PM
(1/4) New Pre-print! 🌟
Embryonic development is usually seen as a continuous process, yet some embryos can pause their development to survive harsh conditions, a phenomenon known as diapause. How this pausing is actively maintained has remained a mystery.
Embryonic development is usually seen as a continuous process, yet some embryos can pause their development to survive harsh conditions, a phenomenon known as diapause. How this pausing is actively maintained has remained a mystery.
Reposted by Miguel Ramalho-Santos
The ISSCR is seeking nominations for Vice President and three Director positions. This is an opportunity to help shape the future of stem cell research and contribute to a global scientific community. Nominations are due 22 October 2025. Learn more 👉 https://www.isscr.org/nominations
2026 Election Nominations — International Society for Stem Cell Research
Elections and nominations for the International Society for Stem Cell Research board of directors and officers.
www.isscr.org
October 8, 2025 at 4:01 PM
The ISSCR is seeking nominations for Vice President and three Director positions. This is an opportunity to help shape the future of stem cell research and contribute to a global scientific community. Nominations are due 22 October 2025. Learn more 👉 https://www.isscr.org/nominations
John Gurdon was a true giant:
- founder of cell reprogramming;
- founder of molecular embryology;
- unabashed advocate for basic research;
- advisor to numerous successful trainees/PIs;
- gentle human that touched so many.
In dark times with science under attack, let his vision be a guiding light.
- founder of cell reprogramming;
- founder of molecular embryology;
- unabashed advocate for basic research;
- advisor to numerous successful trainees/PIs;
- gentle human that touched so many.
In dark times with science under attack, let his vision be a guiding light.
Very saddened to hear of John Gurdon’s passing. I’ve been lucky enough to interact with him at multiple points through my career - from undergrad lectures, through his position as former Chair of @biologists.bsky.social’s Board of Directors, and as an author at @dev-journal.bsky.social.
Nobel Laureate Professor Sir John Gurdon dies aged 92
It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the Gurdon Institute.
www.cam.ac.uk
October 7, 2025 at 7:57 PM
John Gurdon was a true giant:
- founder of cell reprogramming;
- founder of molecular embryology;
- unabashed advocate for basic research;
- advisor to numerous successful trainees/PIs;
- gentle human that touched so many.
In dark times with science under attack, let his vision be a guiding light.
- founder of cell reprogramming;
- founder of molecular embryology;
- unabashed advocate for basic research;
- advisor to numerous successful trainees/PIs;
- gentle human that touched so many.
In dark times with science under attack, let his vision be a guiding light.
🚨 JOB ALERT 🚨
We are hiring TWO principal investigators in systems, cellular, chemical or molecular biology in Toronto, Canada at
@sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.
Apply now or repost!
We are hiring TWO principal investigators in systems, cellular, chemical or molecular biology in Toronto, Canada at
@sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.
Apply now or repost!
Job Alert 🚨
Are you an emerging leader in biomedical discovery or population health data science?
We are looking for outstanding candidates to join our institute!
Learn more & apply:
Biomedical Discovery ➡️ apply.interfolio.com/172703
Population Health Data Science ➡️ apply.interfolio.com/172529
Are you an emerging leader in biomedical discovery or population health data science?
We are looking for outstanding candidates to join our institute!
Learn more & apply:
Biomedical Discovery ➡️ apply.interfolio.com/172703
Population Health Data Science ➡️ apply.interfolio.com/172529
September 24, 2025 at 4:05 PM
🚨 JOB ALERT 🚨
We are hiring TWO principal investigators in systems, cellular, chemical or molecular biology in Toronto, Canada at
@sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.
Apply now or repost!
We are hiring TWO principal investigators in systems, cellular, chemical or molecular biology in Toronto, Canada at
@sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.
Apply now or repost!
Thank you for this honor and the continued trust in our group's research! We hope that our work will honor the memory and legacy of Anne and Max Tanenbaum. It is truly a privilege to be part of the amazing communities of @uoftmedicine.bsky.social and @sinaihealth.bsky.social.
Congratulations to Dr. Miguel Ramalho-Santos, Senior Investigator at the Lunenfeld-Tanenbaum Research Institute, on his appointment as the Anne & Max Tanenbaum Chair of Molecular Medicine at Sinai Health!
September 9, 2025 at 5:06 PM
Thank you for this honor and the continued trust in our group's research! We hope that our work will honor the memory and legacy of Anne and Max Tanenbaum. It is truly a privilege to be part of the amazing communities of @uoftmedicine.bsky.social and @sinaihealth.bsky.social.
(1/4) New preprint from the lab!
The MYC transcription factor is a potent cancer driver when its expression is dysregulated, but efforts to target MYC directly have not been fruitful. We identify CHD1 as a synthetic lethal vulnerability in MYC-driven breast cancer. www.biorxiv.org/content/10.1...
The MYC transcription factor is a potent cancer driver when its expression is dysregulated, but efforts to target MYC directly have not been fruitful. We identify CHD1 as a synthetic lethal vulnerability in MYC-driven breast cancer. www.biorxiv.org/content/10.1...
CHD1 is a synthetic lethal vulnerability in MYC-driven breast cancer
The MYC transcription factor is a key regulator of growth during development and a potent cancer driver when its expression is dysregulated. Strategies to inhibit MYC oncogenic activity would mark a s...
www.biorxiv.org
September 4, 2025 at 7:11 PM
(1/4) New preprint from the lab!
The MYC transcription factor is a potent cancer driver when its expression is dysregulated, but efforts to target MYC directly have not been fruitful. We identify CHD1 as a synthetic lethal vulnerability in MYC-driven breast cancer. www.biorxiv.org/content/10.1...
The MYC transcription factor is a potent cancer driver when its expression is dysregulated, but efforts to target MYC directly have not been fruitful. We identify CHD1 as a synthetic lethal vulnerability in MYC-driven breast cancer. www.biorxiv.org/content/10.1...
Discussed @mrsantos.bsky.social lit review: A single-cell time-lapse of mouse prenatal development from gastrula to birth.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A single-cell time-lapse of mouse prenatal development from gastrula to birth - Nature
Single-cell transcriptome profiling of mouse embryos and newborn pups is combined with previously published data to construct a tree of cell-type relationships tracing development from zygote to birth...
www.nature.com
August 12, 2025 at 2:41 PM
Discussed @mrsantos.bsky.social lit review: A single-cell time-lapse of mouse prenatal development from gastrula to birth.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
🌞 Let's enjoy the summer time in Toronto! 🏖️
July 25, 2025 at 3:17 PM
🌞 Let's enjoy the summer time in Toronto! 🏖️
Discussed @mrsantos.bsky.social lit review:
Recovering undersampled single-cell transcriptomes with HyperCell.
www.researchsquare.com/article/rs-6...
Recovering undersampled single-cell transcriptomes with HyperCell.
www.researchsquare.com/article/rs-6...
Recovering undersampled single-cell transcriptomes with HyperCell
Single-cell transcriptomic technology has now matured, allowing quantification of mRNA transcripts corresponding to tens of thousands of genes within a cell. However, still only a small fraction of th...
www.researchsquare.com
July 22, 2025 at 4:34 PM
Discussed @mrsantos.bsky.social lit review:
Recovering undersampled single-cell transcriptomes with HyperCell.
www.researchsquare.com/article/rs-6...
Recovering undersampled single-cell transcriptomes with HyperCell.
www.researchsquare.com/article/rs-6...
(1/3) Latest preprint from the lab! 📝
This work points towards regulatory roles of alpha satellite RNA in nuclear compartmentalization and tuning ribosomal RNA expression in naïve human embryonic stem cells.
doi.org/10.1101/2025...
This work points towards regulatory roles of alpha satellite RNA in nuclear compartmentalization and tuning ribosomal RNA expression in naïve human embryonic stem cells.
doi.org/10.1101/2025...
Alpha satellite RNA marks the perinucleolar compartment and represses ribosomal RNA expression in naïve human embryonic stem cells
While most newly synthesized RNA is exported to the cytoplasm, a portion of non-coding RNA is retained in the nucleus and remains highly associated with chromatin. The strong binding of this RNA fract...
doi.org
July 21, 2025 at 8:12 PM
(1/3) Latest preprint from the lab! 📝
This work points towards regulatory roles of alpha satellite RNA in nuclear compartmentalization and tuning ribosomal RNA expression in naïve human embryonic stem cells.
doi.org/10.1101/2025...
This work points towards regulatory roles of alpha satellite RNA in nuclear compartmentalization and tuning ribosomal RNA expression in naïve human embryonic stem cells.
doi.org/10.1101/2025...
Reposted by Miguel Ramalho-Santos
⏳Only 1 week left to submit your talk for the Fusion Stem Cells & Cancer Conference!
🧪Share your exciting discoveries with us!!
📍Malta
🗓️Talk Deadline: July 10
🔗http://bit.ly/49sCfJp
@joneslabucsf.bsky.social, Kathrin Plath, @katemiro.bsky.social at @fusionconf.bsky.social
🧪Share your exciting discoveries with us!!
📍Malta
🗓️Talk Deadline: July 10
🔗http://bit.ly/49sCfJp
@joneslabucsf.bsky.social, Kathrin Plath, @katemiro.bsky.social at @fusionconf.bsky.social
One Month to Go!🚨
Countdown for the STEM CELLS & CANCER Fusion Conference — a unique gathering of global leaders sharing their ground breaking research.
🧬Ignite new ideas by Mediterranean Sea-Malta 🏝️
📅Final Deadline: 31 July
🎤Unmissable speakers...🧵
bit.ly/49sCfJp
Countdown for the STEM CELLS & CANCER Fusion Conference — a unique gathering of global leaders sharing their ground breaking research.
🧬Ignite new ideas by Mediterranean Sea-Malta 🏝️
📅Final Deadline: 31 July
🎤Unmissable speakers...🧵
bit.ly/49sCfJp
Stem Cells & Cancer Conference | Fusion Conferences
Our scientific research conferences support the development of physical, medical and life sciences, providing a powerful platform that encourages discussion and collaboration in luxury locations acros...
bit.ly
July 4, 2025 at 8:21 AM
⏳Only 1 week left to submit your talk for the Fusion Stem Cells & Cancer Conference!
🧪Share your exciting discoveries with us!!
📍Malta
🗓️Talk Deadline: July 10
🔗http://bit.ly/49sCfJp
@joneslabucsf.bsky.social, Kathrin Plath, @katemiro.bsky.social at @fusionconf.bsky.social
🧪Share your exciting discoveries with us!!
📍Malta
🗓️Talk Deadline: July 10
🔗http://bit.ly/49sCfJp
@joneslabucsf.bsky.social, Kathrin Plath, @katemiro.bsky.social at @fusionconf.bsky.social
Discussed @mrsantos.bsky.social lit review: Maternal iron deficiency causes male-to-female sex reversal in mouse embryos
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Maternal iron deficiency causes male-to-female sex reversal in mouse embryos - Nature
Iron-deficient conditions in pregnant mice can cause XY mouse embryos to develop female rather than male genitalia, revealing that iron metabolism has a role in determining male sex in mice.
www.nature.com
June 17, 2025 at 4:14 PM
Discussed @mrsantos.bsky.social lit review: Maternal iron deficiency causes male-to-female sex reversal in mouse embryos
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Congrats to Dr. Cho on the successful PhD defense!
June 12, 2025 at 2:06 PM
Congrats to Dr. Cho on the successful PhD defense!
Discussed @mrsantos.bsky.social lit review: Stem-loop binding protein is a multifaceted cellular regulator of HIV-1 replication. pubmed.ncbi.nlm.nih.gov/27454292/
Stem-loop binding protein is a multifaceted cellular regulator of HIV-1 replication - PubMed
A rare subset of HIV-1-infected individuals is able to maintain plasma viral load (VL) at low levels without antiretroviral treatment. Identifying the mechanisms underlying this atypical response to i...
pubmed.ncbi.nlm.nih.gov
June 11, 2025 at 6:50 PM
Discussed @mrsantos.bsky.social lit review: Stem-loop binding protein is a multifaceted cellular regulator of HIV-1 replication. pubmed.ncbi.nlm.nih.gov/27454292/
Discussed @mrsantos.bsky.social lit review: Identification of genes supporting cold resistance of mammalian cells: lessons from a hibernator.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Identification of genes supporting cold resistance of mammalian cells: lessons from a hibernator - Cell Death & Disease
Cell Death & Disease - Identification of genes supporting cold resistance of mammalian cells: lessons from a hibernator
www.nature.com
May 6, 2025 at 1:54 PM
Discussed @mrsantos.bsky.social lit review: Identification of genes supporting cold resistance of mammalian cells: lessons from a hibernator.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Discussed @mrsantos.bsky.social lit review: Genome-coverage single-cell histone modifications for embryo lineage tracing. www.nature.com/articles/s41...
Genome-coverage single-cell histone modifications for embryo lineage tracing - Nature
Two new methods, target chromatin indexing and tagmentation (TACIT) and combined TACIT (CoTACIT), enabled single-cell profiling of the epigenome and lineage tracing from mouse zygotes to blastocy...
www.nature.com
April 30, 2025 at 1:34 PM
Discussed @mrsantos.bsky.social lit review: Genome-coverage single-cell histone modifications for embryo lineage tracing. www.nature.com/articles/s41...
Discussed @mrsantos.bsky.social lit review: How epigenetic inheritance fails to explain the Black-White health gap.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
How epigenetic inheritance fails to explain the Black-White health gap
Slavery, legal segregation, and ongoing discrimination have exacted an unfathomable toll on the black population in the United States, particularly wi…
www.sciencedirect.com
April 23, 2025 at 2:03 PM
Discussed @mrsantos.bsky.social lit review: How epigenetic inheritance fails to explain the Black-White health gap.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Discussed @mrsantos.bsky.social lit review: RNA polymerase II at histone genes predicts outcome in human cancer.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
RNA polymerase II at histone genes predicts outcome in human cancer
Genome-wide hypertranscription is common in human cancer and predicts poor prognosis. To understand how hypertranscription might drive cancer, we applied our formalin-fixed paraffin-embedded (FFPE)–cl...
www.science.org
April 2, 2025 at 7:03 PM
Discussed @mrsantos.bsky.social lit review: RNA polymerase II at histone genes predicts outcome in human cancer.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Thank you @isscr.org Stem Cell Reports for selecting our work for the March cover! Caption:
(1/3) In this issue, Kim and Ramalho-Santos provide a perspective on the history of stem cell transcriptomics. They show that a stemness signature from the early 2000’s foreshadowed hypertranscription.
(1/3) In this issue, Kim and Ramalho-Santos provide a perspective on the history of stem cell transcriptomics. They show that a stemness signature from the early 2000’s foreshadowed hypertranscription.
March 13, 2025 at 9:58 PM
Thank you @isscr.org Stem Cell Reports for selecting our work for the March cover! Caption:
(1/3) In this issue, Kim and Ramalho-Santos provide a perspective on the history of stem cell transcriptomics. They show that a stemness signature from the early 2000’s foreshadowed hypertranscription.
(1/3) In this issue, Kim and Ramalho-Santos provide a perspective on the history of stem cell transcriptomics. They show that a stemness signature from the early 2000’s foreshadowed hypertranscription.
Reposted by Miguel Ramalho-Santos
Read the recent review by @mrsantos.bsky.social that marks
two decades of stem cell breakthroughs 🔬 🙌 🎉
Discover how a serendipitous discovery of a stem cell gene signature has led to understanding hypertranscription, with implications for health and disease.
www.cell.com/stem-cell-re...
two decades of stem cell breakthroughs 🔬 🙌 🎉
Discover how a serendipitous discovery of a stem cell gene signature has led to understanding hypertranscription, with implications for health and disease.
www.cell.com/stem-cell-re...
February 13, 2025 at 4:14 PM
Read the recent review by @mrsantos.bsky.social that marks
two decades of stem cell breakthroughs 🔬 🙌 🎉
Discover how a serendipitous discovery of a stem cell gene signature has led to understanding hypertranscription, with implications for health and disease.
www.cell.com/stem-cell-re...
two decades of stem cell breakthroughs 🔬 🙌 🎉
Discover how a serendipitous discovery of a stem cell gene signature has led to understanding hypertranscription, with implications for health and disease.
www.cell.com/stem-cell-re...
Reposted by Miguel Ramalho-Santos
Two more weeks to apply to join us in Paris !
research.pasteur.fr/en/call/call...
research.pasteur.fr/en/call/call...
Call for applications 2025 - Creation of new research groups at the Institut Pasteur - Research
The Institut Pasteur launches an international call to recruit new junior research group leaders in the application of cutting-edge transdisciplinary approaches to the exploration of host-microbe, tis...
research.pasteur.fr
February 13, 2025 at 6:09 PM
Two more weeks to apply to join us in Paris !
research.pasteur.fr/en/call/call...
research.pasteur.fr/en/call/call...