Miguel Ramalho-Santos
@mrsantos.bsky.social
Scientist and Professor in Developmental Epigenetics.
Lunenfeld-Tanenbaum Research Institute
Dpt Molecular Genetics, University of Toronto, Canada
Lab: mrsantoslab.org
Coimbra, Portugal -> Cambridge, MA, USA -> S. Francisco, CA, USA -> Toronto, ON, Canada
Lunenfeld-Tanenbaum Research Institute
Dpt Molecular Genetics, University of Toronto, Canada
Lab: mrsantoslab.org
Coimbra, Portugal -> Cambridge, MA, USA -> S. Francisco, CA, USA -> Toronto, ON, Canada
Trick or Treat! 👻🎃
November 10, 2025 at 7:23 PM
Trick or Treat! 👻🎃
(1/4) New Pre-print! 🌟
Embryonic development is usually seen as a continuous process, yet some embryos can pause their development to survive harsh conditions, a phenomenon known as diapause. How this pausing is actively maintained has remained a mystery.
Embryonic development is usually seen as a continuous process, yet some embryos can pause their development to survive harsh conditions, a phenomenon known as diapause. How this pausing is actively maintained has remained a mystery.
October 9, 2025 at 8:08 PM
(1/4) New Pre-print! 🌟
Embryonic development is usually seen as a continuous process, yet some embryos can pause their development to survive harsh conditions, a phenomenon known as diapause. How this pausing is actively maintained has remained a mystery.
Embryonic development is usually seen as a continuous process, yet some embryos can pause their development to survive harsh conditions, a phenomenon known as diapause. How this pausing is actively maintained has remained a mystery.
(2/4) We found that knockdown of CHD1 in a xenograft model of MYC-driven breast cancer suppresses tumor growth in vivo. In tissue culture models, knockdown of CHD1 suppresses cell proliferation and induces cell death, specifically when MYC is overexpressed.
September 4, 2025 at 7:11 PM
(2/4) We found that knockdown of CHD1 in a xenograft model of MYC-driven breast cancer suppresses tumor growth in vivo. In tissue culture models, knockdown of CHD1 suppresses cell proliferation and induces cell death, specifically when MYC is overexpressed.
🌞 Let's enjoy the summer time in Toronto! 🏖️
July 25, 2025 at 3:17 PM
🌞 Let's enjoy the summer time in Toronto! 🏖️
Congrats to Dr. Cho on the successful PhD defense!
June 12, 2025 at 2:06 PM
Congrats to Dr. Cho on the successful PhD defense!
Thank you @isscr.org Stem Cell Reports for selecting our work for the March cover! Caption:
(1/3) In this issue, Kim and Ramalho-Santos provide a perspective on the history of stem cell transcriptomics. They show that a stemness signature from the early 2000’s foreshadowed hypertranscription.
(1/3) In this issue, Kim and Ramalho-Santos provide a perspective on the history of stem cell transcriptomics. They show that a stemness signature from the early 2000’s foreshadowed hypertranscription.
March 13, 2025 at 9:58 PM
Thank you @isscr.org Stem Cell Reports for selecting our work for the March cover! Caption:
(1/3) In this issue, Kim and Ramalho-Santos provide a perspective on the history of stem cell transcriptomics. They show that a stemness signature from the early 2000’s foreshadowed hypertranscription.
(1/3) In this issue, Kim and Ramalho-Santos provide a perspective on the history of stem cell transcriptomics. They show that a stemness signature from the early 2000’s foreshadowed hypertranscription.
🗞️Breaking News: our team was just awarded a new, 5-year CIHR Project Grant for our studies of the regulation of hypertranscription! We are very grateful to the Canadian Institutes of Health Research for their continued support of our research in developmental epigenetics.
@sinaihealth.bsky.social
@sinaihealth.bsky.social
January 29, 2025 at 7:33 PM
🗞️Breaking News: our team was just awarded a new, 5-year CIHR Project Grant for our studies of the regulation of hypertranscription! We are very grateful to the Canadian Institutes of Health Research for their continued support of our research in developmental epigenetics.
@sinaihealth.bsky.social
@sinaihealth.bsky.social