Microbial Pathogenicity Mechanisms
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mpm-hki.bsky.social
Microbial Pathogenicity Mechanisms
@mpm-hki.bsky.social
130 followers 190 following 55 posts
Research group @leibniz-hki.de in Jena, Germany.
Studying pathogenicity of yeast-y beasties in the 𝘊𝘢𝘯𝘥𝘪𝘥𝘢 clade. 🧫🔬🦠🍄
Head: Prof Bernhard Hube
Webpage: https://www.leibniz-hki.de/en/microbial-pathogenicity-mechanisms.html
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mpm-hki.bsky.social
Microbial Pathogenicity Mechanisms @mpm-hki.bsky.social · Oct 10
“Pour some sugar on me” — environmental #CandidaAlbicans strains on a sugar diet can evolve enhanced virulence and antifungal resistance.
Read our @leibniz-hki.de most recent discovery @plos.org
doi.org/10.1371/jour...
(1/2)
“Pour some sugar on me”—Environmental Candida albicans isolates and the evolution of increased pathogenicity and antifungal resistance through sugar adaptation
Author summary In this study, we set out to understand whether Candida albicans found in nature can be as dangerous as the strains collected from patients, and whether a diet high in sugar affects the...
doi.org
Reposted by Microbial Pathogenicity Mechanisms
clementsui.bsky.social
Commensalism and pathogenesis of #Candida albicans at the mucosal interface rdcu.be/eia8o
Commensalism and pathogenesis of Candida albicans at the mucosal interface
Nature Reviews Microbiology - In this Review, Hube and colleagues overview the commensal and pathogenic lifestyles of Candida albicans, focusing on how the fungus transitions between these two...
rdcu.be
April 17, 2025 at 3:18 PM
Reposted by Microbial Pathogenicity Mechanisms
julioczuniga1.bsky.social
www.clinicalmicrobiologyandinfection.org/article/S119...
Gender differences in audience participation at infectious disease and microbiology conferences: a prospective observational study
In medicine, women constitute a large proportion of the workforce but remain underrepresented in senior positions. Scientific conferences, critical for career advancement, reflect these inequities, wi...
www.clinicalmicrobiologyandinfection.org
November 15, 2025 at 3:16 AM
Reposted by Microbial Pathogenicity Mechanisms
leibniz-hki.de
📖 Perfect weekend reading for fungal fans! 😉 Our @mpm-hki.bsky.social colleagues uncover how #CandidaAlbicans manages to invade tissue as hyphae but spread as yeast. Published in @femsjournals.bsky.social.

🧑🏻‍🔬: @jlspragu.bsky.social
femsjournals.bsky.social FEMS Journals @femsjournals.bsky.social · 13d
#C.albicans invades tissues as hyphae but spreads as yeast, How?
@jlspragu.bsky.social & coll. show yeast can reach the bloodstream by hitchhiking with invasive hyphae or by switching forms. 🧫 More clues for understanding systemic infections !
👉 buff.ly/0vklJeb
November 7, 2025 at 2:03 PM
Reposted by Microbial Pathogenicity Mechanisms
leibniz-hki.de
🎉 #LeibnizHKI has again been honored with the TOTAL E-QUALITY rating for our equal-opportunities personnel policy – for the 5th time in a row! This year, we also received the Sustainability Prize 2025 for our long-term commitment to equality, diversity & inclusion.

🗞️✨ lmy.de/zVSiL

#TotalEquality
Christine Vogler, Equal Opportunities Officer at Leibniz-HKI, accepted the TOTAL E-QUALITY award and the Sustainability Award.
November 5, 2025 at 1:45 PM
mpm-hki.bsky.social
Check out @jlspragu.bsky.social latest paper!
@leibniz-hki.de
femsjournals.bsky.social FEMS Journals @femsjournals.bsky.social · 13d
#C.albicans invades tissues as hyphae but spreads as yeast, How?
@jlspragu.bsky.social & coll. show yeast can reach the bloodstream by hitchhiking with invasive hyphae or by switching forms. 🧫 More clues for understanding systemic infections !
👉 buff.ly/0vklJeb
November 6, 2025 at 12:00 PM
Reposted by Microbial Pathogenicity Mechanisms
spp2225.bsky.social
Check out another brand-new publication by our EXIT members Theresa Lange, Bernhard Hube, and Sascha Brunke, together with additional co-authors, on #Candidaalbicans in PLOS Pathogens: dx.plos.org/10.1371/jour...
“Pour some sugar on me”—Environmental Candida albicans isolates and the evolution of increased pathogenicity and antifungal resistance through sugar adaptation
Author summary In this study, we set out to understand whether Candida albicans found in nature can be as dangerous as the strains collected from patients, and whether a diet high in sugar affects the...
dx.plos.org
October 20, 2025 at 9:31 AM
Reposted by Microbial Pathogenicity Mechanisms
microverse.bsky.social
🎉 We warmly congratulate Dr Alexander Mosig on his new professorship for Alternative Methods to Animal Testing in Infection & Inflammation Research at #JenaUniversityHospital! From Jan 2026, he’ll also join our Cluster to share expertise in #OrganOnChip and infection research.
October 23, 2025 at 8:57 AM
Reposted by Microbial Pathogenicity Mechanisms
microverse.bsky.social
A great turnout for our latest Microverse Seminar! 🍕🔬

@ameliabarberphd.bsky.social, Junior Group Leader #FungalInformatics, shared fascinating insights in her talk “From Ecology to Genomes: Unraveling Fungal Pathogenicity Across Scales.”

Lively discussions and great connections followed!
October 29, 2025 at 8:02 AM
Reposted by Microbial Pathogenicity Mechanisms
hellmichgroup.bsky.social
We proudly present:
the 2025 Halloween Lab Pumpkin Carving Edition!!! 😁🥳👻
October 29, 2025 at 11:13 PM
Reposted by Microbial Pathogenicity Mechanisms
microverse.bsky.social
🎥 New "3 Questions for …" episode! Prof. Miriam Rosenbaum shows how microbes can produce antibiotics, bioplastics, and find balance under stress. Discover how our #ClusterOfExcellence brings interdisciplinary science to life! 🌱🔬
www.youtube.com/watch?v=FA45...
THREE QUESTIONS FOR ... Miriam Agler-Rosenbaum
YouTube video by Universität Jena
www.youtube.com
October 15, 2025 at 11:10 AM
Reposted by Microbial Pathogenicity Mechanisms
leibniz-hki.de
🍁 Meet our #October #calendar 2025 feature: Zoltán Cseresnyés, imaging specialist at our @appsysbio.bsky.social research group. From 1980s Hungary to super-resolution microscopy at Cambridge, he now helps researchers unlock insights from complex images. 🔬🌌
lmy.de/LsPim

#FacesOfScience #LeibnizHKI
Zoltán Cseresnyés, an older man with short gray hair and a friendly smile, stands indoors beside a long office table. He is wearing a light blue short-sleeved shirt, gray trousers, and brown shoes. He holds a small potted bonsai tree in both hands. On the table next to him are a large potted plant, a green watering can, and a book. The background shows a bright modern room with white walls and wooden flooring. In the upper left, a colorful speech bubble contains the text: “I am an image analyst. I help biologists and chemists to analyze their image data and get information and quantification out of microscopy images, thus allowing them to modify or plan experiments.” The Leibniz-HKI logo appears in blue at the bottom left, and an orange arrow points to the right. Colorful calendar page for October 2025 from the Leibniz-HKI Calendar. The background fades from blue on the left to purple on the right. The word 'OCTOBER' appears in bold orange letters. Below it, the name 'Zoltán Cseresnyés' is written in large green text. At the bottom left, small black text reads 'Leibniz-HKI Calendar 2025' with the blue Leibniz-HKI logo beneath it. On the right side, the word 'SWIPE' is written in black uppercase letters next to an orange arrow pointing right. A close-up photo shows the back of a man’s head as he looks at a computer monitor displaying a complex network of colorful lines and nodes on a dark background – microscopy data visualization. The desk below the monitor holds papers, computer accessories, and cables. In the top left, a colorful speech bubble contains the text: “The real highlight was being there at the very beginning of super-resolution microscopy.” The Leibniz-HKI logo appears in blue at the bottom left, and an orange arrow points to the right. Zoltán Cseresnyés and a younger woman with dark hair, one of his colleagues, sit side by side at a table in a bright office. Zoltán, wearing a light blue short-sleeved shirt, gestures with his hand while explaining something on a laptop screen. The woman listens attentively, wearing a patterned blouse and a wristwatch. Behind them, large windows with blinds fill the room with natural light. A colorful speech bubble above them contains the text: “It is crucial to remain flexible and open – both in mind and in career.” The Leibniz-HKI logo appears in blue at the bottom left of the image.
October 17, 2025 at 2:27 PM
Reposted by Microbial Pathogenicity Mechanisms
slavi-jan.bsky.social
📣 I’m excited to share two open positions in my lab @leibniz-hki.de. For this interdisciplinary project with @luziagyr.bsky.social, I’m seeking (1) an enthusiastic PhD student interested in fungal natural product research and genetic engineering, as well as (2) a technical assistant 👇🏻
October 21, 2025 at 2:48 PM
Reposted by Microbial Pathogenicity Mechanisms
fungalmeg.bsky.social
Thank you so much @mpm-hki.bsky.social for having me - I have enjoyed my first visit to Jena very much
mpm-hki.bsky.social Microbial Pathogenicity Mechanisms @mpm-hki.bsky.social · Oct 2
What a great talk by Megan Lenardon @fungalmeg.bsky.social from the #UNSWSydney! She visited our lab today @leibniz-hki.de and presented her group's work about how to antagonize #Candida albicans infections, either by novel antifungal polymers or via microbiome-based therapeutics. 🦠🧫🔬
October 2, 2025 at 4:56 PM
mpm-hki.bsky.social
“Pour some sugar on me” — environmental #CandidaAlbicans strains on a sugar diet can evolve enhanced virulence and antifungal resistance.
Read our @leibniz-hki.de most recent discovery @plos.org
doi.org/10.1371/jour...
(1/2)
“Pour some sugar on me”—Environmental Candida albicans isolates and the evolution of increased pathogenicity and antifungal resistance through sugar adaptation
Author summary In this study, we set out to understand whether Candida albicans found in nature can be as dangerous as the strains collected from patients, and whether a diet high in sugar affects the...
doi.org
October 10, 2025 at 9:11 AM
mpm-hki.bsky.social
It's a wrap! Thanks to the organizers at @microbiologysociety.org for this great #Candida2025 conference! 🍄👏😊

And congratulations to our PhD student Myrto who won a prize for her excellent poster presentation! 🥳🎉

@leibniz-hki.de
Myrto Katsipoulaki (third from the right) won a prize for her poster
October 9, 2025 at 5:59 PM
mpm-hki.bsky.social
Hope y'all enjoyed our talks at #Candida2025! Theresa presented yesterday one of her PhD projects about the C. glabrata-macrophage interaction. Tim presented today his work about the antibacterial mechanisms of candidalysin, and Sascha presented Osama's work on C. albicans' lipases.
@leibniz-hki.de
Theresa Lange's plenary session talk about C. glabrata's interaction with macrophages Tim Schille's presentation about dissecting the antibacterial functions of candidalysin Sascha Brunke's presentation about Osama Elshafee's work about the C. albicans lipase gene family
October 8, 2025 at 10:37 AM
mpm-hki.bsky.social
At today's poster session at #Candida2025 come and check out Anna's poster #B022! She presents her PhD project about Candida albicans protein kinases and how they affect pathogenicity.

@microbiologysociety.org
@trr124-funginet.bsky.social
@leibniz-hki.de
Anna's poster B22
October 8, 2025 at 7:35 AM
mpm-hki.bsky.social
Don't miss our posters at #Candida2025 today! Myrto presents poster #A12 about dissecting C. albicans isolates using reporter cell lines. Steffi's poster #A6 is about ECE1 in non-albicans Candida species. And Verena presents her multi-reporter cells at poster #A24.
@microbiologysociety.org
Verena's poster A024 Steffi's poster A006 Myrto's poster A012
October 7, 2025 at 11:08 AM
mpm-hki.bsky.social
The #Candida2025 meeting has started! And what a great kick-off with these two keynote speakers: @slg1717.bsky.social introduced her group's work around IL-17 and our boss Bernie presented a great overview about our group's candidalysin research. 🍄🧬🔬

@leibniz-hki.de
@microbiologysociety.org
October 6, 2025 at 6:20 PM
mpm-hki.bsky.social
On our way to the #Candida2025 hosted by the @microbiologysociety.org. Looking forward to see you there! 😊🍄
October 6, 2025 at 9:23 AM
mpm-hki.bsky.social
Excieted to see @fungalmeg.bsky.social
from #UNSW #Sydney present her groundbreaking work on harnessing the human microbiome to combat #CandidaAlbicans, along with advances in antifungal polymers we at @leibniz-hki.de have had the pleasure to collaborate on in the past!
October 2, 2025 at 3:33 PM
mpm-hki.bsky.social
What a great talk by Megan Lenardon @fungalmeg.bsky.social from the #UNSWSydney! She visited our lab today @leibniz-hki.de and presented her group's work about how to antagonize #Candida albicans infections, either by novel antifungal polymers or via microbiome-based therapeutics. 🦠🧫🔬
October 2, 2025 at 12:21 PM
Reposted by Microbial Pathogenicity Mechanisms
health-europe-de.bsky.social
Am Beispiel des Hefepilzes Candida albicans zeigen Forschende unter Leitung von @lableibundgut.bsky.social, mit Kollegen von @mpm-hki.bsky.social am @leibniz-hki.de und @pasteur.fr, wie das #Immunsystem auf unterschiedliche Pilzstämme reagiert. #Mikrobiologie #Pilzinfektion
Forscher decken Pathogenitätsmechanismus von Hefepilz auf
Candida albicans produziert ein Toxin, das krank macht – aber in geringen Mengen hilft es dem Pilz, um dauerhaft in der Mundschleimhaut zu überleben
healthcare-in-europe.com
September 30, 2025 at 10:48 AM
Reposted by Microbial Pathogenicity Mechanisms
leibniz-hki.de
Dose makes the difference! #Candidaalbicans uses the toxin #candidalysin not only to cause infections but also to quietly colonize the mouth – too little fails, too much triggers immune defense.

@natmicrobiol.nature.com
@mpm-hki.bsky.social

picture credits: Erik Böhm, @leibniz-hki.de
September 26, 2025 at 11:58 AM
mpm-hki.bsky.social
#CandidaAlbicans needs the toxin candidalysin to colonize the oral cavity in mice. A new sudy in collaboration with @lableibundgut.bsky.social and @pasteur.fr shows that candidalysin enables the fungus to cross the outer skin layer, resist the immune response, and maintain its niche—(1/2)
September 26, 2025 at 12:16 PM