Mona Alzheimer
@monaalzheimer.bsky.social
Scientific coordinator & infection biologist @Sharmalab.bsky.social | RNA and infection | Deep-sequencing & microfluidics approaches to bacterial pathogenesis | Campylobacter & Helicobacter
Reposted by Mona Alzheimer
If you're interested in developing an open-source image analysis platform/plugin to profile bacteria with deep learning while living in the beautiful city of Paris 🇫🇷, check out this job ad from the @chzimmer.bsky.social lab @pasteur.fr
research.pasteur.fr/fr/job/open-...
research.pasteur.fr/fr/job/open-...
Open-Source Developer for Deep Learning Antibiotic Discovery Platform - Research
Introduction Antimicrobial resistance (AMR) is one of the most urgent global health threats projected to cause up to 10 million deaths per year by 2050. The AI4AMR project brings together teams from I...
research.pasteur.fr
November 15, 2025 at 9:22 AM
If you're interested in developing an open-source image analysis platform/plugin to profile bacteria with deep learning while living in the beautiful city of Paris 🇫🇷, check out this job ad from the @chzimmer.bsky.social lab @pasteur.fr
research.pasteur.fr/fr/job/open-...
research.pasteur.fr/fr/job/open-...
Reposted by Mona Alzheimer
Check this out! A napari plugin for AI-based analysis of microbial bioimages! 🔬🦠💻
🦠🔬🤖🧑💻 #mAIcrobe interface preview, a platform for #DeepLearning enabled bacterial image-based phenotyping. Check it out
💻: github.com/HenriquesLab...
📄: www.biorxiv.org/content/10.1...
💻: github.com/HenriquesLab...
📄: www.biorxiv.org/content/10.1...
November 12, 2025 at 7:15 AM
Check this out! A napari plugin for AI-based analysis of microbial bioimages! 🔬🦠💻
Reposted by Mona Alzheimer
🦠🔬🤖🧑💻 #mAIcrobe is out! With @pinholab.bsky.social's lab, we launched an open-source framework for high-throughput bacterial image analysis. By rockstars A. Brito & B. Saraiva et al, making #DeepLearning for phenotyping accessible! Easy to use, plus model training
📜 www.biorxiv.org/content/10.1...
📜 www.biorxiv.org/content/10.1...
October 22, 2025 at 11:10 AM
🦠🔬🤖🧑💻 #mAIcrobe is out! With @pinholab.bsky.social's lab, we launched an open-source framework for high-throughput bacterial image analysis. By rockstars A. Brito & B. Saraiva et al, making #DeepLearning for phenotyping accessible! Easy to use, plus model training
📜 www.biorxiv.org/content/10.1...
📜 www.biorxiv.org/content/10.1...
What an incredible weekend at the kickoff meeting of the @zeit.de #Zia programme for #VisibleWomenInScience. Deeply grateful to the organisers and the many inspirational women, who shared their stories and energy. Looking forward to the fellowship year ahead with this exceptional group of women!!!
November 10, 2025 at 7:37 PM
What an incredible weekend at the kickoff meeting of the @zeit.de #Zia programme for #VisibleWomenInScience. Deeply grateful to the organisers and the many inspirational women, who shared their stories and energy. Looking forward to the fellowship year ahead with this exceptional group of women!!!
Reposted by Mona Alzheimer
JB Editor's Choice: Waller, Ribardo & Hendrixson show that flagellar length impacts function, with short flagella slowing swimming and reducing host colonization, indicating the important of regulating the lenght of the filament.
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
October 22, 2025 at 1:31 PM
JB Editor's Choice: Waller, Ribardo & Hendrixson show that flagellar length impacts function, with short flagella slowing swimming and reducing host colonization, indicating the important of regulating the lenght of the filament.
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
Reposted by Mona Alzheimer
Die Bayerische Staatsregierung und die @maxplanck.de wollen den Wissenschaftsstandort Würzburg stärken. Ein heute unterzeichnetes Memorandum of Understanding legt den Grundstein für den Ausbau der Forschung in der Biomedizin. Auf eine starke Partnerschaft!
📸 Axel Griesch
📸 Axel Griesch
October 21, 2025 at 2:46 PM
Die Bayerische Staatsregierung und die @maxplanck.de wollen den Wissenschaftsstandort Würzburg stärken. Ein heute unterzeichnetes Memorandum of Understanding legt den Grundstein für den Ausbau der Forschung in der Biomedizin. Auf eine starke Partnerschaft!
📸 Axel Griesch
📸 Axel Griesch
Reposted by Mona Alzheimer
Are you interested in studying RNA phages? We are looking for a PhD student and a postdoc to join the lab!
For more information and how to apply, see below 👇
Please RT!
For more information and how to apply, see below 👇
Please RT!
📢 The #HIRI is looking for a #postdoc & a #PhD student to join the research group of @jenshoer.bsky.social. His lab focuses on understanding the molecular mechanisms of #phages with #RNA genomes during infection, host takeover & anti-phage defense. 🧫🦠 More info: www.helmholtz-hiri.de/en/jobs-tale...
Working at HIRI
At the HIRI, we do not just value excellent research. Short distances, an open door policy, and a good working atmosphere—this is what distinguishes us from others. Have a look at our current job…
www.helmholtz-hiri.de
October 17, 2025 at 12:52 PM
Are you interested in studying RNA phages? We are looking for a PhD student and a postdoc to join the lab!
For more information and how to apply, see below 👇
Please RT!
For more information and how to apply, see below 👇
Please RT!
Reposted by Mona Alzheimer
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
October 15, 2025 at 12:22 PM
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
Reposted by Mona Alzheimer
Glucose capping of 5'-mRNAs in E. coli 😱, presumably is installed during transcriptional initiation #MicroSky #RNASky www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
October 14, 2025 at 6:19 PM
Glucose capping of 5'-mRNAs in E. coli 😱, presumably is installed during transcriptional initiation #MicroSky #RNASky www.pnas.org/doi/10.1073/...
Reposted by Mona Alzheimer
Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.
October 8, 2025 at 9:45 PM
Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.
Reposted by Mona Alzheimer
Disruption to the gut microbiome by non-antibiotics is linked to infection risk http://dlvr.it/TN9lNG
September 19, 2025 at 5:00 PM
Disruption to the gut microbiome by non-antibiotics is linked to infection risk http://dlvr.it/TN9lNG
Reposted by Mona Alzheimer
Looking for a new approach to studying or eliminating phages? Check out our study introducing anti-phage ASOs (antisense oligos) out in @Nature today. nature.com/articles/s4158…
September 10, 2025 at 3:40 PM
Looking for a new approach to studying or eliminating phages? Check out our study introducing anti-phage ASOs (antisense oligos) out in @Nature today. nature.com/articles/s4158…
Reposted by Mona Alzheimer
PhDs & Postdocs of @uni-wuerzburg.de struggling to finish a project? Join our Long Night Against Procrastination!
✅ Tips on motivation & writing
✅ Pizza & plenty of coffee
✅ Work through the night with peers from all disciplines
📅 Oct 23, 2025 | 5pm–midnight
📍 Graduate Schools Building
✅ Tips on motivation & writing
✅ Pizza & plenty of coffee
✅ Work through the night with peers from all disciplines
📅 Oct 23, 2025 | 5pm–midnight
📍 Graduate Schools Building
August 25, 2025 at 10:34 AM
PhDs & Postdocs of @uni-wuerzburg.de struggling to finish a project? Join our Long Night Against Procrastination!
✅ Tips on motivation & writing
✅ Pizza & plenty of coffee
✅ Work through the night with peers from all disciplines
📅 Oct 23, 2025 | 5pm–midnight
📍 Graduate Schools Building
✅ Tips on motivation & writing
✅ Pizza & plenty of coffee
✅ Work through the night with peers from all disciplines
📅 Oct 23, 2025 | 5pm–midnight
📍 Graduate Schools Building
Reposted by Mona Alzheimer
Out yesterday. Using a translation reporter on a mini-tn5 transposon, and high freq. mutagenesis, we looked at translation on whole genome scale independently of genome annotation. academic.oup.com/nar/article/...
PIRT-Seq: a high-resolution whole-genome assay to identify protein-coding genes
Abstract. The advent of high-density mutagenesis and data-mining studies suggest the existence of further coding potential within bacterial genomes. Small
academic.oup.com
August 14, 2025 at 7:00 PM
Out yesterday. Using a translation reporter on a mini-tn5 transposon, and high freq. mutagenesis, we looked at translation on whole genome scale independently of genome annotation. academic.oup.com/nar/article/...
Reposted by Mona Alzheimer
1/16 New pre-print from the Sternberg Lab!
We uncover how temperate phages can use RNA-guided transcription factors to remodel the flagellar composition of their bacterial host and enhance their fitness.
Find the preprint and full story here: tinyurl.com/mshwjd77
We uncover how temperate phages can use RNA-guided transcription factors to remodel the flagellar composition of their bacterial host and enhance their fitness.
Find the preprint and full story here: tinyurl.com/mshwjd77
July 24, 2025 at 7:58 PM
1/16 New pre-print from the Sternberg Lab!
We uncover how temperate phages can use RNA-guided transcription factors to remodel the flagellar composition of their bacterial host and enhance their fitness.
Find the preprint and full story here: tinyurl.com/mshwjd77
We uncover how temperate phages can use RNA-guided transcription factors to remodel the flagellar composition of their bacterial host and enhance their fitness.
Find the preprint and full story here: tinyurl.com/mshwjd77
Reposted by Mona Alzheimer
Finally out! A small screen helps understand a little more about how E. coli regulates major transporters, and reveals how caffeine induces phenotypical antibiotic resistance. Huge thanks to collab @andrenmateus.bsky.social (Umeå) and Christian L. Müller (Munich)!
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Systematic screen uncovers regulator contributions to chemical cues in Escherichia coli
Transport machineries are crucial for antibiotic resistance, but their regulation by external cues is poorly understood. This study identifies environmental chemicals that regulate transporter transcr...
journals.plos.org
July 23, 2025 at 9:15 AM
Finally out! A small screen helps understand a little more about how E. coli regulates major transporters, and reveals how caffeine induces phenotypical antibiotic resistance. Huge thanks to collab @andrenmateus.bsky.social (Umeå) and Christian L. Müller (Munich)!
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Reposted by Mona Alzheimer
How are bacterial transport machineries regulated by external cues? @brochadolab.bsky.social &co identify environmental chemicals that regulate #transporter transcription, identifying the TF Rob as a key modulator of #EffluxPump expression in #Ecoli #AMR @plosbiology.org 🧪 plos.io/46pUM9Q
July 23, 2025 at 9:20 AM
How are bacterial transport machineries regulated by external cues? @brochadolab.bsky.social &co identify environmental chemicals that regulate #transporter transcription, identifying the TF Rob as a key modulator of #EffluxPump expression in #Ecoli #AMR @plosbiology.org 🧪 plos.io/46pUM9Q
🧪We are hiring #MicroSky🧪
Postdoc position in #microbiology #bioinformatics for our @volkswagenstiftung.de funded MOMENTUM project. Join us to study bacterial gene expression with #microfluidics and #microscopy.
➡️ www.uni-wuerzburg.de/fileadmin/03290000/2025/Postdoc_MOMENTUM_Sharma_2025-08.pdf
Postdoc position in #microbiology #bioinformatics for our @volkswagenstiftung.de funded MOMENTUM project. Join us to study bacterial gene expression with #microfluidics and #microscopy.
➡️ www.uni-wuerzburg.de/fileadmin/03290000/2025/Postdoc_MOMENTUM_Sharma_2025-08.pdf
July 16, 2025 at 8:14 AM
🧪We are hiring #MicroSky🧪
Postdoc position in #microbiology #bioinformatics for our @volkswagenstiftung.de funded MOMENTUM project. Join us to study bacterial gene expression with #microfluidics and #microscopy.
➡️ www.uni-wuerzburg.de/fileadmin/03290000/2025/Postdoc_MOMENTUM_Sharma_2025-08.pdf
Postdoc position in #microbiology #bioinformatics for our @volkswagenstiftung.de funded MOMENTUM project. Join us to study bacterial gene expression with #microfluidics and #microscopy.
➡️ www.uni-wuerzburg.de/fileadmin/03290000/2025/Postdoc_MOMENTUM_Sharma_2025-08.pdf
Reposted by Mona Alzheimer
🎉 Congratulations to @angelifriedmann.bsky.social on receiving an @erc.europa.eu Proof of Concept grant! With his project “SulFex”, he is working on a new strategy for treating a specific form of lung cancer #ERCPoC 📷Andreas Heddergott go.uniwue.de/poc-grant-an...
July 14, 2025 at 11:23 AM
🎉 Congratulations to @angelifriedmann.bsky.social on receiving an @erc.europa.eu Proof of Concept grant! With his project “SulFex”, he is working on a new strategy for treating a specific form of lung cancer #ERCPoC 📷Andreas Heddergott go.uniwue.de/poc-grant-an...
Reposted by Mona Alzheimer
#NewResearch
🚨Out now
In situ sub-nanometre structure of the Campylobacter jejuni flagellar motor revealing the periplasmic scaffold and basis for torque generation @beebylab.bsky.social
#MicroSky🦠🧫
www.nature.com/articles/s41...
🚨Out now
In situ sub-nanometre structure of the Campylobacter jejuni flagellar motor revealing the periplasmic scaffold and basis for torque generation @beebylab.bsky.social
#MicroSky🦠🧫
www.nature.com/articles/s41...
In situ structure of a bacterial flagellar motor at subnanometre resolution reveals adaptations for increased torque - Nature Microbiology
In situ cryoEM and modelling of the Campylobacter jejuni flagellar motor characterize the periplasmic scaffold and the structural basis for increased torque generation.
www.nature.com
July 1, 2025 at 3:20 PM
#NewResearch
🚨Out now
In situ sub-nanometre structure of the Campylobacter jejuni flagellar motor revealing the periplasmic scaffold and basis for torque generation @beebylab.bsky.social
#MicroSky🦠🧫
www.nature.com/articles/s41...
🚨Out now
In situ sub-nanometre structure of the Campylobacter jejuni flagellar motor revealing the periplasmic scaffold and basis for torque generation @beebylab.bsky.social
#MicroSky🦠🧫
www.nature.com/articles/s41...
Reposted by Mona Alzheimer
Happy to share the preprint from here in Shanghai, together with @danielfalush.bsky.social, as well as with team Zhizhou Jia, Huqi Wen, and Zhe Xie!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Evolution of hunt, kill, devour in a Vibrio ecospecies
Bacterial ecospecies are a recently recognized genetic structure that is hypothesized to arise by complex adaptation to a new niche. Using coadaptation analysis as a foundation for laboratory experime...
www.biorxiv.org
June 30, 2025 at 7:45 AM
Happy to share the preprint from here in Shanghai, together with @danielfalush.bsky.social, as well as with team Zhizhou Jia, Huqi Wen, and Zhe Xie!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Mona Alzheimer
The study was published in the journal @cp-cellreports.bsky.social: www.sciencedirect.com/science/arti...
Low-input RNA-seq suggests metabolic specialization underlying morphological heterogeneity in a gut commensal bacterium
Isogenic bacteria can be phenotypically diverse. This heterogeneity is evident in the Bacteroidota, a predominant phylum of the human gut microbiota. …
www.sciencedirect.com
June 17, 2025 at 3:22 PM
The study was published in the journal @cp-cellreports.bsky.social: www.sciencedirect.com/science/arti...
Reposted by Mona Alzheimer
New study with an organoid model uncovering the role of tRNA modifications and codon usage in Shigella infection 🦠 #rnasky #microsky 💫💫 www.nature.com/articles/s41... Congrats @mldm.bsky.social
A scalable gut epithelial organoid model reveals the genome-wide colonization landscape of a human-adapted pathogen - Nature Genetics
A genome-wide screen using human gut epithelial organoids combined with transposon-directed insertion sequencing identifies over 100 Shigella flexneri genes required for epithelial colonization.
www.nature.com
June 12, 2025 at 5:45 PM
New study with an organoid model uncovering the role of tRNA modifications and codon usage in Shigella infection 🦠 #rnasky #microsky 💫💫 www.nature.com/articles/s41... Congrats @mldm.bsky.social
Reposted by Mona Alzheimer
Into the Nucleoid:
Single-molecule localisation 🔬 and live-cell imaging reveal fine details of chromosomal organisation in the bacterium E. coli 🦠
@michriscopy.bsky.social @uni-wuerzburg.de @heilemannlab.bsky.social @goetheuni.bsky.social
#microbiology
Single-molecule localisation 🔬 and live-cell imaging reveal fine details of chromosomal organisation in the bacterium E. coli 🦠
@michriscopy.bsky.social @uni-wuerzburg.de @heilemannlab.bsky.social @goetheuni.bsky.social
#microbiology
BPoD | Into the Nucleoid
Into the Nucleoid - Biomedical pictures for April 2025.
bit.ly
May 28, 2025 at 2:25 PM
Into the Nucleoid:
Single-molecule localisation 🔬 and live-cell imaging reveal fine details of chromosomal organisation in the bacterium E. coli 🦠
@michriscopy.bsky.social @uni-wuerzburg.de @heilemannlab.bsky.social @goetheuni.bsky.social
#microbiology
Single-molecule localisation 🔬 and live-cell imaging reveal fine details of chromosomal organisation in the bacterium E. coli 🦠
@michriscopy.bsky.social @uni-wuerzburg.de @heilemannlab.bsky.social @goetheuni.bsky.social
#microbiology
Reposted by Mona Alzheimer
Erfolg auf ganzer Linie: zwei Exzellenzcluster für Würzburg! 🥂🚀
Im Rahmen der #ExStra wird nicht nur der Quantenphysik-Cluster ctd.qmat weiterhin gefördert. Mit NUCLEATE, einem Forschungsprojekt zu Nukleinsäuren, kommt noch ein zweiter Cluster hinzu!
➡️ go.uniwue.de/xstra25
Im Rahmen der #ExStra wird nicht nur der Quantenphysik-Cluster ctd.qmat weiterhin gefördert. Mit NUCLEATE, einem Forschungsprojekt zu Nukleinsäuren, kommt noch ein zweiter Cluster hinzu!
➡️ go.uniwue.de/xstra25
May 22, 2025 at 4:49 PM
Erfolg auf ganzer Linie: zwei Exzellenzcluster für Würzburg! 🥂🚀
Im Rahmen der #ExStra wird nicht nur der Quantenphysik-Cluster ctd.qmat weiterhin gefördert. Mit NUCLEATE, einem Forschungsprojekt zu Nukleinsäuren, kommt noch ein zweiter Cluster hinzu!
➡️ go.uniwue.de/xstra25
Im Rahmen der #ExStra wird nicht nur der Quantenphysik-Cluster ctd.qmat weiterhin gefördert. Mit NUCLEATE, einem Forschungsprojekt zu Nukleinsäuren, kommt noch ein zweiter Cluster hinzu!
➡️ go.uniwue.de/xstra25