Marie Grandjean
@mmgrandjean.bsky.social
Postdoc @ulbruxelles.bsky.social in Jurenas lab, Assistant editor @bio-protocol.bsky.social. All about Secretion Systems, Biofilms and Redox Biology.
Reposted by Marie Grandjean
How does Pseudomonas putida keep its redox balance steady across different metabolic states?
Our new preprint shows that two transhydrogenases -membrane-bound PntAB and soluble SthA - act together as a flexible, reversible system to control NAD(H)/NADP(H) ratios.
www.biorxiv.org/content/10.1...
Our new preprint shows that two transhydrogenases -membrane-bound PntAB and soluble SthA - act together as a flexible, reversible system to control NAD(H)/NADP(H) ratios.
www.biorxiv.org/content/10.1...
Integrated control of redox and energy metabolism by the membrane-bound and soluble transhydrogenases of Pseudomonas putida across metabolic regimes
Redox homeostasis is central to microbial physiology and stress adaptation, yet the functional roles of transhydrogenases remain poorly understood beyond a few organisms. In this study, we systematica...
www.biorxiv.org
November 9, 2025 at 7:59 PM
How does Pseudomonas putida keep its redox balance steady across different metabolic states?
Our new preprint shows that two transhydrogenases -membrane-bound PntAB and soluble SthA - act together as a flexible, reversible system to control NAD(H)/NADP(H) ratios.
www.biorxiv.org/content/10.1...
Our new preprint shows that two transhydrogenases -membrane-bound PntAB and soluble SthA - act together as a flexible, reversible system to control NAD(H)/NADP(H) ratios.
www.biorxiv.org/content/10.1...
Reposted by Marie Grandjean
Strain displacement in microbiomes via ecological competition
Cool @natmicrobiol.nature.com publication by @erikbakkeren.bsky.social
@vit-pi.bsky.social @meganleeny.bsky.social @microscape.bsky.social & Kevin Foster
www.nature.com/articles/s41...
Cool @natmicrobiol.nature.com publication by @erikbakkeren.bsky.social
@vit-pi.bsky.social @meganleeny.bsky.social @microscape.bsky.social & Kevin Foster
www.nature.com/articles/s41...
Strain displacement in microbiomes via ecological competition - Nature Microbiology
Mathematical modelling and experimental tests reveal principles that govern displacement of a resident strain by an invader in microbial communities.
www.nature.com
November 7, 2025 at 2:19 PM
Strain displacement in microbiomes via ecological competition
Cool @natmicrobiol.nature.com publication by @erikbakkeren.bsky.social
@vit-pi.bsky.social @meganleeny.bsky.social @microscape.bsky.social & Kevin Foster
www.nature.com/articles/s41...
Cool @natmicrobiol.nature.com publication by @erikbakkeren.bsky.social
@vit-pi.bsky.social @meganleeny.bsky.social @microscape.bsky.social & Kevin Foster
www.nature.com/articles/s41...
Reposted by Marie Grandjean
Thinking only of Rosalind Franklin today, and what was stolen from her (and so many other female scientists alongside her).
Rosalind Franklin and the damage of gender harassment
Spurred by a recent report on sexual harassment in academia, our columnist revisits a historical case and reflects on what has changed—and what hasn’t
www.science.org
November 7, 2025 at 7:58 PM
Thinking only of Rosalind Franklin today, and what was stolen from her (and so many other female scientists alongside her).
Reposted by Marie Grandjean
So happy to share this! Bacteriocins were first discovered over 100 years ago, but what do they actually do? We look at >1000 bacteriocin plasmids and find links to virulence and antimicrobial resistance, and frequent bacteriocin sharing in Enterobacteriaceae.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Bacterial warfare is associated with virulence and antimicrobial resistance - Nature Communications
Bacteria employ a range of competition systems that deliver toxins to inhibit competing strains. This study shows that these systems are particularly important for the ecology of virulent and antibiot...
www.nature.com
November 5, 2025 at 7:32 AM
So happy to share this! Bacteriocins were first discovered over 100 years ago, but what do they actually do? We look at >1000 bacteriocin plasmids and find links to virulence and antimicrobial resistance, and frequent bacteriocin sharing in Enterobacteriaceae.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Marie Grandjean
Exciting #postdoc opportunity in T. Gensollen's group!
How early-life interactions between the immune system and microbiota shape lifelong immune imprinting and disease risk
Learn more: shorturl.at/F8hqE
Deadline: January 15, 2026
Contact: recruit@ipbs.fr
#Immunology #Microbiology #Microbiota #Omics
How early-life interactions between the immune system and microbiota shape lifelong immune imprinting and disease risk
Learn more: shorturl.at/F8hqE
Deadline: January 15, 2026
Contact: recruit@ipbs.fr
#Immunology #Microbiology #Microbiota #Omics
Early-life Immune Imprinting and Inflammatory Diseases - IPBS-Toulouse
Our team studies neonatal immunity. We are particularly interested in mapping the mucosal cell subsets[…]
shorturl.at
November 4, 2025 at 5:32 AM
Exciting #postdoc opportunity in T. Gensollen's group!
How early-life interactions between the immune system and microbiota shape lifelong immune imprinting and disease risk
Learn more: shorturl.at/F8hqE
Deadline: January 15, 2026
Contact: recruit@ipbs.fr
#Immunology #Microbiology #Microbiota #Omics
How early-life interactions between the immune system and microbiota shape lifelong immune imprinting and disease risk
Learn more: shorturl.at/F8hqE
Deadline: January 15, 2026
Contact: recruit@ipbs.fr
#Immunology #Microbiology #Microbiota #Omics
Reposted by Marie Grandjean
Exciting #postdoc opportunity in KL Ung's group!
Understanding the molecular mechanisms of cell wall remodeling in pathogens
Learn more: shorturl.at/gPuFV
Deadline: January 15, 2026
Contact: recruit@ipbs.fr
#Protein #Biochemistry #StructuralBiology #Biophysics #CryoEM
Understanding the molecular mechanisms of cell wall remodeling in pathogens
Learn more: shorturl.at/gPuFV
Deadline: January 15, 2026
Contact: recruit@ipbs.fr
#Protein #Biochemistry #StructuralBiology #Biophysics #CryoEM
November 4, 2025 at 5:34 AM
Exciting #postdoc opportunity in KL Ung's group!
Understanding the molecular mechanisms of cell wall remodeling in pathogens
Learn more: shorturl.at/gPuFV
Deadline: January 15, 2026
Contact: recruit@ipbs.fr
#Protein #Biochemistry #StructuralBiology #Biophysics #CryoEM
Understanding the molecular mechanisms of cell wall remodeling in pathogens
Learn more: shorturl.at/gPuFV
Deadline: January 15, 2026
Contact: recruit@ipbs.fr
#Protein #Biochemistry #StructuralBiology #Biophysics #CryoEM
Reposted by Marie Grandjean
📢 Postdoc position: Cell Biology of Cyanobacteria
in my group, as part of the Excellence Cluster "Microbes for Climate" (M4C) in Marburg, Germany.
More information at shorturl.at/wNnDT (see Project 2)
🔗Apply at shorturl.at/VsEDl
📅Deadline: Nov 16, 2025
Please repost. #Postdoc
in my group, as part of the Excellence Cluster "Microbes for Climate" (M4C) in Marburg, Germany.
More information at shorturl.at/wNnDT (see Project 2)
🔗Apply at shorturl.at/VsEDl
📅Deadline: Nov 16, 2025
Please repost. #Postdoc
November 2, 2025 at 7:13 PM
📢 Postdoc position: Cell Biology of Cyanobacteria
in my group, as part of the Excellence Cluster "Microbes for Climate" (M4C) in Marburg, Germany.
More information at shorturl.at/wNnDT (see Project 2)
🔗Apply at shorturl.at/VsEDl
📅Deadline: Nov 16, 2025
Please repost. #Postdoc
in my group, as part of the Excellence Cluster "Microbes for Climate" (M4C) in Marburg, Germany.
More information at shorturl.at/wNnDT (see Project 2)
🔗Apply at shorturl.at/VsEDl
📅Deadline: Nov 16, 2025
Please repost. #Postdoc
Reposted by Marie Grandjean
#microsky #mevosky @spp2389.bsky.social
A PhD position is available in my lab to work on:
Emergence and self-organisation of bacterial metabolism in consortia of cross-feeding bacteria.
Please RT
Deadline: 12.11.25
More infos 👇
shorturl.at/rAKAT
A PhD position is available in my lab to work on:
Emergence and self-organisation of bacterial metabolism in consortia of cross-feeding bacteria.
Please RT
Deadline: 12.11.25
More infos 👇
shorturl.at/rAKAT
October 28, 2025 at 8:43 AM
#microsky #mevosky @spp2389.bsky.social
A PhD position is available in my lab to work on:
Emergence and self-organisation of bacterial metabolism in consortia of cross-feeding bacteria.
Please RT
Deadline: 12.11.25
More infos 👇
shorturl.at/rAKAT
A PhD position is available in my lab to work on:
Emergence and self-organisation of bacterial metabolism in consortia of cross-feeding bacteria.
Please RT
Deadline: 12.11.25
More infos 👇
shorturl.at/rAKAT
Reposted by Marie Grandjean
Quorum sensing regulates a polysaccharide biosynthesis gene to control cell aggregation in Paracoccus denitrifican
in #ISMEComms
academic.oup.com/ismecommun/a...
in #ISMEComms
academic.oup.com/ismecommun/a...
Quorum sensing regulates a polysaccharide biosynthesis gene to control cell aggregation in Paracoccus denitrificans
Abstract. Most biofilm research has centered on a few motile model organisms that form thick biofilms. During dispersal, motile bacteria actively escape th
academic.oup.com
November 1, 2025 at 11:45 AM
Quorum sensing regulates a polysaccharide biosynthesis gene to control cell aggregation in Paracoccus denitrifican
in #ISMEComms
academic.oup.com/ismecommun/a...
in #ISMEComms
academic.oup.com/ismecommun/a...
Reposted by Marie Grandjean
Applications closing tonight (midnight French time) !!!
Still a few hours to apply !!
Still a few hours to apply !!
Open position to work on Type IX secretion (#T9SS) in our lab, in collaboration withe the group of Eric Reynolds at the Dental School of the University of Melbourne. Please spread the word, and forward to anyone potentially interested ! Apply here:
emploi.cnrs.fr/Offres/Docto...
emploi.cnrs.fr/Offres/Docto...
Portail Emploi CNRS - Offre d'emploi - Thèse en Microbiologie-Biochimie (H/F)
emploi.cnrs.fr
October 30, 2025 at 1:17 PM
Applications closing tonight (midnight French time) !!!
Still a few hours to apply !!
Still a few hours to apply !!
Reposted by Marie Grandjean
Chromosome replication and cell division cycles are not synchronized in Staphylococcus aureus, with cells exhibiting two segregated origins of replication at the start of the cell cycle
#bacteria #microbiology
#bacteria #microbiology
Chromosome segregation dynamics during the cell cycle of Staphylococcus aureus - Nature Communications
Our understanding of chromosome organization and dynamics in spherical bacteria, such as Staphylococcus aureus, remains limited. Here, the authors show that chromosome replication and cell division cycles are not synchronized in S. aureus, with cells exhibiting two segregated origins of replication at the start of the cell cycle.
bit.ly
October 21, 2025 at 2:51 PM
Chromosome replication and cell division cycles are not synchronized in Staphylococcus aureus, with cells exhibiting two segregated origins of replication at the start of the cell cycle
#bacteria #microbiology
#bacteria #microbiology
Reposted by Marie Grandjean
Exogenous glutamate restores gentamicin efficacy against antibiotic-resistant P. aeruginosa by reprogramming bacterial metabolism to enhance membrane permeability. The effect is mediated through increased biosynthesis of unsaturated fatty acids. #mSystems: asm.social/2Ez
October 21, 2025 at 4:36 PM
Exogenous glutamate restores gentamicin efficacy against antibiotic-resistant P. aeruginosa by reprogramming bacterial metabolism to enhance membrane permeability. The effect is mediated through increased biosynthesis of unsaturated fatty acids. #mSystems: asm.social/2Ez
Reposted by Marie Grandjean
We have a new preprint modeling the regulatory networks of efflux pumps to predict the evolution of multidrug resistance in P. aeruginosa. Also explore cross-resistance, collateral sensitivity & loss of resistance. With @suvamroy.bsky.social @elibbyscience.bsky.social www.biorxiv.org/content/10.1...
Forecasting multi-trait resistance evolution under antibiotic stress
Many bacteria rely on efflux pumps to survive antibiotic stress, and exposure to antibiotics often leads to mutations in pump genes or their regulators that increase pump expression. Predicting the sp...
www.biorxiv.org
October 20, 2025 at 6:21 AM
We have a new preprint modeling the regulatory networks of efflux pumps to predict the evolution of multidrug resistance in P. aeruginosa. Also explore cross-resistance, collateral sensitivity & loss of resistance. With @suvamroy.bsky.social @elibbyscience.bsky.social www.biorxiv.org/content/10.1...
Reposted by Marie Grandjean
Extracellular ATP is an environmental cue in bacteria
@cp-cellreports.bsky.social
www.cell.com/cell-reports...
@cp-cellreports.bsky.social
www.cell.com/cell-reports...
Extracellular ATP is an environmental cue in bacteria
Extracellular ATP acts as a signal regulating physiology and immunity in eukaryotes
and is elevated during intestinal infection or damage. Tronnet et al. show that extracellular
ATP reprograms the tra...
www.cell.com
October 11, 2025 at 11:59 AM
Extracellular ATP is an environmental cue in bacteria
@cp-cellreports.bsky.social
www.cell.com/cell-reports...
@cp-cellreports.bsky.social
www.cell.com/cell-reports...
Reposted by Marie Grandjean
Open position to work on Type IX secretion (#T9SS) in our lab, in collaboration withe the group of Eric Reynolds at the Dental School of the University of Melbourne. Please spread the word, and forward to anyone potentially interested ! Apply here:
emploi.cnrs.fr/Offres/Docto...
emploi.cnrs.fr/Offres/Docto...
Portail Emploi CNRS - Offre d'emploi - Thèse en Microbiologie-Biochimie (H/F)
emploi.cnrs.fr
October 9, 2025 at 12:18 PM
Open position to work on Type IX secretion (#T9SS) in our lab, in collaboration withe the group of Eric Reynolds at the Dental School of the University of Melbourne. Please spread the word, and forward to anyone potentially interested ! Apply here:
emploi.cnrs.fr/Offres/Docto...
emploi.cnrs.fr/Offres/Docto...
Reposted by Marie Grandjean
Logic-gating the HaloTag system with Conditional-Halo-ligator 'CHalo' reagents https://www.biorxiv.org/content/10.1101/2025.09.23.676741v1
September 23, 2025 at 11:31 PM
Logic-gating the HaloTag system with Conditional-Halo-ligator 'CHalo' reagents https://www.biorxiv.org/content/10.1101/2025.09.23.676741v1
Reposted by Marie Grandjean
🧐Checkout our preprint revealing the stepwise firing💥 mechanism of a Contractile Injection System @xujwet.bsky.social&@chipericson.bsky.social trapped the complex by structure-guided engineering🧪 in multiple intermediate states and imaged them by multimodal #cryoEM❄️🔬
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
October 8, 2025 at 9:18 PM
🧐Checkout our preprint revealing the stepwise firing💥 mechanism of a Contractile Injection System @xujwet.bsky.social&@chipericson.bsky.social trapped the complex by structure-guided engineering🧪 in multiple intermediate states and imaged them by multimodal #cryoEM❄️🔬
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Marie Grandjean
Now published! www.nature.com/articles/s41...
Very nice collaboration with Hoogenboom ( @ucl.ac.uk ) and Bonev ( @uniofnottingham.bsky.social ) labs.
Very nice collaboration with Hoogenboom ( @ucl.ac.uk ) and Bonev ( @uniofnottingham.bsky.social ) labs.
September 29, 2025 at 2:24 PM
Now published! www.nature.com/articles/s41...
Very nice collaboration with Hoogenboom ( @ucl.ac.uk ) and Bonev ( @uniofnottingham.bsky.social ) labs.
Very nice collaboration with Hoogenboom ( @ucl.ac.uk ) and Bonev ( @uniofnottingham.bsky.social ) labs.
Reposted by Marie Grandjean
Open position !!
Either at the Engineer or post-doctoral level, to work on filamentous phages. Collaboration between Laetitia Houot's group and Thierry Doan @thicoz.bsky.social.
To apply at the E level:
emploi.cnrs.fr/Offres/CDD/U...
To apply at the post-doc level:
emploi.cnrs.fr/Offres/CDD/U...
Either at the Engineer or post-doctoral level, to work on filamentous phages. Collaboration between Laetitia Houot's group and Thierry Doan @thicoz.bsky.social.
To apply at the E level:
emploi.cnrs.fr/Offres/CDD/U...
To apply at the post-doc level:
emploi.cnrs.fr/Offres/CDD/U...
September 28, 2025 at 9:24 AM
Open position !!
Either at the Engineer or post-doctoral level, to work on filamentous phages. Collaboration between Laetitia Houot's group and Thierry Doan @thicoz.bsky.social.
To apply at the E level:
emploi.cnrs.fr/Offres/CDD/U...
To apply at the post-doc level:
emploi.cnrs.fr/Offres/CDD/U...
Either at the Engineer or post-doctoral level, to work on filamentous phages. Collaboration between Laetitia Houot's group and Thierry Doan @thicoz.bsky.social.
To apply at the E level:
emploi.cnrs.fr/Offres/CDD/U...
To apply at the post-doc level:
emploi.cnrs.fr/Offres/CDD/U...
Reposted by Marie Grandjean
Hah, one more story on Tat machinery detected! ❤️🔥 Congratulations to the authors, teams of @smlea.bsky.social @pstansfeld.bsky.social and Ben Berks!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Structure and substrate recognition by the Twin-arginine translocation (Tat) pathway core complex
The twin-arginine translocation (Tat) system is a mechanistically unique protein transport pathway moving folded proteins across membranes (1-4). It is found in all domains of life and is essential fo...
www.biorxiv.org
September 21, 2025 at 6:49 AM
Hah, one more story on Tat machinery detected! ❤️🔥 Congratulations to the authors, teams of @smlea.bsky.social @pstansfeld.bsky.social and Ben Berks!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Marie Grandjean
In our new article, we show how P. aeruginosa, a major cause of chronic respiratory infections in #cysticfibrosis (CF), uses the Type VI Secretion System #T6SS and specific #toxins to eliminate competing bacteria
www.cell.com/cell-reports...
#cryoEM @dshatskiy.bsky.social @jakecolautti.bsky.social
www.cell.com/cell-reports...
#cryoEM @dshatskiy.bsky.social @jakecolautti.bsky.social
September 14, 2025 at 8:52 AM
In our new article, we show how P. aeruginosa, a major cause of chronic respiratory infections in #cysticfibrosis (CF), uses the Type VI Secretion System #T6SS and specific #toxins to eliminate competing bacteria
www.cell.com/cell-reports...
#cryoEM @dshatskiy.bsky.social @jakecolautti.bsky.social
www.cell.com/cell-reports...
#cryoEM @dshatskiy.bsky.social @jakecolautti.bsky.social
Reposted by Marie Grandjean
A recent cool preprint by John Whitney's lab on a new family of antibacterial proteins secreted by Gram-positive bacteria that enter and kill a broad spectrum of bacteria. Cell entry is receptor-independent and relies on cleavage by a co-secreted protease and the PMF.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Proteolytically activated antibacterial toxins inhibit the growth of diverse Gram-positive bacteria
Many species of bacteria produce small-molecule antibiotics that enter and kill a wide range of competitor microbes. However, diffusible antibacterial proteins that share this broad-spectrum activity ...
www.biorxiv.org
September 23, 2025 at 8:28 PM
A recent cool preprint by John Whitney's lab on a new family of antibacterial proteins secreted by Gram-positive bacteria that enter and kill a broad spectrum of bacteria. Cell entry is receptor-independent and relies on cleavage by a co-secreted protease and the PMF.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Marie Grandjean
We're looking for a technician at Institut Pasteur for experimental work on satellite-phage-bacteria interactions, working directly with @jmouradesousa.bsky.social and myself in the lab of @epcrocha.bsky.social ! ANR funded.
Link to the job emploi.pasteur.fr/offre-de-emp...
Thx for sharing!
Link to the job emploi.pasteur.fr/offre-de-emp...
Thx for sharing!
INSTITUT PASTEUR - Technicien de recherche Microbiologie H/F
emploi.pasteur.fr
September 12, 2025 at 2:42 PM
We're looking for a technician at Institut Pasteur for experimental work on satellite-phage-bacteria interactions, working directly with @jmouradesousa.bsky.social and myself in the lab of @epcrocha.bsky.social ! ANR funded.
Link to the job emploi.pasteur.fr/offre-de-emp...
Thx for sharing!
Link to the job emploi.pasteur.fr/offre-de-emp...
Thx for sharing!
Reposted by Marie Grandjean
Naturally acquired promoter variation influences #Streptococcus pneumoniae infection outcomes.
Certain S. pneumoniae promoters contain long stretches of sequential adenines. Promoter mutations potentiate heterogeneous gene expression during infections.
www.cell.com/cell-host-mi... #MicroSky #IDSky
Certain S. pneumoniae promoters contain long stretches of sequential adenines. Promoter mutations potentiate heterogeneous gene expression during infections.
www.cell.com/cell-host-mi... #MicroSky #IDSky
September 4, 2025 at 4:11 PM
Naturally acquired promoter variation influences #Streptococcus pneumoniae infection outcomes.
Certain S. pneumoniae promoters contain long stretches of sequential adenines. Promoter mutations potentiate heterogeneous gene expression during infections.
www.cell.com/cell-host-mi... #MicroSky #IDSky
Certain S. pneumoniae promoters contain long stretches of sequential adenines. Promoter mutations potentiate heterogeneous gene expression during infections.
www.cell.com/cell-host-mi... #MicroSky #IDSky
Reposted by Marie Grandjean
Sub-cellular chemical mapping in bacteria using correlated cryogenic electron and mass spectrometry imaging
Congrats Hannah Ochner and authors on this important paper! Strong collaboration with @kiranrpatil.bsky.social
www.biorxiv.org/cgi/content/...
@mrclmb.bsky.social @wellcometrust.bsky.social
Congrats Hannah Ochner and authors on this important paper! Strong collaboration with @kiranrpatil.bsky.social
www.biorxiv.org/cgi/content/...
@mrclmb.bsky.social @wellcometrust.bsky.social
August 31, 2025 at 6:44 PM
Sub-cellular chemical mapping in bacteria using correlated cryogenic electron and mass spectrometry imaging
Congrats Hannah Ochner and authors on this important paper! Strong collaboration with @kiranrpatil.bsky.social
www.biorxiv.org/cgi/content/...
@mrclmb.bsky.social @wellcometrust.bsky.social
Congrats Hannah Ochner and authors on this important paper! Strong collaboration with @kiranrpatil.bsky.social
www.biorxiv.org/cgi/content/...
@mrclmb.bsky.social @wellcometrust.bsky.social