Melissa Call
@mjcall.bsky.social
Associate Professor, @ WEHI, Melbourne AU. Structural immunologist and deep mutational scanning enthusiast.
Reposted by Melissa Call
Cryo-EM of fertilisation complex Pfs230-Pfs48/45 from malaria parasites! 💕💗
🦟 Transgenic parasites without Pfs230 D13D14 do not transmit
🦙 💉Nanobodies + mRNA induced antibodies reduce transmission
New in @Science.org
www.science.org/doi/10.1126/...
#ScienceResearch #Malaria #WEHI
🦟 Transgenic parasites without Pfs230 D13D14 do not transmit
🦙 💉Nanobodies + mRNA induced antibodies reduce transmission
New in @Science.org
www.science.org/doi/10.1126/...
#ScienceResearch #Malaria #WEHI
August 1, 2025 at 12:58 AM
Cryo-EM of fertilisation complex Pfs230-Pfs48/45 from malaria parasites! 💕💗
🦟 Transgenic parasites without Pfs230 D13D14 do not transmit
🦙 💉Nanobodies + mRNA induced antibodies reduce transmission
New in @Science.org
www.science.org/doi/10.1126/...
#ScienceResearch #Malaria #WEHI
🦟 Transgenic parasites without Pfs230 D13D14 do not transmit
🦙 💉Nanobodies + mRNA induced antibodies reduce transmission
New in @Science.org
www.science.org/doi/10.1126/...
#ScienceResearch #Malaria #WEHI
The battle of the decades is complete. Thank you Leann Tilley for the excellent chairing and all the speakers for a fun session. @lorneproteins.bsky.social
February 11, 2025 at 12:52 PM
The battle of the decades is complete. Thank you Leann Tilley for the excellent chairing and all the speakers for a fun session. @lorneproteins.bsky.social
James Whisstock takes us to the present day highlighting some of the coolest techniques presented at #Lorneproteins in the past decade.
February 11, 2025 at 9:58 AM
James Whisstock takes us to the present day highlighting some of the coolest techniques presented at #Lorneproteins in the past decade.
A Protein structure was not enough to get a talk by the early-mid 2000s (unless it was a membrane protein :-) ) Jacqui Matthews @lorneproteins.bsky.social
February 11, 2025 at 9:47 AM
A Protein structure was not enough to get a talk by the early-mid 2000s (unless it was a membrane protein :-) ) Jacqui Matthews @lorneproteins.bsky.social
Protein missing is pretty important - Robin Anders @lorneproteins.bsky.social
February 11, 2025 at 9:33 AM
Protein missing is pretty important - Robin Anders @lorneproteins.bsky.social
Marilyn Anderson reminisces on the beginning of Protein design in the late 80s #Lorneproteins @lorneproteins.bsky.social
February 11, 2025 at 9:24 AM
Marilyn Anderson reminisces on the beginning of Protein design in the late 80s #Lorneproteins @lorneproteins.bsky.social
Lindsay Sparrow tells us there was only 23 structures in the PDB when #Lorneproteins started in 1976! @lorneproteins.bsky.social
February 11, 2025 at 9:11 AM
Lindsay Sparrow tells us there was only 23 structures in the PDB when #Lorneproteins started in 1976! @lorneproteins.bsky.social
Congratulations Frances Separovic on winning the Leach Medal - #lorneproteins
February 9, 2025 at 8:45 AM
Congratulations Frances Separovic on winning the Leach Medal - #lorneproteins
Deb Leach sharing her thoughts on her father, Syd Leach, who started #Lorneproteins
February 9, 2025 at 8:37 AM
Deb Leach sharing her thoughts on her father, Syd Leach, who started #Lorneproteins
The 50th Lorne Conference on Protein Structure and Function - Beautiful Welcome to Country #lorneproteins
February 9, 2025 at 4:20 AM
The 50th Lorne Conference on Protein Structure and Function - Beautiful Welcome to Country #lorneproteins
Reposted by Melissa Call
Phosphotyrosine Signal Profiling of Clinical CAR-T Reveals Tonic Signaling Associated with Therapeutic Efficacy https://www.biorxiv.org/content/10.1101/2024.12.22.629940v1
December 23, 2024 at 5:16 AM
Phosphotyrosine Signal Profiling of Clinical CAR-T Reveals Tonic Signaling Associated with Therapeutic Efficacy https://www.biorxiv.org/content/10.1101/2024.12.22.629940v1
Reposted by Melissa Call
Scalable emulation of protein equilibrium ensembles with
generative deep learning www.biorxiv.org/content/10.1...
No code is available yet, but sounds huge. Effectively does MD-sim, but fast!
generative deep learning www.biorxiv.org/content/10.1...
No code is available yet, but sounds huge. Effectively does MD-sim, but fast!
December 6, 2024 at 10:51 AM
Scalable emulation of protein equilibrium ensembles with
generative deep learning www.biorxiv.org/content/10.1...
No code is available yet, but sounds huge. Effectively does MD-sim, but fast!
generative deep learning www.biorxiv.org/content/10.1...
No code is available yet, but sounds huge. Effectively does MD-sim, but fast!
Reposted by Melissa Call
ICYMI: this really interesting @science.org paper on possible underlying mechanisms of post-accute #COVID19 syndrome ( #PACS ) aka " #LongCOVID" from last January!
ICYMI: Analysis of blood serum found #LongCOVID was characterized by altered levels of certain immune complement proteins. These changes linked to complement activation and signs of dysregulation of the coagulation system. #Immunosky
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Persistent complement dysregulation with signs of thromboinflammation in active Long Covid
Analysis of blood revealed that Long COVID is characterized by changes to complement proteins and platelet activation.
www.science.org
December 3, 2024 at 4:51 PM
ICYMI: this really interesting @science.org paper on possible underlying mechanisms of post-accute #COVID19 syndrome ( #PACS ) aka " #LongCOVID" from last January!
Reposted by Melissa Call
A massively parallel reporter assay library to screen short synthetic promoters in mammalian cells
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A massively parallel reporter assay library to screen short synthetic promoters in mammalian cells - Nature Communications
Context-dependent, responsive synthetic promoters are crucial for a wide range of applications, yet currently available options are limited. Here, authors develop a library of thousands of candidate p...
www.nature.com
November 29, 2024 at 11:01 AM
A massively parallel reporter assay library to screen short synthetic promoters in mammalian cells
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Melissa Call
De novo functional discovery of peptide-MHC restricted CARs from recombinase-constructed large-diversity monoclonal T cell libraries https://www.biorxiv.org/content/10.1101/2024.11.27.625413v1
De novo functional discovery of peptide-MHC restricted CARs from recombinase-constructed large-diversity monoclonal T cell libraries https://www.biorxiv.org/content/10.1101/2024.11.27.625413v1
Chimeric antigen receptors (CAR) that mimic T cell receptors (TCR) on eliciting peptide-major histoc
www.biorxiv.org
November 30, 2024 at 2:46 AM
De novo functional discovery of peptide-MHC restricted CARs from recombinase-constructed large-diversity monoclonal T cell libraries https://www.biorxiv.org/content/10.1101/2024.11.27.625413v1
Reposted by Melissa Call
Development of antigen-dextramers for detection and evaluation of CAR T cells https://www.biorxiv.org/content/10.1101/2024.11.27.625576v1
Development of antigen-dextramers for detection and evaluation of CAR T cells https://www.biorxiv.org/content/10.1101/2024.11.27.625576v1
Background: Chimeric antigen receptor (CAR) T cell therapy has transformed the treatment landscape o
www.biorxiv.org
November 30, 2024 at 3:46 AM
Development of antigen-dextramers for detection and evaluation of CAR T cells https://www.biorxiv.org/content/10.1101/2024.11.27.625576v1
Reposted by Melissa Call
Design of high specificity binders for peptide-MHC-I complexes www.biorxiv.org/content/10.1...
New from the Baker lab
New from the Baker lab
November 30, 2024 at 5:07 AM
Design of high specificity binders for peptide-MHC-I complexes www.biorxiv.org/content/10.1...
New from the Baker lab
New from the Baker lab
Reposted by Melissa Call
C/O the #adelaideproteingroup The Lorne Proteins Conference 2025 is coming up! Feb 9–13, 2025, it’s a must for protein science enthusiasts.
🇦🇺 Lorne, Victoria
💡 Connect with international experts, share your research, and explore the latest advancements.
📅 Register now: lorneproteins.org
🇦🇺 Lorne, Victoria
💡 Connect with international experts, share your research, and explore the latest advancements.
📅 Register now: lorneproteins.org
Lorne Proteins 2025
lorneproteins.org
November 18, 2024 at 4:35 AM
C/O the #adelaideproteingroup The Lorne Proteins Conference 2025 is coming up! Feb 9–13, 2025, it’s a must for protein science enthusiasts.
🇦🇺 Lorne, Victoria
💡 Connect with international experts, share your research, and explore the latest advancements.
📅 Register now: lorneproteins.org
🇦🇺 Lorne, Victoria
💡 Connect with international experts, share your research, and explore the latest advancements.
📅 Register now: lorneproteins.org