Michaela Müller-McNicoll
@mixmue.bsky.social
RNAholic, Scientist, interested in architectural roles, packaging and binding codes
#RNA, #splicing, #condensates
#RNA, #splicing, #condensates
Reposted by Michaela Müller-McNicoll
🤯This is wow! Molecular mechanism of mRNA export. by @juliusbrennecke.bsky.social @plaschkalab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 6, 2025 at 5:20 PM
🤯This is wow! Molecular mechanism of mRNA export. by @juliusbrennecke.bsky.social @plaschkalab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
It was a true pleasure.
Special thanks to my examiners @becklab.bsky.social, @mixmue.bsky.social, @heilemannlab.bsky.social and Volker Dötsch for a fun discussion round that concluded it, and to the Beck lab for a great PhD hat!
November 7, 2025 at 5:48 PM
It was a true pleasure.
Reposted by Michaela Müller-McNicoll
Great work of @deglushk.bsky.social from my PhD lab @mpibp.bsky.social on how to get more information out of all the membranes you see in cryoET data!
Glushkova, Böhm, & Beck @maxplanck.de develop a publicly available computational method to measure the thickness of biological membranes in cryo-electron tomograms. Analysis of algae & human cells reveals systematic membrane thickness variations within & across organelles rupress.org/jcb/article/...
November 6, 2025 at 5:32 AM
Great work of @deglushk.bsky.social from my PhD lab @mpibp.bsky.social on how to get more information out of all the membranes you see in cryoET data!
Reposted by Michaela Müller-McNicoll
1/ Excited to share our new study with @brumbaugh-lab.bsky.social, out in @natbiotech.nature.com! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵 www.nature.com/articles/s41...
Selective RNA sequestration in biomolecular condensates directs cell fate transitions - Nature Biotechnology
Stem cell differentiation is controlled by manipulating RNA condensates.
www.nature.com
October 28, 2025 at 4:02 PM
1/ Excited to share our new study with @brumbaugh-lab.bsky.social, out in @natbiotech.nature.com! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵 www.nature.com/articles/s41...
Reposted by Michaela Müller-McNicoll
Im Exzellenzcluster @cpi-exstra.bsky.social untersuchen #Forschende interdisziplinär das Zusammenspiel von Herz und Lunge, Ziel ist u.a. die Entwicklung neuartiger Therapeutika. Zum Interview mit Prof. Dr. Dr. h.c. Stefanie Dimmeler von der @goetheuni.bsky.social geht es hier: youtu.be/aik52E5AlXg
RMU Insights: Exzellenzcluster Cardiopulmonary Institute (CPI)
YouTube video by Rhein-Main-Universitäten (RMU)
youtu.be
October 27, 2025 at 4:32 PM
Im Exzellenzcluster @cpi-exstra.bsky.social untersuchen #Forschende interdisziplinär das Zusammenspiel von Herz und Lunge, Ziel ist u.a. die Entwicklung neuartiger Therapeutika. Zum Interview mit Prof. Dr. Dr. h.c. Stefanie Dimmeler von der @goetheuni.bsky.social geht es hier: youtu.be/aik52E5AlXg
Reposted by Michaela Müller-McNicoll
Our photoswitchable HaloTag is out in Angewandte Chemie @angewandtechemie.bsky.social ! We now also show that this system can be used to control emitter density in SMLM. Congrats to Franzi, Bego, and our amazing collaborators. Check it out: onlinelibrary.wiley.com/doi/full/10....
A Photoswitchable HaloTag for Spatiotemporal Control of Fluorescence in Living Cells
Photoswitchable fluorophores are critical for advanced bioimaging. Here, we develop a photoswitchable self-labeling HaloTag that can reversibly modulate the emission of a bound fluorogenic dye via a ....
onlinelibrary.wiley.com
October 25, 2025 at 8:56 AM
Our photoswitchable HaloTag is out in Angewandte Chemie @angewandtechemie.bsky.social ! We now also show that this system can be used to control emitter density in SMLM. Congrats to Franzi, Bego, and our amazing collaborators. Check it out: onlinelibrary.wiley.com/doi/full/10....
Reposted by Michaela Müller-McNicoll
Thrilled to share our work on transcription initiation and termination being spatially coordinated out today in Science! www.science.org/doi/10.1126/...
mRNA initiation and termination are spatially coordinated
Transcriptional initiation and termination decisions drive messenger RNA (mRNA) isoform diversity but the relationship between them remains poorly understood. By systematically profiling joint usage o...
www.science.org
October 10, 2025 at 6:14 PM
Thrilled to share our work on transcription initiation and termination being spatially coordinated out today in Science! www.science.org/doi/10.1126/...
Reposted by Michaela Müller-McNicoll
SCALE is a pioneering research center in partnership with Max Planck Institute of Biophysics, Max Planck Institute for Brain Research, FIAS - Frankfurt Institute for Advanced Studies, Universität des Saarlandes, Johannes Gutenberg University Mainz, and EMBL.
👉 Learn more: scale-frankfurt.org
👉 Learn more: scale-frankfurt.org
October 22, 2025 at 9:41 AM
SCALE is a pioneering research center in partnership with Max Planck Institute of Biophysics, Max Planck Institute for Brain Research, FIAS - Frankfurt Institute for Advanced Studies, Universität des Saarlandes, Johannes Gutenberg University Mainz, and EMBL.
👉 Learn more: scale-frankfurt.org
👉 Learn more: scale-frankfurt.org
Join the SCALE Community!
🚀 Exciting Job Opportunity: Project Coordinator at the Cluster of Excellence SCALE
We’re thrilled to announce an exceptional opportunity to join the newly founded Cluster of Excellence SCALE – Subcellular Architecture of Life from the @goetheuni.bsky.social.
👉 Learn more and apply here:
We’re thrilled to announce an exceptional opportunity to join the newly founded Cluster of Excellence SCALE – Subcellular Architecture of Life from the @goetheuni.bsky.social.
👉 Learn more and apply here:
October 22, 2025 at 8:12 PM
Join the SCALE Community!
Reposted by Michaela Müller-McNicoll
Wow! Max Planck is coming to Würzburg! 🥳
Die Bayerische Staatsregierung und die @maxplanck.de wollen den Wissenschaftsstandort Würzburg stärken. Ein heute unterzeichnetes Memorandum of Understanding legt den Grundstein für den Ausbau der Forschung in der Biomedizin. Auf eine starke Partnerschaft!
📸 Axel Griesch
📸 Axel Griesch
October 22, 2025 at 11:16 AM
Wow! Max Planck is coming to Würzburg! 🥳
Congrats Mandy 🥳🤩
Excited to share our new @narjournal.bsky.social paper!
Using ReLo and AlphaFold, we described a network of interactions between Drosophila piRNA pathway factors suggesting new links how they coordinate to ensure transposon silencing and genome integrity.
academic.oup.com/nar/article/...
Using ReLo and AlphaFold, we described a network of interactions between Drosophila piRNA pathway factors suggesting new links how they coordinate to ensure transposon silencing and genome integrity.
academic.oup.com/nar/article/...
October 18, 2025 at 8:14 AM
Congrats Mandy 🥳🤩
Reposted by Michaela Müller-McNicoll
❓What if you could peek between your tilt series ❓ We are proud to introduce cryoTIGER -- deep-learning based tilt interpolation for enhanced reconstruction in cryo-ET. A great collaboration between Turoňová lab, @becklab.bsky.social, @hummerlab.bsky.social #teamtomo www.nature.com/articles/s42...
cryoTIGER: deep-learning based tilt interpolation generator for enhanced reconstruction in cryo electron tomography - Communications Biology
Deep learning-based interpolation using cryoTIGER enhances angular sampling in cryoET, improving 3D reconstructions, particle localization, and structural recovery without increasing electron dose.
www.nature.com
October 10, 2025 at 10:35 AM
❓What if you could peek between your tilt series ❓ We are proud to introduce cryoTIGER -- deep-learning based tilt interpolation for enhanced reconstruction in cryo-ET. A great collaboration between Turoňová lab, @becklab.bsky.social, @hummerlab.bsky.social #teamtomo www.nature.com/articles/s42...
Reposted by Michaela Müller-McNicoll
Heartfelt congratulations to @ralfsteinhilper.bsky.social @bjmurphylab.bsky.social on successfully defending his PhD thesis with summa cum laude! 👏💪🏆 For his doctoral research, Ralf used anaerobic sample preparation to study redox enzymes by single-particle cryo-EM.🔬 #phdlife #biophysics #excellence
October 16, 2025 at 12:51 PM
Heartfelt congratulations to @ralfsteinhilper.bsky.social @bjmurphylab.bsky.social on successfully defending his PhD thesis with summa cum laude! 👏💪🏆 For his doctoral research, Ralf used anaerobic sample preparation to study redox enzymes by single-particle cryo-EM.🔬 #phdlife #biophysics #excellence
Reposted by Michaela Müller-McNicoll
Q.E.D works amazingly well! I was a skeptic at the beginning and then just really really impressed. For change 🥂
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
October 15, 2025 at 10:09 PM
Q.E.D works amazingly well! I was a skeptic at the beginning and then just really really impressed. For change 🥂
Reposted by Michaela Müller-McNicoll
Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.
October 8, 2025 at 9:45 PM
Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.
Reposted by Michaela Müller-McNicoll
For the attention of all the Organelle researchers in Germany, the Annual meeting of the @gbmev.bsky.social study section Cellular Organelles will be held in Düsseldorf …. Seats fast filling up … please submit your abstract … information below:
gbm-online.de/de/tagungska...
gbm-online.de/de/tagungska...
2nd Meeting of the Study Group "Cellular Organelles" - Homepage der Gesellschaft für Biochemie und Molekularbiologie e.V.
organized by Arun Kumar Kondadi and Andreas Reichert
gbm-online.de
October 7, 2025 at 4:20 PM
For the attention of all the Organelle researchers in Germany, the Annual meeting of the @gbmev.bsky.social study section Cellular Organelles will be held in Düsseldorf …. Seats fast filling up … please submit your abstract … information below:
gbm-online.de/de/tagungska...
gbm-online.de/de/tagungska...
Reposted by Michaela Müller-McNicoll
Stress granules have a limited impact on global translation regulation but serve to protect small ribosomal subunits and preinitiation complexes from degradation
October 4, 2025 at 6:37 PM
Stress granules have a limited impact on global translation regulation but serve to protect small ribosomal subunits and preinitiation complexes from degradation
Reposted by Michaela Müller-McNicoll
How are RNAs sorted for export vs. degradation in the nucleus? In collaboration with @heick.bsky.social’s lab we (@clemensplaschka.bsky.social and @juliusbrennecke.bsky.social labs) discovered a direct mechanistic link between the export and decay machineries: www.biorxiv.org/content/10.1... (1/x)
Molecular basis of polyadenylated RNA fate determination in the nucleus
Eukaryotic genomes generate a plethora of polyadenylated (pA+) RNAs[1][1],[2][2], that are packaged into ribonucleoprotein particles (RNPs). To ensure faithful gene expression, functional pA+ RNPs, in...
www.biorxiv.org
September 22, 2025 at 11:23 PM
How are RNAs sorted for export vs. degradation in the nucleus? In collaboration with @heick.bsky.social’s lab we (@clemensplaschka.bsky.social and @juliusbrennecke.bsky.social labs) discovered a direct mechanistic link between the export and decay machineries: www.biorxiv.org/content/10.1... (1/x)
Reposted by Michaela Müller-McNicoll
Reposted by Michaela Müller-McNicoll
Our study on the biogenesis of neuronal circular RNAs is out in Genes&Development @genesdev.bsky.social !
genesdev.cshlp.org/content/earl...
Our celebration picture features first authors @carlosalfonsog.bsky.social and @shimengjin.bsky.social holding the fabulous circular cake, and most co-authors.
genesdev.cshlp.org/content/earl...
Our celebration picture features first authors @carlosalfonsog.bsky.social and @shimengjin.bsky.social holding the fabulous circular cake, and most co-authors.
September 19, 2025 at 8:01 AM
Our study on the biogenesis of neuronal circular RNAs is out in Genes&Development @genesdev.bsky.social !
genesdev.cshlp.org/content/earl...
Our celebration picture features first authors @carlosalfonsog.bsky.social and @shimengjin.bsky.social holding the fabulous circular cake, and most co-authors.
genesdev.cshlp.org/content/earl...
Our celebration picture features first authors @carlosalfonsog.bsky.social and @shimengjin.bsky.social holding the fabulous circular cake, and most co-authors.
Reposted by Michaela Müller-McNicoll
We followed with a day packed with CryoEM! We heard about the cryoEM from Werner Kühlbrandt, STEM-EELs from Bonnie Murphy and CryoET from Martin Beck.
September 18, 2025 at 3:28 PM
We followed with a day packed with CryoEM! We heard about the cryoEM from Werner Kühlbrandt, STEM-EELs from Bonnie Murphy and CryoET from Martin Beck.
Reposted by Michaela Müller-McNicoll
GBM Compact Focus on Condensate Biology is opened by Edward Lemke. Looking forward to a great meeting!
September 18, 2025 at 11:09 AM
GBM Compact Focus on Condensate Biology is opened by Edward Lemke. Looking forward to a great meeting!
Reposted by Michaela Müller-McNicoll
How do cells sort which RNAs to keep or destroy? New preprint from THJ, Brenneke and Plaschka labs shows that export and decay machineries (TREX2/PAXT) both recognise UAP56-bound RNAs. Whether they’re exported or degraded depends on where in the nucleus this happens.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Molecular basis of polyadenylated RNA fate determination in the nucleus
Eukaryotic genomes generate a plethora of polyadenylated (pA+) RNAs, that are packaged into ribonucleoprotein particles (RNPs). To ensure faithful gene expression, functional pA+ RNPs, including prote...
www.biorxiv.org
September 17, 2025 at 10:31 AM
How do cells sort which RNAs to keep or destroy? New preprint from THJ, Brenneke and Plaschka labs shows that export and decay machineries (TREX2/PAXT) both recognise UAP56-bound RNAs. Whether they’re exported or degraded depends on where in the nucleus this happens.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Michaela Müller-McNicoll
Liquid-liquid phase separation of HP1? Not in our mouse fibroblasts… This paper by the Fabian Erdel group offers a fresh perspective on how this can be reconciled with seemingly conflicting reports: The phase separation propensity of HP1 decreases from yeast → fly → mouse. doi.org/10.1038/s414...
July 11, 2025 at 5:35 AM
Liquid-liquid phase separation of HP1? Not in our mouse fibroblasts… This paper by the Fabian Erdel group offers a fresh perspective on how this can be reconciled with seemingly conflicting reports: The phase separation propensity of HP1 decreases from yeast → fly → mouse. doi.org/10.1038/s414...
Reposted by Michaela Müller-McNicoll
My lab @mpi-muenster.bsky.social is looking for a computational biologist with a passion for imaging and spatial biology. A staff scientist position with long-term perspective! Apply and spread the word 🙏 jobs.mpi-muenster.mpg.de/jobposting/0...
Computational image analyst (m/f/d)
The Max Planck Institute for Molecular Biomedicine in Münster, Germany, has an opening for a
jobs.mpi-muenster.mpg.de
September 12, 2025 at 6:17 AM
My lab @mpi-muenster.bsky.social is looking for a computational biologist with a passion for imaging and spatial biology. A staff scientist position with long-term perspective! Apply and spread the word 🙏 jobs.mpi-muenster.mpg.de/jobposting/0...