Mitro Miihkinen
@mitroe.bsky.social
Computational drug development dude //
University of Helsinki, Institute for Molecular Medicine Finland (FIMM)
University of Helsinki, Institute for Molecular Medicine Finland (FIMM)
Pre-print alert: defining colon fibroblast species by their location and the genes they express, in health and in cancer: www.biorxiv.org/content/10.1...
www.biorxiv.org
August 5, 2025 at 7:15 AM
Pre-print alert: defining colon fibroblast species by their location and the genes they express, in health and in cancer: www.biorxiv.org/content/10.1...
Reposted by Mitro Miihkinen
2 weeks left to apply for our new fully funded postdoc position studying plasticity regulators in metastatic CRC!
We are recruiting! We're searching for a postdoctoral research fellow to study patient-specific regulators of plasticity in primary and metastatic CRC. Please reach out if you have any questions! www.ucl.ac.uk/work-at-ucl/...
June 10, 2025 at 5:32 AM
2 weeks left to apply for our new fully funded postdoc position studying plasticity regulators in metastatic CRC!
Reposted by Mitro Miihkinen
Delighted to share the work of @gounismichalis.bsky.social describing how metabolic reprogramming of micrometastatic cells influences EV release to generate invasive microenvironments.Michalis is an immense talent & it really is an honour to share his PhD work & my first senior author paper #ProudPI
@gounismichalis.bsky.social et al. show that cells that seed early lung #metastasis in #BreastCancer have altered #metabolism. These metabolic alterations lead them to release extracellular vesicles which engender a microenvironment conducive to invasive growth. rupress.org/jcb/article/...
June 9, 2025 at 7:16 PM
Delighted to share the work of @gounismichalis.bsky.social describing how metabolic reprogramming of micrometastatic cells influences EV release to generate invasive microenvironments.Michalis is an immense talent & it really is an honour to share his PhD work & my first senior author paper #ProudPI
Reposted by Mitro Miihkinen
These are not just grants. This is thousands of people who devoted their lives and careers - taking pay cuts, working long hours, living with uncertainty - all for the chance to try to make people's lives a bit better for you and your loved ones. This breaks my heart.
Cutting NIH or NSF funding sounds abstract. Seeing what research is actually being cut makes it real. Kudos to @nytimes.com for this piece:
www.nytimes.com/interactive/...
www.nytimes.com/interactive/...
Here Are the Nearly 2,500 Medical Research Grants Canceled or Delayed by Trump
Some cuts have been starkly visible, but the country’s medical grant-making machinery has also radically transformed outside the public eye.
www.nytimes.com
June 4, 2025 at 8:20 PM
These are not just grants. This is thousands of people who devoted their lives and careers - taking pay cuts, working long hours, living with uncertainty - all for the chance to try to make people's lives a bit better for you and your loved ones. This breaks my heart.
How complete are the current single-cell profiling efforts? Happy to share our updated manuscript now online in www.biorxiv.org/content/10.1...
Estimating the completeness of large-scale single-cell sequencing projects
During embryonic development, cells undergo differentiation into highly specialized cell types. Capitalizing on single-cell RNA sequencing, many initiatives and substantial resources have been establi...
www.biorxiv.org
June 4, 2025 at 2:55 PM
How complete are the current single-cell profiling efforts? Happy to share our updated manuscript now online in www.biorxiv.org/content/10.1...
Reposted by Mitro Miihkinen
Now online in Cancer Discovery: Activated T Cells Break Tumor Immunosuppression by Macrophage Re-education - by Rosa Trotta, Silvia Rivis, Shikang Zhao, Massimiliano Mazzone and colleagues doi.org/10.1158/2159...
April 7, 2025 at 2:23 PM
Now online in Cancer Discovery: Activated T Cells Break Tumor Immunosuppression by Macrophage Re-education - by Rosa Trotta, Silvia Rivis, Shikang Zhao, Massimiliano Mazzone and colleagues doi.org/10.1158/2159...
Reposted by Mitro Miihkinen
This is catastrophic for pancreatic cancer patients
March 26, 2025 at 12:11 PM
This is catastrophic for pancreatic cancer patients
Reposted by Mitro Miihkinen
We are looking for a doctoral candidate to join the lab! If you are interested in working with human breast tissue samples straight from the clinic and do not fear large data sets, this might just be your dream project ☺️ Apply now ⬇️
ats.talentadore.com/apply/vaitos...
📸 @oonapaavolainen.bsky.social
ats.talentadore.com/apply/vaitos...
📸 @oonapaavolainen.bsky.social
March 20, 2025 at 2:04 PM
We are looking for a doctoral candidate to join the lab! If you are interested in working with human breast tissue samples straight from the clinic and do not fear large data sets, this might just be your dream project ☺️ Apply now ⬇️
ats.talentadore.com/apply/vaitos...
📸 @oonapaavolainen.bsky.social
ats.talentadore.com/apply/vaitos...
📸 @oonapaavolainen.bsky.social
Reposted by Mitro Miihkinen
Calling all researchers interested in drug repurposing!🔬💊
A new review on computational drug repurposing resources from the REMEDi4ALL consortium has been published in Nature Reviews Drug Discovery!🎉📄
📖Full review: loom.ly/F7KIRjM
🌐More: loom.ly/d1YRQyM
A new review on computational drug repurposing resources from the REMEDi4ALL consortium has been published in Nature Reviews Drug Discovery!🎉📄
📖Full review: loom.ly/F7KIRjM
🌐More: loom.ly/d1YRQyM
March 18, 2025 at 10:03 AM
Calling all researchers interested in drug repurposing!🔬💊
A new review on computational drug repurposing resources from the REMEDi4ALL consortium has been published in Nature Reviews Drug Discovery!🎉📄
📖Full review: loom.ly/F7KIRjM
🌐More: loom.ly/d1YRQyM
A new review on computational drug repurposing resources from the REMEDi4ALL consortium has been published in Nature Reviews Drug Discovery!🎉📄
📖Full review: loom.ly/F7KIRjM
🌐More: loom.ly/d1YRQyM
How to find new uses for existing drugs? Our massive review on computational drug repurposing is now online on Nature Reviews Drug Discovery. Team effort from the REMEDi4ALL consortium. doi.org/10.1038/s415...
March 18, 2025 at 10:45 AM
How to find new uses for existing drugs? Our massive review on computational drug repurposing is now online on Nature Reviews Drug Discovery. Team effort from the REMEDi4ALL consortium. doi.org/10.1038/s415...
Spatial transcriptomics study of the human prostate: ANO7 (PrCa risk gene) shows a switch-like on/off expression patterns in adjacent epithelia, which differ in the amount of NK cell infiltration and lipid metabolism among other things. Super interesting and fun collaboration
March 18, 2025 at 10:14 AM
Spatial transcriptomics study of the human prostate: ANO7 (PrCa risk gene) shows a switch-like on/off expression patterns in adjacent epithelia, which differ in the amount of NK cell infiltration and lipid metabolism among other things. Super interesting and fun collaboration
Reposted by Mitro Miihkinen
So excited that our study made the cover of Nature Genetics this month!
March 17, 2025 at 3:21 PM
So excited that our study made the cover of Nature Genetics this month!
Reposted by Mitro Miihkinen
Today's #microscopy session inspired me to do some art. These ovarioles look like trees, don't you think? If you want to learn what made them this way, stay tuned for our #SingleCell analysis of these - preprint coming soon!
March 4, 2025 at 3:05 PM
Today's #microscopy session inspired me to do some art. These ovarioles look like trees, don't you think? If you want to learn what made them this way, stay tuned for our #SingleCell analysis of these - preprint coming soon!
🧬 Are single-cell atlases complete? This was an interesting one to do: www.biorxiv.org/content/10.1... #scRNAseq #single-cell #atlas #cell #biodiversity #biostatistics
www.biorxiv.org
March 5, 2025 at 1:35 PM
🧬 Are single-cell atlases complete? This was an interesting one to do: www.biorxiv.org/content/10.1... #scRNAseq #single-cell #atlas #cell #biodiversity #biostatistics
Reposted by Mitro Miihkinen
We are looking for exceptional #AIScientist|s to join our #AI@HHMI initiative at #HHMIJanelia. We want to uncover fundamental principles underlying complex biological systems that are inaccessible without new innovations that combine #AI with experimental design.
ai.hhmi.org#join-our-team
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ai.hhmi.org#join-our-team
1/4
November 15, 2024 at 2:13 PM
We are looking for exceptional #AIScientist|s to join our #AI@HHMI initiative at #HHMIJanelia. We want to uncover fundamental principles underlying complex biological systems that are inaccessible without new innovations that combine #AI with experimental design.
ai.hhmi.org#join-our-team
1/4
ai.hhmi.org#join-our-team
1/4
16 funded PhD positions for 2025 in metastatic studies adaptmet.eu/recruitment/
Recruitment
Recruitment is now open!
Apply for one of the 16 positions availablein the Adaptmet network and build your futureas a researcher in metastasis!
Adaptmet is offering generous three-year fellowship...
adaptmet.eu
November 18, 2024 at 1:26 PM
16 funded PhD positions for 2025 in metastatic studies adaptmet.eu/recruitment/