Mitchell Dumais, MD
@mitchdumais.bsky.social
Infectious Diseases Fellow in Washington, DC by way of @MayoClinic and @UWMedicine. Interests in #Virology, #HIV, #GeneTherapy, #Immunology and #Biodefense. Amateur brewer, fisherman, cat dad. 🩺🦠🧬💊💉
All views/posts are my own.
All views/posts are my own.
Reposted by Mitchell Dumais, MD
“Between 2022 and 2024, resistance to ceftriaxone and cefixime, the primary antibiotics used to treat gonorrhoea, rose sharply from 0.8% to 5% and from 1.7% to 11% respectively, with resistant strains detected in more countries… resistance to ciprofloxacin reached 95%.”
More countries report rising levels of drug-resistant gonorrhoea, warns WHO
The World Health Organization (WHO) warns that gonorrhoea, a sexually transmitted infection, is becoming increasingly resistant to antibiotics, according to new data from its Enhanced Gonococcal Antim...
www.who.int
November 19, 2025 at 12:24 PM
“Between 2022 and 2024, resistance to ceftriaxone and cefixime, the primary antibiotics used to treat gonorrhoea, rose sharply from 0.8% to 5% and from 1.7% to 11% respectively, with resistant strains detected in more countries… resistance to ciprofloxacin reached 95%.”
Reposted by Mitchell Dumais, MD
The deadly fever in Ethiopia has been identified as Marburg disease.
It’s the first time a Marburg outbreak has been identified in Ethiopia.
#IDsky 🧪
www.afro.who.int/countries/et...
It’s the first time a Marburg outbreak has been identified in Ethiopia.
#IDsky 🧪
www.afro.who.int/countries/et...
Ethiopia confirms first outbreak of Marburg virus disease
Ethiopia’s Ministry of Health has confirmed an outbreak of Marburg virus disease in the South Ethiopia Region, the first of its kind in the country, following laboratory testing of samples from a clus...
www.afro.who.int
November 14, 2025 at 8:07 PM
The deadly fever in Ethiopia has been identified as Marburg disease.
It’s the first time a Marburg outbreak has been identified in Ethiopia.
#IDsky 🧪
www.afro.who.int/countries/et...
It’s the first time a Marburg outbreak has been identified in Ethiopia.
#IDsky 🧪
www.afro.who.int/countries/et...
Gene therapies are on the cusp of changing how we manage certain chronic diseases. Soon, patients may have a choice between:
1. Daily medication 💊
2. Single injection 💉
Phase 1 Trial of CRISPR-Cas9 Gene Editing Targeting ANGPTL3 | New England Journal of Medicine www.nejm.org/doi/full/10....
1. Daily medication 💊
2. Single injection 💉
Phase 1 Trial of CRISPR-Cas9 Gene Editing Targeting ANGPTL3 | New England Journal of Medicine www.nejm.org/doi/full/10....
Phase 1 Trial of CRISPR-Cas9 Gene Editing Targeting ANGPTL3 | NEJM
Angiopoietin-like protein 3 (ANGPTL3) inhibits lipoprotein and endothelial lipases. ANGPTL3 loss-of-function genetic variants are associated with decreased levels of low-density lipoprotein cholest...
www.nejm.org
November 10, 2025 at 4:31 PM
Gene therapies are on the cusp of changing how we manage certain chronic diseases. Soon, patients may have a choice between:
1. Daily medication 💊
2. Single injection 💉
Phase 1 Trial of CRISPR-Cas9 Gene Editing Targeting ANGPTL3 | New England Journal of Medicine www.nejm.org/doi/full/10....
1. Daily medication 💊
2. Single injection 💉
Phase 1 Trial of CRISPR-Cas9 Gene Editing Targeting ANGPTL3 | New England Journal of Medicine www.nejm.org/doi/full/10....
Profiling of HIV-1 elite neutralizer cohort reveals a CD4bs bnAb for HIV-1 prevention and therapy | Nature Immunology share.google/FBKwDoY0t8rX...
"04_A06, a broadly neutralizing antibody ... with remarkable breadth and potency against multiclade pseudovirus panels (98.5%, 332 strains)"
"04_A06, a broadly neutralizing antibody ... with remarkable breadth and potency against multiclade pseudovirus panels (98.5%, 332 strains)"
Profiling of HIV-1 elite neutralizer cohort reveals a CD4bs bnAb for HIV-1 prevention and therapy - Nature Immunology
Klein and colleagues characterize 04_A06, a new VH1-2-encoded broadly neutralizing antibody that has marked breadth and potency against extended multiclade HIV-1 pseudovirus panels and can maintain fu...
share.google
November 3, 2025 at 7:50 PM
Profiling of HIV-1 elite neutralizer cohort reveals a CD4bs bnAb for HIV-1 prevention and therapy | Nature Immunology share.google/FBKwDoY0t8rX...
"04_A06, a broadly neutralizing antibody ... with remarkable breadth and potency against multiclade pseudovirus panels (98.5%, 332 strains)"
"04_A06, a broadly neutralizing antibody ... with remarkable breadth and potency against multiclade pseudovirus panels (98.5%, 332 strains)"
Reposted by Mitchell Dumais, MD
Ebola is one of the nasty viruses that can hide in the body even after a patient recovers and tests negative. It can reemerge and trigger a new outbreak years later. How do they survive? And how can they be kayoed? n.pr/4hB9gXN
Some viruses can play a deadly game of hide and seek inside the human body
Ebola is one of the nasty viruses that can hide in the body even after a patient recovers and tests negative. It can reemerge and trigger a new outbreak years later. How do they survive? And how can they be kayoed?
n.pr
October 24, 2025 at 9:23 PM
Ebola is one of the nasty viruses that can hide in the body even after a patient recovers and tests negative. It can reemerge and trigger a new outbreak years later. How do they survive? And how can they be kayoed? n.pr/4hB9gXN
“We should be cautious not to apply AI indiscriminately as a solution in search of a problem... AI will not absolve us from making difficult ethical decisions, especially decisions concerning life and death.”
October 20, 2025 at 4:20 PM
“We should be cautious not to apply AI indiscriminately as a solution in search of a problem... AI will not absolve us from making difficult ethical decisions, especially decisions concerning life and death.”
Reposted by Mitchell Dumais, MD
my latest investigation for @consumerreports.org is based on months of reporting and 60+ lab tests of leading protein supplements
we found that most protein powders and shakes have more lead in one serving than our experts say is safe to have in a day (🧵)
www.consumerreports.org/lead/protein...
we found that most protein powders and shakes have more lead in one serving than our experts say is safe to have in a day (🧵)
www.consumerreports.org/lead/protein...
Protein Powders and Shakes Contain High Levels of Lead - Consumer Reports
CR tests of 23 popular protein powders and shakes found that most contain high levels of lead.
www.consumerreports.org
October 14, 2025 at 4:37 PM
my latest investigation for @consumerreports.org is based on months of reporting and 60+ lab tests of leading protein supplements
we found that most protein powders and shakes have more lead in one serving than our experts say is safe to have in a day (🧵)
www.consumerreports.org/lead/protein...
we found that most protein powders and shakes have more lead in one serving than our experts say is safe to have in a day (🧵)
www.consumerreports.org/lead/protein...
Reposted by Mitchell Dumais, MD
Neat
Association Between Apple Eaters and Physician Visits
This cross-sectional observational study does not support that “an apple a day keeps the doctor away”; however, the small fraction of US adults who eat an apple a day do appear to use fewer prescripti...
jamanetwork.com
October 13, 2025 at 2:31 AM
Neat
Reposted by Mitchell Dumais, MD
“A study, published on Wednesday in the New England Journal of Medicine, showed that last season’s 2024–2025 mRNA COVID vaccines reduced people’s risk of emergency department visits by 29%, their risk of hospitalizations by 39% & their risk of death by 64%”
Benefits were seen even if 0 risk factors
Benefits were seen even if 0 risk factors
Annual COVID Vaccines Protect People against Severe Disease, Even with Prior Immunity
"The new research also “calls into question the idea that younger individuals and those without risk factors don’t need the vaccine,” Viswanathan says."
"The new research also “calls into question the idea that younger individuals and those without risk factors don’t need the vaccine,” Viswanathan says."
Annual COVID Vaccines Save Lives, New Study Shows
A new study shows that receiving an updated COVID vaccine reduced people’s risk of severe disease and death in all age groups, regardless of immunity from prior infection or vaccination
www.scientificamerican.com
October 9, 2025 at 11:48 AM
“A study, published on Wednesday in the New England Journal of Medicine, showed that last season’s 2024–2025 mRNA COVID vaccines reduced people’s risk of emergency department visits by 29%, their risk of hospitalizations by 39% & their risk of death by 64%”
Benefits were seen even if 0 risk factors
Benefits were seen even if 0 risk factors
Reposted by Mitchell Dumais, MD
A new Cochrane review pooled >100,000 participants across 14 trials of RSV vaccines:
- In older adults,RSV vaccines ⬇️ RSV-related lower resp illness by ~70%.
- In pregnant people, vaccination halved the risk of infants needing medical care for RSV & ⬇️severe dz by ~74%.
www.gavi.org/vaccineswork...
- In older adults,RSV vaccines ⬇️ RSV-related lower resp illness by ~70%.
- In pregnant people, vaccination halved the risk of infants needing medical care for RSV & ⬇️severe dz by ~74%.
www.gavi.org/vaccineswork...
RSV vaccines offer vital protection for the most vulnerable, study confirms
A review of 14 clinical trials involving more than 100,000 participants supports widespread RSV vaccination to reduce severe illness and hospitalisations.
www.gavi.org
October 1, 2025 at 4:05 PM
A new Cochrane review pooled >100,000 participants across 14 trials of RSV vaccines:
- In older adults,RSV vaccines ⬇️ RSV-related lower resp illness by ~70%.
- In pregnant people, vaccination halved the risk of infants needing medical care for RSV & ⬇️severe dz by ~74%.
www.gavi.org/vaccineswork...
- In older adults,RSV vaccines ⬇️ RSV-related lower resp illness by ~70%.
- In pregnant people, vaccination halved the risk of infants needing medical care for RSV & ⬇️severe dz by ~74%.
www.gavi.org/vaccineswork...
Reposted by Mitchell Dumais, MD
Replacing old immune cells called microglia with fresh ones holds promise for addressing brain conditions such as Alzheimer’s disease @nature.com @heidiledford.bsky.social
nature.com/articles/d41...
nature.com/articles/d41...
Swapping old immune cells in the brain with fresh ones could treat disease
Replacing immune cells called microglia holds promise for addressing brain conditions such as Alzheimer’s disease.
nature.com
September 26, 2025 at 4:39 PM
Replacing old immune cells called microglia with fresh ones holds promise for addressing brain conditions such as Alzheimer’s disease @nature.com @heidiledford.bsky.social
nature.com/articles/d41...
nature.com/articles/d41...
Reposted by Mitchell Dumais, MD
Antagonistic interaction between posaconazole & olorofim in a murine model of invasive pulmonary aspergillosis
Posaconazole ⬇️ the effect of olorofim in vivo. Combination of olorofim+azole likely efficacious in wt infections, may be suboptimal in azole R infections
academic.oup.com/jac/article/...
Posaconazole ⬇️ the effect of olorofim in vivo. Combination of olorofim+azole likely efficacious in wt infections, may be suboptimal in azole R infections
academic.oup.com/jac/article/...
Antagonistic interaction between posaconazole and olorofim in a murine model of invasive pulmonary aspergillosis
AbstractBackground. Olorofim is a new antifungal agent with a novel mechanism of action with in vitro activity against Aspergillus fumigatus and other clin
academic.oup.com
September 24, 2025 at 6:35 PM
Antagonistic interaction between posaconazole & olorofim in a murine model of invasive pulmonary aspergillosis
Posaconazole ⬇️ the effect of olorofim in vivo. Combination of olorofim+azole likely efficacious in wt infections, may be suboptimal in azole R infections
academic.oup.com/jac/article/...
Posaconazole ⬇️ the effect of olorofim in vivo. Combination of olorofim+azole likely efficacious in wt infections, may be suboptimal in azole R infections
academic.oup.com/jac/article/...
Reposted by Mitchell Dumais, MD
A drug that provides near-perfect protection against HIV with shots just twice a year will be made available at $40 per patient annually in low- and middle-income countries, offering new hope for ending the epidemic.
Philanthropies Strike a Promising Deal to Turn Back H.I.V.
Low- and middle-income countries will be able to purchase an effective preventative at a reduced price. The arrangements may help stem the epidemic 40 years after it began.
nyti.ms
September 24, 2025 at 4:30 PM
A drug that provides near-perfect protection against HIV with shots just twice a year will be made available at $40 per patient annually in low- and middle-income countries, offering new hope for ending the epidemic.
An excellent project that came together from my time during residency - a great analysis of this difficult bug 🦠!
Clinical and microbiologic features of Achromobacter species: a 10-year, multicenter experience | Journal of Clinical Microbiology journals.asm.org/doi/10.1128/...
Clinical and microbiologic features of Achromobacter species: a 10-year, multicenter experience | Journal of Clinical Microbiology journals.asm.org/doi/10.1128/...
Clinical and microbiologic features of Achromobacter species: a 10-year, multicenter experience | Journal of Clinical Microbiology
Achromobacter is a rare but important genus of bacteria that tends to cause infection in those
with cystic fibrosis, recurrent healthcare exposures, and/or an immunocompromising
condition. There is li...
journals.asm.org
September 24, 2025 at 1:34 AM
An excellent project that came together from my time during residency - a great analysis of this difficult bug 🦠!
Clinical and microbiologic features of Achromobacter species: a 10-year, multicenter experience | Journal of Clinical Microbiology journals.asm.org/doi/10.1128/...
Clinical and microbiologic features of Achromobacter species: a 10-year, multicenter experience | Journal of Clinical Microbiology journals.asm.org/doi/10.1128/...
Reposted by Mitchell Dumais, MD
"bUt tHe WhiTe cOuNT iS nOrmAL"
I see this pattern of laboratory evaluation almost every day in the ICU
anyone involved in evaluating acutely ill patients must be able to recognize this evolution, like the face of an old friend
what is going on here? #EMIMCC 🧵 #1/5
I see this pattern of laboratory evaluation almost every day in the ICU
anyone involved in evaluating acutely ill patients must be able to recognize this evolution, like the face of an old friend
what is going on here? #EMIMCC 🧵 #1/5
September 22, 2025 at 1:35 PM
"bUt tHe WhiTe cOuNT iS nOrmAL"
I see this pattern of laboratory evaluation almost every day in the ICU
anyone involved in evaluating acutely ill patients must be able to recognize this evolution, like the face of an old friend
what is going on here? #EMIMCC 🧵 #1/5
I see this pattern of laboratory evaluation almost every day in the ICU
anyone involved in evaluating acutely ill patients must be able to recognize this evolution, like the face of an old friend
what is going on here? #EMIMCC 🧵 #1/5
Reposted by Mitchell Dumais, MD
Some 154 million people in the United States get health care through their employer — and for many, their costs are about to go way up.
Health care costs are soaring. Blame insurers, drug companies — and your employer
Some 154 million people in the United States get health care through their employer — and for many, their costs are about to go way up.
n.pr
September 12, 2025 at 11:46 AM
Some 154 million people in the United States get health care through their employer — and for many, their costs are about to go way up.
Reposted by Mitchell Dumais, MD
Death from sub-acute sclerosing panencephalitis (SSPE) in a child in Los Angeles
SSPE is a rare sequel of #measles infection that appears years after the initial infection, and is uniformly fatal. So sorry for this family. As things are going on the US, we'll be seeing more of these cases.
SSPE is a rare sequel of #measles infection that appears years after the initial infection, and is uniformly fatal. So sorry for this family. As things are going on the US, we'll be seeing more of these cases.
Child dies from rare measles-related complication, LA County health officials say
Health officials reported the death of a Los Angeles County child from a complication of measles infection acquired during infancy.
abc7.com
September 11, 2025 at 8:54 PM
Death from sub-acute sclerosing panencephalitis (SSPE) in a child in Los Angeles
SSPE is a rare sequel of #measles infection that appears years after the initial infection, and is uniformly fatal. So sorry for this family. As things are going on the US, we'll be seeing more of these cases.
SSPE is a rare sequel of #measles infection that appears years after the initial infection, and is uniformly fatal. So sorry for this family. As things are going on the US, we'll be seeing more of these cases.
Reposted by Mitchell Dumais, MD
Good to see @bsky.app has emerged as the social media platform of choice for science stuff
arstechnica.com/science/2025...
arstechnica.com/science/2025...
Bluesky now platform of choice for science community
It’s not just you. Survey says: “Twitter sucks now and all the cool kids are moving to Bluesky”…
arstechnica.com
August 27, 2025 at 5:33 PM
Good to see @bsky.app has emerged as the social media platform of choice for science stuff
arstechnica.com/science/2025...
arstechnica.com/science/2025...
Reposted by Mitchell Dumais, MD
I studied infectious diseases because I get bored easily and needed to be in a field in which there is never a dull moment. The US just confirmed its first human case of myiasis in many decades in a returning traveller from El Salvador.
www.npr.org/2025/08/25/n...
www.npr.org/2025/08/25/n...
The U.S. confirms its first human case of New World screwworm. What is it?
U.S. officials confirmed a case of the flesh-eating parasite in a person who traveled from El Salvador. Screwworm typically affects cattle in South America, but has spread north in recent years.
www.npr.org
August 25, 2025 at 8:59 PM
I studied infectious diseases because I get bored easily and needed to be in a field in which there is never a dull moment. The US just confirmed its first human case of myiasis in many decades in a returning traveller from El Salvador.
www.npr.org/2025/08/25/n...
www.npr.org/2025/08/25/n...
Me, signing up for yet another conference with free food
Serebii Picture: Official render for Mega Victreebel www.serebii.net
August 21, 2025 at 5:39 PM
Me, signing up for yet another conference with free food
Reposted by Mitchell Dumais, MD
Happy DOTS Day, to those who celebrate. jamanetwork.com/journals/jam...
Dalbavancin for Treatment of Staphylococcus aureus Bacteremia
This clinical trial compares the efficacy and safety of dalbavancin vs standard therapy for completion of treatment of complicated Staphylococcus aureus bacteremia in hospitalized patients.
jamanetwork.com
August 13, 2025 at 8:00 PM
Happy DOTS Day, to those who celebrate. jamanetwork.com/journals/jam...
Reposted by Mitchell Dumais, MD
"But the popular idea that this disease only affects immigrants or travelers is dangerously outdated."
www.statnews.com/2025/08/08/c...
www.statnews.com/2025/08/08/c...
A ‘tropical’ disease is spreading in American wildlife
This neglected tropical disease is no longer confined to the tropics. It’s here, in the United States, spreading silently in wildlife.
www.statnews.com
August 8, 2025 at 11:03 AM
"But the popular idea that this disease only affects immigrants or travelers is dangerously outdated."
www.statnews.com/2025/08/08/c...
www.statnews.com/2025/08/08/c...
Reposted by Mitchell Dumais, MD
Measles is horrible. It has already impacted thousands of young kids. This will only grow as vaccines become less accessible.
And when measles is joined by epidemics of rubella, mumps, and polio, we will see children suffer and die at national scale.
www.nbcnews.com/health/healt...
And when measles is joined by epidemics of rubella, mumps, and polio, we will see children suffer and die at national scale.
www.nbcnews.com/health/healt...
Day care measles exposure forces Iowa family to take weeks off work for baby: 'It only takes one'
There have been at least 1,309 confirmed cases of measles in the U.S. this year. Hundreds or thousands of other families have most likely had their lives upended after being exposed.
www.nbcnews.com
July 18, 2025 at 9:54 AM
Measles is horrible. It has already impacted thousands of young kids. This will only grow as vaccines become less accessible.
And when measles is joined by epidemics of rubella, mumps, and polio, we will see children suffer and die at national scale.
www.nbcnews.com/health/healt...
And when measles is joined by epidemics of rubella, mumps, and polio, we will see children suffer and die at national scale.
www.nbcnews.com/health/healt...
Reposted by Mitchell Dumais, MD
🚨 IDSA has released the first guidelines for the management and treatment of complicated urinary tract infections (cUTIs)!
The new guidelines simplify the prior definitions of uncomplicated UTIs and cUTIs, & address treatment for cUTIs.
View guidelines: bit.ly/4lUjN1a
The new guidelines simplify the prior definitions of uncomplicated UTIs and cUTIs, & address treatment for cUTIs.
View guidelines: bit.ly/4lUjN1a
July 17, 2025 at 7:07 PM
🚨 IDSA has released the first guidelines for the management and treatment of complicated urinary tract infections (cUTIs)!
The new guidelines simplify the prior definitions of uncomplicated UTIs and cUTIs, & address treatment for cUTIs.
View guidelines: bit.ly/4lUjN1a
The new guidelines simplify the prior definitions of uncomplicated UTIs and cUTIs, & address treatment for cUTIs.
View guidelines: bit.ly/4lUjN1a