Mike Pazin
@mikepazin.bsky.social
All views/posts are my personal opinions; Functional genomics program officer; drums and music; running and bicycling; photography; learning how things work; creative thinking
Reposted by Mike Pazin
🎉 New in #GENETICS: Functional Genomics & Systems Biology section! Highlighting cutting-edge studies on molecular networks, systems-level insights, and innovative methods.
Read more: buff.ly/wWVZdrS%F0%9...
Read more: buff.ly/wWVZdrS%F0%9...
Announcing the new “Functional Genomics and Systems Biology” section in GENETICS
The GSA Journals are introducing Functional Genomics and Systems Biology, a new section led by Brenda Andrews and Marian Walhout that highlights systems-level studies of genetic networks and pathways.
buff.ly
October 21, 2025 at 4:06 PM
🎉 New in #GENETICS: Functional Genomics & Systems Biology section! Highlighting cutting-edge studies on molecular networks, systems-level insights, and innovative methods.
Read more: buff.ly/wWVZdrS%F0%9...
Read more: buff.ly/wWVZdrS%F0%9...
Possible new treatment for Lyme disease:
pubmed.ncbi.nlm.nih.gov/40267215/
pubmed.ncbi.nlm.nih.gov/40267215/
A high-resolution screen identifies a preexisting beta-lactam that specifically treats Lyme disease in mice - PubMed
Lyme disease, caused by <i>Borrelia burgdorferi</i> in the United States, is an escalating human health problem that can cause severe disease if not properly treated. Doxycycline is the primary treatm...
pubmed.ncbi.nlm.nih.gov
May 20, 2025 at 9:50 AM
Possible new treatment for Lyme disease:
pubmed.ncbi.nlm.nih.gov/40267215/
pubmed.ncbi.nlm.nih.gov/40267215/
Possible mechanism for chronic illness following Lyme disease
pubmed.ncbi.nlm.nih.gov/40267217/
pubmed.ncbi.nlm.nih.gov/40267217/
The peptidoglycan of Borrelia burgdorferi can persist in discrete tissues and cause systemic responses consistent with chronic illness - PubMed
Persistent symptoms after an acute infection is an emerging public health concern, but the pathobiology of such conditions is not well understood. One possible scenario involves the persistence of lin...
pubmed.ncbi.nlm.nih.gov
May 20, 2025 at 9:48 AM
Possible mechanism for chronic illness following Lyme disease
pubmed.ncbi.nlm.nih.gov/40267217/
pubmed.ncbi.nlm.nih.gov/40267217/
Reposted by Mike Pazin
The 80-year recipe stoking America’s Prosperity:
1) Free-market capital investments in brilliant ideas…
2) enabled by Engineering Innovations…
3) based on Science Research in Universities…
4) funded by Grants from the US Government.
It’s time more people understood this.
1) Free-market capital investments in brilliant ideas…
2) enabled by Engineering Innovations…
3) based on Science Research in Universities…
4) funded by Grants from the US Government.
It’s time more people understood this.
May 17, 2025 at 1:36 PM
The 80-year recipe stoking America’s Prosperity:
1) Free-market capital investments in brilliant ideas…
2) enabled by Engineering Innovations…
3) based on Science Research in Universities…
4) funded by Grants from the US Government.
It’s time more people understood this.
1) Free-market capital investments in brilliant ideas…
2) enabled by Engineering Innovations…
3) based on Science Research in Universities…
4) funded by Grants from the US Government.
It’s time more people understood this.
pubmed.ncbi.nlm.nih.gov/40229440/ How the United States became a science superpower- and how quickly it could crumble
How the United States became a science superpower - and how quickly it could crumble - PubMed
How the United States became a science superpower - and how quickly it could crumble
pubmed.ncbi.nlm.nih.gov
May 7, 2025 at 9:22 PM
pubmed.ncbi.nlm.nih.gov/40229440/ How the United States became a science superpower- and how quickly it could crumble
I ran the Pittsburgh marathon Sunday. I was thrilled with how the race and training went. Personal record for me for marathon, and better than my target for today. Thanks to my partner Andrea and my sons and Tiny Dog for their support from training to race day (coach Jack!).
May 5, 2025 at 11:49 AM
I ran the Pittsburgh marathon Sunday. I was thrilled with how the race and training went. Personal record for me for marathon, and better than my target for today. Thanks to my partner Andrea and my sons and Tiny Dog for their support from training to race day (coach Jack!).
I ran the Nashville Rock ‘n’ Roll half marathon Saturday, benefitting cancer research at St. Jude Children’s Research Hospital. I loved running “with” my son. Personal record for me. Last tune up before next week’s marathon. I love that money is being raised to improve people’s health.
April 29, 2025 at 11:20 AM
I ran the Nashville Rock ‘n’ Roll half marathon Saturday, benefitting cancer research at St. Jude Children’s Research Hospital. I loved running “with” my son. Personal record for me. Last tune up before next week’s marathon. I love that money is being raised to improve people’s health.
Economists consider impact of changes to funding science and universities www.nytimes.com/2025/03/31/b...
Trump Science Funding Cuts May Hurt Economy, Experts Say
Since World War II, U.S. research funding has led to discoveries that fueled economic gains. Now cutbacks are seen as putting that legacy in jeopardy.
www.nytimes.com
April 1, 2025 at 10:21 PM
Economists consider impact of changes to funding science and universities www.nytimes.com/2025/03/31/b...
Reposted by Mike Pazin
Last call for a postdoc position in single cell analysis/perturb-seq with @nikashakiba.bsky.social at UBC in beautiful Vancouver Canada!
ubc.wd10.myworkdayjobs.com/en-US/ubcfac...
ubc.wd10.myworkdayjobs.com/en-US/ubcfac...
March 20, 2025 at 9:40 PM
Last call for a postdoc position in single cell analysis/perturb-seq with @nikashakiba.bsky.social at UBC in beautiful Vancouver Canada!
ubc.wd10.myworkdayjobs.com/en-US/ubcfac...
ubc.wd10.myworkdayjobs.com/en-US/ubcfac...
Reposted by Mike Pazin
Women live longer than men, but how much longer varies widely around the world
March 20, 2025 at 3:40 PM
Women live longer than men, but how much longer varies widely around the world
Reposted by Mike Pazin
Sitting in a journal club-style class right now and after the main presenters present, there are "roles" from others in the group, like the "archeologist" who looks into the citation trail, the "private investigator" who tries to dig into the history, and the "industry practitioner", etc. Cool idea!
March 18, 2025 at 3:15 PM
Sitting in a journal club-style class right now and after the main presenters present, there are "roles" from others in the group, like the "archeologist" who looks into the citation trail, the "private investigator" who tries to dig into the history, and the "industry practitioner", etc. Cool idea!
Reposted by Mike Pazin
oh this is so good
March 17, 2025 at 8:14 PM
oh this is so good
Analysis of NIH found that for every $1.00 of funded research there was $2.56 in economic activity. See the jobs created and economic activity in your state. Read recent research highlights. The “business” of the NIH is improving our health.
www.unitedformedicalresearch.org/wp-content/u...
www.unitedformedicalresearch.org/wp-content/u...
www.unitedformedicalresearch.org
March 16, 2025 at 4:06 PM
Analysis of NIH found that for every $1.00 of funded research there was $2.56 in economic activity. See the jobs created and economic activity in your state. Read recent research highlights. The “business” of the NIH is improving our health.
www.unitedformedicalresearch.org/wp-content/u...
www.unitedformedicalresearch.org/wp-content/u...
Reposted by Mike Pazin
90% of people diagnosed with pancreatic cancer die from the disease. That's why the medical community is excited about the results of a small trial in which nearly half of the pancreatic cancer patients who received an mRNA vaccine for the disease remained relapse-free three years later.
A Vaccine For Pancreatic Cancer Continues To Show Promise
In a small trial, nearly half of pancreatic cancer patients who received an mRNA vaccine for the disease had no relapse three years later.
www.sciencefriday.com
March 16, 2025 at 2:09 PM
90% of people diagnosed with pancreatic cancer die from the disease. That's why the medical community is excited about the results of a small trial in which nearly half of the pancreatic cancer patients who received an mRNA vaccine for the disease remained relapse-free three years later.
I ran the DC Rock ‘n’ Roll half marathon today, benefitting cancer research at St. Jude Children’s Research Hospital. I was thrilled with how the race and training went. Personal record for me, much better than my previous best half marathon, and better than my target for today.
March 15, 2025 at 8:13 PM
I ran the DC Rock ‘n’ Roll half marathon today, benefitting cancer research at St. Jude Children’s Research Hospital. I was thrilled with how the race and training went. Personal record for me, much better than my previous best half marathon, and better than my target for today.
Nice work assessing the effects of genetic variants in primary human T cells leading to enhanced T cell immunotherapy
youtu.be/jO6ybztQnzs?...
youtu.be/jO6ybztQnzs?...
"Massively scalable assessment of variant effects in primary human T cells" - Zachary Walsh
YouTube video by Variant Effects
youtu.be
March 12, 2025 at 12:15 PM
Nice work assessing the effects of genetic variants in primary human T cells leading to enhanced T cell immunotherapy
youtu.be/jO6ybztQnzs?...
youtu.be/jO6ybztQnzs?...
Reposted by Mike Pazin
March 10, 2025 at 5:12 PM
Reposted by Mike Pazin
Congratulations to the new fellows.
The AACR is proud to announce our newly elected class of Fellows of the AACR Academy. The AACR Academy honors distinguished scientists whose contributions have propelled significant innovation and progress against cancer. Learn more: buff.ly/8a8WUn9 #AACRFellows
March 11, 2025 at 9:22 AM
Congratulations to the new fellows.
I think this short video does a great job explaining why we should all be happy that a small portion of our tax dollars funds basic research youtu.be/GmhD-RWNL6c?...
*Winner* Funding Basic Science to Revolutionize Medicine, 2013 FASEB Stand Up for Science
YouTube video by Federation of American Societies for Experimental Biology
youtu.be
March 7, 2025 at 11:45 AM
I think this short video does a great job explaining why we should all be happy that a small portion of our tax dollars funds basic research youtu.be/GmhD-RWNL6c?...
Exciting seminar on calibrating results from high-throughput functional genomics assays and predictive models for clinical interpretation.
youtu.be/TY-C7Dz-Wi4?...
@shawnfayer.bsky.social
@dougfowler.bsky.social @leastarita.bsky.social #VESS
youtu.be/TY-C7Dz-Wi4?...
@shawnfayer.bsky.social
@dougfowler.bsky.social @leastarita.bsky.social #VESS
"Reassessing the Calibration of Variant Effect Predictors for Clinical Interpretation"
YouTube video by Variant Effects
youtu.be
March 5, 2025 at 10:36 PM
Exciting seminar on calibrating results from high-throughput functional genomics assays and predictive models for clinical interpretation.
youtu.be/TY-C7Dz-Wi4?...
@shawnfayer.bsky.social
@dougfowler.bsky.social @leastarita.bsky.social #VESS
youtu.be/TY-C7Dz-Wi4?...
@shawnfayer.bsky.social
@dougfowler.bsky.social @leastarita.bsky.social #VESS
Overcoming challenges associated with broad sharing of human genomic data
Thoughtful perspective on challenges of data sharing followed with recommendations
pubmed.ncbi.nlm.nih.gov/39843657/
Thoughtful perspective on challenges of data sharing followed with recommendations
pubmed.ncbi.nlm.nih.gov/39843657/
Overcoming challenges associated with broad sharing of human genomic data - PubMed
Since the Human Genome Project, the consensus position in genomics has been that data should be shared widely to achieve the greatest societal benefit. This position relies on imprecise definitions of...
pubmed.ncbi.nlm.nih.gov
March 5, 2025 at 5:50 PM
Overcoming challenges associated with broad sharing of human genomic data
Thoughtful perspective on challenges of data sharing followed with recommendations
pubmed.ncbi.nlm.nih.gov/39843657/
Thoughtful perspective on challenges of data sharing followed with recommendations
pubmed.ncbi.nlm.nih.gov/39843657/
Exciting seminar on understanding receptor-ligand signaling using mutational scanning. How does a receptor decode ligands to decide whether to signal, or how strongly?
youtu.be/hDlJU6HI9Os?...
youtu.be/hDlJU6HI9Os?...
"Mutational scanning to understand ligand efficacy and potency in GPCRs"- Matthew Howard
YouTube video by Variant Effects
youtu.be
March 4, 2025 at 11:18 PM
Exciting seminar on understanding receptor-ligand signaling using mutational scanning. How does a receptor decode ligands to decide whether to signal, or how strongly?
youtu.be/hDlJU6HI9Os?...
youtu.be/hDlJU6HI9Os?...