Michael Kearse
@michaelkearse.bsky.social
Asst. Professor of Biological Chemistry & Pharmacology, Center for RNA Biology, The Ohio State University; we study ribosomes & mRNA translation in human biology & disease; advocate for equity & diversity; www.kearselab.org
Reposted by Michael Kearse
Latest from the lab! Analysis of everyone’s favorite regulatory mechanism in bacteria — the RF2 programmed frameshift! Likely present in the ancestor of bacteria, use of this mechanism is influenced by stop codon usage! Big congrats to @cassidyprints.bsky.social
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
Conservation and evolution of the programmed ribosomal frameshift in prfB across the bacterial domain | mBio
Translation termination is catalyzed by one of two release factors in bacteria, RF1 or RF2. It has been known for decades that RF2 levels in Escherichia coli are regulated by a programmed ribosomal frameshift within the prfB gene that encodes RF2. We ...
journals.asm.org
August 19, 2025 at 7:44 PM
Latest from the lab! Analysis of everyone’s favorite regulatory mechanism in bacteria — the RF2 programmed frameshift! Likely present in the ancestor of bacteria, use of this mechanism is influenced by stop codon usage! Big congrats to @cassidyprints.bsky.social
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
Very proud of our recently published work in @narjournal.bsky.social led by senior PhD candidate Julia Warrick. #RNA
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
An autism spectrum disorder mutation in Topoisomerase 3β causes accumulation of covalent mRNA intermediates by disrupting metal binding within the zinc finger domain
Abstract. The loss and mutation of Topoisomerase 3β (TOP3B), the only known eukaryotic topoisomerase with the ability to catalyze RNA strand passage reacti
academic.oup.com
November 10, 2025 at 12:21 AM
Very proud of our recently published work in @narjournal.bsky.social led by senior PhD candidate Julia Warrick. #RNA
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
Reposted by Michael Kearse
Great lab, great mentor and I love UNC Biology!
The Johri Lab has an open postdoc position. Please send me an email, if interested. Start date is flexible. Please do share! Thank you in advance.
October 29, 2025 at 12:33 AM
Great lab, great mentor and I love UNC Biology!
Reposted by Michael Kearse
The Johri Lab has an open postdoc position. Please send me an email, if interested. Start date is flexible. Please do share! Thank you in advance.
October 28, 2025 at 9:31 PM
The Johri Lab has an open postdoc position. Please send me an email, if interested. Start date is flexible. Please do share! Thank you in advance.
Reposted by Michael Kearse
We have a new preprint for you. Naked mole rats are very long-lived rodents and have increased translational fidelity.
Interestingly, 28S ribosomal RNA is split. Here we investigated the structure of the ribosome by single particle cryo-EM. Take a look.
www.biorxiv.org/content/10.1...
Interestingly, 28S ribosomal RNA is split. Here we investigated the structure of the ribosome by single particle cryo-EM. Take a look.
www.biorxiv.org/content/10.1...
Cryo-EM structure of the naked mole-rat ribosome reveals a stabilized split 28S rRNA
The naked mole-rat (Heterocephalus glaber) is a long-lived mammal with remarkable resistance to cancer and hypoxia, suggesting the evolution of robust proteostasis networks. The ribosome, the central ...
www.biorxiv.org
October 28, 2025 at 3:24 PM
We have a new preprint for you. Naked mole rats are very long-lived rodents and have increased translational fidelity.
Interestingly, 28S ribosomal RNA is split. Here we investigated the structure of the ribosome by single particle cryo-EM. Take a look.
www.biorxiv.org/content/10.1...
Interestingly, 28S ribosomal RNA is split. Here we investigated the structure of the ribosome by single particle cryo-EM. Take a look.
www.biorxiv.org/content/10.1...
Reposted by Michael Kearse
Want to do a PhD in biology? Our projects for 2026 are now live! If you're considering a PhD, or know someone who is, we have projects that span the biosciences to serve as inspiration.
Reach out to our academics to discuss these or more options if you have an idea of your own 👇
bit.ly/dphilbio25
Reach out to our academics to discuss these or more options if you have an idea of your own 👇
bit.ly/dphilbio25
October 20, 2025 at 8:51 AM
Want to do a PhD in biology? Our projects for 2026 are now live! If you're considering a PhD, or know someone who is, we have projects that span the biosciences to serve as inspiration.
Reach out to our academics to discuss these or more options if you have an idea of your own 👇
bit.ly/dphilbio25
Reach out to our academics to discuss these or more options if you have an idea of your own 👇
bit.ly/dphilbio25
Reposted by Michael Kearse
From MBoC: Timothy J. Stasevich, Colorado State University, developed All Probes Plasmids (APPs) to simplify single-mRNA translation imaging—just 2 plasmids for multicolor, long-term tracking. www.molbiolcell.org/doi/10.1091/... #CellBiology
October 13, 2025 at 10:24 PM
From MBoC: Timothy J. Stasevich, Colorado State University, developed All Probes Plasmids (APPs) to simplify single-mRNA translation imaging—just 2 plasmids for multicolor, long-term tracking. www.molbiolcell.org/doi/10.1091/... #CellBiology
Reposted by Michael Kearse
Check out the latest work from our lab, led by Arash Latifkar @ara-latifkar.bsky.social , www.biorxiv.org/content/10.1...
mRNA poly(A)-tail length is a battleground for coronavirus–host competition
Most eukaryotic mRNAs contain a poly(A) tail, which in post-embryonic cells enhances their stability. Many cytoplasmic RNA viruses also harbor poly(A) tails on their genomic RNA and mRNAs. Here, we re...
www.biorxiv.org
October 13, 2025 at 7:44 PM
Check out the latest work from our lab, led by Arash Latifkar @ara-latifkar.bsky.social , www.biorxiv.org/content/10.1...
Reposted by Michael Kearse
Reposted by Michael Kearse
The @crick.ac.uk is recruiting Early Career Group Leaders
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
Early career group leaders
We appoint researchers from across biology and biomedicine to set up their first groups at the Crick.
www.crick.ac.uk
October 10, 2025 at 8:20 AM
The @crick.ac.uk is recruiting Early Career Group Leaders
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
Reposted by Michael Kearse
Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.
October 8, 2025 at 9:45 PM
Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.
Reposted by Michael Kearse
I am hiring! - looking for a Staff Scientist to co-run my research group with me. Staff Scientist is a senior professional scientist role at EMBL. Please forward to people you might know who could be interested! embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Staff Scientist
About EMBL-EBI EMBL’s European Bioinformatics Institute is a data powerhouse, utilised on a global scale to advance scientific discovery through bioinformatics and solutions to some of the world’s mos...
embl.wd103.myworkdayjobs.com
October 10, 2025 at 7:30 AM
I am hiring! - looking for a Staff Scientist to co-run my research group with me. Staff Scientist is a senior professional scientist role at EMBL. Please forward to people you might know who could be interested! embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Reposted by Michael Kearse
Much needed good news!! Our paper is just out in @jcb.org. We found a crazy antagonistic motor function that explains the elongation/retraction phenotype we see during LRRK2-dependent lysosomal tubulation. I am especially proud of Tsion, Nuria, Mia and Irene's contribution. Check it out!
@lysoluis.bsky.social, @markrcookson.bsky.social et al. show how two distinct pRAB effectors and RHD members, JIP4 and RILPL1, provide antagonistic motor force to regulate #lysosome tubulation. rupress.org/jcb/article/...
September 24, 2025 at 3:49 PM
Much needed good news!! Our paper is just out in @jcb.org. We found a crazy antagonistic motor function that explains the elongation/retraction phenotype we see during LRRK2-dependent lysosomal tubulation. I am especially proud of Tsion, Nuria, Mia and Irene's contribution. Check it out!
Reposted by Michael Kearse
Job alert ‼️ UChicago Micro is hiring! Open to tenured/tenure track faculty at all levels in any area of microbiology. Come join our amazing and growing department. apply.interfolio.com/174404
October 4, 2025 at 6:44 PM
Job alert ‼️ UChicago Micro is hiring! Open to tenured/tenure track faculty at all levels in any area of microbiology. Come join our amazing and growing department. apply.interfolio.com/174404
Reposted by Michael Kearse
🚀 Our new paper is out @natmethods.nature.com!
Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.
🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/
Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.
🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/
September 22, 2025 at 6:27 PM
🚀 Our new paper is out @natmethods.nature.com!
Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.
🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/
Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.
🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/
Reposted by Michael Kearse
🎉 Congratulations to Needhi Bhalla, UC Santa Cruz (www.bhallalab.com
), named a 2025 #ASCB Fellow! This honor celebrates her outstanding contributions to cell biology, leadership, & service. Fellows will be recognized at #CellBio2025 in Philadelphia this December. #CellBiology
), named a 2025 #ASCB Fellow! This honor celebrates her outstanding contributions to cell biology, leadership, & service. Fellows will be recognized at #CellBio2025 in Philadelphia this December. #CellBiology
September 19, 2025 at 7:37 PM
🎉 Congratulations to Needhi Bhalla, UC Santa Cruz (www.bhallalab.com
), named a 2025 #ASCB Fellow! This honor celebrates her outstanding contributions to cell biology, leadership, & service. Fellows will be recognized at #CellBio2025 in Philadelphia this December. #CellBiology
), named a 2025 #ASCB Fellow! This honor celebrates her outstanding contributions to cell biology, leadership, & service. Fellows will be recognized at #CellBio2025 in Philadelphia this December. #CellBiology
Reposted by Michael Kearse
@joachimgoedhart.bsky.social and Flurescent protein colleagues--help! With advice from imaging freinds, we tagged a protein of interest with "tagRFP", which we now know from its protein sequence and digging is a derivative of
eqFP578 from Entacmaea quadricolor. We want an antibody to it but 1/n
eqFP578 from Entacmaea quadricolor. We want an antibody to it but 1/n
September 19, 2025 at 6:55 PM
@joachimgoedhart.bsky.social and Flurescent protein colleagues--help! With advice from imaging freinds, we tagged a protein of interest with "tagRFP", which we now know from its protein sequence and digging is a derivative of
eqFP578 from Entacmaea quadricolor. We want an antibody to it but 1/n
eqFP578 from Entacmaea quadricolor. We want an antibody to it but 1/n
Reposted by Michael Kearse
This preprint was accepted @rnajournal.bsky.social! It is now online ahead of print! @cancer-inst-purdue.bsky.social @purduernaclub.bsky.social rnajournal.cshlp.org/content/earl...
September 18, 2025 at 3:04 PM
This preprint was accepted @rnajournal.bsky.social! It is now online ahead of print! @cancer-inst-purdue.bsky.social @purduernaclub.bsky.social rnajournal.cshlp.org/content/earl...
Reposted by Michael Kearse
I’m excited to share that I’ve started a new chapter as Assistant Professor & Clinical Microbiology Section Director at @dukemedschool.bsky.social 🏥🔬.
This is a dream opportunity, and I’m so grateful 🙏. Looking forward to growing, learning, and advancing clinical microbiology & patient care 🚀💙.
This is a dream opportunity, and I’m so grateful 🙏. Looking forward to growing, learning, and advancing clinical microbiology & patient care 🚀💙.
August 31, 2025 at 3:22 PM
I’m excited to share that I’ve started a new chapter as Assistant Professor & Clinical Microbiology Section Director at @dukemedschool.bsky.social 🏥🔬.
This is a dream opportunity, and I’m so grateful 🙏. Looking forward to growing, learning, and advancing clinical microbiology & patient care 🚀💙.
This is a dream opportunity, and I’m so grateful 🙏. Looking forward to growing, learning, and advancing clinical microbiology & patient care 🚀💙.
Reposted by Michael Kearse
My MCDB dept is accepting applications for a faculty position at the Assistant Professor level!
Applications Due by October 15, 2025
We welcome applications from all areas of physiology and neuroscience, spanning molecular, cellular, systems, and organismal levels.
lsa.umich.edu/mcdb/news-ev...
Applications Due by October 15, 2025
We welcome applications from all areas of physiology and neuroscience, spanning molecular, cellular, systems, and organismal levels.
lsa.umich.edu/mcdb/news-ev...
MCDB Opens Search for Faculty | U-M LSA Molecular, Cellular, and Developmental Biology (MCDB)
MCDB welcomes applications at the Assistant Professor level from outstanding biological scientists in all areas of physiology and neuroscience, spanning molecular, cellular, systems, and organismal le...
lsa.umich.edu
August 26, 2025 at 1:29 PM
My MCDB dept is accepting applications for a faculty position at the Assistant Professor level!
Applications Due by October 15, 2025
We welcome applications from all areas of physiology and neuroscience, spanning molecular, cellular, systems, and organismal levels.
lsa.umich.edu/mcdb/news-ev...
Applications Due by October 15, 2025
We welcome applications from all areas of physiology and neuroscience, spanning molecular, cellular, systems, and organismal levels.
lsa.umich.edu/mcdb/news-ev...
Reposted by Michael Kearse
I am delighted to share that I have started my lab in the Dept. of Biochemistry @uofubiochem.bsky.social at the University of Utah @utah.edu. My laboratory will study key aspects of protein synthesis and translational control in healthy and diseased states. #RNAsky sinha.biochem.utah.edu
The Sinha Lab
The Sinha lab studies key aspects of protein synthesis and translational control in healthy and diseased states. We study the multifaceted roles of ribosomes as critical sensors of cellular stress.
sinha.biochem.utah.edu
August 21, 2025 at 7:09 PM
I am delighted to share that I have started my lab in the Dept. of Biochemistry @uofubiochem.bsky.social at the University of Utah @utah.edu. My laboratory will study key aspects of protein synthesis and translational control in healthy and diseased states. #RNAsky sinha.biochem.utah.edu
Reposted by Michael Kearse
Excited to announce that I’ll be the Director of the Huck Institutes of the Life Sciences Genomics Core Facility starting mid September 🧬🧪🧫
www.psu.edu/news/huck-in...
www.psu.edu/news/huck-in...
New director appointed at Huck Institutes Genomics Core | Penn State University
Research Professor Cheryl Keller has been named the new director of the Genomics Core Facility in the Huck Institutes of the Life Sciences.
www.psu.edu
August 22, 2025 at 9:09 PM
Excited to announce that I’ll be the Director of the Huck Institutes of the Life Sciences Genomics Core Facility starting mid September 🧬🧪🧫
www.psu.edu/news/huck-in...
www.psu.edu/news/huck-in...
Summer lab party with building and lab neighbors and friends from across campus. Lots to celebrate!
July 27, 2025 at 2:10 AM
Summer lab party with building and lab neighbors and friends from across campus. Lots to celebrate!
Reposted by Michael Kearse
We have an Open Rank tenure-track faculty position in the Department of Nutrition & Integrative Physiology! Looking for a new colleague interested in making the University of Utah their new home to build a metabolic research program. Please share! @uofunuip.bsky.social
Open Rank, Tenure Track Position – Metabolic Physiology - Salt Lake City, Utah job with University of Utah | 674355
The Department of Nutrition and Integrated Physiology (NUIP) at the University of Utah seeks a Tenure Track faculty member at the rank of Assistant...
jobs.sciencecareers.org
July 21, 2025 at 7:25 PM
We have an Open Rank tenure-track faculty position in the Department of Nutrition & Integrative Physiology! Looking for a new colleague interested in making the University of Utah their new home to build a metabolic research program. Please share! @uofunuip.bsky.social