Kyle Cottrell
@kylecottrell.bsky.social
Father | Assistant Professor @PurdueBiochem (RNA editing and regulation) | Postdoc & PhD @WUSTL | MS & BS @MissouriState | #firstgen #NewPI #NIHMOSAIC K99/R00 (posts and comments are my own and do not reflect my employer)
We start the module on nerve gasses in my course today - queue Nick Cage!
a man is kneeling down with his arms outstretched in front of a body of water with a bridge in the background
ALT: a man is kneeling down with his arms outstretched in front of a body of water with a bridge in the background
media.tenor.com
October 28, 2025 at 12:46 PM
We start the module on nerve gasses in my course today - queue Nick Cage!
Well, I'm going to find out, eventually.
Will CSR receipt and referral respect study section service for delayed NIH grant submission when those study sections didn’t meet? Stay tuned…
October 17, 2025 at 4:13 PM
Well, I'm going to find out, eventually.
Reposted by Kyle Cottrell
RNA Club returns on Friday with Iman Mevaa from the @kasinskilab.bsky.social presenting a talk titled Targeted Delivery of Tumor-Suppressive miR-34a for Osteosarcoma Treatment.
We will meet in ABE B061 at 3:30 on October 10.
We will meet in ABE B061 at 3:30 on October 10.
October 6, 2025 at 8:06 PM
RNA Club returns on Friday with Iman Mevaa from the @kasinskilab.bsky.social presenting a talk titled Targeted Delivery of Tumor-Suppressive miR-34a for Osteosarcoma Treatment.
We will meet in ABE B061 at 3:30 on October 10.
We will meet in ABE B061 at 3:30 on October 10.
My first trip out of the Purdue Airport went... well, it didn't. I ended up on the shuttle to ORD anyway. It could be great to fly out of LAF, but there probably needs to be more volume to make it reliable.
October 5, 2025 at 3:05 PM
My first trip out of the Purdue Airport went... well, it didn't. I ended up on the shuttle to ORD anyway. It could be great to fly out of LAF, but there probably needs to be more volume to make it reliable.
Important aster update!
September 26, 2025 at 3:21 AM
Important aster update!
How are we supposed to advise undergraduates interested in applying to graduate school soon? They are scared that their options will be limited. They don't know if it is better to rush to get in or wait until things maybe get better. They don't have as many options for post-bacc programs. It's rough
September 24, 2025 at 4:30 PM
How are we supposed to advise undergraduates interested in applying to graduate school soon? They are scared that their options will be limited. They don't know if it is better to rush to get in or wait until things maybe get better. They don't have as many options for post-bacc programs. It's rough
This preprint was accepted @rnajournal.bsky.social! It is now online ahead of print! @cancer-inst-purdue.bsky.social @purduernaclub.bsky.social rnajournal.cshlp.org/content/earl...
September 18, 2025 at 3:04 PM
This preprint was accepted @rnajournal.bsky.social! It is now online ahead of print! @cancer-inst-purdue.bsky.social @purduernaclub.bsky.social rnajournal.cshlp.org/content/earl...
Patience was rewarded. Wonderfully set and no soggy bottom.
September 8, 2025 at 3:30 PM
Patience was rewarded. Wonderfully set and no soggy bottom.
What to do while you wait for the apple pie to cool? Eat the mini pie you made with the extra pastry, of course. This hack brought to you by my grandma.
September 6, 2025 at 11:46 PM
What to do while you wait for the apple pie to cool? Eat the mini pie you made with the extra pastry, of course. This hack brought to you by my grandma.
The fall bloomers are starting to make an appearance! Skip the mums, plant asters!
August 29, 2025 at 12:13 AM
The fall bloomers are starting to make an appearance! Skip the mums, plant asters!
Reposted by Kyle Cottrell
Welcome to the bsky account for the Purdue RNA Club! Our meeting dates for Fall 2025 are September 12, October 10, November 14, and December 5.
August 26, 2025 at 5:36 PM
Welcome to the bsky account for the Purdue RNA Club! Our meeting dates for Fall 2025 are September 12, October 10, November 14, and December 5.
Anyone in the West Lafayette area have an explanation for why they closed the right lane of River Road here? It's closed for maybe 200 ft. I think that they did this either to intentionally make traffic worse or to further aggravate the businesses that didn't sell their land.
August 25, 2025 at 1:22 AM
Anyone in the West Lafayette area have an explanation for why they closed the right lane of River Road here? It's closed for maybe 200 ft. I think that they did this either to intentionally make traffic worse or to further aggravate the businesses that didn't sell their land.
I might need to dial back the jalapeños for the next batch. 🔥🔥
August 18, 2025 at 12:57 AM
I might need to dial back the jalapeños for the next batch. 🔥🔥
Our tomatillos finally started producing!
August 17, 2025 at 6:18 PM
Our tomatillos finally started producing!
This manuscript was accepted @rnajournal.bsky.social and is online ahead of publication now! Congratulations to first author Addison Young and all the co-authors (for several this is their first publication). @cancer-inst-purdue.bsky.social 1/2 rnajournal.cshlp.org/content/earl...
August 14, 2025 at 2:33 PM
This manuscript was accepted @rnajournal.bsky.social and is online ahead of publication now! Congratulations to first author Addison Young and all the co-authors (for several this is their first publication). @cancer-inst-purdue.bsky.social 1/2 rnajournal.cshlp.org/content/earl...
Here is the post thread I promised: We have been interested in ADAR1 as a therapeutic target for triple-negative breast cancer for a while. That project was supported by the NIH before Trump terminated it, but that is another story. While ADAR1 is a promising target - there aren't any inhibitors 1/n
Our second preprint is out today! Post thread to come later.
ZYS-1 is not an ADAR1 inhibitor https://www.biorxiv.org/content/10.1101/2025.08.08.669362v1
August 13, 2025 at 4:35 PM
Here is the post thread I promised: We have been interested in ADAR1 as a therapeutic target for triple-negative breast cancer for a while. That project was supported by the NIH before Trump terminated it, but that is another story. While ADAR1 is a promising target - there aren't any inhibitors 1/n
Our second preprint is out today! Post thread to come later.
ZYS-1 is not an ADAR1 inhibitor https://www.biorxiv.org/content/10.1101/2025.08.08.669362v1
August 9, 2025 at 11:23 AM
Our second preprint is out today! Post thread to come later.
So, when this gets packaged into an exosome, is it a virus? I'm only being a little sarcastic.
A promising new approach for self-amplifying RNA that avoids triggering strong inflammatory responses in cells, paving the way for safer, longer-lasting gene therapies without immune suppression.
buff.ly/xQWCPhJ
buff.ly/xQWCPhJ
August 2, 2025 at 10:47 PM
So, when this gets packaged into an exosome, is it a virus? I'm only being a little sarcastic.
A moment of beauty in the garden provides a brief distraction from the slow death of science in this country.
July 25, 2025 at 9:22 PM
A moment of beauty in the garden provides a brief distraction from the slow death of science in this country.
I wonder if tenure committees and university administration will consider this when making tenure/promotion decisions?
Funding policy for 2025 from NCI. Was just released: 4 percentile…maybe!
www.cancer.gov/grants-train...
www.cancer.gov/grants-train...
Funding Policy - Research Grants
NCI funding policy for research project grant (RPG) awards reflects the funding goals of the institute, NIH, and HHS.
www.cancer.gov
July 23, 2025 at 10:31 PM
I wonder if tenure committees and university administration will consider this when making tenure/promotion decisions?
This is terrible, and unfortunately, based on my experience sharing this information with others, many in academia (especially more senior faculty) aren't even aware of this change.
The NIH ‘s new forward funding approach is an accounting trick designed to artificially reduce the budget by committing next year’s funds to this year’s budget without making the funds available. It’s an excuse to fund fewer grants. Bureaucratic authoritarianism to nullify congressional intent.
July 18, 2025 at 11:18 AM
This is terrible, and unfortunately, based on my experience sharing this information with others, many in academia (especially more senior faculty) aren't even aware of this change.
I treated the lab to a trip to the San Diego Zoo to celebrate our first preprint and for the members attending their first conference, surviving #RNA25. While the zoo is famous for the pandas, the koalas were my favorite!
June 1, 2025 at 11:32 PM
I treated the lab to a trip to the San Diego Zoo to celebrate our first preprint and for the members attending their first conference, surviving #RNA25. While the zoo is famous for the pandas, the koalas were my favorite!
This evening, the newest Cottrell Lab graduate student, Cassandra Smoak, will be presenting poster 402. Over the last few months she has been evaluating a recently published ADAR1 inhibitor - ZYS-1. I'll let her tell you if it is a good inhibitor or not... #RNA25
May 30, 2025 at 7:23 PM
This evening, the newest Cottrell Lab graduate student, Cassandra Smoak, will be presenting poster 402. Over the last few months she has been evaluating a recently published ADAR1 inhibitor - ZYS-1. I'll let her tell you if it is a good inhibitor or not... #RNA25
Purdue Biochemistry and @cancer-inst-purdue.bsky.social at #RNA25
May 29, 2025 at 10:07 PM
Purdue Biochemistry and @cancer-inst-purdue.bsky.social at #RNA25
Just in time for #RNA25, the Cottrell Lab has posted our first independent preprint to bioRxiv. This is the first first-author publication from graduate student Addison Young and the first publication for the four undergraduate co-authors.
www.biorxiv.org/content/10.1... 1/n
www.biorxiv.org/content/10.1... 1/n
PACT suppresses PKR activation through dsRNA binding and dimerization, and is a therapeutic target for triple-negative breast cancer
Triple-negative breast cancer (TNBC), the deadliest breast cancer subtype, lacks broadly applicable targeted therapies. Induction of viral mimicry by activation of viral double-stranded RNA (dsRNA) se...
www.biorxiv.org
May 29, 2025 at 5:14 PM
Just in time for #RNA25, the Cottrell Lab has posted our first independent preprint to bioRxiv. This is the first first-author publication from graduate student Addison Young and the first publication for the four undergraduate co-authors.
www.biorxiv.org/content/10.1... 1/n
www.biorxiv.org/content/10.1... 1/n