Michael Silverman
@michael-silverman.bsky.social
passionate about discovering ways to leverage early life microbiome/ immune development to prevent autoimmune disease, pediatric infectious disease physician and immunologist.
Reposted by Michael Silverman
I'm happy to share a perspective that
@soniamodilevsky.bsky.social
and I wrote about a new and exciting paper in @science.org
with big implications for IBD.
Check it out:
A bacterial toxin disarms gut defenses against inflammation | Science
www.science.org/doi/10.1126/...
@soniamodilevsky.bsky.social
and I wrote about a new and exciting paper in @science.org
with big implications for IBD.
Check it out:
A bacterial toxin disarms gut defenses against inflammation | Science
www.science.org/doi/10.1126/...
A bacterial toxin disarms gut defenses against inflammation
Macrophage-toxic bacteria from patients with ulcerative colitis worsen gut inflammation in mice
www.science.org
November 20, 2025 at 8:28 PM
I'm happy to share a perspective that
@soniamodilevsky.bsky.social
and I wrote about a new and exciting paper in @science.org
with big implications for IBD.
Check it out:
A bacterial toxin disarms gut defenses against inflammation | Science
www.science.org/doi/10.1126/...
@soniamodilevsky.bsky.social
and I wrote about a new and exciting paper in @science.org
with big implications for IBD.
Check it out:
A bacterial toxin disarms gut defenses against inflammation | Science
www.science.org/doi/10.1126/...
Reposted by Michael Silverman
Registration is now open for @keystonesymposia.bsky.social "Beyond #Antibiotics: Emerging Strategies Combating #BacterialInfection." Deadline for scholarships and abstract selected short talks is Jan 7! Join us this May for an amazing meeting! keysym.us/KSBeyondAntibiotics26 #KSBeyondAntibiotics26
Beyond Antibiotics: Emerging Strategies for Combating Bacterial Infection | Keystone Symposia
Join us at the Keystone Symposia on Beyond Antibiotics: Emerging Strategies for Combating Bacterial Infection, May 2026, in Breckenridge, with field leaders!
keysym.us
November 19, 2025 at 5:37 PM
Registration is now open for @keystonesymposia.bsky.social "Beyond #Antibiotics: Emerging Strategies Combating #BacterialInfection." Deadline for scholarships and abstract selected short talks is Jan 7! Join us this May for an amazing meeting! keysym.us/KSBeyondAntibiotics26 #KSBeyondAntibiotics26
Reposted by Michael Silverman
Another banger from the @harriswang.bsky.social Lab this month!
“Fecal exfoliome sequencing captures immune dynamics of the healthy and inflamed gut” www.nature.com/articles/s41...
“Fecal exfoliome sequencing captures immune dynamics of the healthy and inflamed gut” www.nature.com/articles/s41...
Fecal exfoliome sequencing captures immune dynamics of the healthy and inflamed gut - Nature Biotechnology
Profiling host RNA shed in feces reveals disease states in the gut.
www.nature.com
November 18, 2025 at 12:59 AM
Another banger from the @harriswang.bsky.social Lab this month!
“Fecal exfoliome sequencing captures immune dynamics of the healthy and inflamed gut” www.nature.com/articles/s41...
“Fecal exfoliome sequencing captures immune dynamics of the healthy and inflamed gut” www.nature.com/articles/s41...
Reposted by Michael Silverman
Very excited to share our latest work in Science on metagenomic editing (MetaEdit) of the gut microbiome in vivo & directly modifying unculturable immune-modulatory SFB bug in the small intestine. 🦠🧬🛠️
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Metagenomic editing of commensal bacteria in vivo using CRISPR-associated transposases
Although metagenomic sequencing has revealed a rich microbial biodiversity in the mammalian gut, methods to genetically alter specific species in the microbiome are highly limited. Here, we introduce ...
www.science.org
November 13, 2025 at 8:53 PM
Very excited to share our latest work in Science on metagenomic editing (MetaEdit) of the gut microbiome in vivo & directly modifying unculturable immune-modulatory SFB bug in the small intestine. 🦠🧬🛠️
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Michael Silverman
Nov issue of #Science #Immunology out now!
This week: exTH17 cells sustain #IL17 –independent rheumatoid #arthritis; CXCR4+ mesodermal progenitors → rostral blood vessels, prodefinitive hematopoiesis, & postnatal tissue #macrophages; & how #Bcells acquire antigens from #parasites!
scim.ag/4qQA6Q6
This week: exTH17 cells sustain #IL17 –independent rheumatoid #arthritis; CXCR4+ mesodermal progenitors → rostral blood vessels, prodefinitive hematopoiesis, & postnatal tissue #macrophages; & how #Bcells acquire antigens from #parasites!
scim.ag/4qQA6Q6
November 7, 2025 at 10:19 PM
Nov issue of #Science #Immunology out now!
This week: exTH17 cells sustain #IL17 –independent rheumatoid #arthritis; CXCR4+ mesodermal progenitors → rostral blood vessels, prodefinitive hematopoiesis, & postnatal tissue #macrophages; & how #Bcells acquire antigens from #parasites!
scim.ag/4qQA6Q6
This week: exTH17 cells sustain #IL17 –independent rheumatoid #arthritis; CXCR4+ mesodermal progenitors → rostral blood vessels, prodefinitive hematopoiesis, & postnatal tissue #macrophages; & how #Bcells acquire antigens from #parasites!
scim.ag/4qQA6Q6
Reposted by Michael Silverman
A great conversation - thank you for the opportunity!
#breastfeeding #humanmilk #breastmilk #microbiome
🧪 🤱🏻
#breastfeeding #humanmilk #breastmilk #microbiome
🧪 🤱🏻
GenoWrite is back with a new interview! This time, we spoke with @meghanazad.bsky.social, Professor of Pediatrics and Child Health at @umanitoba.bsky.social about breast milk in infants. You'll read about the microbiome, asthma, and helpful advice about breastfeeding.
genowrite.com/breast-milk-...
genowrite.com/breast-milk-...
Breast milk: a mother's amazing gift to her child - GenoWrite
Learn how breast milk is the best gift a mother can give to her baby from birth, from optimal immune regulation to nutritional benefits.
genowrite.com
November 6, 2025 at 11:30 PM
A great conversation - thank you for the opportunity!
#breastfeeding #humanmilk #breastmilk #microbiome
🧪 🤱🏻
#breastfeeding #humanmilk #breastmilk #microbiome
🧪 🤱🏻
Reposted by Michael Silverman
@biorxiv-immuno.bsky.social Identification of distinct cDC2 subpopulations that direct microbiota-specific T cell differentiation
www.biorxiv.org/content/10.1...
@ucberkeleyofficial.bsky.social
www.biorxiv.org/content/10.1...
@ucberkeleyofficial.bsky.social
November 6, 2025 at 2:42 AM
@biorxiv-immuno.bsky.social Identification of distinct cDC2 subpopulations that direct microbiota-specific T cell differentiation
www.biorxiv.org/content/10.1...
@ucberkeleyofficial.bsky.social
www.biorxiv.org/content/10.1...
@ucberkeleyofficial.bsky.social
Reposted by Michael Silverman
Reposted by Michael Silverman
Esther Obeng leads a research group focused on myelodysplastic syndromes (MDS) @emoryuniversity.bsky.social
@jem.org spoke with Esther about her career, how her patients inform her research, and more
#WomenInSTEM
rupress.org/jem/article/...
@jem.org spoke with Esther about her career, how her patients inform her research, and more
#WomenInSTEM
rupress.org/jem/article/...
November 6, 2025 at 1:47 AM
Esther Obeng leads a research group focused on myelodysplastic syndromes (MDS) @emoryuniversity.bsky.social
@jem.org spoke with Esther about her career, how her patients inform her research, and more
#WomenInSTEM
rupress.org/jem/article/...
@jem.org spoke with Esther about her career, how her patients inform her research, and more
#WomenInSTEM
rupress.org/jem/article/...
Reposted by Michael Silverman
BREAKING: Pennsylvania voters approve to retain three state Supreme Court justices, NBC News projects, preserving Democrats’ 5-2 majority on the state’s high court.
Pennsylvania voters retain three state Supreme Court justices, preserving Democrats' 5-2 majority
NBC News projects the incumbents survived an up-or-down vote to keep their seats on the battleground state’s high court.
nbcnews.to
November 5, 2025 at 1:42 AM
BREAKING: Pennsylvania voters approve to retain three state Supreme Court justices, NBC News projects, preserving Democrats’ 5-2 majority on the state’s high court.
Reposted by Michael Silverman
Scripps Research Prof. Luc Teyton has received a $3.2M grant from the NIDDK to study how VAFs—rare pancreatic cells involved in antigen presentation—may contribute to type 1 diabetes. In collaboration with Asst. Prof. Joseph Jardine, the team will examine how inflammation disrupts immune tolerance.
Scripps Research professor awarded $3.2 million to advance type 1 diabetes research
ow.ly
October 30, 2025 at 5:09 PM
Scripps Research Prof. Luc Teyton has received a $3.2M grant from the NIDDK to study how VAFs—rare pancreatic cells involved in antigen presentation—may contribute to type 1 diabetes. In collaboration with Asst. Prof. Joseph Jardine, the team will examine how inflammation disrupts immune tolerance.
Reposted by Michael Silverman
Great primer from #NobelPrize winner Dr. Mary Brunkow on @npr.org's Here & Now: how FOXP3 and T regs help keep the immune system from harming the body. (~6 min) @wbur.org
🎧 www.wbur.org/hereandnow/2...
🎧 www.wbur.org/hereandnow/2...
Nobel Prize winner Mary Brunkow on immune system research
Mary Brunkow was awarded the 2025 Nobel Prize in Physiology or Medicine, along with Fred Ramsdell and Shimon Sakaguchi, for their "groundbreaking discoveries concerning peripheral immune tolerance tha...
www.wbur.org
October 15, 2025 at 8:39 PM
Great primer from #NobelPrize winner Dr. Mary Brunkow on @npr.org's Here & Now: how FOXP3 and T regs help keep the immune system from harming the body. (~6 min) @wbur.org
🎧 www.wbur.org/hereandnow/2...
🎧 www.wbur.org/hereandnow/2...
Reposted by Michael Silverman
Immunization against respiratory syncytial virus delivered to infants following birth is safe and provides high antibody levels, regardless of the mother’s RSV vaccination status, according to new research presented at #IDWeek2025. bit.ly/3J9fIbS
RSV Immunization in Infants Is Safe and Provides High Antibody Levels Regardless of Mother’s Vaccination Status
bit.ly
October 20, 2025 at 5:45 PM
Immunization against respiratory syncytial virus delivered to infants following birth is safe and provides high antibody levels, regardless of the mother’s RSV vaccination status, according to new research presented at #IDWeek2025. bit.ly/3J9fIbS
Reposted by Michael Silverman
All Democrats want is to lower health care costs for Americans. Republicans in Congress won’t even come to the table.
How out of touch are they that they can't see we are in a health care crisis?
How out of touch are they that they can't see we are in a health care crisis?
October 20, 2025 at 6:14 PM
All Democrats want is to lower health care costs for Americans. Republicans in Congress won’t even come to the table.
How out of touch are they that they can't see we are in a health care crisis?
How out of touch are they that they can't see we are in a health care crisis?
Reposted by Michael Silverman
Looks interesting 👀: Distinguishing diet- and microbe-derived metabolites in the human gut microbiomejournal.biomedcentral.com/articles/10....
Distinguishing diet- and microbe-derived metabolites in the human gut - Microbiome
Background Human gut microbes metabolize food and host secretions, consuming and producing small molecules that are important to health and homeostasis. Here, we present an atlas of diet- and microbio...
microbiomejournal.biomedcentral.com
October 18, 2025 at 7:07 PM
Looks interesting 👀: Distinguishing diet- and microbe-derived metabolites in the human gut microbiomejournal.biomedcentral.com/articles/10....
Reposted by Michael Silverman
Reposted by Michael Silverman
Thrilled to share my promotion to Associate Professor with tenure at @pitt-immunology.bsky.social! Huge thanks to my incredible lab, collaborators, department, colleagues, family & friends. Science is a team effort, and I'm so proud of our work & excited for what's next! Stay tuned!
Congratulations to Dr. Amanda Poholek @poholeklab.bsky.social for her promotion to Associate Professor with tenure! Learn more about Dr. Poholek and her research: buff.ly/q14wey8
October 6, 2025 at 3:34 PM
Thrilled to share my promotion to Associate Professor with tenure at @pitt-immunology.bsky.social! Huge thanks to my incredible lab, collaborators, department, colleagues, family & friends. Science is a team effort, and I'm so proud of our work & excited for what's next! Stay tuned!
Reposted by Michael Silverman
Huge congratulations not only to the team leaders, but all the students, technicians and expert scientists who did the work that underpins this discovery. Their work, and the work of those following in their footsteps, is changing the future for autoimmune, transplant and oncology patients!
October 6, 2025 at 11:21 AM
Huge congratulations not only to the team leaders, but all the students, technicians and expert scientists who did the work that underpins this discovery. Their work, and the work of those following in their footsteps, is changing the future for autoimmune, transplant and oncology patients!
Reposted by Michael Silverman
Congrats, @immunojake.bsky.social & Erica Culberson DeshmukhLab @cincyresearch.bsky.social
Antibiotic-induced microbiome disruption impairs infant antiviral immunity by reducing inosine levels to disturb CD8 T programming
www.cell.com/cell/abstrac...
@cellcellpress.bsky.social
Antibiotic-induced microbiome disruption impairs infant antiviral immunity by reducing inosine levels to disturb CD8 T programming
www.cell.com/cell/abstrac...
@cellcellpress.bsky.social
Microbiota-derived inosine programs protective CD8+ T cell responses against influenza in newborns
Stevens et al. reveal that antibiotic-induced microbiome disruption impairs infant
antiviral immunity by reducing inosine levels, which disturbs CD8+ T cell programming.
Remarkably, Bifidobacterium co...
www.cell.com
June 11, 2025 at 12:35 AM
Congrats, @immunojake.bsky.social & Erica Culberson DeshmukhLab @cincyresearch.bsky.social
Antibiotic-induced microbiome disruption impairs infant antiviral immunity by reducing inosine levels to disturb CD8 T programming
www.cell.com/cell/abstrac...
@cellcellpress.bsky.social
Antibiotic-induced microbiome disruption impairs infant antiviral immunity by reducing inosine levels to disturb CD8 T programming
www.cell.com/cell/abstrac...
@cellcellpress.bsky.social
Reposted by Michael Silverman
New commentary co-authored w/ collaborators Liat Shenhav & Mike Silverman 🧪🤱🏻
We are intrigued by weaning:
- How does it affect the infant #microbiome? Immune development?
- Is it the stopping of milk, or the starting of other foods that drives these processes?
www.sciencedirect.com/science/arti...
We are intrigued by weaning:
- How does it affect the infant #microbiome? Immune development?
- Is it the stopping of milk, or the starting of other foods that drives these processes?
www.sciencedirect.com/science/arti...
June 13, 2025 at 12:41 AM
New commentary co-authored w/ collaborators Liat Shenhav & Mike Silverman 🧪🤱🏻
We are intrigued by weaning:
- How does it affect the infant #microbiome? Immune development?
- Is it the stopping of milk, or the starting of other foods that drives these processes?
www.sciencedirect.com/science/arti...
We are intrigued by weaning:
- How does it affect the infant #microbiome? Immune development?
- Is it the stopping of milk, or the starting of other foods that drives these processes?
www.sciencedirect.com/science/arti...
Reposted by Michael Silverman
Interaction between breast milk antibodies and gut microbes shape immune responses during weaning @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
August 15, 2025 at 3:14 AM
Interaction between breast milk antibodies and gut microbes shape immune responses during weaning @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Michael Silverman
Congratulations!!!! Well deserved!
Tregs rock!
Tregs rock!
October 6, 2025 at 10:11 AM
Congratulations!!!! Well deserved!
Tregs rock!
Tregs rock!