Michele Acconcia
mich-acconcia.bsky.social
Michele Acconcia
@mich-acconcia.bsky.social
PhD student in the @gozziale.bsky.social Functional Neuroimaging Lab
Reposted by Michele Acconcia
How distributed is the brain-wide network that is recruited for cognition? A Perspective by Matthew C. Rosen & David J. Freedman

#neuroscience #neuroskyence

www.nature.com/articles/s41...
How distributed is the brain-wide network that is recruited for cognition? - Nature Reviews Neuroscience
Both localized and distributed views on the functional organization of the brain have been put forward. In this Perspective, Rosen and Freedman examine the degree to which these two views account for ...
www.nature.com
December 4, 2025 at 9:30 AM
Reposted by Michele Acconcia
I wrote a book: "The brain, in theory".
First chapter and TOC:

romainbrette.fr/WordPress3/w...
romainbrette.fr
December 18, 2024 at 6:50 AM
Reposted by Michele Acconcia
very nice talk by Joe McCaffrey on functional localization— it’s an easy listen with tons of great information about the debate.

m.youtube.com/watch?v=eRmD...
Lunchtime Talk - Joe McCaffrey 11/7/25
YouTube video by Center for Philosophy of Science
m.youtube.com
November 9, 2025 at 9:54 PM
Reposted by Michele Acconcia
🚨 New paper alert! 🚨(1/6)

Excited to share our work, out now in Science Advances

We show that a rapid norepinephrine surge along a brainstem pathway (LC→PRN) is a key driver of sound-evoked awakenings
www.science.org/doi/10.1126/...
An early surge of norepinephrine along brainstem pathways drives sensory-evoked awakening
The locus coeruleus has a specialized pathway to the brainstem that controls sound-evoked awakening from sleep.
www.science.org
September 10, 2025 at 6:30 PM
Reposted by Michele Acconcia
Working link to the preprint 👇
www.biorxiv.org/content/10.1...
See thread below for a looong explainer
🚨 Excited to share the latest preprint form the lab ➡️https://tinyurl.com/32d3be9f

Here we tackle a long-standing chicken-or-egg 🐣🥚question in #autism and developmental neuroscience

➡️ Is excitation–inhibition (E:I) imbalance a "cause" or a "consequence" of #autism?

Check out what we found!
🧵1/n
September 10, 2025 at 5:48 PM
Reposted by Michele Acconcia
Too often, I see people talk about a replication as if the first study has established something, and the replication study is a double-check. What people often fail to understand is that we do not do replication studies to *check* a finding, but to *establish* a finding. 1/x
August 17, 2025 at 6:36 AM
Reposted by Michele Acconcia
Thinking about writing a pop science book about the brain (“Your Brain on Everything”) where the big reveal is that all the brain names were randomized and I was actually talking about psychology the whole time.
July 13, 2025 at 8:21 PM
Reposted by Michele Acconcia
Our new paper is out in Science.

We identified a subgroup of cholinergic neurons that mediate sensory modality-specific attention. They change their funcitonal properties within secs of behavioral context change.

Congrats to Bin for the great thesis, and the team!

www.science.org/doi/10.1126/...
Cholinergic feedback for modality- and context-specific modulation of sensory representations
The brain’s ability to prioritize sensory information is crucial for adaptive behavior, yet its mechanisms remain unclear. We investigated basal forebrain cholinergic neurons modulating olfactory bulb...
www.science.org
June 20, 2025 at 3:32 PM
Reposted by Michele Acconcia
Advances in neuroscience have yielded massive, rich datasets from various analysis techniques and modalities. 🧠📈

In a @natureneuro.bsky.social perspective, researchers underscore the importance of an integrative approach to render a more complete picture of the brain.
Integrating multimodal data to understand cortical circuit architecture and function - Nature Neuroscience
This paper discusses how experimental and computational studies integrating multimodal data, such as RNA expression, connectivity and neural activity, are advancing our understanding of the architectu...
www.nature.com
March 25, 2025 at 6:59 PM
Reposted by Michele Acconcia
Beyond Mechanism—Extending Our Concepts of Causation in Neuroscience onlinelibrary.wiley.com/doi/10.1111/... - really pleased that this paper with Henry Potter is now published in the European Journal of Neuroscience 😊
Beyond Mechanism—Extending Our Concepts of Causation in Neuroscience
The search for neural mechanisms of behaviour often relies on a synchronic, driving view of causation, where neural activity drives more neural activity, which eventually drives behaviour. The real c...
onlinelibrary.wiley.com
March 14, 2025 at 10:25 AM