Yuval Nir
@labnir.bsky.social
A hippocampal ‘sharp-wave sleep’ state that is dissociable from cortical sleep
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A hippocampal ‘sharp-wave sleep’ state that is dissociable from cortical sleep - Nature Neuroscience
Through continuous multiday recordings in rats, the authors reveal that hippocampal sharp waves reflect sleep need and define a homeostatically regulated sleep state that enables the hippocampus to di...
www.nature.com
December 14, 2025 at 9:07 PM
A hippocampal ‘sharp-wave sleep’ state that is dissociable from cortical sleep
www.nature.com/articles/s41...
www.nature.com/articles/s41...
VTA dopaminergic neuronal activity during NREM sleep is modulated by learning and facilitates motor memory consolidation | Science Advances www.science.org/doi/full/10....
VTA dopaminergic neuronal activity during NREM sleep is modulated by learning and facilitates motor memory consolidation
Activity of VTA dopaminergic neurons during NREM sleep facilitates motor memory consolidation and is coordinated with spindles.
www.science.org
December 6, 2025 at 8:11 PM
VTA dopaminergic neuronal activity during NREM sleep is modulated by learning and facilitates motor memory consolidation | Science Advances www.science.org/doi/full/10....
The Mind's Eye: A quest from vision to consciousness - Symposium in honor of Rafi Malach
Incredible lineup assembled celebrating the career of an amazing scientist
Join us on December 14-15 at the Weizmann Institute !
Incredible lineup assembled celebrating the career of an amazing scientist
Join us on December 14-15 at the Weizmann Institute !
November 30, 2025 at 5:51 AM
The Mind's Eye: A quest from vision to consciousness - Symposium in honor of Rafi Malach
Incredible lineup assembled celebrating the career of an amazing scientist
Join us on December 14-15 at the Weizmann Institute !
Incredible lineup assembled celebrating the career of an amazing scientist
Join us on December 14-15 at the Weizmann Institute !
Interesting! Simultaneous stomach-brain electrophysiology reveals dynamic coupling in human sleep:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Simultaneous stomach-brain electrophysiology reveals dynamic coupling in human sleep
Sleep involves continuous communication between the brain and body, yet the dynamics of peripheral signals during human sleep remain poorly understood. Here we tested whether gastric electrophysiology...
www.biorxiv.org
November 18, 2025 at 10:31 AM
Interesting! Simultaneous stomach-brain electrophysiology reveals dynamic coupling in human sleep:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Attentional failures after sleep deprivation are locked to joint neurovascular, pupil and cerebrospinal fluid flow dynamics
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Attentional failures after sleep deprivation are locked to joint neurovascular, pupil and cerebrospinal fluid flow dynamics - Nature Neuroscience
Yang et al. show that moments of failed attention we experience after sleep deprivation reflect brief ‘sleep-like’ episodes in the brain, corresponding to a brain- and body-wide event with altered bra...
www.nature.com
November 2, 2025 at 6:00 AM
Attentional failures after sleep deprivation are locked to joint neurovascular, pupil and cerebrospinal fluid flow dynamics
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Checkout this article I found at PLOS: dx.plos.org/10.1371/jour...
Hemispherotomy leads to persistent sleep-like slow waves in the isolated cortex of awake humans
Hemispherotomy is a neurosurgical procedure for treating refractory epilepsy by disconnecting a significant portion of the cortex. This study shows that the isolated cortex exhibits EEG patterns resem...
dx.plos.org
October 21, 2025 at 7:45 PM
Checkout this article I found at PLOS: dx.plos.org/10.1371/jour...
Head-direction cells as a neural compass in bats navigating outdoors on a remote oceanic island | Science www.science.org/doi/10.1126/...
Head-direction cells as a neural compass in bats navigating outdoors on a remote oceanic island
Animals and humans rely on their navigation skills to survive. However, spatial neurons in the brain’s “navigation circuit” had not previously been studied under real-world conditions. We conducted an...
www.science.org
October 18, 2025 at 7:45 PM
Head-direction cells as a neural compass in bats navigating outdoors on a remote oceanic island | Science www.science.org/doi/10.1126/...
Convergent Control of NREM Sleep and Anesthesia by Prefrontal Layer 5 Extratelencephalic Neurons:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Convergent Control of NREM Sleep and Anesthesia by Prefrontal Layer 5 Extratelencephalic Neurons
The cortical mechanisms that actively suppress consciousness remain poorly understood. Here, we identify a specific subset of prefrontal cortical (PFC) neurons preferentially active under anesthesia w...
www.biorxiv.org
October 18, 2025 at 7:16 AM
Convergent Control of NREM Sleep and Anesthesia by Prefrontal Layer 5 Extratelencephalic Neurons:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Proud and delighted to deliver the keynote presentation at “Sleep Down Under 2025” Adelaide, organized by the Australasian Sleep Association #SleepDownUnder
October 9, 2025 at 4:27 AM
Proud and delighted to deliver the keynote presentation at “Sleep Down Under 2025” Adelaide, organized by the Australasian Sleep Association #SleepDownUnder
Reposted by Yuval Nir
Reposted by Yuval Nir
Excited to share our latest paper - now out in @science.org - we showed how oxytocin modulates maternally-directed behavior in young mice (P15).
September 12, 2025 at 3:21 PM
Excited to share our latest paper - now out in @science.org - we showed how oxytocin modulates maternally-directed behavior in young mice (P15).
🚨 New paper alert! 🚨(1/6)
Excited to share our work, out now in Science Advances
We show that a rapid norepinephrine surge along a brainstem pathway (LC→PRN) is a key driver of sound-evoked awakenings
www.science.org/doi/10.1126/...
Excited to share our work, out now in Science Advances
We show that a rapid norepinephrine surge along a brainstem pathway (LC→PRN) is a key driver of sound-evoked awakenings
www.science.org/doi/10.1126/...
An early surge of norepinephrine along brainstem pathways drives sensory-evoked awakening
The locus coeruleus has a specialized pathway to the brainstem that controls sound-evoked awakening from sleep.
www.science.org
September 10, 2025 at 6:30 PM
🚨 New paper alert! 🚨(1/6)
Excited to share our work, out now in Science Advances
We show that a rapid norepinephrine surge along a brainstem pathway (LC→PRN) is a key driver of sound-evoked awakenings
www.science.org/doi/10.1126/...
Excited to share our work, out now in Science Advances
We show that a rapid norepinephrine surge along a brainstem pathway (LC→PRN) is a key driver of sound-evoked awakenings
www.science.org/doi/10.1126/...
Aperiodic EEG Activity Provides a Linear, Bidirectional, and Spatially Uniform Marker of Subjective and Objective Vigilance in Humans, Both Within and Across States www.biorxiv.org/content/10.1...
Aperiodic EEG Activity Provides a Linear, Bidirectional, and Spatially Uniform Marker of Subjective and Objective Vigilance in Humans, Both Within and Across States
Vigilance is increasingly conceived as a continuum, ranging from full alertness to deep sleep. Despite its fundamental role in cognition, behaviour, and health, reliable physiological markers of vigil...
www.biorxiv.org
September 9, 2025 at 10:16 AM
Aperiodic EEG Activity Provides a Linear, Bidirectional, and Spatially Uniform Marker of Subjective and Objective Vigilance in Humans, Both Within and Across States www.biorxiv.org/content/10.1...
Sleep-like slow waves during wakefulness uncover a malignant form of Parkinson’s disease www.medrxiv.org/content/10.1...
Sleep-like slow waves during wakefulness uncover a malignant form of Parkinson’s disease
Slow waves during sleep are fundamental for neural homeostasis, metabolic regulation, and waste clearance, and are known to be altered in neurodegenerative diseases. Sleep-like slow waves (SLSW) have ...
www.medrxiv.org
September 9, 2025 at 10:16 AM
Sleep-like slow waves during wakefulness uncover a malignant form of Parkinson’s disease www.medrxiv.org/content/10.1...
Rate and noise in human amygdala drive increased exploration in aversive learning:
Congratulations to my colleagues Rony Paz, Ido Strauss, Firas Fahoum for landing this exciting paper in Nature!
rdcu.be/eCJLb
Congratulations to my colleagues Rony Paz, Ido Strauss, Firas Fahoum for landing this exciting paper in Nature!
rdcu.be/eCJLb
Rate and noise in human amygdala drive increased exploration in aversive learning
Nature - Human exploration is driven by two distinct neural mechanisms, a valence-independent rate signal and a valence-dependent global noise signal.
rdcu.be
September 6, 2025 at 9:07 PM
Rate and noise in human amygdala drive increased exploration in aversive learning:
Congratulations to my colleagues Rony Paz, Ido Strauss, Firas Fahoum for landing this exciting paper in Nature!
rdcu.be/eCJLb
Congratulations to my colleagues Rony Paz, Ido Strauss, Firas Fahoum for landing this exciting paper in Nature!
rdcu.be/eCJLb
Human hippocampal ripples align new experiences with a grid-like schema: Neuron www.cell.com/neuron/fullt...
Human hippocampal ripples align new experiences with a grid-like schema
Xiao et al. show that brief bursts of hippocampal activity (ripples) help the brain
link new experiences into an internal “mental map.” During rest, ripples engage a
medial frontal brain region that o...
www.cell.com
August 30, 2025 at 7:54 PM
Human hippocampal ripples align new experiences with a grid-like schema: Neuron www.cell.com/neuron/fullt...
Enhancement of Sleep Slow Wave Activity using Transcranial Electrical Stimulation with Temporal Interference www.medrxiv.org/content/10.1...
Enhancement of Sleep Slow Wave Activity using Transcranial Electrical Stimulation with Temporal Interference
Slow waves mediate restorative functions of non-rapid eye movement (NREM) sleep. To enhance slow wave activity (SWA, 0.5-4 Hz) non-invasively, we employed a novel neuromodulatory tool, Transcranial El...
www.medrxiv.org
August 20, 2025 at 7:11 AM
Enhancement of Sleep Slow Wave Activity using Transcranial Electrical Stimulation with Temporal Interference www.medrxiv.org/content/10.1...
Reposted by Yuval Nir
No one ever steps in the same movie twice. Anticipatory gaze 👁️ indicate episodic memory seconds before an event occurs. 🧠🐾 Very robust effects across both natural and crafted movies, and of course, after sleep! 😴. Out today in Communication Psychology:
www.nature.com/articles/s44...
Check it out!
www.nature.com/articles/s44...
Check it out!
Anticipatory eye gaze as a marker of memory - Communications Psychology
Anticipatory eye movements during repeated movie viewing reveal when and what is remembered. Gaze patterns correlate with explicit reports, offering a method to detect memory for events without verbal...
www.nature.com
August 11, 2025 at 10:11 PM
No one ever steps in the same movie twice. Anticipatory gaze 👁️ indicate episodic memory seconds before an event occurs. 🧠🐾 Very robust effects across both natural and crafted movies, and of course, after sleep! 😴. Out today in Communication Psychology:
www.nature.com/articles/s44...
Check it out!
www.nature.com/articles/s44...
Check it out!
How interesting! Activity patterns in individual neurons drift over time, even in subcortical sleep- and wake-promoting regions -- while populations remain stable. Beautiful work from @Tidis__ @CaroGHerrera:
www.researchsquare.com/article/rs-6...
www.researchsquare.com/article/rs-6...
Temporal drift of sleep-wake representations in hypothalamic neuronal ensembles
Correlative and causal evidence implicate distinct genetically-defined and evolutionary-conserved hypothalamic neurons in regulating wakefulness, non-rapid eye movement (NREM), and rapid eye movement ...
www.researchsquare.com
August 11, 2025 at 6:02 AM
How interesting! Activity patterns in individual neurons drift over time, even in subcortical sleep- and wake-promoting regions -- while populations remain stable. Beautiful work from @Tidis__ @CaroGHerrera:
www.researchsquare.com/article/rs-6...
www.researchsquare.com/article/rs-6...
Closed-loop electrical stimulation prevents focal epilepsy progression and long-term memory impairment:
rdcu.be/ezjNt
rdcu.be/ezjNt
Closed-loop electrical stimulation prevents focal epilepsy progression and long-term memory impairment
Nature Neuroscience - Pathological neural communication drives the spread of the epileptic network and contributes to memory impairment in focal epilepsy. The authors show that closed-loop...
rdcu.be
August 5, 2025 at 7:43 AM
Closed-loop electrical stimulation prevents focal epilepsy progression and long-term memory impairment:
rdcu.be/ezjNt
rdcu.be/ezjNt
Sleep-like Slow Waves During Wakefulness Mediate Attention and Vigilance Difficulties in Adult ADHD
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Sleep-like Slow Waves During Wakefulness Mediate Attention and Vigilance Difficulties in Adult Attention-Deficit/Hyperactivity Disorder
Background Attention-Deficit/Hyperactivity Disorder (ADHD) is characterised by behavioural variability and heightened inattention associated with increased mind wandering (MW) and mind blanking (MB). ...
www.biorxiv.org
August 4, 2025 at 6:24 AM
Sleep-like Slow Waves During Wakefulness Mediate Attention and Vigilance Difficulties in Adult ADHD
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
