Yuval Nir
@labnir.bsky.social
Attentional failures after sleep deprivation are locked to joint neurovascular, pupil and cerebrospinal fluid flow dynamics
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Attentional failures after sleep deprivation are locked to joint neurovascular, pupil and cerebrospinal fluid flow dynamics - Nature Neuroscience
Yang et al. show that moments of failed attention we experience after sleep deprivation reflect brief ‘sleep-like’ episodes in the brain, corresponding to a brain- and body-wide event with altered bra...
www.nature.com
November 2, 2025 at 6:00 AM
Attentional failures after sleep deprivation are locked to joint neurovascular, pupil and cerebrospinal fluid flow dynamics
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Checkout this article I found at PLOS: dx.plos.org/10.1371/jour...
Hemispherotomy leads to persistent sleep-like slow waves in the isolated cortex of awake humans
Hemispherotomy is a neurosurgical procedure for treating refractory epilepsy by disconnecting a significant portion of the cortex. This study shows that the isolated cortex exhibits EEG patterns resem...
dx.plos.org
October 21, 2025 at 7:45 PM
Checkout this article I found at PLOS: dx.plos.org/10.1371/jour...
Head-direction cells as a neural compass in bats navigating outdoors on a remote oceanic island | Science www.science.org/doi/10.1126/...
Head-direction cells as a neural compass in bats navigating outdoors on a remote oceanic island
Animals and humans rely on their navigation skills to survive. However, spatial neurons in the brain’s “navigation circuit” had not previously been studied under real-world conditions. We conducted an...
www.science.org
October 18, 2025 at 7:45 PM
Head-direction cells as a neural compass in bats navigating outdoors on a remote oceanic island | Science www.science.org/doi/10.1126/...
Convergent Control of NREM Sleep and Anesthesia by Prefrontal Layer 5 Extratelencephalic Neurons:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Convergent Control of NREM Sleep and Anesthesia by Prefrontal Layer 5 Extratelencephalic Neurons
The cortical mechanisms that actively suppress consciousness remain poorly understood. Here, we identify a specific subset of prefrontal cortical (PFC) neurons preferentially active under anesthesia w...
www.biorxiv.org
October 18, 2025 at 7:16 AM
Convergent Control of NREM Sleep and Anesthesia by Prefrontal Layer 5 Extratelencephalic Neurons:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Proud and delighted to deliver the keynote presentation at “Sleep Down Under 2025” Adelaide, organized by the Australasian Sleep Association #SleepDownUnder
October 9, 2025 at 4:27 AM
Proud and delighted to deliver the keynote presentation at “Sleep Down Under 2025” Adelaide, organized by the Australasian Sleep Association #SleepDownUnder
Reposted by Yuval Nir
Reposted by Yuval Nir
Excited to share our latest paper - now out in @science.org - we showed how oxytocin modulates maternally-directed behavior in young mice (P15).
September 12, 2025 at 3:21 PM
Excited to share our latest paper - now out in @science.org - we showed how oxytocin modulates maternally-directed behavior in young mice (P15).
🚨 New paper alert! 🚨(1/6)
Excited to share our work, out now in Science Advances
We show that a rapid norepinephrine surge along a brainstem pathway (LC→PRN) is a key driver of sound-evoked awakenings
www.science.org/doi/10.1126/...
Excited to share our work, out now in Science Advances
We show that a rapid norepinephrine surge along a brainstem pathway (LC→PRN) is a key driver of sound-evoked awakenings
www.science.org/doi/10.1126/...
An early surge of norepinephrine along brainstem pathways drives sensory-evoked awakening
The locus coeruleus has a specialized pathway to the brainstem that controls sound-evoked awakening from sleep.
www.science.org
September 10, 2025 at 6:30 PM
🚨 New paper alert! 🚨(1/6)
Excited to share our work, out now in Science Advances
We show that a rapid norepinephrine surge along a brainstem pathway (LC→PRN) is a key driver of sound-evoked awakenings
www.science.org/doi/10.1126/...
Excited to share our work, out now in Science Advances
We show that a rapid norepinephrine surge along a brainstem pathway (LC→PRN) is a key driver of sound-evoked awakenings
www.science.org/doi/10.1126/...
Aperiodic EEG Activity Provides a Linear, Bidirectional, and Spatially Uniform Marker of Subjective and Objective Vigilance in Humans, Both Within and Across States www.biorxiv.org/content/10.1...
Aperiodic EEG Activity Provides a Linear, Bidirectional, and Spatially Uniform Marker of Subjective and Objective Vigilance in Humans, Both Within and Across States
Vigilance is increasingly conceived as a continuum, ranging from full alertness to deep sleep. Despite its fundamental role in cognition, behaviour, and health, reliable physiological markers of vigil...
www.biorxiv.org
September 9, 2025 at 10:16 AM
Aperiodic EEG Activity Provides a Linear, Bidirectional, and Spatially Uniform Marker of Subjective and Objective Vigilance in Humans, Both Within and Across States www.biorxiv.org/content/10.1...
Sleep-like slow waves during wakefulness uncover a malignant form of Parkinson’s disease www.medrxiv.org/content/10.1...
Sleep-like slow waves during wakefulness uncover a malignant form of Parkinson’s disease
Slow waves during sleep are fundamental for neural homeostasis, metabolic regulation, and waste clearance, and are known to be altered in neurodegenerative diseases. Sleep-like slow waves (SLSW) have ...
www.medrxiv.org
September 9, 2025 at 10:16 AM
Sleep-like slow waves during wakefulness uncover a malignant form of Parkinson’s disease www.medrxiv.org/content/10.1...
Rate and noise in human amygdala drive increased exploration in aversive learning:
Congratulations to my colleagues Rony Paz, Ido Strauss, Firas Fahoum for landing this exciting paper in Nature!
rdcu.be/eCJLb
Congratulations to my colleagues Rony Paz, Ido Strauss, Firas Fahoum for landing this exciting paper in Nature!
rdcu.be/eCJLb
Rate and noise in human amygdala drive increased exploration in aversive learning
Nature - Human exploration is driven by two distinct neural mechanisms, a valence-independent rate signal and a valence-dependent global noise signal.
rdcu.be
September 6, 2025 at 9:07 PM
Rate and noise in human amygdala drive increased exploration in aversive learning:
Congratulations to my colleagues Rony Paz, Ido Strauss, Firas Fahoum for landing this exciting paper in Nature!
rdcu.be/eCJLb
Congratulations to my colleagues Rony Paz, Ido Strauss, Firas Fahoum for landing this exciting paper in Nature!
rdcu.be/eCJLb
Human hippocampal ripples align new experiences with a grid-like schema: Neuron www.cell.com/neuron/fullt...
Human hippocampal ripples align new experiences with a grid-like schema
Xiao et al. show that brief bursts of hippocampal activity (ripples) help the brain
link new experiences into an internal “mental map.” During rest, ripples engage a
medial frontal brain region that o...
www.cell.com
August 30, 2025 at 7:54 PM
Human hippocampal ripples align new experiences with a grid-like schema: Neuron www.cell.com/neuron/fullt...
Enhancement of Sleep Slow Wave Activity using Transcranial Electrical Stimulation with Temporal Interference www.medrxiv.org/content/10.1...
Enhancement of Sleep Slow Wave Activity using Transcranial Electrical Stimulation with Temporal Interference
Slow waves mediate restorative functions of non-rapid eye movement (NREM) sleep. To enhance slow wave activity (SWA, 0.5-4 Hz) non-invasively, we employed a novel neuromodulatory tool, Transcranial El...
www.medrxiv.org
August 20, 2025 at 7:11 AM
Enhancement of Sleep Slow Wave Activity using Transcranial Electrical Stimulation with Temporal Interference www.medrxiv.org/content/10.1...
Reposted by Yuval Nir
No one ever steps in the same movie twice. Anticipatory gaze 👁️ indicate episodic memory seconds before an event occurs. 🧠🐾 Very robust effects across both natural and crafted movies, and of course, after sleep! 😴. Out today in Communication Psychology:
www.nature.com/articles/s44...
Check it out!
www.nature.com/articles/s44...
Check it out!
Anticipatory eye gaze as a marker of memory - Communications Psychology
Anticipatory eye movements during repeated movie viewing reveal when and what is remembered. Gaze patterns correlate with explicit reports, offering a method to detect memory for events without verbal...
www.nature.com
August 11, 2025 at 10:11 PM
No one ever steps in the same movie twice. Anticipatory gaze 👁️ indicate episodic memory seconds before an event occurs. 🧠🐾 Very robust effects across both natural and crafted movies, and of course, after sleep! 😴. Out today in Communication Psychology:
www.nature.com/articles/s44...
Check it out!
www.nature.com/articles/s44...
Check it out!
How interesting! Activity patterns in individual neurons drift over time, even in subcortical sleep- and wake-promoting regions -- while populations remain stable. Beautiful work from @Tidis__ @CaroGHerrera:
www.researchsquare.com/article/rs-6...
www.researchsquare.com/article/rs-6...
Temporal drift of sleep-wake representations in hypothalamic neuronal ensembles
Correlative and causal evidence implicate distinct genetically-defined and evolutionary-conserved hypothalamic neurons in regulating wakefulness, non-rapid eye movement (NREM), and rapid eye movement ...
www.researchsquare.com
August 11, 2025 at 6:02 AM
How interesting! Activity patterns in individual neurons drift over time, even in subcortical sleep- and wake-promoting regions -- while populations remain stable. Beautiful work from @Tidis__ @CaroGHerrera:
www.researchsquare.com/article/rs-6...
www.researchsquare.com/article/rs-6...
Closed-loop electrical stimulation prevents focal epilepsy progression and long-term memory impairment:
rdcu.be/ezjNt
rdcu.be/ezjNt
Closed-loop electrical stimulation prevents focal epilepsy progression and long-term memory impairment
Nature Neuroscience - Pathological neural communication drives the spread of the epileptic network and contributes to memory impairment in focal epilepsy. The authors show that closed-loop...
rdcu.be
August 5, 2025 at 7:43 AM
Closed-loop electrical stimulation prevents focal epilepsy progression and long-term memory impairment:
rdcu.be/ezjNt
rdcu.be/ezjNt
Sleep-like Slow Waves During Wakefulness Mediate Attention and Vigilance Difficulties in Adult ADHD
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Sleep-like Slow Waves During Wakefulness Mediate Attention and Vigilance Difficulties in Adult Attention-Deficit/Hyperactivity Disorder
Background Attention-Deficit/Hyperactivity Disorder (ADHD) is characterised by behavioural variability and heightened inattention associated with increased mind wandering (MW) and mind blanking (MB). ...
www.biorxiv.org
August 4, 2025 at 6:24 AM
Sleep-like Slow Waves During Wakefulness Mediate Attention and Vigilance Difficulties in Adult ADHD
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Sleep need–dependent plasticity of a thalamic circuit promotes homeostatic recovery sleep | Science www.science.org/doi/10.1126/...
Sleep need–dependent plasticity of a thalamic circuit promotes homeostatic recovery sleep
Prolonged wakefulness leads to persistent, deep recovery sleep (RS). However, the neuronal circuits that mediate this process remain elusive. From a circuit screen in mice, we identified a group of th...
www.science.org
June 19, 2025 at 7:33 PM
Sleep need–dependent plasticity of a thalamic circuit promotes homeostatic recovery sleep | Science www.science.org/doi/10.1126/...
Had a brilliant time at #SXSWLondon Corundum Neuroscience panel discussing the future of sleep - issues ranging from monitoring health, through unique interventions, recording EEG via earbuds, to disengaging from ruminations falling asleep & lucid dreaming w/ Caroline Lustenberger, Simon Bachmann
June 5, 2025 at 6:12 PM
Had a brilliant time at #SXSWLondon Corundum Neuroscience panel discussing the future of sleep - issues ranging from monitoring health, through unique interventions, recording EEG via earbuds, to disengaging from ruminations falling asleep & lucid dreaming w/ Caroline Lustenberger, Simon Bachmann
So very proud of our own @OmerBenBarak1 who received the prestigious Sieratzki PhD scholarship for her research on pupillometry and gaze imaging in closed eye conditions, well done Omer!
May 21, 2025 at 12:47 PM
So very proud of our own @OmerBenBarak1 who received the prestigious Sieratzki PhD scholarship for her research on pupillometry and gaze imaging in closed eye conditions, well done Omer!
