meanderingdave.bsky.social
meanderingdave.bsky.social
@meanderingdave.bsky.social
Should I build on a chassis used 1,000 times before? Or attempt a big leap forward by using an unconventional chassis? I know which option seems like more fun!

Broad-Host-Range Synthetic Biology: Rethinking Microbial Chassis as a Design Variable | ACS Synthetic Biology pubs.acs.org/doi/10.1021/...
Broad-Host-Range Synthetic Biology: Rethinking Microbial Chassis as a Design Variable
Broad-host-range synthetic microbiology is redefining the role of microbial hosts in genetic design by moving beyond the traditional organisms. Historically, synthetic biology has focused on optimizin...
pubs.acs.org
October 15, 2025 at 1:13 AM
Reposted by meanderingdave.bsky.social
Supplementary info of scientific articles enhances #transparency, #reproducibility & scientific impact. This study presents #FAIR-SMART, a tool that enables #FAIR computational access to these materials at scale, improving findability, interoperability & reuse @plosbiology.org 🧪 plos.io/3KBYLHs
October 10, 2025 at 4:28 PM
Reposted by meanderingdave.bsky.social
From the microbial networks behind kombucha fermentation to engineered strains powering sustainable fuels, #FEMSYeastRes brings you high-quality studies with major relevance across the field. 📊 Read the journal's most-read papers for the first half of 2025 buff.ly/NLKSc4N
August 19, 2025 at 10:02 AM
Reposted by meanderingdave.bsky.social
There are untold species of bacteria scientists have never seen. This lab develops techniques that allow scientists to see them #NBTintheNews www.rockefeller.edu/news/38243-t...
There are untold species of bacteria scientists have never seen. This lab develops techniques that allow scientists to see them. - News
Bacteria have long been a key source of lifesaving antibiotics, but most species cannot be grown in the lab—leaving their therapeutic potential untapped even as multidrug resistance becomes an increas...
www.rockefeller.edu
September 16, 2025 at 3:40 PM
Reposted by meanderingdave.bsky.social
Sometimes you meet absolutely incredible bioinfo-magicians.
It was a huge privilege when @shenwei356.bsky.social
joined our group for a year on an @embl.org sabbatical.
While here, he developed a new way of aligning to
millions of bacteria, called LexicMap 1/n
www.nature.com/articles/s41...
Efficient sequence alignment against millions of prokaryotic genomes with LexicMap - Nature Biotechnology
LexicMap uses a fixed set of probes to efficiently query gene sequences for fast and low-memory alignment.
www.nature.com
September 10, 2025 at 9:12 AM
Reposted by meanderingdave.bsky.social
Last Universal Common Ancestor (LUCA) had a genome of at least 2.5 Mb encoding around 2,600 proteins, comparable to modern
prokaryotes….LUCA was a prokaryote-grade anaerobic acetogen that possessed an early immune system….
capable of both building its own molecules & using those produced by others 🤯
November 23, 2024 at 5:15 PM
Reposted by meanderingdave.bsky.social
Ever wonder if GO can help with metabolomics? Mahajan et al. have developed a tool for GO analysis of a metabolite list. Read more at community.alliancegenome.org/t/go-gene-fu...
🧪
January 20, 2024 at 12:44 AM