Catarina Marques
@marquescata.bsky.social
Hi! I’m a postdoc at University of Glasgow looking into how Trypanosomes and Leishmania replicate their DNA!
Reposted by Catarina Marques
Save the dates!! @bspparasitology.bsky.social Spring Meeting 2026 will be in Bonnie Glasgow! 7-9 April 2026, with a drinks reception in Glasgow City Chambers on the 6th of April 2026!
Keep an eye on the BSP website for registration and abstract submission!
Logo by @shannaraeilean.bsky.social! 🦟
Keep an eye on the BSP website for registration and abstract submission!
Logo by @shannaraeilean.bsky.social! 🦟
September 11, 2025 at 11:09 AM
Save the dates!! @bspparasitology.bsky.social Spring Meeting 2026 will be in Bonnie Glasgow! 7-9 April 2026, with a drinks reception in Glasgow City Chambers on the 6th of April 2026!
Keep an eye on the BSP website for registration and abstract submission!
Logo by @shannaraeilean.bsky.social! 🦟
Keep an eye on the BSP website for registration and abstract submission!
Logo by @shannaraeilean.bsky.social! 🦟
Reposted by Catarina Marques
Pleased 2 share our new article: single-molecule replication mapping in Leishmania using DNAscent.
We show widespread stochastic origin firing and insights into genome variability.
www.cell.com/cell-reports...
We show widespread stochastic origin firing and insights into genome variability.
www.cell.com/cell-reports...
August 6, 2025 at 8:20 AM
Pleased 2 share our new article: single-molecule replication mapping in Leishmania using DNAscent.
We show widespread stochastic origin firing and insights into genome variability.
www.cell.com/cell-reports...
We show widespread stochastic origin firing and insights into genome variability.
www.cell.com/cell-reports...
Reposted by Catarina Marques
So happy to share the first preprint from our lab on post-transcriptional regulation at the VSG expression-site body in trypanosomes. @ybri-uoy.bsky.social @york.ac.uk
Specialised RNA decay fine-tunes monogenic antigen expression in African trypanosomes
Antigenic variation is a sophisticated immune evasion strategy employed by many pathogens. Trypanosoma brucei expresses a single Variant-Surface-Glycoprotein (VSG) from a large genetic repertoire, whi...
www.biorxiv.org
May 27, 2025 at 10:28 AM
So happy to share the first preprint from our lab on post-transcriptional regulation at the VSG expression-site body in trypanosomes. @ybri-uoy.bsky.social @york.ac.uk
Reposted by Catarina Marques
DNA replication beyond the cores of megabase chromosomes of T. brucei -- some of my PhD work is FINALLY out! doi.org/10.1038/s414... thank you to @rmc9z.bsky.social @marquescata.bsky.social Emma, Dario, Kathryn, Graham and Craig!
Nanopore sequencing reveals that DNA replication compartmentalisation dictates genome stability and instability in Trypanosoma brucei - Nature Communications
A full description of trypanosome genome replication has proved elusive. Here, after genome assembly, the authors reveal compartmentalisation of DNA replication activity and stability between transcri...
doi.org
January 17, 2025 at 6:29 AM
DNA replication beyond the cores of megabase chromosomes of T. brucei -- some of my PhD work is FINALLY out! doi.org/10.1038/s414... thank you to @rmc9z.bsky.social @marquescata.bsky.social Emma, Dario, Kathryn, Graham and Craig!
Reposted by Catarina Marques
New paper @uofgsii.bsky.social led by @scotomorph.bsky.social @marquescata.bsky.social where we show that T. brucei DNA replication dynamics reflect structural and functional compartmentalisation of the genome, including stability. Well done Marija, and thanks all co-authors!
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Nanopore sequencing reveals that DNA replication compartmentalisation dictates genome stability and instability in Trypanosoma brucei - Nature Communications
A full description of trypanosome genome replication has proved elusive. Here, after genome assembly, the authors reveal compartmentalisation of DNA replication activity and stability between transcri...
doi.org
January 17, 2025 at 9:48 AM
New paper @uofgsii.bsky.social led by @scotomorph.bsky.social @marquescata.bsky.social where we show that T. brucei DNA replication dynamics reflect structural and functional compartmentalisation of the genome, including stability. Well done Marija, and thanks all co-authors!
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Reposted by Catarina Marques
New preprint from others in the lab - Mapping origins of DNA replication in Leishmania.
Great work Jeziel, Gabriel, @marquescata.bsky.social, Marija, Craig, Dario and the boss!
www.biorxiv.org/content/10.1...
Great work Jeziel, Gabriel, @marquescata.bsky.social, Marija, Craig, Dario and the boss!
www.biorxiv.org/content/10.1...
Nuclear DNA replication in Leishmania major relies on a single constitutive origin per chromosome supplemented by thousands of stochastic initiation events
Understanding genome duplication requires characterisation of the locations where DNA replication initiates, termed origins. Genome-wide mapping of DNA replication origins has mainly been derived from...
www.biorxiv.org
November 18, 2024 at 10:00 AM
New preprint from others in the lab - Mapping origins of DNA replication in Leishmania.
Great work Jeziel, Gabriel, @marquescata.bsky.social, Marija, Craig, Dario and the boss!
www.biorxiv.org/content/10.1...
Great work Jeziel, Gabriel, @marquescata.bsky.social, Marija, Craig, Dario and the boss!
www.biorxiv.org/content/10.1...
Reposted by Catarina Marques
Extremely excited to meet former colleagues from my PhD, other BoP 2019 @mblscience.bsky.social alumni, old friends and colleagues, as well as many new!
November 6, 2024 at 9:28 PM
Extremely excited to meet former colleagues from my PhD, other BoP 2019 @mblscience.bsky.social alumni, old friends and colleagues, as well as many new!