Mark Blaser, PhD
@markcblaser.bsky.social
Research Scientist (Junior Faculty) @ CICS / Brigham & Women's / Harvard Med | #cardiovascularbiology + #multi-omics + #extracellularvesicles + #bioengineering + #drugdiscovery | via @bme-uoft.bsky.social & McGill ChemE
linkedin.com/in/markblaser
linkedin.com/in/markblaser
I love this whole article so so much! Had no idea it's peak Canadian!
“Gretz brought the loonie in the room and everybody went nuts. It was a gong show in there.” Me in @defector.com on the hockey-related rise of "gong show"
How A Campy 1970s Game Show Became Part Of Canada's National Lexicon | Defector
On tiny Hornby Island northwest of Vancouver, after the Women’s World Cup in the summer of 2015, our bed-and-breakfast host was telling us about the town. The pizza place in the park is terrific, he s...
defector.com
November 26, 2025 at 7:25 PM
I love this whole article so so much! Had no idea it's peak Canadian!
I'm delighted to have been appointed as a member of @ahajournals.bsky.social Circulation Research's Early Career Editorial Board for 2025-26!
Thank you to @janefreedmanmd.bsky.social, @drkoupenova.bsky.social, & Gemma Bridges-Lyman for this selection.
www.ahajournals.org/res/editoria...
Thank you to @janefreedmanmd.bsky.social, @drkoupenova.bsky.social, & Gemma Bridges-Lyman for this selection.
www.ahajournals.org/res/editoria...
Circulation Research | Editorial Board | AHA/ASA Journals
www.ahajournals.org
October 15, 2025 at 4:17 PM
I'm delighted to have been appointed as a member of @ahajournals.bsky.social Circulation Research's Early Career Editorial Board for 2025-26!
Thank you to @janefreedmanmd.bsky.social, @drkoupenova.bsky.social, & Gemma Bridges-Lyman for this selection.
www.ahajournals.org/res/editoria...
Thank you to @janefreedmanmd.bsky.social, @drkoupenova.bsky.social, & Gemma Bridges-Lyman for this selection.
www.ahajournals.org/res/editoria...
Excited to have this work from Casey Clift & myself out in #ATVB!
We leverage mass spectrometry proteomics of human plasma & aortic valve tissues to assess potential drivers of sexual dimorphism in #AS aortic valve stenosis.
Mini-explainer thread below!
www.ahajournals.org/eprint/MF7VI...
We leverage mass spectrometry proteomics of human plasma & aortic valve tissues to assess potential drivers of sexual dimorphism in #AS aortic valve stenosis.
Mini-explainer thread below!
www.ahajournals.org/eprint/MF7VI...
American Heart Association Journals
www.ahajournals.org
September 29, 2025 at 9:04 PM
Excited to have this work from Casey Clift & myself out in #ATVB!
We leverage mass spectrometry proteomics of human plasma & aortic valve tissues to assess potential drivers of sexual dimorphism in #AS aortic valve stenosis.
Mini-explainer thread below!
www.ahajournals.org/eprint/MF7VI...
We leverage mass spectrometry proteomics of human plasma & aortic valve tissues to assess potential drivers of sexual dimorphism in #AS aortic valve stenosis.
Mini-explainer thread below!
www.ahajournals.org/eprint/MF7VI...
Reposted by Mark Blaser, PhD
Member publication alert:
Sexual Dimorphism of Plasma and Tissue Proteomes in Human Calcific Aortic Valve Stenosis Pathogenesis
www.ahajournals.org/doi/10.1161/...
Sexual Dimorphism of Plasma and Tissue Proteomes in Human Calcific Aortic Valve Stenosis Pathogenesis
www.ahajournals.org/doi/10.1161/...
Sexual Dimorphism of Plasma and Tissue Proteomes in Human Calcific Aortic Valve Stenosis Pathogenesis | Arteriosclerosis, Thrombosis, and Vascular Biology
BACKGROUND: Calcific aortic valve stenosis is a global clinical burden, impacting around 2% of
the population over 65 years of age. No pharmacotherapeutics exist, with surgical
repair and transcathete...
www.ahajournals.org
August 23, 2025 at 9:59 PM
Member publication alert:
Sexual Dimorphism of Plasma and Tissue Proteomes in Human Calcific Aortic Valve Stenosis Pathogenesis
www.ahajournals.org/doi/10.1161/...
Sexual Dimorphism of Plasma and Tissue Proteomes in Human Calcific Aortic Valve Stenosis Pathogenesis
www.ahajournals.org/doi/10.1161/...
Reposted by Mark Blaser, PhD
ISACB is searching for candidates to serve as new members of our Committees and Executive Council!
We welcome applications from members at all career stages who wish to contribute to the growth of our society.
Please apply now via: forms.gle/2E1eyPznNJXn...
We welcome applications from members at all career stages who wish to contribute to the growth of our society.
Please apply now via: forms.gle/2E1eyPznNJXn...
July 10, 2025 at 2:30 PM
ISACB is searching for candidates to serve as new members of our Committees and Executive Council!
We welcome applications from members at all career stages who wish to contribute to the growth of our society.
Please apply now via: forms.gle/2E1eyPznNJXn...
We welcome applications from members at all career stages who wish to contribute to the growth of our society.
Please apply now via: forms.gle/2E1eyPznNJXn...
Reposted by Mark Blaser, PhD
Save-the-Date for #ISACB2026 in #Miami!
We are excited to announce that the next Biennial @appliedcvb.bsky.social ISACB meeting will be held in beautiful #Miami from November 11-14, 2026.
Be sure to save the date in your calendar! More details coming soon.
We are excited to announce that the next Biennial @appliedcvb.bsky.social ISACB meeting will be held in beautiful #Miami from November 11-14, 2026.
Be sure to save the date in your calendar! More details coming soon.
July 10, 2025 at 2:12 PM
Save-the-Date for #ISACB2026 in #Miami!
We are excited to announce that the next Biennial @appliedcvb.bsky.social ISACB meeting will be held in beautiful #Miami from November 11-14, 2026.
Be sure to save the date in your calendar! More details coming soon.
We are excited to announce that the next Biennial @appliedcvb.bsky.social ISACB meeting will be held in beautiful #Miami from November 11-14, 2026.
Be sure to save the date in your calendar! More details coming soon.
oh the irony...
July 6, 2025 at 9:43 PM
oh the irony...
Reposted by Mark Blaser, PhD
You haven’t really written an academic paper until you’ve cut the paragraph you built the entire paper around.
June 16, 2025 at 1:02 PM
You haven’t really written an academic paper until you’ve cut the paragraph you built the entire paper around.
Reposted by Mark Blaser, PhD
Member publication alert:
Multiomic Landscape of Extracellular Vesicles in Human Carotid Atherosclerotic Plaque Reveals Endothelial Communication Networks
www.ahajournals.org/doi/10.1161/...
Multiomic Landscape of Extracellular Vesicles in Human Carotid Atherosclerotic Plaque Reveals Endothelial Communication Networks
www.ahajournals.org/doi/10.1161/...
Multiomic Landscape of Extracellular Vesicles in Human Carotid Atherosclerotic Plaque Reveals Endothelial Communication Networks | Arteriosclerosis, Thrombosis, and Vascular Biology
BACKGROUND: Carotid atherosclerosis is orchestrated by cell-cell communication that drives progression
along a clinical continuum (asymptomatic to symptomatic). Extracellular vesicles (EVs)
are cell-d...
www.ahajournals.org
June 1, 2025 at 11:05 PM
Member publication alert:
Multiomic Landscape of Extracellular Vesicles in Human Carotid Atherosclerotic Plaque Reveals Endothelial Communication Networks
www.ahajournals.org/doi/10.1161/...
Multiomic Landscape of Extracellular Vesicles in Human Carotid Atherosclerotic Plaque Reveals Endothelial Communication Networks
www.ahajournals.org/doi/10.1161/...
How does EV–vascular cell communication drive dynamic changes in atherosclerotic plaques?
www.ahajournals.org/doi/10.1161/...
www.ahajournals.org/doi/10.1161/...
Multiomic Landscape of Extracellular Vesicles in Human Carotid Atherosclerotic Plaque Reveals Endothelial Communication Networks | Arteriosclerosis, Thrombosis, and Vascular Biology
BACKGROUND: Carotid atherosclerosis is orchestrated by cell-cell communication that drives progression
along a clinical continuum (asymptomatic to symptomatic). Extracellular vesicles (EVs)
are cell-d...
www.ahajournals.org
May 30, 2025 at 3:08 AM
How does EV–vascular cell communication drive dynamic changes in atherosclerotic plaques?
www.ahajournals.org/doi/10.1161/...
www.ahajournals.org/doi/10.1161/...
Long-weekend vibes!
May 27, 2025 at 6:11 AM
Long-weekend vibes!
Reposted by Mark Blaser, PhD
Join @ACHA_Heart and millions of patients with #CHD in asking Congress to fund the Congenital Heart Futures Reauthorization Act of 2024. This legislation is vital to fund CHD research👇
#ACHD #ACCACPC #cardiosky #medsky
www.achaheart.org/get-involved...
#ACHD #ACCACPC #cardiosky #medsky
www.achaheart.org/get-involved...
Take Action Today on CHFRA
www.achaheart.org
April 2, 2025 at 1:40 AM
Join @ACHA_Heart and millions of patients with #CHD in asking Congress to fund the Congenital Heart Futures Reauthorization Act of 2024. This legislation is vital to fund CHD research👇
#ACHD #ACCACPC #cardiosky #medsky
www.achaheart.org/get-involved...
#ACHD #ACCACPC #cardiosky #medsky
www.achaheart.org/get-involved...
I had a fantastic time at my first @us-hupo.org #USHUPO2025, sharing our work on multi-omics of aortic valve stenosis!
On #TranslatingProteomics, Parag Mallick highlights advances in the scale and application of #proteomics in #biomedicine (with shout-outs to Forest White and @markcblaser.bsky.social) as two things he was particularly impressed by at #USHUPO. Full episode:
www.nautilus.bio/blog/us-hupo...
www.nautilus.bio/blog/us-hupo...
March 31, 2025 at 7:26 PM
I had a fantastic time at my first @us-hupo.org #USHUPO2025, sharing our work on multi-omics of aortic valve stenosis!
Reposted by Mark Blaser, PhD
Cassandra Clift, postdoc in Elena Aikawa's lab, presents her poster full of exciting research on proteomics as it applies to cardiovascular biomaterials at #USHUPO2025
February 25, 2025 at 11:05 PM
Cassandra Clift, postdoc in Elena Aikawa's lab, presents her poster full of exciting research on proteomics as it applies to cardiovascular biomaterials at #USHUPO2025
Reposted by Mark Blaser, PhD
Dr. Taku Kasai of @toleafgirl.bsky.social ‘s Proteomics group shares new in-source CID HCD fragmentation technologies for ADPr in human primary macrophages with fellow proteomics enthusiasts at @us-hupo.bsky.social #USHUPO2025
February 25, 2025 at 12:25 AM
Dr. Taku Kasai of @toleafgirl.bsky.social ‘s Proteomics group shares new in-source CID HCD fragmentation technologies for ADPr in human primary macrophages with fellow proteomics enthusiasts at @us-hupo.bsky.social #USHUPO2025
Reposted by Mark Blaser, PhD
We're so excited to share our science at #USHUPO2025! Tomorrow, @markcblaser.bsky.social and Taku Kasai will represent CICS at the Pre-clinical Proteomics and Lightning Talk 1/Poster session 1 events!
February 23, 2025 at 11:51 PM
We're so excited to share our science at #USHUPO2025! Tomorrow, @markcblaser.bsky.social and Taku Kasai will represent CICS at the Pre-clinical Proteomics and Lightning Talk 1/Poster session 1 events!
Blood forces are key drivers of cardiovascular disease, but mechanisms are difficult to study in humans. We're excited to share an ultrasound image velocimetry-based approach to enable non-invasive quantification of complex hemodynamics in small animal models: www.sciencedirect.com/science/arti...
February 18, 2025 at 4:43 PM
Blood forces are key drivers of cardiovascular disease, but mechanisms are difficult to study in humans. We're excited to share an ultrasound image velocimetry-based approach to enable non-invasive quantification of complex hemodynamics in small animal models: www.sciencedirect.com/science/arti...
Reposted by Mark Blaser, PhD
not paying indirect costs for research is like only paying the players in the Super Bowl.
can't have a Super Bowl without coaches, referees, security, janitors, announcers, stadium staff, and a stadium - and you can't have research without supporting people and facilities
can't have a Super Bowl without coaches, referees, security, janitors, announcers, stadium staff, and a stadium - and you can't have research without supporting people and facilities
February 9, 2025 at 11:00 PM
not paying indirect costs for research is like only paying the players in the Super Bowl.
can't have a Super Bowl without coaches, referees, security, janitors, announcers, stadium staff, and a stadium - and you can't have research without supporting people and facilities
can't have a Super Bowl without coaches, referees, security, janitors, announcers, stadium staff, and a stadium - and you can't have research without supporting people and facilities
Reposted by Mark Blaser, PhD
Reposted by Mark Blaser, PhD
Let me give a concrete example of the importance of applications with high risk-high reward as well as the role of NIH staff in taking risks.
Decades ago, a physical chemist proposed ideas about doing mass spectrometry on proteins (when this was deemed probably impossible).
1/n
Decades ago, a physical chemist proposed ideas about doing mass spectrometry on proteins (when this was deemed probably impossible).
1/n
January 26, 2025 at 9:51 PM
Let me give a concrete example of the importance of applications with high risk-high reward as well as the role of NIH staff in taking risks.
Decades ago, a physical chemist proposed ideas about doing mass spectrometry on proteins (when this was deemed probably impossible).
1/n
Decades ago, a physical chemist proposed ideas about doing mass spectrometry on proteins (when this was deemed probably impossible).
1/n
Reposted by Mark Blaser, PhD
Like every MBTA commuter, I complain a lot. But the improvements made over the last two years in the subways under Phil Eng have been remarkable.
With massive patches of slow zones now mostly repaired, MBTA officials have set their sights on pushing some subway speeds to even higher levels as one of the next major goals.
The T wants to pick up speed on the Red and Orange lines
With massive patches of slow zones now mostly repaired, MBTA officials have set their sights on pushing some subway speeds to even higher levels as one of the next major goals.
www.wbur.org
January 24, 2025 at 1:15 PM
Like every MBTA commuter, I complain a lot. But the improvements made over the last two years in the subways under Phil Eng have been remarkable.
Reposted by Mark Blaser, PhD
Early-career researchers describe to Nature Careers how they juggled workloads, emotions and finances after having children. #AcademicSky 🧪
PhD parents: the pros and cons of having a child during your doctorate
Early-career researchers describe how they juggled workloads, emotions and finances after having children.
go.nature.com
January 19, 2025 at 7:04 PM
Early-career researchers describe to Nature Careers how they juggled workloads, emotions and finances after having children. #AcademicSky 🧪
Heads-up to all my Toronto peeps!
Excited to speak at the @medicinebydesign.bsky.social Global Speaker Series on Jan 21! I'll be sharing recent work from @bostonchildrens.bsky.social & @harvardmed.bsky.social. Looking forward to great discussions & meeting amazing faculty!
mbd.utoronto.ca/event/global...
January 13, 2025 at 1:51 PM
Heads-up to all my Toronto peeps!
There are glaring sex disparities in the pathology & tx of aortic stenosis #AS. Here's a sneak peak at work led by Dr. Casey Clift & I, where we begin to unravel sexually-dimorphic molecular fingerprints associated with fibrocalcific disease progression:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Sexual Dimorphism of Plasma and Tissue Proteomes in Human Calcific Aortic Valve Stenosis Pathogenesis
BACKGROUND: Calcific aortic valve stenosis (CAVS) is a global clinical burden, impacting around 2% of the population over 65 years of age. No pharmacotherapeutics exist, with surgical repair and trans...
www.biorxiv.org
December 16, 2024 at 2:31 PM
There are glaring sex disparities in the pathology & tx of aortic stenosis #AS. Here's a sneak peak at work led by Dr. Casey Clift & I, where we begin to unravel sexually-dimorphic molecular fingerprints associated with fibrocalcific disease progression:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Mark Blaser, PhD
Member publication alert:
Calcific aortic stenosis: omics-based target discovery and therapy development
academic.oup.com/eurheartj/ad...
Calcific aortic stenosis: omics-based target discovery and therapy development
academic.oup.com/eurheartj/ad...
Calcific aortic stenosis: omics-based target discovery and therapy development
Abstract. Calcific aortic valve disease (CAVD) resulting in aortic stenosis (AS) is the most common form of valvular heart disease, affecting 2% of those o
academic.oup.com
December 16, 2024 at 2:24 AM
Member publication alert:
Calcific aortic stenosis: omics-based target discovery and therapy development
academic.oup.com/eurheartj/ad...
Calcific aortic stenosis: omics-based target discovery and therapy development
academic.oup.com/eurheartj/ad...