Mariano Martín
@marianomartin.bsky.social
Reposted by Mariano Martín
We are looking for a PhD student in (mostly )wet-lab biochemistry to work on short linear motifs, intrinsically disordered regions, in the context of the Marie Curie network "IDPro". More info an apply here: www.uu.se/en/about-uu/...
PhD student in Biochemistry - Uppsala University
PhD student in Biochemistry, Disciplinary Domain of Science and Technology, Faculty of Chemistry, Department of Chemistry - BMC, Uppsala University
www.uu.se
June 30, 2025 at 8:39 AM
We are looking for a PhD student in (mostly )wet-lab biochemistry to work on short linear motifs, intrinsically disordered regions, in the context of the Marie Curie network "IDPro". More info an apply here: www.uu.se/en/about-uu/...
Reposted by Mariano Martín
Solving the many mysteries of amyloids 🧩🧬, next up at #VariantEffect25: @marianomartin.bsky.social from @bennibolo.bsky.social Lab presents:
Deep mutagenesis reveals the interplay between RIPKs amyloid nucleation and protein activity
Deep mutagenesis reveals the interplay between RIPKs amyloid nucleation and protein activity
May 23, 2025 at 7:58 AM
Solving the many mysteries of amyloids 🧩🧬, next up at #VariantEffect25: @marianomartin.bsky.social from @bennibolo.bsky.social Lab presents:
Deep mutagenesis reveals the interplay between RIPKs amyloid nucleation and protein activity
Deep mutagenesis reveals the interplay between RIPKs amyloid nucleation and protein activity
Reposted by Mariano Martín
May 23, 2025 at 8:13 AM
Reposted by Mariano Martín
VSS people are always hungry for more heatmaps discussion! (and burgers!) #VariantEffect25
May 22, 2025 at 7:06 AM
VSS people are always hungry for more heatmaps discussion! (and burgers!) #VariantEffect25
Reposted by Mariano Martín
The first poster session just started! #VariantEffect25
May 21, 2025 at 11:39 AM
The first poster session just started! #VariantEffect25
Reposted by Mariano Martín
Good morning #VariantEffect25! Kicking things off we have Mafalda Dias, @bennibolo.bsky.social @muffley.bsky.social welcoming us to this 8th annual symposium. We have 250 in-person participants, 60 people online, from 20 countries!
May 21, 2025 at 7:45 AM
Good morning #VariantEffect25! Kicking things off we have Mafalda Dias, @bennibolo.bsky.social @muffley.bsky.social welcoming us to this 8th annual symposium. We have 250 in-person participants, 60 people online, from 20 countries!
Reposted by Mariano Martín
@marianomartin.bsky.social discussing amyloid formation from random sequence extensions at our first CNS 🧠network event @ibecbarcelona.eu
Find out more this week on @pnas.org!
www.pnas.org/doi/10.1073/...
Find out more this week on @pnas.org!
www.pnas.org/doi/10.1073/...
May 9, 2025 at 3:00 PM
@marianomartin.bsky.social discussing amyloid formation from random sequence extensions at our first CNS 🧠network event @ibecbarcelona.eu
Find out more this week on @pnas.org!
www.pnas.org/doi/10.1073/...
Find out more this week on @pnas.org!
www.pnas.org/doi/10.1073/...
Proud to be part of this big collaborative effort!
We studied MCT8 deficiency via genomic, functional & deep learning integration.
🔗 www.nature.com/articles/s41...
We studied MCT8 deficiency via genomic, functional & deep learning integration.
🔗 www.nature.com/articles/s41...
Mapping variants in thyroid hormone transporter MCT8 to disease severity by genomic, phenotypic, functional, structural and deep learning integration - Nature Communications
Loss-of-function variants in thyroid hormone transporter MCT8 cause a neurodevelopmental and metabolic disorder. Here the authors identify genotype-phenotype relationships, advance insights in MCT8 (d...
www.nature.com
May 5, 2025 at 7:43 AM
Proud to be part of this big collaborative effort!
We studied MCT8 deficiency via genomic, functional & deep learning integration.
🔗 www.nature.com/articles/s41...
We studied MCT8 deficiency via genomic, functional & deep learning integration.
🔗 www.nature.com/articles/s41...
Excited to share our latest in @SciAdvances! 🔍
We quantified ~100k sequences to train CANYA, an interpretable deep learning model for predicting amyloid formation.
🔗 www.science.org/doi/10.1126/...
We quantified ~100k sequences to train CANYA, an interpretable deep learning model for predicting amyloid formation.
🔗 www.science.org/doi/10.1126/...
Massive experimental quantification allows interpretable deep learning of protein aggregation
xAI trained on >100,000 random peptides predicts and elucidates primary sequence determinants of aggregation.
www.science.org
May 5, 2025 at 7:42 AM
Excited to share our latest in @SciAdvances! 🔍
We quantified ~100k sequences to train CANYA, an interpretable deep learning model for predicting amyloid formation.
🔗 www.science.org/doi/10.1126/...
We quantified ~100k sequences to train CANYA, an interpretable deep learning model for predicting amyloid formation.
🔗 www.science.org/doi/10.1126/...
Our new paper is out in PNAS! 🧪
We used deep mutational scanning & random extensions to uncover how Bri2 becomes amyloidogenic upon C-terminal extension.
🔗 www.pnas.org/doi/10.1073/...
We used deep mutational scanning & random extensions to uncover how Bri2 becomes amyloidogenic upon C-terminal extension.
🔗 www.pnas.org/doi/10.1073/...
Massive mutagenesis reveals an incomplete amyloid motif in Bri2 that turns amyloidogenic upon C-terminal extension | PNAS
Stop-loss mutations cause over twenty different diseases. The effects of stop-loss
mutations can have multiple consequences that are, however, hard...
www.pnas.org
May 5, 2025 at 7:40 AM
Our new paper is out in PNAS! 🧪
We used deep mutational scanning & random extensions to uncover how Bri2 becomes amyloidogenic upon C-terminal extension.
🔗 www.pnas.org/doi/10.1073/...
We used deep mutational scanning & random extensions to uncover how Bri2 becomes amyloidogenic upon C-terminal extension.
🔗 www.pnas.org/doi/10.1073/...
Reposted by Mariano Martín
🗓️ Mark your calendars! This is one not to miss!
www.varianteffect.org/seminar-series
www.varianteffect.org/seminar-series
January 24, 2025 at 2:36 PM
🗓️ Mark your calendars! This is one not to miss!
www.varianteffect.org/seminar-series
www.varianteffect.org/seminar-series
Reposted by Mariano Martín
Countdown has started! Excited to welcome you in Barcelona for the 8th Mutational Scanning Symposium #VariantEffect25
🌍 @ibecbarcelona.eu @crg.eu @varianteffect.bsky.social
events.ibecbarcelona.eu/mutational-s...
🌍 @ibecbarcelona.eu @crg.eu @varianteffect.bsky.social
events.ibecbarcelona.eu/mutational-s...
January 24, 2025 at 3:49 PM
Countdown has started! Excited to welcome you in Barcelona for the 8th Mutational Scanning Symposium #VariantEffect25
🌍 @ibecbarcelona.eu @crg.eu @varianteffect.bsky.social
events.ibecbarcelona.eu/mutational-s...
🌍 @ibecbarcelona.eu @crg.eu @varianteffect.bsky.social
events.ibecbarcelona.eu/mutational-s...