Benedetta Bolognesi
@bennibolo.bsky.social
Biologist, Explorer. Group Leader @ibecbarcelona.eu Protein Phase Transitions.
Reposted by Benedetta Bolognesi
In the nucleus, many intrinsically disordered proteins (IDPs) form condensates. What IDP sequence features drive this behavior? We developed CondenSeq, a high-throughput approach to measure nuclear condensate formation, and applied it to ~14,000 IDPs to find out!
rdcu.be/eq975
rdcu.be/eq975
Characterizing protein sequence determinants of nuclear condensates by high-throughput pooled imaging with CondenSeq
Nature Methods - CondenSeq is an imaging-based, high-throughput platform for characterizing condensate formation within the nuclear environment, uncovering the protein sequence features that...
rdcu.be
June 17, 2025 at 3:26 AM
In the nucleus, many intrinsically disordered proteins (IDPs) form condensates. What IDP sequence features drive this behavior? We developed CondenSeq, a high-throughput approach to measure nuclear condensate formation, and applied it to ~14,000 IDPs to find out!
rdcu.be/eq975
rdcu.be/eq975
New cocktail 🍹 in town - in collaboration with @benlehner.bsky.social : Massive combinatorial mutagenesis + amyloid kinetics selection + thermodynamic modelling showing us the portrait 🎨 of an amyloid transition state. Read about it in this great thread:
Alzheimer’s disease 🧠starts with a molecular domino effect - but what triggers the first piece to fall?
In our new study we cracked open the black box of early protein aggregation, and the findings could reshape how we fight neurodegeneration. 🧵👇
www.science.org/doi/10.1126/...
In our new study we cracked open the black box of early protein aggregation, and the findings could reshape how we fight neurodegeneration. 🧵👇
www.science.org/doi/10.1126/...
Massively parallel genetic perturbation suggests the energetic structure of an amyloid-β transition state
The aggregation rates of >140,000 mutants reveal the energetic structure of an amyloid-β nucleation reaction transition state.
www.science.org
June 12, 2025 at 1:30 PM
New cocktail 🍹 in town - in collaboration with @benlehner.bsky.social : Massive combinatorial mutagenesis + amyloid kinetics selection + thermodynamic modelling showing us the portrait 🎨 of an amyloid transition state. Read about it in this great thread:
Reposted by Benedetta Bolognesi
A black hole in the early universe? Sometimes I like to imagine that I operate a telescope, not a microscope 😁. The hole in the middle of the image is actually a blood vessel. The stars are astrocytes🟡 in the human brain, interacting with beta-amyloid🔵. The brain is from a donor with #Alzheimer.
June 5, 2025 at 6:27 AM
A black hole in the early universe? Sometimes I like to imagine that I operate a telescope, not a microscope 😁. The hole in the middle of the image is actually a blood vessel. The stars are astrocytes🟡 in the human brain, interacting with beta-amyloid🔵. The brain is from a donor with #Alzheimer.
Candle-lit commuting sponsored by @rodalies.info 🕯️🕯️🕯️
June 4, 2025 at 6:57 PM
Candle-lit commuting sponsored by @rodalies.info 🕯️🕯️🕯️
Reposted by Benedetta Bolognesi
Full slide deck here from our talk yesterday on the gender divide and relationship recession, featuring many more countries and plenty of economic data too: www.dropbox.com/scl/fi/1lp1d...
June 4, 2025 at 1:08 PM
Full slide deck here from our talk yesterday on the gender divide and relationship recession, featuring many more countries and plenty of economic data too: www.dropbox.com/scl/fi/1lp1d...
Reposted by Benedetta Bolognesi
I urge everyone to read Unbreaking’s new page on everything the govt is doing to destroy & diminish medical research funding.
It’s the best thing I’ve read on this topic: @lizneeley.bsky.social & co have such done an incredible job.
unbreaking.org/issues/medic...
It’s the best thing I’ve read on this topic: @lizneeley.bsky.social & co have such done an incredible job.
unbreaking.org/issues/medic...
Medical Research Funding — Unbreaking
How the administration is breaking the government, and what that means for all of us.
unbreaking.org
May 30, 2025 at 9:38 PM
I urge everyone to read Unbreaking’s new page on everything the govt is doing to destroy & diminish medical research funding.
It’s the best thing I’ve read on this topic: @lizneeley.bsky.social & co have such done an incredible job.
unbreaking.org/issues/medic...
It’s the best thing I’ve read on this topic: @lizneeley.bsky.social & co have such done an incredible job.
unbreaking.org/issues/medic...
And what a great talk to end #VariantEffect25 ! Thanks to the amazing crowd that travelled to Barcelona and made MSS25 such a fantastic meeting. Lots to think about now! 🧦🗺️☀️
And now, the final talk of #VariantEffect25. @roseorenbuch-art.bsky.social from Harvard Medical School presents work from our long-standing collaboration, and one that’s very close to my heart: Proteome-wide model for human disease genetics
May 23, 2025 at 3:18 PM
And what a great talk to end #VariantEffect25 ! Thanks to the amazing crowd that travelled to Barcelona and made MSS25 such a fantastic meeting. Lots to think about now! 🧦🗺️☀️
Fantastic talk #VariantEffect25 by @pollyfordyce.bsky.social on how much we can understand about sequence-function relationships once we are able to factor in kinetic 🏎️rates. Microfluidics 💧💧for the win!
Next up at #VariantEffect25: @pollyfordyce.bsky.social presents: Microfluidics for quantitative and high-throughput biophysics and biochemistry 💧
May 22, 2025 at 12:58 PM
Fantastic talk #VariantEffect25 by @pollyfordyce.bsky.social on how much we can understand about sequence-function relationships once we are able to factor in kinetic 🏎️rates. Microfluidics 💧💧for the win!
Reposted by Benedetta Bolognesi
May 22, 2025 at 12:49 PM
Reposted by Benedetta Bolognesi
Good views, food and even better company at #VariantEffect25
May 21, 2025 at 11:05 PM
Good views, food and even better company at #VariantEffect25
Reposted by Benedetta Bolognesi
The first poster session just started! #VariantEffect25
May 21, 2025 at 11:39 AM
The first poster session just started! #VariantEffect25
Reposted by Benedetta Bolognesi
Welcome back from the lunch break. Kicking off the afternoon session at #VariantEffect25 we welcome Patrick Hsu @pdhsu.bsky.social all the way from @arcinstitute.org – Bridging biology and AI for genome design 💥🧬🤖 #SynBio #AI Let’s gooo! 🚀
May 21, 2025 at 12:26 PM
Welcome back from the lunch break. Kicking off the afternoon session at #VariantEffect25 we welcome Patrick Hsu @pdhsu.bsky.social all the way from @arcinstitute.org – Bridging biology and AI for genome design 💥🧬🤖 #SynBio #AI Let’s gooo! 🚀
Reposted by Benedetta Bolognesi
It is a deeply inspiring story, reminding us why we do what we do.
May 21, 2025 at 10:09 AM
It is a deeply inspiring story, reminding us why we do what we do.
Reposted by Benedetta Bolognesi
Welcome back from the coffee break and to the last session of Workshop 1 of #VariantEffect25. @pascalnotin.bsky.social is giving us an overview of protein fitness prediction models! #AI #ProteinML
May 20, 2025 at 3:44 PM
Welcome back from the coffee break and to the last session of Workshop 1 of #VariantEffect25. @pascalnotin.bsky.social is giving us an overview of protein fitness prediction models! #AI #ProteinML
Reposted by Benedetta Bolognesi
Next up at #VariantEffect25 Workshop 1 we have Noelia Ferruz! From Rosetta to Flow Matching: The Evolution of Protein Design -How Should You Begin Today?
May 20, 2025 at 2:18 PM
Next up at #VariantEffect25 Workshop 1 we have Noelia Ferruz! From Rosetta to Flow Matching: The Evolution of Protein Design -How Should You Begin Today?
Reposted by Benedetta Bolognesi
Let’s get this party started! Kicking off workshop 1 of #VariantEffect25 we have Albert Escobedo — From Fitness to Free Energy: Thermodynamic Modeling of Protein DMS Data for Accurate Genetic Prediction with MoCHI 🍡🧬
May 20, 2025 at 1:20 PM
Let’s get this party started! Kicking off workshop 1 of #VariantEffect25 we have Albert Escobedo — From Fitness to Free Energy: Thermodynamic Modeling of Protein DMS Data for Accurate Genetic Prediction with MoCHI 🍡🧬
Reposted by Benedetta Bolognesi
Reposted by Benedetta Bolognesi
there are 1,100 words in this article and zero of them are "bus"
Uber to introduce fixed-route shuttles in major US cities designed for commuters
Uber to introduce fixed-route shuttles in major US cities designed for commuters | TechCrunch
Ride-hail and delivery giant Uber is introducing cheap, fixed-route rides along busy corridors during weekday commute hours in major U.S. cities -- one
techcrunch.com
May 14, 2025 at 7:05 PM
there are 1,100 words in this article and zero of them are "bus"
@marianomartin.bsky.social discussing amyloid formation from random sequence extensions at our first CNS 🧠network event @ibecbarcelona.eu
Find out more this week on @pnas.org!
www.pnas.org/doi/10.1073/...
Find out more this week on @pnas.org!
www.pnas.org/doi/10.1073/...
May 9, 2025 at 3:00 PM
@marianomartin.bsky.social discussing amyloid formation from random sequence extensions at our first CNS 🧠network event @ibecbarcelona.eu
Find out more this week on @pnas.org!
www.pnas.org/doi/10.1073/...
Find out more this week on @pnas.org!
www.pnas.org/doi/10.1073/...
Countdown officially started! #VariantEffect25 @varianteffect.bsky.social
Very nice blogpost from @pascalnotin.bsky.social. You can catch him in Barcelona at www.varianteffect.org/mss2025/ #VariantEffect25 in a couple of weeks if you want to chat! Also, watch this space -- hoping to continue this discussion soon!
May 9, 2025 at 2:37 PM
Countdown officially started! #VariantEffect25 @varianteffect.bsky.social
Blackout pipetting @ibecbarcelona.eu
April 28, 2025 at 12:07 PM
Blackout pipetting @ibecbarcelona.eu
Reposted by Benedetta Bolognesi
🏆 Congrats to #IBEC researcher Dr. Irene Marco-Rius on winning the 2025 Anatole Abragam Prize! 🎉
Her groundbreaking work in hyperpolarized #MRI & organ-on-a-chip tech is transforming disease diagnosis & therapy monitoring. 🔬👏
#MagneticResonance #ScienceExcellence #ISMARENC2025
Her groundbreaking work in hyperpolarized #MRI & organ-on-a-chip tech is transforming disease diagnosis & therapy monitoring. 🔬👏
#MagneticResonance #ScienceExcellence #ISMARENC2025
April 8, 2025 at 11:01 AM
🏆 Congrats to #IBEC researcher Dr. Irene Marco-Rius on winning the 2025 Anatole Abragam Prize! 🎉
Her groundbreaking work in hyperpolarized #MRI & organ-on-a-chip tech is transforming disease diagnosis & therapy monitoring. 🔬👏
#MagneticResonance #ScienceExcellence #ISMARENC2025
Her groundbreaking work in hyperpolarized #MRI & organ-on-a-chip tech is transforming disease diagnosis & therapy monitoring. 🔬👏
#MagneticResonance #ScienceExcellence #ISMARENC2025
Reposted by Benedetta Bolognesi
David Baker talks about how the current uncertainty and instability hinder creativity because of the difficulty in thinking long-term. From this week’s Night Science Podcast nightscience.buzzsprout.com/1744020/epis... @nightsciencepod.bsky.social
March 25, 2025 at 12:02 PM
David Baker talks about how the current uncertainty and instability hinder creativity because of the difficulty in thinking long-term. From this week’s Night Science Podcast nightscience.buzzsprout.com/1744020/epis... @nightsciencepod.bsky.social
Reposted by Benedetta Bolognesi
We’re looking for fellow nerds to help us make disordered proteins druggable. Love #IDPs, #MD, #NMR, #AI, #DrugDiscovery, or #MassSpec? Let’s talk.
@bindresearch.org is hiring across the board: bindresearch.org/careers/
#compchem #compbio #NMRChat #TeamMassSpec #chemjobs @chemjobber.bsky.social
@bindresearch.org is hiring across the board: bindresearch.org/careers/
#compchem #compbio #NMRChat #TeamMassSpec #chemjobs @chemjobber.bsky.social
Careers
Careers
bindresearch.org
March 24, 2025 at 10:51 AM
We’re looking for fellow nerds to help us make disordered proteins druggable. Love #IDPs, #MD, #NMR, #AI, #DrugDiscovery, or #MassSpec? Let’s talk.
@bindresearch.org is hiring across the board: bindresearch.org/careers/
#compchem #compbio #NMRChat #TeamMassSpec #chemjobs @chemjobber.bsky.social
@bindresearch.org is hiring across the board: bindresearch.org/careers/
#compchem #compbio #NMRChat #TeamMassSpec #chemjobs @chemjobber.bsky.social