Marta Badia Graset
@mbadiagraset.bsky.social
Reposted by Marta Badia Graset
New cocktail 🍹 in town - in collaboration with @benlehner.bsky.social : Massive combinatorial mutagenesis + amyloid kinetics selection + thermodynamic modelling showing us the portrait 🎨 of an amyloid transition state. Read about it in this great thread:
Alzheimer’s disease 🧠starts with a molecular domino effect - but what triggers the first piece to fall?
In our new study we cracked open the black box of early protein aggregation, and the findings could reshape how we fight neurodegeneration. 🧵👇
www.science.org/doi/10.1126/...
In our new study we cracked open the black box of early protein aggregation, and the findings could reshape how we fight neurodegeneration. 🧵👇
www.science.org/doi/10.1126/...
Massively parallel genetic perturbation suggests the energetic structure of an amyloid-β transition state
The aggregation rates of >140,000 mutants reveal the energetic structure of an amyloid-β nucleation reaction transition state.
www.science.org
June 12, 2025 at 1:30 PM
New cocktail 🍹 in town - in collaboration with @benlehner.bsky.social : Massive combinatorial mutagenesis + amyloid kinetics selection + thermodynamic modelling showing us the portrait 🎨 of an amyloid transition state. Read about it in this great thread:
Reposted by Marta Badia Graset
Solving the many mysteries of amyloids 🧩🧬, next up at #VariantEffect25: @marianomartin.bsky.social from @bennibolo.bsky.social Lab presents:
Deep mutagenesis reveals the interplay between RIPKs amyloid nucleation and protein activity
Deep mutagenesis reveals the interplay between RIPKs amyloid nucleation and protein activity
May 23, 2025 at 7:58 AM
Solving the many mysteries of amyloids 🧩🧬, next up at #VariantEffect25: @marianomartin.bsky.social from @bennibolo.bsky.social Lab presents:
Deep mutagenesis reveals the interplay between RIPKs amyloid nucleation and protein activity
Deep mutagenesis reveals the interplay between RIPKs amyloid nucleation and protein activity
Reposted by Marta Badia Graset
May 22, 2025 at 10:06 AM
Reposted by Marta Badia Graset
May 22, 2025 at 8:09 AM
VSS people are always hungry for more heatmaps discussion! (and burgers!) #VariantEffect25
May 22, 2025 at 7:06 AM
VSS people are always hungry for more heatmaps discussion! (and burgers!) #VariantEffect25
Reposted by Marta Badia Graset
May 21, 2025 at 10:25 AM
Reposted by Marta Badia Graset
🔬🗣 Warming up for the 8th Mutational Scanning Symposium with a satellite workshop at #IBEC on how to choose a model for variant interpretation and protein design
Great line-up of speakers for an interactive quantitative biology session!
Great line-up of speakers for an interactive quantitative biology session!
May 20, 2025 at 3:50 PM
🔬🗣 Warming up for the 8th Mutational Scanning Symposium with a satellite workshop at #IBEC on how to choose a model for variant interpretation and protein design
Great line-up of speakers for an interactive quantitative biology session!
Great line-up of speakers for an interactive quantitative biology session!