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maelloueug.bsky.social
Maël
@maelloueug.bsky.social
27 followers 67 following 10 posts
22 | Artist, wildlife enjoyer and history nerd
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sailorrooscout.bsky.social
blocks its ability to infect cells. This innovative approach has successfully neutralized ALL tested SARS-CoV-2 variants and could pave the way for longer-lasting treatments. If further developed, it may even work against other coronaviruses, influenza, AND HIV.
March 9, 2025 at 4:02 PM
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sailorrooscout.bsky.social
The study has been published in Science. YES, it is PEER-REVIEWED.
• www.science.org/doi/10.1126/...
Abstract The ongoing emergence of severe acute respiratory syndrome coronavirus (SARS-CoV-2) variants of concern (VOCs) that reduce the effectiveness of antibody therapeutics necessitates development of next-generation antibody modalities that are resilient to viral evolution. Here, we characterized amino-terminal domain (NTD)- and receptor binding domain (RBD) -specific monoclonal antibodies previously isolated from coronavirus disease 2019 (COVID-19) convalescent donors for their activity against emergent SARS-CoV-2 VOCs. Among these, the NTD-specific antibody C1596 displayed the greatest breadth of binding to VOCs, with cryo-electron microscopy structural analysis revealing recognition of a distinct NTD epitope outside of the site i antigenic supersite. Given C1596's favorable binding profile, we designed a series of bispecific antibodies (bsAbs), termed CoV2-biRNs, that featured both NTD and RBD specificities. Two of the C1596-inclusive bsAbs, CoV2-biRN5 and CoV2-biRN7, retained potent in vitro neutralization activity against all Omicron variants tested, including XBB.1.5, BA.2.86, and JN.1, contrasting the diminished potency of parental antibodies delivered as monotherapies or as a cocktail. Furthermore, prophylactic delivery of CoV2-biRN5 reduced the viral load within the lungs of K18-hACE2 mice after challenge with SARS-CoV-2 XBB.1.5. In conclusion, NTD-RBD bAbs offer promising potential for the design of resilient, next-generation antibody therapeutics against SARS-CoV-2 VOCs. An illustration of the bispecific antibodies the Stanford-led research team developed to neutralize the virus that causes COVID-19. Named “CoV2-biRN,” these two antibodies work together by attaching to different areas of the virus. Credit: Christopher O. Barnes/Adonis Rubi The bispecific antibodies target two areas of the virus: One attaches to the “NTD,” or Spike N-terminal domain, an area on the virus that does not change very much. This allows the second antibody to attach to the “RBD,” or receptor-binding domain, essentially preventing the virus from infecting human cells. Credit: Christopher O. Barnes/Adonis Rubio
March 9, 2025 at 4:01 PM
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sailorrooscout.bsky.social
THIS IS HUGE! Researchers at Stanford University have developed a dual-antibody treatment that remains effective against ALL SARS-CoV-2 variants by targeting a less-mutable part of the virus. This breakthrough could lead to longer-lasting therapies that OUTPACE viral evolution. 🧪🧵⬇️
March 9, 2025 at 4:00 PM
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camillelaurene.bsky.social
Illustration à la gouache réalisée l'année dernière.
Illustration d'une femme en peignoir allongée sur son trône d'oreillers.
October 4, 2023 at 5:14 PM
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daniellieske.com
And this one deserves its own post, I guess.
A weather-bent pine tree in a mountain scenario.
October 8, 2023 at 5:31 PM
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campmustelid.bsky.social
We’re open for business!!! 🍄🍄🍄
September 26, 2023 at 5:24 PM
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kleinman.bsky.social
October 6, 2023 at 4:53 PM
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jphillll.bsky.social
Shoutout to every senior who doesn't know how to stop the noise coming from their phone rn
October 4, 2023 at 6:19 PM
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shamerli.bsky.social
Part of the reference sheet i drew for Faux-Kai-Sun
#furry #art
September 28, 2023 at 7:06 PM
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howfightracism.bsky.social
Meme posted by Indigenous peoples movement. The meme shows a picture of a blue big pen and red big lighter on a white background Above the picture it says in black text: the two most stolen items in the world. The big pen has text written next to it saying: Surplus values of workers labor The lighter has written text next to it saying: Indigenous land.
September 23, 2023 at 9:05 AM
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bombsfall.bsky.social
Everyone has imposter syndrome after that guy wasted Shinzo Abe with a thingy
September 22, 2023 at 4:37 PM
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debmaluk.bsky.social
Blue Jays are looking extra special with the golden Fall foliage 😊🪶
Blue Jay in flight through golden leaves Blue Jay perched on a white woven arch looking toward the camera
September 22, 2023 at 4:29 AM
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jphillll.bsky.social
Amazing work everybody, keep it up!!
Fox: Police shortages reported nationwide amid record-low morale and recruitment
September 20, 2023 at 3:46 PM
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ourka.bsky.social
Small break 🕊️
September 20, 2023 at 3:35 PM
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mattielubchansky.com
"trans people in the past were medicinewomen and shamans and seers! revered priestesses!" not me. i'm sitting around carving those little sculptures of the guys with the huge hogs and doing absolutely nothing else to help out around town. everyone in Uruk is entirely sick of my shit
September 20, 2023 at 12:35 PM
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bombsfall.bsky.social
remember when that submersible imploded
September 20, 2023 at 1:40 PM
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dasbluestorm.bsky.social
Hi everyone!!
I'm Blue (or Kósmos), a French self-taught artist who draws felines most of the time! :]

Here one of my recent work featuring Bluestorm the main character from my universe : Upside-down ✨
September 19, 2023 at 7:18 PM
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lennguine.bsky.social
say it ain't stoat
September 3, 2023 at 5:02 PM