Marcel Issler
@macl-i.bsky.social
Biophysicist tying to make sense of life.
Interdisciplinary @FWOVlaanderen PhD Fellow with @ColindaScheele at @vib_ccb.
Interdisciplinary @FWOVlaanderen PhD Fellow with @ColindaScheele at @vib_ccb.
Where are you! Can't wait :)
September 30, 2025 at 8:32 AM
Where are you! Can't wait :)
Reposted by Marcel Issler
😍 🩷 A little sneak peak of #cellmech2025
September 30, 2025 at 7:54 AM
😍 🩷 A little sneak peak of #cellmech2025
Reposted by Marcel Issler
Shroff, N. P., Xu, P., Kim, S., Shelton, E. R., Gross, B. J., Liu, Y., ... & Klein, O. D. (2024). Proliferation-driven mechanical compression induces signalling centre formation during mammalian organ development. Nature cell biology, #EpithelialMechanics www.nature.com/articles/s41...
September 23, 2025 at 7:00 AM
Shroff, N. P., Xu, P., Kim, S., Shelton, E. R., Gross, B. J., Liu, Y., ... & Klein, O. D. (2024). Proliferation-driven mechanical compression induces signalling centre formation during mammalian organ development. Nature cell biology, #EpithelialMechanics www.nature.com/articles/s41...
Reposted by Marcel Issler
We're looking for highly motivated candidates for PhD positions in the physics of living systems.
Our group uses theoretical physics to understand how cells collectively self-organize.
If you're interested, get in touch & check out the Biozentrum PhD Fellowship program, deadline October 12th!
Our group uses theoretical physics to understand how cells collectively self-organize.
If you're interested, get in touch & check out the Biozentrum PhD Fellowship program, deadline October 12th!
Apply now for the prestigious and independent #BiozentrumPhDFellowships. Great science. Unique rotation-based selection of research group and other incentives. The summer call is open until October 12, 2025. bit.ly/4caiqqX @biozentrum.unibas.ch @unibas.ch #fellowship #PhD#Switzerland
Biozentrum PhD Fellowships
Share your passion for life sciences. If you are talented and highly motivated, want to broaden your horizons and are interested in a wide range of research topics, apply for one of the sought after B...
bit.ly
September 15, 2025 at 10:04 AM
We're looking for highly motivated candidates for PhD positions in the physics of living systems.
Our group uses theoretical physics to understand how cells collectively self-organize.
If you're interested, get in touch & check out the Biozentrum PhD Fellowship program, deadline October 12th!
Our group uses theoretical physics to understand how cells collectively self-organize.
If you're interested, get in touch & check out the Biozentrum PhD Fellowship program, deadline October 12th!
Reposted by Marcel Issler
1/11 In @science.org: A new perspective on how our intestines renew. Cells are not “pushed out” by crowding or die from apoptosis. Instead, cells play a mechanical tug-of-war, where weaker cells extrude, reframing gut renewal as force-regulated. www.science.org/doi/10.1126/...
Epithelial tension controls intestinal cell extrusion
Cell extrusion is essential for homeostatic self-renewal of the intestinal epithelium. Extrusion is thought to be triggered by crowding-induced compression of cells at the intestinal villus tip. In th...
www.science.org
September 6, 2025 at 7:36 PM
1/11 In @science.org: A new perspective on how our intestines renew. Cells are not “pushed out” by crowding or die from apoptosis. Instead, cells play a mechanical tug-of-war, where weaker cells extrude, reframing gut renewal as force-regulated. www.science.org/doi/10.1126/...
Reposted by Marcel Issler
We're happy to announce the 2025 International OME-NGFF workshop 🎉
📅 Dates:
- Symposium: Nov 10–11, 2025
- Hackathon: Nov 12–14, 2025
📍 Location: Zurich, Switzerland
Full details & registration: www.biovisioncenter.uzh.ch/en/events/Up...
#bioimaging #openscience #OMENGFF #OMEZarr
(1/x 🧵)
📅 Dates:
- Symposium: Nov 10–11, 2025
- Hackathon: Nov 12–14, 2025
📍 Location: Zurich, Switzerland
Full details & registration: www.biovisioncenter.uzh.ch/en/events/Up...
#bioimaging #openscience #OMENGFF #OMEZarr
(1/x 🧵)
August 25, 2025 at 9:07 AM
We're happy to announce the 2025 International OME-NGFF workshop 🎉
📅 Dates:
- Symposium: Nov 10–11, 2025
- Hackathon: Nov 12–14, 2025
📍 Location: Zurich, Switzerland
Full details & registration: www.biovisioncenter.uzh.ch/en/events/Up...
#bioimaging #openscience #OMENGFF #OMEZarr
(1/x 🧵)
📅 Dates:
- Symposium: Nov 10–11, 2025
- Hackathon: Nov 12–14, 2025
📍 Location: Zurich, Switzerland
Full details & registration: www.biovisioncenter.uzh.ch/en/events/Up...
#bioimaging #openscience #OMENGFF #OMEZarr
(1/x 🧵)
Reposted by Marcel Issler
Very happy to see it out, another fun collaboration with the Sixt group at @istaresearch.bsky.social ! See Mehmet's thread for a summary of how different immune cells can "surf" on each other's self-generated gradients to drive efficient co-migration!
🚨 New paper out in @pnas.org! 🚨
We show that self-generated gradients allow heterogeneous cell mixtures to co-migrate efficiently over long distances —while optimizing their physical interactions!
(See below for 🧵)
www.pnas.org/doi/10.1073/... 🧪
We show that self-generated gradients allow heterogeneous cell mixtures to co-migrate efficiently over long distances —while optimizing their physical interactions!
(See below for 🧵)
www.pnas.org/doi/10.1073/... 🧪
August 22, 2025 at 8:34 AM
Very happy to see it out, another fun collaboration with the Sixt group at @istaresearch.bsky.social ! See Mehmet's thread for a summary of how different immune cells can "surf" on each other's self-generated gradients to drive efficient co-migration!
Reposted by Marcel Issler
Oh, nice, just found a paper from @joergenderlein.bsky.social and co on blind estimation of IRF for FLIM measurements pmc.ncbi.nlm.nih.gov/articles/PMC...
It should be useful!
It should be useful!
August 19, 2025 at 3:35 PM
Oh, nice, just found a paper from @joergenderlein.bsky.social and co on blind estimation of IRF for FLIM measurements pmc.ncbi.nlm.nih.gov/articles/PMC...
It should be useful!
It should be useful!
Reposted by Marcel Issler
Have we started the science shitposting yet
July 10, 2023 at 7:49 PM
Have we started the science shitposting yet
Reposted by Marcel Issler
Waiting for Sam to tell us that GPT-6 will be Nobel level of intelligence and that it can see more colours than a mantis shrimp
August 8, 2025 at 12:23 PM
Waiting for Sam to tell us that GPT-6 will be Nobel level of intelligence and that it can see more colours than a mantis shrimp
Reposted by Marcel Issler
for MCF10A also seems to be dependent a lot on density! looks very different compared to this (over)confluent epithelia i imaged some time ago on confocal. +1 for zarr+dask, has been working great for us with on data 👌 any tricks on how to convert .czi to .zarr without loosing compression?
July 26, 2025 at 3:49 PM
for MCF10A also seems to be dependent a lot on density! looks very different compared to this (over)confluent epithelia i imaged some time ago on confocal. +1 for zarr+dask, has been working great for us with on data 👌 any tricks on how to convert .czi to .zarr without loosing compression?
Reposted by Marcel Issler
first data from the new LLSM in PertzLab @olivierpertz.bsky.social! i always thought nuclei were spherical but they are pancakes???? so much more to see in 3d, but data volume produced is insane, we will have to rethink our analysis pipelines. tips welcome! here shown in @napari.org
July 26, 2025 at 8:29 AM
first data from the new LLSM in PertzLab @olivierpertz.bsky.social! i always thought nuclei were spherical but they are pancakes???? so much more to see in 3d, but data volume produced is insane, we will have to rethink our analysis pipelines. tips welcome! here shown in @napari.org
Reposted by Marcel Issler
🚀 Big news! The napari hub has been reimplemented and is now community-run! :tada: It's still the go-to place for finding and sharing napari plugins, but the website is now snappier and lighter-weight. Check it out 👉 www.napari-hub.org
July 23, 2025 at 5:24 PM
🚀 Big news! The napari hub has been reimplemented and is now community-run! :tada: It's still the go-to place for finding and sharing napari plugins, but the website is now snappier and lighter-weight. Check it out 👉 www.napari-hub.org
Reposted by Marcel Issler
Have you ever thought about inflating tissues?
Or maybe quickly deflating those inflated tissues?
New #EpithelialMechanics pre-print: doi.org/10.1101/2025...
🧵 with pressure control, multiscale buckling, controlled wrinkling
Or maybe quickly deflating those inflated tissues?
New #EpithelialMechanics pre-print: doi.org/10.1101/2025...
🧵 with pressure control, multiscale buckling, controlled wrinkling
July 3, 2025 at 2:23 PM
Have you ever thought about inflating tissues?
Or maybe quickly deflating those inflated tissues?
New #EpithelialMechanics pre-print: doi.org/10.1101/2025...
🧵 with pressure control, multiscale buckling, controlled wrinkling
Or maybe quickly deflating those inflated tissues?
New #EpithelialMechanics pre-print: doi.org/10.1101/2025...
🧵 with pressure control, multiscale buckling, controlled wrinkling
Reposted by Marcel Issler
Very happy to share it’s online! If you read the preprint, updates include tracking cells and tissue flow, Histo4i timecourse (69 Abs) comparing spatial patterning emergence and a new WLS KO ipsc line establishing mechanosensing via YAP-WLS/WNT caudalizes organoids www.nature.com/articles/s41...
Morphodynamics of human early brain organoid development - Nature
Human brain morphodynamics are explored using organoids.
www.nature.com
July 1, 2025 at 8:36 PM
Very happy to share it’s online! If you read the preprint, updates include tracking cells and tissue flow, Histo4i timecourse (69 Abs) comparing spatial patterning emergence and a new WLS KO ipsc line establishing mechanosensing via YAP-WLS/WNT caudalizes organoids www.nature.com/articles/s41...
Reposted by Marcel Issler
The 2025 VIB.AI International PhD Call closes June 22nd.
We’re offering 4 fully funded PhD positions across labs tackling big questions in biology with AI and machine learning, covering protein design, computational neuroscience, gene regulation, and more.
👉 https://tinyurl.com/53nc9vnd
We’re offering 4 fully funded PhD positions across labs tackling big questions in biology with AI and machine learning, covering protein design, computational neuroscience, gene regulation, and more.
👉 https://tinyurl.com/53nc9vnd
June 18, 2025 at 9:37 AM
The 2025 VIB.AI International PhD Call closes June 22nd.
We’re offering 4 fully funded PhD positions across labs tackling big questions in biology with AI and machine learning, covering protein design, computational neuroscience, gene regulation, and more.
👉 https://tinyurl.com/53nc9vnd
We’re offering 4 fully funded PhD positions across labs tackling big questions in biology with AI and machine learning, covering protein design, computational neuroscience, gene regulation, and more.
👉 https://tinyurl.com/53nc9vnd
Reposted by Marcel Issler
Unfortunately, we need to cancel the upcoming #GloBIAS seminar. Please check our webpage: www.globias.org/activities/b... for updates/ new date for this session.
June 18, 2025 at 11:14 AM
Unfortunately, we need to cancel the upcoming #GloBIAS seminar. Please check our webpage: www.globias.org/activities/b... for updates/ new date for this session.
Reposted by Marcel Issler
Hey bioimaging folks, join us for the next OME-NGFF Community Call on June 24 at 9:00 CEST and 17:00 CEST!
Details and agenda on the one and only image.sc here: forum.image.sc/t/join-us-fo...
Details and agenda on the one and only image.sc here: forum.image.sc/t/join-us-fo...
June 3, 2025 at 10:17 AM
Hey bioimaging folks, join us for the next OME-NGFF Community Call on June 24 at 9:00 CEST and 17:00 CEST!
Details and agenda on the one and only image.sc here: forum.image.sc/t/join-us-fo...
Details and agenda on the one and only image.sc here: forum.image.sc/t/join-us-fo...
Reposted by Marcel Issler
🧠 Interested in extending #Zarr?
Let us know what you think about ZEP10 "Generic extensions". Current plan is for voting on the proposal mid-June. 📅
github.com/zarr-develop...
Let us know what you think about ZEP10 "Generic extensions". Current plan is for voting on the proposal mid-June. 📅
github.com/zarr-develop...
ZEP10: Generic extensions (v3.2 spec changes) by joshmoore · Pull Request #344 · zarr-developers/zarr-specs
This is the implementation of ZEP10 which introduces a generic extensions object.
☝🏽 👉🏽 Rendered ZEP10 page: https://zeps--67.org.readthedocs.build/en/67/draft/ZEP0010.html
🗓️ Proposed...
github.com
May 16, 2025 at 3:05 PM
🧠 Interested in extending #Zarr?
Let us know what you think about ZEP10 "Generic extensions". Current plan is for voting on the proposal mid-June. 📅
github.com/zarr-develop...
Let us know what you think about ZEP10 "Generic extensions". Current plan is for voting on the proposal mid-June. 📅
github.com/zarr-develop...
Reposted by Marcel Issler
🚨📣 New preprint alert!
Excited to share my new postdoc work on direct force and mechanical properties measurements in live embryos!
A great team effort with A. Chamolly (theory), under the supervision of F. Corson and @jeromegros.bsky.social
📄 www.biorxiv.org/content/10.1...
#devbio #mechanics
Excited to share my new postdoc work on direct force and mechanical properties measurements in live embryos!
A great team effort with A. Chamolly (theory), under the supervision of F. Corson and @jeromegros.bsky.social
📄 www.biorxiv.org/content/10.1...
#devbio #mechanics
Direct measurements of active forces and material properties unveil the active mechanics of early embryogenesis
Despite progress in probing tissue mechanics, direct long-term measurements in live embryonic epithelia are lacking. This limits our understanding of amniote embryonic morphogenesis, which takes place...
www.biorxiv.org
May 12, 2025 at 2:01 PM
🚨📣 New preprint alert!
Excited to share my new postdoc work on direct force and mechanical properties measurements in live embryos!
A great team effort with A. Chamolly (theory), under the supervision of F. Corson and @jeromegros.bsky.social
📄 www.biorxiv.org/content/10.1...
#devbio #mechanics
Excited to share my new postdoc work on direct force and mechanical properties measurements in live embryos!
A great team effort with A. Chamolly (theory), under the supervision of F. Corson and @jeromegros.bsky.social
📄 www.biorxiv.org/content/10.1...
#devbio #mechanics
Reposted by Marcel Issler
Thanks to Hanjin Liu, napari now has a command palette! 🎨 This thing is really nice to use — the core team can no longer live without it — and it even works with plugin commands! 🤩
April 11, 2025 at 10:36 AM
Thanks to Hanjin Liu, napari now has a command palette! 🎨 This thing is really nice to use — the core team can no longer live without it — and it even works with plugin commands! 🤩
Reposted by Marcel Issler
🚀 We’re very excited to share our latest preprint on OME-Zarr! 🚀
Our report on the 2024 OME-NGFF Workflows Hackathon is a deep dive into the status of OME-Zarr and the great work that happened last November at the BioVisionCenter in Zurich.
🔗 Read the preprint: osf.io/preprints/bi...
🧵 (1/15)
Our report on the 2024 OME-NGFF Workflows Hackathon is a deep dive into the status of OME-Zarr and the great work that happened last November at the BioVisionCenter in Zurich.
🔗 Read the preprint: osf.io/preprints/bi...
🧵 (1/15)
OSF
osf.io
March 11, 2025 at 11:59 AM
🚀 We’re very excited to share our latest preprint on OME-Zarr! 🚀
Our report on the 2024 OME-NGFF Workflows Hackathon is a deep dive into the status of OME-Zarr and the great work that happened last November at the BioVisionCenter in Zurich.
🔗 Read the preprint: osf.io/preprints/bi...
🧵 (1/15)
Our report on the 2024 OME-NGFF Workflows Hackathon is a deep dive into the status of OME-Zarr and the great work that happened last November at the BioVisionCenter in Zurich.
🔗 Read the preprint: osf.io/preprints/bi...
🧵 (1/15)
Reposted by Marcel Issler
"Why don't you buy a new centrifuge"
Because everyone knows that any appliances in that shade of yellow will outlive you and your entire family, look at it
Because everyone knows that any appliances in that shade of yellow will outlive you and your entire family, look at it
March 20, 2025 at 6:06 PM
"Why don't you buy a new centrifuge"
Because everyone knows that any appliances in that shade of yellow will outlive you and your entire family, look at it
Because everyone knows that any appliances in that shade of yellow will outlive you and your entire family, look at it
Reposted by Marcel Issler
Fun group retreat in the Austrian alps with @priscaliberali.bsky.social! And perfect time to celebrate our new joint paper (from Shi-Lei Xue & Qiutan Yang) out on how mechanochemical bistability confers robustness to intestinal organoids! www.nature.com/articles/s41... - see 🧵! (1/n)
March 10, 2025 at 11:49 AM
Fun group retreat in the Austrian alps with @priscaliberali.bsky.social! And perfect time to celebrate our new joint paper (from Shi-Lei Xue & Qiutan Yang) out on how mechanochemical bistability confers robustness to intestinal organoids! www.nature.com/articles/s41... - see 🧵! (1/n)
Reposted by Marcel Issler
Excellent talk at today's #VirtualPub by Chiara Stringiari, France BioImaging, exploring the technical possibilities & limitations of #FLIM and providing a fantastic overview of recent applications. Want to try it out? Available in #openaccess via France BioImaging & other EuroBioImaging Nodes!
February 21, 2025 at 1:45 PM
Excellent talk at today's #VirtualPub by Chiara Stringiari, France BioImaging, exploring the technical possibilities & limitations of #FLIM and providing a fantastic overview of recent applications. Want to try it out? Available in #openaccess via France BioImaging & other EuroBioImaging Nodes!