Lung-Yu Liang
@lungyul.bsky.social
Reposted by Lung-Yu Liang
Our first lab paper is out! We identify and solve the first structure of the SND3 translocon involved in fungal membrane protein insertion. Congratulations @tzujingyang.bsky.social, and our colleagues @saumyakm.bsky.social, @hummerlab.bsky.social and Julian Langer. Read more ⬇️ and ➡️ rdcu.be/eNgIO
SNDing proteins into the membrane! Our new publication from @melaniemcdowell.bsky.social ’s group identifies the SND3 protein as a new route for membrane protein insertion! 🍄 📘 Read more here: www.mpg.de/25599408/102... Image: Louise Duever.
October 30, 2025 at 5:42 PM
Our first lab paper is out! We identify and solve the first structure of the SND3 translocon involved in fungal membrane protein insertion. Congratulations @tzujingyang.bsky.social, and our colleagues @saumyakm.bsky.social, @hummerlab.bsky.social and Julian Langer. Read more ⬇️ and ➡️ rdcu.be/eNgIO
Reposted by Lung-Yu Liang
#InflammaZoom free Webinar is back on Monday October 20th! With James Murphy (WEHI, Melbourne, Australia) @pseudokinase.bsky.social and Jonathan Maelfait (VIB-UGent, Ghent, Belgium)
Register now: bit.ly/4iXGqjw
Register now: bit.ly/4iXGqjw
October 17, 2025 at 6:29 AM
#InflammaZoom free Webinar is back on Monday October 20th! With James Murphy (WEHI, Melbourne, Australia) @pseudokinase.bsky.social and Jonathan Maelfait (VIB-UGent, Ghent, Belgium)
Register now: bit.ly/4iXGqjw
Register now: bit.ly/4iXGqjw
Reposted by Lung-Yu Liang
We are looking for motivated #postdocs to join the lab! Biochemistry/microbiology/cryo-EM experience? Excited by #cryo-EM/ET, #chromatin? ❄️🧬🧫
Interdisciplinary projects, top EMBL facilities!
Email CV + short cover letter → svetlana.dodonova@embl.de
Info about the group: www.embl.org/groups/dodon...
Interdisciplinary projects, top EMBL facilities!
Email CV + short cover letter → svetlana.dodonova@embl.de
Info about the group: www.embl.org/groups/dodon...
Dodonova Group – Organisational principles and 3D architecture of archaeal chromatin
www.embl.org
October 15, 2025 at 10:38 AM
We are looking for motivated #postdocs to join the lab! Biochemistry/microbiology/cryo-EM experience? Excited by #cryo-EM/ET, #chromatin? ❄️🧬🧫
Interdisciplinary projects, top EMBL facilities!
Email CV + short cover letter → svetlana.dodonova@embl.de
Info about the group: www.embl.org/groups/dodon...
Interdisciplinary projects, top EMBL facilities!
Email CV + short cover letter → svetlana.dodonova@embl.de
Info about the group: www.embl.org/groups/dodon...
Reposted by Lung-Yu Liang
Fantastic new work from our researchers!
Check out their work on 🐯 cryoTIGER for cryoET 🐯
Check out their work on 🐯 cryoTIGER for cryoET 🐯
❓What if you could peek between your tilt series ❓ We are proud to introduce cryoTIGER -- deep-learning based tilt interpolation for enhanced reconstruction in cryo-ET. A great collaboration between Turoňová lab, @becklab.bsky.social, @hummerlab.bsky.social #teamtomo www.nature.com/articles/s42...
cryoTIGER: deep-learning based tilt interpolation generator for enhanced reconstruction in cryo electron tomography - Communications Biology
Deep learning-based interpolation using cryoTIGER enhances angular sampling in cryoET, improving 3D reconstructions, particle localization, and structural recovery without increasing electron dose.
www.nature.com
October 10, 2025 at 11:38 AM
Fantastic new work from our researchers!
Check out their work on 🐯 cryoTIGER for cryoET 🐯
Check out their work on 🐯 cryoTIGER for cryoET 🐯
Reposted by Lung-Yu Liang
We recently discovered a brand-new (and unique!) anti-phage defense system in bacteria. Check out this Pursuit article from @Melbourne University featuring our recent work. Terrific effort from our PhD student Somavally!
lnkd.in/geXUApmK
lnkd.in/geXUApmK
September 10, 2025 at 2:23 PM
We recently discovered a brand-new (and unique!) anti-phage defense system in bacteria. Check out this Pursuit article from @Melbourne University featuring our recent work. Terrific effort from our PhD student Somavally!
lnkd.in/geXUApmK
lnkd.in/geXUApmK
This is promised to be a great course!
We’re hosting the @embo.org Practical Course on In-situ structural biology by CryoFIB and CryoET in April 2026! 🧬❄️ You can expect hands-on training, cutting-edge methods, and a chance to work alongside leading experts in structural biology. 🔗 Apply by Dec 8, 2025: meetings.embo.org/event/26-in-...
August 20, 2025 at 6:19 PM
This is promised to be a great course!
Reposted by Lung-Yu Liang
Cryo-EM of fertilisation complex Pfs230-Pfs48/45 from malaria parasites! 💕💗
🦟 Transgenic parasites without Pfs230 D13D14 do not transmit
🦙 💉Nanobodies + mRNA induced antibodies reduce transmission
New in @Science.org
www.science.org/doi/10.1126/...
#ScienceResearch #Malaria #WEHI
🦟 Transgenic parasites without Pfs230 D13D14 do not transmit
🦙 💉Nanobodies + mRNA induced antibodies reduce transmission
New in @Science.org
www.science.org/doi/10.1126/...
#ScienceResearch #Malaria #WEHI
August 1, 2025 at 12:58 AM
Cryo-EM of fertilisation complex Pfs230-Pfs48/45 from malaria parasites! 💕💗
🦟 Transgenic parasites without Pfs230 D13D14 do not transmit
🦙 💉Nanobodies + mRNA induced antibodies reduce transmission
New in @Science.org
www.science.org/doi/10.1126/...
#ScienceResearch #Malaria #WEHI
🦟 Transgenic parasites without Pfs230 D13D14 do not transmit
🦙 💉Nanobodies + mRNA induced antibodies reduce transmission
New in @Science.org
www.science.org/doi/10.1126/...
#ScienceResearch #Malaria #WEHI
Reposted by Lung-Yu Liang
AI for Cryo-ET 🌟 Our new paper presents a deep-learning framework that cleans up faulty tilt series in a more automated, precise and powerful way! 💪 Read more here: www.sciencedirect.com/science/arti...
Automated removal of corrupted tilts in cryo-electron tomography
Cryo-electron tomography (cryo-ET) enables the visualization of macromolecular structures in their near-native cellular environment. However, acquired…
www.sciencedirect.com
July 25, 2025 at 10:14 AM
AI for Cryo-ET 🌟 Our new paper presents a deep-learning framework that cleans up faulty tilt series in a more automated, precise and powerful way! 💪 Read more here: www.sciencedirect.com/science/arti...
Reposted by Lung-Yu Liang
In their new study, Beata Turoňová and Tomáš Majtner trained 13 neural networks to automatically detect and remove those corrupted frames, speeding up processing and saving time for tomographers 🥳
July 25, 2025 at 10:14 AM
In their new study, Beata Turoňová and Tomáš Majtner trained 13 neural networks to automatically detect and remove those corrupted frames, speeding up processing and saving time for tomographers 🥳
Reposted by Lung-Yu Liang
New from my colleagues Markus Schreiber & Beata Turoňová: TANGO, an #opensource tool for more holistic spatial analysis of cryo-ET particles. It can clean or cluster particles, analyze lattices, and identify patterns. #TeamTomo
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Twist and Scout: Analysis and Curation of Particles in Cryo-Electron Tomography Using TANGO
Cryo-electron tomography (cryo-ET) enables the visualization of cellular structures in near-native environments, but its potential for spatial analysis has been underutilized due to a lack of versatil...
www.biorxiv.org
July 23, 2025 at 8:14 AM
New from my colleagues Markus Schreiber & Beata Turoňová: TANGO, an #opensource tool for more holistic spatial analysis of cryo-ET particles. It can clean or cluster particles, analyze lattices, and identify patterns. #TeamTomo
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Lung-Yu Liang
Proud to share our first lab pre-print: “SND3 is the membrane insertase within a fungal multipass translocon” where @tzujingyang.bsky.social solved the structure of a ribosome-associated SND3-translocon complex involved in ER membrane protein insertion ➡️ doi.org/10.1101/2025...
July 12, 2025 at 12:49 AM
Proud to share our first lab pre-print: “SND3 is the membrane insertase within a fungal multipass translocon” where @tzujingyang.bsky.social solved the structure of a ribosome-associated SND3-translocon complex involved in ER membrane protein insertion ➡️ doi.org/10.1101/2025...
Reposted by Lung-Yu Liang
This is Ana’s third ERC grant! We’re proud to celebrate her success and groundbreaking work here at the Max Planck Institute of Biophysics. #ERCAdG Read more here 🔗 www.biophys.mpg.de/2872321/garcia-saez-awarded-erc-grant
Ana García-Sáez Awarded Prestigious ERC Grant
www.biophys.mpg.de
June 17, 2025 at 12:17 PM
This is Ana’s third ERC grant! We’re proud to celebrate her success and groundbreaking work here at the Max Planck Institute of Biophysics. #ERCAdG Read more here 🔗 www.biophys.mpg.de/2872321/garcia-saez-awarded-erc-grant
Reposted by Lung-Yu Liang
(1/3) Together with the labs of Valerie Doye @vdoye.bsky.social and Hans-Georg-Kräusslich, we analyzed NPC structure in Nup133 null mESCs. We found heterogenous NPCs featuring non-canonical symmetries and missing subunits. Now online @naturecellbiology.bsky.social.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
April 11, 2025 at 1:26 PM
(1/3) Together with the labs of Valerie Doye @vdoye.bsky.social and Hans-Georg-Kräusslich, we analyzed NPC structure in Nup133 null mESCs. We found heterogenous NPCs featuring non-canonical symmetries and missing subunits. Now online @naturecellbiology.bsky.social.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Lung-Yu Liang
New preprint on 3D heterochromatin architecture in human cells! Great collab with @sergiocruzleon.bsky.social & @johannesbetz.bsky.social from @hummerlab.bsky.social, @marinalusic.bsky.social & the Turoňová lab. Many thanks to my supervisor @becklab.bsky.social. bioRxiv: tinyurl.com/3a74uanv 🧵👇
April 11, 2025 at 9:04 AM
New preprint on 3D heterochromatin architecture in human cells! Great collab with @sergiocruzleon.bsky.social & @johannesbetz.bsky.social from @hummerlab.bsky.social, @marinalusic.bsky.social & the Turoňová lab. Many thanks to my supervisor @becklab.bsky.social. bioRxiv: tinyurl.com/3a74uanv 🧵👇
Reposted by Lung-Yu Liang
Delighted to share our recent work in Nat Comms. This is a "Story of a dwarf predator"
www.nature.com/articles/s41...
www.nature.com/articles/s41...
March 29, 2025 at 1:26 PM
Delighted to share our recent work in Nat Comms. This is a "Story of a dwarf predator"
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Lung-Yu Liang
In situ evidence for systematic membrane thickness variation across cellular organelles https://www.biorxiv.org/content/10.1101/2025.03.13.642912v1
March 14, 2025 at 6:47 AM
In situ evidence for systematic membrane thickness variation across cellular organelles https://www.biorxiv.org/content/10.1101/2025.03.13.642912v1
Reposted by Lung-Yu Liang
Automated Removal of Corrupted Tilts in Cryo-Electron Tomography https://www.biorxiv.org/content/10.1101/2025.03.13.642992v1
March 15, 2025 at 7:17 AM
Automated Removal of Corrupted Tilts in Cryo-Electron Tomography https://www.biorxiv.org/content/10.1101/2025.03.13.642992v1
Congrats Natalia!
Excited to share that I have received a Marie Skłodowska-Curie Actions Postdoctoral Fellowship for my project SynLncRNAs! Looking forward to uncovering mechanisms of gene regulation by lncRNAs in vivo using synthetic biology in the Mundlos Lab @molgen.mpg.de 🧬
The 2024 Marie Skłodowska-Curie Actions Postdoctoral Fellowship call results are in.
With a budget of €417 million, we are funding nearly 1,700 researchers from 🇪🇺 and beyond.
They will strengthen EU research in key areas such as social inclusion, AI, and cancer research ↓
europa.eu/!BmWRkh
With a budget of €417 million, we are funding nearly 1,700 researchers from 🇪🇺 and beyond.
They will strengthen EU research in key areas such as social inclusion, AI, and cancer research ↓
europa.eu/!BmWRkh
February 17, 2025 at 7:56 AM
Congrats Natalia!
Reposted by Lung-Yu Liang
Great to see this out in print. Not only a nice review from Hanadi Hoblos but also a beautiful artwork of RHIMs by Hanadi on the cover
❄️♥️Our February issue is online♥️❄️
On the cover - how posttranslational modifications and intermolecular interactions of protein kinases allosterically regulate necrosome activation from @pseudokinase.bsky.social and colleagues.
Find this and the rest of the issue 👉 www.cell.com/trends/bioch...
On the cover - how posttranslational modifications and intermolecular interactions of protein kinases allosterically regulate necrosome activation from @pseudokinase.bsky.social and colleagues.
Find this and the rest of the issue 👉 www.cell.com/trends/bioch...
February 6, 2025 at 8:03 PM
Great to see this out in print. Not only a nice review from Hanadi Hoblos but also a beautiful artwork of RHIMs by Hanadi on the cover
Reposted by Lung-Yu Liang
Congrats, Max! And big thanks and congratulations to our coauthors at MPI for Marine Microbiology, Bremen, MPI-CBG in Dresden, and in-house at the MPI of Biophysics! It's been great working with you all! @mpimarinemicrobio.bsky.social, @mpicbg.bsky.social sky.social, @hummerlab.bsky.social
Exciting green news! 🦠 Do you know how certain microorganisms make a living by transforming CO2 into useful molecules? Check out our new work on the molecular choreography behind acetyl-CoA synthesis in the CODH/ACS protein complex. 👩🔬 🔗 www.biophys.mpg.de/2844976/micr...
January 31, 2025 at 4:18 PM
Congrats, Max! And big thanks and congratulations to our coauthors at MPI for Marine Microbiology, Bremen, MPI-CBG in Dresden, and in-house at the MPI of Biophysics! It's been great working with you all! @mpimarinemicrobio.bsky.social, @mpicbg.bsky.social sky.social, @hummerlab.bsky.social
Reposted by Lung-Yu Liang
So happy that my main PhD project on HIV-1 nuclear entry is now out in Cell. I want to especially thank my supervisor Martin @becklab.bsky.social and our amazing collaborators @maziarheidari.bsky.social from @hummerlab.bsky.social, Vojtech Zila from the Kräusslich lab and many others.
In a great collaboration with @hummerlab.bsky.social and the Kräusslich lab: HIV capsid doesn't break at the NPC; instead, it cracks open the NPC itself! Details in Cell: authors.elsevier.com/sd/article/S... @mpibp.bsky.social @uniheidelberg.bsky.social A thread below:
January 17, 2025 at 6:53 PM
So happy that my main PhD project on HIV-1 nuclear entry is now out in Cell. I want to especially thank my supervisor Martin @becklab.bsky.social and our amazing collaborators @maziarheidari.bsky.social from @hummerlab.bsky.social, Vojtech Zila from the Kräusslich lab and many others.