Lucas Bouys
@lucasbouys.bsky.social
MD in Endocrinology | PhD in Genetics | Chain Florey TTI Fellow @mrc-lms.bsky.social @imperialcollegeldn.bsky.social | Dad, husband 🫶| Sunday cyclist |
Pinned
Lucas Bouys
@lucasbouys.bsky.social
· Feb 21
Validate User
doi.org
1/2 In late 2021 we identified KDM1A germline mutations as the genetic cause of hereditary Primary Bilateral Macronodular Adrenal Hyperplasia with food(GIP)-dependent #Cushing’s syndrome (FDCS) 🍔🍟 3 years later, we report its extensive screening in 301 index cases in @eurojendo.bsky.social 🧬
Reposted by Lucas Bouys
Unexpected discrepancies between steroid intra-tissular content in adrenal tumors and clinical diagnosis of steroid excess by Fidéline Bonnet-Serrano et al
EJE Volume 193, Issue 1, July 2025
Full article 👉 doi.org/10.1093/ejen...
ESE members free via 👉 my.ese-hormones.org
EJE Volume 193, Issue 1, July 2025
Full article 👉 doi.org/10.1093/ejen...
ESE members free via 👉 my.ese-hormones.org
September 9, 2025 at 11:37 AM
Unexpected discrepancies between steroid intra-tissular content in adrenal tumors and clinical diagnosis of steroid excess by Fidéline Bonnet-Serrano et al
EJE Volume 193, Issue 1, July 2025
Full article 👉 doi.org/10.1093/ejen...
ESE members free via 👉 my.ese-hormones.org
EJE Volume 193, Issue 1, July 2025
Full article 👉 doi.org/10.1093/ejen...
ESE members free via 👉 my.ese-hormones.org
Reposted by Lucas Bouys
An article in the BMJ just highlighted the free fall in clinician scientist numbers www.bmj.com/content/390/... - a catastrophe in waiting for health! At the @mrc-lms.bsky.social we support next gen clinician scientists in discovery research and experimental medicine
lms.mrc.ac.uk/work-and-stu...
lms.mrc.ac.uk/work-and-stu...
Chain Florey Clinician Scientist Programme
The Chain Florey programmes allow clinicians at all stages of their careers to experience research and flourish in a dual career.
lms.mrc.ac.uk
September 3, 2025 at 11:59 AM
An article in the BMJ just highlighted the free fall in clinician scientist numbers www.bmj.com/content/390/... - a catastrophe in waiting for health! At the @mrc-lms.bsky.social we support next gen clinician scientists in discovery research and experimental medicine
lms.mrc.ac.uk/work-and-stu...
lms.mrc.ac.uk/work-and-stu...
Reposted by Lucas Bouys
🚀 Exciting Research Assistant opportunity!
Join Dr Melanie Chan’s team at the LMS as a Research Assistant to uncover the genetics of kidney disease using cutting-edge genomics and bioinformatics!
Apply here 👇
Join Dr Melanie Chan’s team at the LMS as a Research Assistant to uncover the genetics of kidney disease using cutting-edge genomics and bioinformatics!
Apply here 👇
Research Assistant - MRC Laboratory of Medical Sciences
Research Assistant to support Dr Melanie Chan
lms.mrc.ac.uk
August 21, 2025 at 9:11 AM
🚀 Exciting Research Assistant opportunity!
Join Dr Melanie Chan’s team at the LMS as a Research Assistant to uncover the genetics of kidney disease using cutting-edge genomics and bioinformatics!
Apply here 👇
Join Dr Melanie Chan’s team at the LMS as a Research Assistant to uncover the genetics of kidney disease using cutting-edge genomics and bioinformatics!
Apply here 👇
Reposted by Lucas Bouys
Le 41ème Congrès de la @sfendocrino.bsky.social à Lille, c’est dans 50 jours 📆 ! Les inscriptions restent ouvertes !
Et rejoignez nous pour la Soirée des Jeunes de la SFE du mercredi 24/09 pour passer un moment convivial et fun : on vous attend nombreux 😇 ! Des surprises et cadeaux sont prévus 😎 !
Et rejoignez nous pour la Soirée des Jeunes de la SFE du mercredi 24/09 pour passer un moment convivial et fun : on vous attend nombreux 😇 ! Des surprises et cadeaux sont prévus 😎 !
August 5, 2025 at 9:30 AM
Le 41ème Congrès de la @sfendocrino.bsky.social à Lille, c’est dans 50 jours 📆 ! Les inscriptions restent ouvertes !
Et rejoignez nous pour la Soirée des Jeunes de la SFE du mercredi 24/09 pour passer un moment convivial et fun : on vous attend nombreux 😇 ! Des surprises et cadeaux sont prévus 😎 !
Et rejoignez nous pour la Soirée des Jeunes de la SFE du mercredi 24/09 pour passer un moment convivial et fun : on vous attend nombreux 😇 ! Des surprises et cadeaux sont prévus 😎 !
Reposted by Lucas Bouys
Application deadline for up to 5 @mrc-lms.bsky.social postdoc positions in developmental epigenetics closes soon - don’t miss out! Positions across both experimental and computational projects. Come and join our fantastic team science community!
Interested in developmental epigenetics? So are we! Apply now to join us for your postdoc!
Multiple positions across multiple groups @mrc-lms.bsky.social
Projects spanning germline demethylation, gene regulation, genome architecture in development & disease 👇👇
lms.mrc.ac.uk/work/vacanci...
Multiple positions across multiple groups @mrc-lms.bsky.social
Projects spanning germline demethylation, gene regulation, genome architecture in development & disease 👇👇
lms.mrc.ac.uk/work/vacanci...
MRC Postdoctoral Research Scientists x 5 - MRC Laboratory of Medical Sciences
Applications are now open for up to five postdoctoral positions in the area of developmental epigenetics.
lms.mrc.ac.uk
August 1, 2025 at 9:47 AM
Application deadline for up to 5 @mrc-lms.bsky.social postdoc positions in developmental epigenetics closes soon - don’t miss out! Positions across both experimental and computational projects. Come and join our fantastic team science community!
Reposted by Lucas Bouys
Interested in developmental epigenetics? So are we! Apply now to join us for your postdoc!
Multiple positions across multiple groups @mrc-lms.bsky.social
Projects spanning germline demethylation, gene regulation, genome architecture in development & disease 👇👇
lms.mrc.ac.uk/work/vacanci...
Multiple positions across multiple groups @mrc-lms.bsky.social
Projects spanning germline demethylation, gene regulation, genome architecture in development & disease 👇👇
lms.mrc.ac.uk/work/vacanci...
MRC Postdoctoral Research Scientists x 5 - MRC Laboratory of Medical Sciences
Applications are now open for up to five postdoctoral positions in the area of developmental epigenetics.
lms.mrc.ac.uk
July 14, 2025 at 5:15 PM
Interested in developmental epigenetics? So are we! Apply now to join us for your postdoc!
Multiple positions across multiple groups @mrc-lms.bsky.social
Projects spanning germline demethylation, gene regulation, genome architecture in development & disease 👇👇
lms.mrc.ac.uk/work/vacanci...
Multiple positions across multiple groups @mrc-lms.bsky.social
Projects spanning germline demethylation, gene regulation, genome architecture in development & disease 👇👇
lms.mrc.ac.uk/work/vacanci...
Reposted by Lucas Bouys
We’re excited to welcome tesscacciottolo.bsky.social and lucasbouys.bsky.social to our Chain Florey Clinician Scientist Programme at the LMS!
This programme offers world-class training to clinicians to develop essential research skills at key stages of their careers.
This programme offers world-class training to clinicians to develop essential research skills at key stages of their careers.
Introducing: Dr Tessa Cacciottolo and Dr Lucas Bouys
We’re excited to welcome Dr Tessa Cacciottolo and Dr Lucas Bouys to the MRC Laboratory of Medical Sciences (LMS) as part of the Chain Florey Clinician Scientist Programme. Both are part of the Transit...
lms.mrc.ac.uk
May 22, 2025 at 9:37 AM
We’re excited to welcome tesscacciottolo.bsky.social and lucasbouys.bsky.social to our Chain Florey Clinician Scientist Programme at the LMS!
This programme offers world-class training to clinicians to develop essential research skills at key stages of their careers.
This programme offers world-class training to clinicians to develop essential research skills at key stages of their careers.
Reposted by Lucas Bouys
Day 2 at joint esendocrinology.bsky.social and #ESPE #ECE2025 in #Copenhagen #becausehormonesmatter #connectingendocrinology #EndocrinologyAcrossTheLifeCourse #MedSky #EndoSky
May 12, 2025 at 3:03 AM
Reposted by Lucas Bouys
Mild autonomous cortisol secretion (MACS) associated with #unilateral #adrenal #incidentalomas is responsible for secondary #hypertension that can be safely improved by minimally-invasive #adrenalectomy www.thelancet.com/journals/lan...
#MedSky #EndoSky #OncSky #CardioSky
#MedSky #EndoSky #OncSky #CardioSky
Surgery for the treatment of arterial hypertension in patients with unilateral adrenal incidentalomas and mild autonomous cortisol secretion (CHIRACIC): a multicentre, open-label, superiority randomis...
MACS associated with unilateral adrenal incidentalomas is responsible for secondary
hypertension that can be safely improved by minimally-invasive adrenalectomy.
www.thelancet.com
May 12, 2025 at 10:43 PM
Mild autonomous cortisol secretion (MACS) associated with #unilateral #adrenal #incidentalomas is responsible for secondary #hypertension that can be safely improved by minimally-invasive #adrenalectomy www.thelancet.com/journals/lan...
#MedSky #EndoSky #OncSky #CardioSky
#MedSky #EndoSky #OncSky #CardioSky
Amazing #ChainFlorey Retreat Day! happy to be part of this exciting community of young #clinicianscientists
Great day with the amazing early career #clinicianscientists of the @mrc-lms.bsky.social #ChainFlorey cohort doing discovery science & experimental medicine - join us! lms.mrc.ac.uk/work-and-stu...
March 14, 2025 at 7:00 PM
Amazing #ChainFlorey Retreat Day! happy to be part of this exciting community of young #clinicianscientists
Reposted by Lucas Bouys
ICYMI: New content online: Adrenocortical stem cells in health and disease
Adrenocortical stem cells in health and disease
Nature Reviews Endocrinology, Published online: 10 March 2025; doi:10.1038/s41574-025-01091-2This Review outlines the mechanisms that regulate the establishment and maintenance of the adrenal stem cell niche — comprising capsular stem cells and cortical…
www.nature.com
March 12, 2025 at 9:01 PM
ICYMI: New content online: Adrenocortical stem cells in health and disease
Reposted by Lucas Bouys
New Review by Martin Fassnacht & colleagues:
Adrenocortical carcinoma: a practical guide for clinicians thelancet.com/journals/lan...
#adrenocortical #carcinoma #adrenal
#OpenAccess
#MedSky #EndoSky #OncSky
Adrenocortical carcinoma: a practical guide for clinicians thelancet.com/journals/lan...
#adrenocortical #carcinoma #adrenal
#OpenAccess
#MedSky #EndoSky #OncSky
Adrenocortical carcinoma: a practical guide for clinicians
Adrenocortical carcinoma is a rare endocrine malignancy. The management of patients
with adrenocortical carcinoma is challenging for several reasons, including its heterogeneous
but frequently aggress...
thelancet.com
March 12, 2025 at 7:07 AM
New Review by Martin Fassnacht & colleagues:
Adrenocortical carcinoma: a practical guide for clinicians thelancet.com/journals/lan...
#adrenocortical #carcinoma #adrenal
#OpenAccess
#MedSky #EndoSky #OncSky
Adrenocortical carcinoma: a practical guide for clinicians thelancet.com/journals/lan...
#adrenocortical #carcinoma #adrenal
#OpenAccess
#MedSky #EndoSky #OncSky
Reposted by Lucas Bouys
This morning, @sncf-voyageurs.bsky.social and @alstom.bsky.social finally unveiled the brand-new #TGVM to the public!
Let’s take a look inside the latest generation of high-speed trains 🚄🇫🇷
A thread 👇
Let’s take a look inside the latest generation of high-speed trains 🚄🇫🇷
A thread 👇
March 11, 2025 at 6:38 PM
This morning, @sncf-voyageurs.bsky.social and @alstom.bsky.social finally unveiled the brand-new #TGVM to the public!
Let’s take a look inside the latest generation of high-speed trains 🚄🇫🇷
A thread 👇
Let’s take a look inside the latest generation of high-speed trains 🚄🇫🇷
A thread 👇
Reposted by Lucas Bouys
Late breaking abstract submission for the Joint Congress of ESPE and ESE 2025 opens today 10 March!
Share new data, exciting breakthroughs or innovations before the deadline 21 March 2025.
Submit your abstract now👉 bit.ly/3PXTqcB
Share new data, exciting breakthroughs or innovations before the deadline 21 March 2025.
Submit your abstract now👉 bit.ly/3PXTqcB
March 10, 2025 at 10:31 AM
Late breaking abstract submission for the Joint Congress of ESPE and ESE 2025 opens today 10 March!
Share new data, exciting breakthroughs or innovations before the deadline 21 March 2025.
Submit your abstract now👉 bit.ly/3PXTqcB
Share new data, exciting breakthroughs or innovations before the deadline 21 March 2025.
Submit your abstract now👉 bit.ly/3PXTqcB
Crucial findings, a must read for all those interested in tumour suppressor genes 🧬 Simple but impactful 👊
Released this week in Nature Genetics @naturegenet.bsky.social
rdcu.be/ebIiO
Released this week in Nature Genetics @naturegenet.bsky.social
rdcu.be/ebIiO
Cancer-independent somatic mutation of the wild-type NF1 allele in normal tissues in neurofibromatosis type 1
Nature Genetics - Histologically normal tissues of individuals with a germline NF1 mutation exhibited multiple second NF1 hits, unrelated to their tumors, that conferred a selective advantage.
rdcu.be
February 28, 2025 at 5:08 PM
Crucial findings, a must read for all those interested in tumour suppressor genes 🧬 Simple but impactful 👊
Released this week in Nature Genetics @naturegenet.bsky.social
rdcu.be/ebIiO
Released this week in Nature Genetics @naturegenet.bsky.social
rdcu.be/ebIiO
Reposted by Lucas Bouys
Today is #RareDiseaseDay!
There are more than 400 rare diseases related to the endocrine system, which affect more than 30 million Europeans.
Find out more👉 rarediseaseday.org
#BecauseHormonesMatter
There are more than 400 rare diseases related to the endocrine system, which affect more than 30 million Europeans.
Find out more👉 rarediseaseday.org
#BecauseHormonesMatter
February 28, 2025 at 11:18 AM
Today is #RareDiseaseDay!
There are more than 400 rare diseases related to the endocrine system, which affect more than 30 million Europeans.
Find out more👉 rarediseaseday.org
#BecauseHormonesMatter
There are more than 400 rare diseases related to the endocrine system, which affect more than 30 million Europeans.
Find out more👉 rarediseaseday.org
#BecauseHormonesMatter
Reposted by Lucas Bouys
Glad to see this study in 4th-year Med Stud at @upcite.bsky.social : gender-equitable self-perceptions (opposing women underestimating their abilities by the past). Happy to have contributed as a one of the 130 included evaluators to this experiment 😀
bmcmededuc.biomedcentral.com/articles/10....
bmcmededuc.biomedcentral.com/articles/10....
Impact of gender on self-assessment accuracy among fourth-year French medical students on faculty’s online Objective Structured Clinical Examinations - BMC Medical Education
Background Historically, women have been shown to underestimate their abilities, while men often assess themselves more accurately or overestimate. This study aims to determine self-assessment accurac...
bmcmededuc.biomedcentral.com
February 27, 2025 at 8:54 AM
Glad to see this study in 4th-year Med Stud at @upcite.bsky.social : gender-equitable self-perceptions (opposing women underestimating their abilities by the past). Happy to have contributed as a one of the 130 included evaluators to this experiment 😀
bmcmededuc.biomedcentral.com/articles/10....
bmcmededuc.biomedcentral.com/articles/10....
1/2 In late 2021 we identified KDM1A germline mutations as the genetic cause of hereditary Primary Bilateral Macronodular Adrenal Hyperplasia with food(GIP)-dependent #Cushing’s syndrome (FDCS) 🍔🍟 3 years later, we report its extensive screening in 301 index cases in @eurojendo.bsky.social 🧬
Validate User
doi.org
February 21, 2025 at 11:46 AM
1/2 In late 2021 we identified KDM1A germline mutations as the genetic cause of hereditary Primary Bilateral Macronodular Adrenal Hyperplasia with food(GIP)-dependent #Cushing’s syndrome (FDCS) 🍔🍟 3 years later, we report its extensive screening in 301 index cases in @eurojendo.bsky.social 🧬
Reposted by Lucas Bouys
Calling clinician scientists with focus on mechanistic discovery science and experimental medicine who recently have completed or are about to complete their clinical training - great opportunity! Please re-skeet and apply to @mrc-lms.bsky.social by 4th March 2025 lms.mrc.ac.uk/work/vacanci...
Chain Florey Post CCT Transition to Independence Fellowship - MRC Laboratory of Medical Sciences
The Chain Florey Transition-to-Independence (TTI) Fellowship scheme provides a unique opportunity to clinician scientists who have recently completed their clinical training (or will do so in the next...
lms.mrc.ac.uk
February 19, 2025 at 7:31 AM
Calling clinician scientists with focus on mechanistic discovery science and experimental medicine who recently have completed or are about to complete their clinical training - great opportunity! Please re-skeet and apply to @mrc-lms.bsky.social by 4th March 2025 lms.mrc.ac.uk/work/vacanci...
The recipe for your perfect morning eggs 🥚 ⚠️ 10 pages/32 mn/2 alternating cooking temperatures/8 cycles: looks like a very simplified PCR but still for well-organised cooks only 🧑🍳 let’s hope that will work with other eggs than those from Naples 🤓
A paper in Communications Engineering presents a new method to optimally cook both the yolk and white of a boiled chicken egg. "Periodic cooking” yields an evenly-cooked egg with a higher nutritional content than shell-on eggs cooked by conventional methods. https://go.nature.com/4hJWNzU 🧪
February 12, 2025 at 8:50 PM
The recipe for your perfect morning eggs 🥚 ⚠️ 10 pages/32 mn/2 alternating cooking temperatures/8 cycles: looks like a very simplified PCR but still for well-organised cooks only 🧑🍳 let’s hope that will work with other eggs than those from Naples 🤓
Looking for your next move as a clinician-scientist? 3 positions of Transition to Independence Fellow for 3 years in @mrc-lms.bsky.social @imperialcollegeldn.bsky.social 80% protected research time + 20% clinics in an amazing scientific environment in London 👩🏻⚕️👨🏻⚕️👩🏻🔬👨🏻🔬 🧫🔬deadline 4th March! DM me for info
Description
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
www.imperial.ac.uk
February 12, 2025 at 12:39 PM
Looking for your next move as a clinician-scientist? 3 positions of Transition to Independence Fellow for 3 years in @mrc-lms.bsky.social @imperialcollegeldn.bsky.social 80% protected research time + 20% clinics in an amazing scientific environment in London 👩🏻⚕️👨🏻⚕️👩🏻🔬👨🏻🔬 🧫🔬deadline 4th March! DM me for info
Reposted by Lucas Bouys
❤️Three year fully-funded post-CCT fellowship in Cardiac imaging / AI at @mrc-lms.bsky.social and @imperialcollegeldn.bsky.social. The Chain Florey Transition to Independence scheme offers a unique opportunity for early career clinicians. Closes 2nd March! www.imperial.ac.uk/jobs/search-...
February 11, 2025 at 8:21 AM
❤️Three year fully-funded post-CCT fellowship in Cardiac imaging / AI at @mrc-lms.bsky.social and @imperialcollegeldn.bsky.social. The Chain Florey Transition to Independence scheme offers a unique opportunity for early career clinicians. Closes 2nd March! www.imperial.ac.uk/jobs/search-...
Out today in Orphanet Journal of Rare Diseases: 12 years of ARMC5 history + practical tools for clinicians and geneticists for ARMC5 variant interpretation in macronodular adrenal hyperplasia, based on the literature and our experience of this beloved yet naughty gene 🧬 #adrenal #cushing #genetics
The mutational landscape of ARMC5 in Primary Bilateral Macronodular Adrenal Hyperplasia: an update - Orphanet Journal of Rare Diseases
Background Primary Bilateral Macronodular Adrenal Hyperplasia (PBMAH) is a rare cause of Cushing’s syndrome due to bilateral adrenocortical macronodules. Germline inactivating variants of the tumor su...
ojrd.biomedcentral.com
February 5, 2025 at 12:14 PM
Reposted by Lucas Bouys
Superbes conférences « surrénales » des Dr Violon & Jouinot de @institutcochin.bsky.social et du Pr Lefebvre de @univrouen.bsky.social variants génétiques , BMAD & MACS : changement de terminologie : progrès médical ou mode ? Aux Rencontres Nationales d’Endocrinologie @hopitalcochin.bsky.social
January 31, 2025 at 11:10 AM
Superbes conférences « surrénales » des Dr Violon & Jouinot de @institutcochin.bsky.social et du Pr Lefebvre de @univrouen.bsky.social variants génétiques , BMAD & MACS : changement de terminologie : progrès médical ou mode ? Aux Rencontres Nationales d’Endocrinologie @hopitalcochin.bsky.social
Reposted by Lucas Bouys
Wanting to connect with busy senior scientists, this #PhD student took a risk and invited them to lunch.
Read their story in this week's #ScienceWorkingLife: https://scim.ag/3EakRh3
Read their story in this week's #ScienceWorkingLife: https://scim.ag/3EakRh3
January 27, 2025 at 7:29 PM
Wanting to connect with busy senior scientists, this #PhD student took a risk and invited them to lunch.
Read their story in this week's #ScienceWorkingLife: https://scim.ag/3EakRh3
Read their story in this week's #ScienceWorkingLife: https://scim.ag/3EakRh3