Lindsay Guzman
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lindsayguzman.bsky.social
Lindsay Guzman
@lindsayguzman.bsky.social
Chemical biology post-doc at Stanford University in the Bertozzi lab
Reposted by Lindsay Guzman
For those who perform thermal proteome profiling (TPP) experiments, you might find this new data analysis approach (and open source Python software) useful. Developed by postdoc @jfhevler.bsky.social 🙏

arxiv.org/abs/2508.096...
Thermal Tracks: A Gaussian process-based framework for universal melting curve analysis enabling unconstrained hit identification in thermal proteome profiling experiments
Thermal Tracks is a Python-based statistical framework for analyzing protein thermal stability data that overcomes key limitations of existing thermal proteome profiling (TPP) work-flows. Unlike stand...
arxiv.org
October 24, 2025 at 10:18 PM
Reposted by Lindsay Guzman
Article by @cenmag.bsky.social on the #BethesdaDeclaration by NIH scientists and staff released earlier this morning:

cen.acs.org/policy/resea...
NIH staff break ranks in open letter to Director Jay Bhattacharya
Bethesda Declaration urges reversal of recent policies, including funding cuts
cen.acs.org
June 9, 2025 at 7:01 PM
Reposted by Lindsay Guzman
Good tutorial on how measles infections work, fortunately all of this is avoidable.

www.nytimes.com/interactive/...
How Measles Attacks an Unvaccinated Child
With falling vaccination rates and outbreaks that have caused more than 580 U.S. cases and at least two deaths, health experts expect hundreds or even thousands more to be infected in the coming month...
www.nytimes.com
April 6, 2025 at 7:28 PM
Reposted by Lindsay Guzman
We are seeking to hire a lab tech, this is an HHMI funded position, please share the job posting:

hhmi.wd1.myworkdayjobs.com/en-US/Extern...
Lab Administration Research Technician- Bertozzi Lab
Primary Work Address: Beckman Center, Stanford, CA, 94305-5323 Current HHMI Employees, click here to apply via your Workday account. We are currently looking for a highly motivated Lab Administration ...
hhmi.wd1.myworkdayjobs.com
March 27, 2025 at 1:51 AM
Reposted by Lindsay Guzman
A friend drove two hours today for her breast cancer chemotherapy only to learn it was canceled due to NIH cuts. Clinical trial ended midstream. No treatment, no restart, no plan, no information. Her bro-in-law's chemo was also canceled.
March 20, 2025 at 8:24 PM
Reposted by Lindsay Guzman
It is important at this pivotal moment to @standupforscience.bsky.social. Looking forward to sharing my thoughts on why this should be a national priority at tomorrow’s rally in SF:
March 5, 2025 at 4:54 PM
Reposted by Lindsay Guzman
Looking forward to celebrating 80 years of federally funded science, technology and innovation @standupforscience.bsky.social SF, March 7, Civic Center, 1-3 pm 🧪 🧫 🧬
March 3, 2025 at 6:55 PM
Reposted by Lindsay Guzman
Happy to share this new #glycotime work with collaborator Tony Wyss-Coray, led by grad student Sophia Shi, mucin loss at the BBB is associated with aging and cognitive decline, can be reversed by restoration with with gene therapy. Aging is a mucinopathy!

www.nature.com/articles/s41...
Glycocalyx dysregulation impairs blood–brain barrier in ageing and disease - Nature
Disruption of mucin-domain glycoprotein expression and function in the endothelial glycocalyx are associated with ageing and Alzheimer’s disease, leading to dysregulated blood–brain barrier function.
www.nature.com
February 26, 2025 at 9:58 PM
Reposted by Lindsay Guzman
Excited to share this new work led by postdoc Brendan Floyd, deep mapping of cell-surface protein interactomes of T and B cells reveals maverick mitochondrial proteins and immune modulatory complexes.

www.biorxiv.org/content/10.1...
Mapping the nanoscale organization of the human cell surface proteome reveals new functional associations and surface antigen clusters
The cell surface is a dynamic interface that controls cell-cell communication and signal transduction relevant to organ development, homeostasis and repair, immune reactivity, and pathologies driven b...
www.biorxiv.org
February 18, 2025 at 7:27 PM
Reposted by Lindsay Guzman
congrats to Brendan Floyd, postdoc in @carolynbertozzi.bskyverified.social lab on his exciting work "mapping the nanoscale organization of the human cell surface proteome"

High resolution, High Effort, and Creative Analytics produce new views of the cell surface

www.biorxiv.org/content/10.1...
February 18, 2025 at 4:31 PM
Reposted by Lindsay Guzman
It is a reminder that NIH is, at its heart, a collection of dedicated humans - scientists, physicians and staff - all public servants trying their best to advocate for and support the rest of us 🇺🇸
November 23, 2024 at 3:52 PM