@lilyvays.bsky.social
Reposted
The ancestral protein of the CRISPR–Cas9 system — less than half the size of its famous descendant — is engineered into an effective DNA-targeting tool that can be delivered by AAV as an epigenome editor for in vivo gene silencing #NBTNV go.nature.com/43JRgno
rdcu.be/eyorl
rdcu.be/eyorl
Resurrecting a miniature Cas9 ancestor for genome and epigenome editing - Nature Biotechnology
The ancestral protein of the CRISPR–Cas9 system — less than half the size of its famous descendant — is engineered into an effective DNA-targeting tool that can be delivered by AAV as an epigenome edi...
go.nature.com
July 30, 2025 at 12:51 PM
The ancestral protein of the CRISPR–Cas9 system — less than half the size of its famous descendant — is engineered into an effective DNA-targeting tool that can be delivered by AAV as an epigenome editor for in vivo gene silencing #NBTNV go.nature.com/43JRgno
rdcu.be/eyorl
rdcu.be/eyorl
Reposted
10 courses to get you started with bioinformatics 🧵 Bookmark!
1/ rafalab.dfci.harvard.edu/pages/harva... by the almighty Rafa
1/ rafalab.dfci.harvard.edu/pages/harva... by the almighty Rafa
harvardx
rafalab.github.io
May 18, 2025 at 1:15 PM
10 courses to get you started with bioinformatics 🧵 Bookmark!
1/ rafalab.dfci.harvard.edu/pages/harva... by the almighty Rafa
1/ rafalab.dfci.harvard.edu/pages/harva... by the almighty Rafa
Reposted
Really happy that our work on ribosome frame shifting and RNA decay has been published now in Molecular cell. Great work leaded by Yujie Zhang where we uncovered a totally unexpected mechanism that has been overlooked for many years (from bacteria to human). Here the link doi.org/10.1016/j.mo...
A study by @pelechanolab.bsky.social reveals how cells adapt to nutrient scarcity by altering their genetic instructions. The discovery, published in @cp-molcell.bsky.social, sheds light on cellular stress responses and has potential therapeutic implications 🧪 #CellBiology news.ki.se/new-study-un...
May 16, 2025 at 7:46 AM
Really happy that our work on ribosome frame shifting and RNA decay has been published now in Molecular cell. Great work leaded by Yujie Zhang where we uncovered a totally unexpected mechanism that has been overlooked for many years (from bacteria to human). Here the link doi.org/10.1016/j.mo...
Reposted
GenomicsSky! Asking for suggestions for genomics/data analysis workshops that grad students can take this summer (or whenever) 🙏 Pleast RT.
In a time where opportunities have been slashed everywhere, any prof dev opportunities for students would be incredibly welcome!
In a time where opportunities have been slashed everywhere, any prof dev opportunities for students would be incredibly welcome!
April 28, 2025 at 5:48 PM
GenomicsSky! Asking for suggestions for genomics/data analysis workshops that grad students can take this summer (or whenever) 🙏 Pleast RT.
In a time where opportunities have been slashed everywhere, any prof dev opportunities for students would be incredibly welcome!
In a time where opportunities have been slashed everywhere, any prof dev opportunities for students would be incredibly welcome!
Reposted
Research is essential to making progress in cancer science and medicine. Advances in basic, clinical, translational, and population sciences lead to improvements in prevention, diagnosis, and treatment. https://buff.ly/3EJeTE8
#CancerResearchSavesLives®
#CancerResearchSavesLives®
February 17, 2025 at 8:53 PM
Research is essential to making progress in cancer science and medicine. Advances in basic, clinical, translational, and population sciences lead to improvements in prevention, diagnosis, and treatment. https://buff.ly/3EJeTE8
#CancerResearchSavesLives®
#CancerResearchSavesLives®
Reposted
Estrogen Receptors/E2F1/CDKN3 Axis Protects from UV-induced Skin Cancers in Females https://www.biorxiv.org/content/10.1101/2025.02.12.637819v1
February 17, 2025 at 2:56 AM
Estrogen Receptors/E2F1/CDKN3 Axis Protects from UV-induced Skin Cancers in Females https://www.biorxiv.org/content/10.1101/2025.02.12.637819v1
Reposted
RNA translation in #cancer!
Check out this fun story about amplification of 12q13-15 leading to a quirky new role for METTL1.
Led by Alejandro Gutierrez, Richard Gregory and teams, and it was a pleasure to contribute ourselves!
#RNAsky
#Ribosome
#CANsky
#genomics
🧪
🧬 💻
www.cell.com/molecular-ce...
Check out this fun story about amplification of 12q13-15 leading to a quirky new role for METTL1.
Led by Alejandro Gutierrez, Richard Gregory and teams, and it was a pleasure to contribute ourselves!
#RNAsky
#Ribosome
#CANsky
#genomics
🧪
🧬 💻
www.cell.com/molecular-ce...
A methyltransferase-independent role for METTL1 in tRNA aminoacylation and oncogenic transformation
Ali et al. report that multiple 12q-amplified genes collaborate with AKT in sarcomagenesis,
including METTL1. This oncogenic function of METTL1 is independent of its methyltransferase
activity. METTL1...
www.cell.com
February 4, 2025 at 3:05 AM
Reposted
Nature research paper: Targeting FOXM1 condensates reduces breast tumour growth and metastasis
https://go.nature.com/4g7BNC8
https://go.nature.com/4g7BNC8
Targeting FOXM1 condensates reduces breast tumour growth and metastasis - Nature
The transcription factor FOXM1 forms functional condensates, the formation of which can be targeted with a specific peptide to suppress breast cancer growth and metastasis.
go.nature.com
January 16, 2025 at 8:58 PM
Nature research paper: Targeting FOXM1 condensates reduces breast tumour growth and metastasis
https://go.nature.com/4g7BNC8
https://go.nature.com/4g7BNC8