@lazlotoronto.bsky.social
Reposted
Online Now: Structure of the transcriptional co-activator SAGA complex, including the histone acetyltransferase module Online now:
Structure of the transcriptional co-activator SAGA complex, including the histone acetyltransferase module
Mattoo et al. determined the HAT module structure within the SAGA complex using cryo-electron microscopy. This provides insights into histone acetylation and the overall architecture of the SAGA complex. They identified two SAGA core subunits involved in anchoring the HAT module, enhancing the understanding of the RNA polymerase II chromatin transcription mechanism.
dlvr.it
November 18, 2025 at 8:14 PM
Online Now: Structure of the transcriptional co-activator SAGA complex, including the histone acetyltransferase module Online now:
Reposted
Larry Elmore's Ancient Red
My favorite art for all of D&D.
Have you ever wondered what happened to that brave warrior facing off against that awesome Red Dragon?
The answer was given to us in 1983 way before any modern interpretations. A thread 🧵
My favorite art for all of D&D.
Have you ever wondered what happened to that brave warrior facing off against that awesome Red Dragon?
The answer was given to us in 1983 way before any modern interpretations. A thread 🧵
November 18, 2025 at 4:03 AM
Larry Elmore's Ancient Red
My favorite art for all of D&D.
Have you ever wondered what happened to that brave warrior facing off against that awesome Red Dragon?
The answer was given to us in 1983 way before any modern interpretations. A thread 🧵
My favorite art for all of D&D.
Have you ever wondered what happened to that brave warrior facing off against that awesome Red Dragon?
The answer was given to us in 1983 way before any modern interpretations. A thread 🧵
Reposted
Ancient Red was used for the art on the 1983 Basic Rules Set, known as the Red Box or Mentzer edition. It was my first D&D box set. My brother has our battered but well loved original books. This is a replacement. 3/?
November 18, 2025 at 4:11 AM
Ancient Red was used for the art on the 1983 Basic Rules Set, known as the Red Box or Mentzer edition. It was my first D&D box set. My brother has our battered but well loved original books. This is a replacement. 3/?
Reposted
At long last, a piece I've been working on since summer is ready. A dive into the work and influence of Glen Morgan and James Wong, from The X-Files, to Space:Above and Beyond, and Millennium. Come with me as I argue that modern television owes them an unpayable debt. ericsipple.com/the-writers-...
The Writers Who Invented Modern Television
Let’s pick a fight right out of the gate: Modern television began on September 24, 1995. Like all beginnings, it went unnoticed, misattributed to other moments, and lost under the shadows of more visi...
ericsipple.com
November 16, 2025 at 12:21 AM
At long last, a piece I've been working on since summer is ready. A dive into the work and influence of Glen Morgan and James Wong, from The X-Files, to Space:Above and Beyond, and Millennium. Come with me as I argue that modern television owes them an unpayable debt. ericsipple.com/the-writers-...
Reposted
Here's some early concept art of Knuckles the Echidna for Sonic 3 before they settled on the final design we all know and love today!
November 12, 2025 at 3:57 PM
Here's some early concept art of Knuckles the Echidna for Sonic 3 before they settled on the final design we all know and love today!
Reposted
Legendary game designer and programmer Michael Cranford talks about the creation of "The Bard's Tale!" Join the stalwart band of adventurers and watch this panel!
www.youtube.com/watch?v=oHc5...
#prge #prge2025 #retrogaming #thebardstale
www.youtube.com/watch?v=oHc5...
#prge #prge2025 #retrogaming #thebardstale
The History of “The Bard's Tale” by Michael Cranford - PRGE 2025 Portland Retro Gaming Expo
YouTube video by Portland Retro Gaming Expo
www.youtube.com
November 7, 2025 at 12:12 AM
Legendary game designer and programmer Michael Cranford talks about the creation of "The Bard's Tale!" Join the stalwart band of adventurers and watch this panel!
www.youtube.com/watch?v=oHc5...
#prge #prge2025 #retrogaming #thebardstale
www.youtube.com/watch?v=oHc5...
#prge #prge2025 #retrogaming #thebardstale
Reposted
Fu et al. used comparative genomics to investigate the evolution of rock-inhabiting fungi. They reveal these fungi have compact, gene-dense genomes, and two genes under positive selection across multiple lineages.
🔗 doi.org/10.1093/molbev/msaf249
#evobio #molbio #fungi
🔗 doi.org/10.1093/molbev/msaf249
#evobio #molbio #fungi
October 31, 2025 at 12:24 PM
Fu et al. used comparative genomics to investigate the evolution of rock-inhabiting fungi. They reveal these fungi have compact, gene-dense genomes, and two genes under positive selection across multiple lineages.
🔗 doi.org/10.1093/molbev/msaf249
#evobio #molbio #fungi
🔗 doi.org/10.1093/molbev/msaf249
#evobio #molbio #fungi
Reposted
New online: Mechanisms of DNMT3A–3L-mediated de novo DNA methylation on chromatin
Mechanisms of DNMT3A–3L-mediated de novo DNA methylation on chromatin
Nature Structural & Molecular Biology, Published online: 31 October 2025; doi:10.1038/s41594-025-01704-4Yan et al. use cryo-EM to obtain structures that reveal how DNMT3A2 and DNMT3L cooperate to read histone signals and bind chromatin, illustrating a mechanism that controls DNA methylation and shapes epigenetic regulation.
go.nature.com
October 31, 2025 at 11:29 AM
New online: Mechanisms of DNMT3A–3L-mediated de novo DNA methylation on chromatin
Reposted
Interesting to see new papers connecting Pol II stalling to heterochromatin formation.
www.cell.com/molecular-ce...
Reminiscent of our work in S. pombe:
pmc.ncbi.nlm.nih.gov/articles/PMC...
www.cell.com/molecular-ce...
Reminiscent of our work in S. pombe:
pmc.ncbi.nlm.nih.gov/articles/PMC...
The Piwi-piRNA complex initiates transposon silencing via transcription termination factors PNUTS and Senataxin
Wu et al. reveal that the SFiNX complex triggers transposon silencing through the
association of Sov with two transcription termination factors, PNUTS and Senataxin,
leading to RNA Pol II stalling. Th...
www.cell.com
October 29, 2025 at 3:47 PM
Interesting to see new papers connecting Pol II stalling to heterochromatin formation.
www.cell.com/molecular-ce...
Reminiscent of our work in S. pombe:
pmc.ncbi.nlm.nih.gov/articles/PMC...
www.cell.com/molecular-ce...
Reminiscent of our work in S. pombe:
pmc.ncbi.nlm.nih.gov/articles/PMC...
Reposted
New OA Article: "RNA m6A regulates the transcription and heterochromatin state of retrotransposons in Arabidopsis" rdcu.be/eM95H
m6A is recognized by nuclear readers CPSF30-L and ECT12, which associate with SUVH4/5/6 and ATXR5/6 to enhance histone methylation...
m6A is recognized by nuclear readers CPSF30-L and ECT12, which associate with SUVH4/5/6 and ATXR5/6 to enhance histone methylation...
October 28, 2025 at 7:10 PM
New OA Article: "RNA m6A regulates the transcription and heterochromatin state of retrotransposons in Arabidopsis" rdcu.be/eM95H
m6A is recognized by nuclear readers CPSF30-L and ECT12, which associate with SUVH4/5/6 and ATXR5/6 to enhance histone methylation...
m6A is recognized by nuclear readers CPSF30-L and ECT12, which associate with SUVH4/5/6 and ATXR5/6 to enhance histone methylation...
Reposted
An article on Model Organisms, published in Science in 2005, lists the Models that together represent "the diversity of life".
Guess which model is missing from the list?
This view is one major reason why it's so difficult to obtain funding for basic plant research.
#PlantBlindness #PlantScience
Guess which model is missing from the list?
This view is one major reason why it's so difficult to obtain funding for basic plant research.
#PlantBlindness #PlantScience
October 24, 2025 at 8:10 AM
An article on Model Organisms, published in Science in 2005, lists the Models that together represent "the diversity of life".
Guess which model is missing from the list?
This view is one major reason why it's so difficult to obtain funding for basic plant research.
#PlantBlindness #PlantScience
Guess which model is missing from the list?
This view is one major reason why it's so difficult to obtain funding for basic plant research.
#PlantBlindness #PlantScience
Reposted
This study @science.org finds what appears to be the long-lost RNA subunit of C. elegans telomerase. The TERC RNA is encoded within an intron of a germline-upregulated gene, nmy-2🪱🔬🧬Nematode telomerase RNA hitchhikes on introns of germline–up-regulated genes | Science www.science.org/doi/10.1126/...
October 23, 2025 at 9:38 PM
This study @science.org finds what appears to be the long-lost RNA subunit of C. elegans telomerase. The TERC RNA is encoded within an intron of a germline-upregulated gene, nmy-2🪱🔬🧬Nematode telomerase RNA hitchhikes on introns of germline–up-regulated genes | Science www.science.org/doi/10.1126/...