Engineering human microglia with a Down-syndrome-linked myeloid gene variant resists tau-induced dysfunction and protects neurons in chimeric brains, offering proof of concept for transformative micro...

Cellular & Molecular Immunology - Microglia across evolution: from conserved origins to functional divergence

Using a mouse model that selectively lacks TET2 in myeloid cells, Sharma et al. show that myeloid cells and sympathetic neurons form a signaling nexus that controls serotonin production by enterochromaffin cells, which modulates colonic inflammation. Further, physiological stress uses sympathetic cues to drive serotonin production and worsen colitis.

Gliomas respond poorly to therapy and are considered immunologically “cold” tumors. Cakmak et al. identify tertiary lymphoid structures (TLSs) in a subset of gliomas that show signs of functional adaptive immune activation and are associated with longer overall patient survival and an immune-permissive tumor microenvironment. Such TLSs may represent a key determinant of glioma immune landscape, with clinical relevance.

AbstractBACKGROUND. The use of CAR T-cell therapy has been delayed in primary central nervous system lymphomas (PCNSL) due to the fear of unacceptable neur

Nimbus, a deep learning model, uses a large multiplexed imaging dataset to predict the likelihood of marker positivity in single cells.

Glioblastoma—the deadliest form of brain cancer—alters the calvarial bone and its marrow components, pushing it toward producing more myeloid cells and contributing to an immunosuppressive environment.

Recent research has revealed a remarkable role for immunosurveillance in healthy and diseased brains, dispelling the notion that this organ is a passive immune-privileged site (1–3). Better understand...