Amanda Mauro, PhD
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lamandaa.bsky.social
Amanda Mauro, PhD
@lamandaa.bsky.social
Reposted by Amanda Mauro, PhD
Who has made this 🤣
December 7, 2025 at 1:49 PM
Reposted by Amanda Mauro, PhD
Join us in raising money for the Greater Boston Food Bank throughout November. We're accepting monetary donations at the registers in store through November 23. Learn more about volunteering, donating food or money, and receiving assistance at their website: www.gbfb.org
November 6, 2025 at 1:01 PM
Reposted by Amanda Mauro, PhD
ICE has been seizing people in Allston. Boston area folks, spread the word about the LUCE hotline to report ICE sightings. And here's stickers you can print and put up anywhere:
Massachusetts folks: I made these stickers sharing LUCE's ICE hotline ☎️ 617-370-5023--they verify sightings and share confirmed info. Stickers fit 1"x2.6" label (Avery 5160). Image below or follow link for a full sheet. Print, stick every&anywhere. www.dropbox.com/scl/fi/7v098...
November 5, 2025 at 2:08 PM
Reposted by Amanda Mauro, PhD
There's been a death in a #CRISPR study, something the field has long feared. A man who was recently hospitalized with liver injury a few weeks after receiving Intellia's experimental gene editing therapy died last night. More details in my story for @endpts.com endpoints.news/patient-in-i...
Patient in Intellia CRISPR trial dies after being hospitalized with liver injury
Patient in 80s dies after receiving Intellia Therapeutics' CRISPR therapy nex-z for ATTR. Death follows liver injury; exact cause unclear. CEO John Leonard announces trial pause.
endpoints.news
November 7, 2025 at 3:46 AM
Reposted by Amanda Mauro, PhD
November 4, 2025 at 4:57 PM
Reposted by Amanda Mauro, PhD
🎙️Rebecca Ahrens-Nicklas, a pediatrician and gene therapy scientist at CHOP, and Kiran Musunuru, a UPenn gene editing scientist, join Post-Hoc Live to talk about the next steps to replicate "Baby KJ"'s bespoke CRISPR editing therapy. Watch live at 9.45am ET.
www.youtube.com/live/ig4gEOa...
The plan to make more custom CRISPR therapies — with Kiran Musunuru and Rebecca Ahrens-Nicklas
In February, a team of scientists achieved a long-held scientific goal — creating a bespoke CRISPR editing therapy to treat a single patient with a unique genetic mutation. “Baby KJ” got his own custo...
www.youtube.com
October 31, 2025 at 12:16 PM
Reposted by Amanda Mauro, PhD
The Cambridge Commission on Immigrant Rights and Citizenship and the MA Office of Refugees and Immigrants present 2 virtual workshops with practical tools for bystanders to intervene and de-escalate situations.

@theharvardcrimson.bsky.social @cambridgeday.com

www.cambridgema.gov/Departments/...
October 24, 2025 at 6:48 PM
Reposted by Amanda Mauro, PhD
Mass. resources for those losing SNAP benefits during shutdown | Click on the image to read the full story
Mass. resources for those losing SNAP benefits during shutdown
With more than 1 million Massachusetts residents expected to lose access to their SNAP benefits next month, these local resources may be able to offer support.
www.wcvb.com
October 24, 2025 at 6:14 PM
Reposted by Amanda Mauro, PhD
Earlier this year I visited Bexorg to see its brain-in-a-bucket experiments in person. The approach raises many technical and ethical questions which I dug into in my profile of the startup in June. Read more here:
endpoints.news/rebooting-de...
Exclusive: Rebooting dead human brains, a biotech startup seeks to reinvent early drug testing work
Startup Bexorg, led by Zvonimir Vrselja, keeps human brains alive to test drugs. Their BrainEx system sustains brain cells for 24 hours to improve drug development and reduce animal testing.
endpoints.news
October 15, 2025 at 1:25 PM
Reposted by Amanda Mauro, PhD
The Yale spinout Bexorg has raised a $23M series A for its cutting-edge and unconventional approch to preclinical research: testing drugs on ‘rebooted’ human brains from organ donors. My story for @endpts.com has the details: endpoints.news/bexorg-raise...
Yale spinout raises $23M to test drugs on ‘rebooted’ human brains from organ donors
Bexorg has collected $23 million in a Series A raise to scale up its human brain experiments, bringing its total funding to $42.5 million, the startup announced Wednesday.
endpoints.news
October 15, 2025 at 1:25 PM
Reposted by Amanda Mauro, PhD
ICE kidnapped a 7th-grader with a pending asylum claim and spirited him out of state without notifying his parents, seemingly with the cooperation of the local police in Everett, MA.

www.bostonglobe.com/2025/10/12/m...
October 12, 2025 at 9:43 PM
Reposted by Amanda Mauro, PhD
[Me, a poor, on the subway, glowering jealously at all those fat cat, fancy pants rich people on the public bus]
October 10, 2025 at 3:00 PM
Reposted by Amanda Mauro, PhD
Nexstar is trying to close a multi-billion dollar merger with Tegna. It requires the approval of Trump's FCC.
Nexstar and Sinclair, which own a combined 20% of local ABC affiliates, will still not broadcast Jimmy Kimmel.

Sinclair is a conservative company that donates to and supports right-wing causes.
September 23, 2025 at 3:40 PM
Reposted by Amanda Mauro, PhD
A Black man and a homeless man were found hanging from trees in Mississippi yesterday, for those who haven’t seen yet because it’s barely made it out of local news.
September 16, 2025 at 2:30 PM
Reposted by Amanda Mauro, PhD
Hampton University, Virginia State University, Bethune Cookman University (BCU) and Alabama State University were all on lockdown after receiving “potential threats to campus safety,” according to posts on school social media pages. buff.ly/yK7CDN1
Potential threats trigger lockdowns at several Historically Black Colleges and Universities across the South
Originally Published: 11 SEP 25 14:36 ET By Alisha Ebrahimji, CNN (CNN) — Multiple Historically Black Universities and Colleges in the South were on lockdown or have cancelled classes on Thursday…
madison365.com
September 11, 2025 at 6:44 PM
Reposted by Amanda Mauro, PhD
Holy shit, they did it. They wrote the headline.
July 30, 2025 at 1:10 AM
Reposted by Amanda Mauro, PhD
Very cool new paper by @thegulab.bsky.social published in Cell, showing that arterial endothelial coupling via gap junctions determines the speed and spread of vasodilation induced by neuronal activity ! #cerebrovascular #bloodflow #endothelium
Brain endothelial gap junction coupling enables rapid vasodilation propagation during neurovascular coupling
Vasodilatory signals are rapidly communicated across long distances by endothelial-endothelial gap junctions, enabling coordinated dilation of the arterial network during neurovascular coupling.
www.cell.com
July 25, 2025 at 7:17 AM
Reposted by Amanda Mauro, PhD
A massive proteomics study analyzed 250 million protein markers from 18,600 people, uncovering new — and familiar — clues about Alzheimer’s and other neurodegenerative diseases.
endpoints.news/massive-prot...
Massive proteomics study reveals new clues about Alzheimer’s and rekindles old ones
Amyloid plaques and tau tangles are the most well-known protein structures associated with Alzheimer’s, but a new study bolsters the longstanding notion that there’s a lot more going on in the disease...
endpoints.news
July 17, 2025 at 8:24 PM
Reposted by Amanda Mauro, PhD
Exclusive: FDA's Makary sought rejection of KalVista’s drug in an unusual move by commissioner, sources say
endpoints.news/sources-fda-...
Exclusive: FDA's Makary sought rejection of KalVista’s drug in an unusual move by commissioner, sources say
FDA Commissioner Marty Makary reportedly attempted to reject KalVista Pharmaceuticals' drug application, sources said. An HHS spokesperson calls the claim 'totally false.'
endpoints.news
June 24, 2025 at 5:36 PM
Reposted by Amanda Mauro, PhD
The second reviews the literature assessing the effect of acute fluctuations in sex hormones on large artery endothelial function, including across the menstrual cycle and the diurnal cycle of testosterone secretion journals.physiology.org/doi/abs/10.1... 3/3
The effect of transient sex hormone fluctuations on endothelial function | American Journal of Physiology-Heart and Circulatory Physiology | American Physiological Society
This review article summarizes the current literature investigating the effects of transient sex hormone fluctuations on large artery endothelial function, primarily concerning the menstrual cycle and the diurnal rhythm of testosterone secretion. Women and men experience acute fluctuations in circulating levels of sex hormones, and there is substantial variability in circulating levels of sex hormones in both sexes. These acute fluctuations in sex hormones generally coincide with alterations in endothelial cell function and in vivo endothelium-dependent vasodilation, and we see that the timing of these acute fluctuations match the timing of cardiovascular events in both women and men. It is important to improve our understanding of how acute fluctuations in sex hormones affect endothelial function in women and men, as clinical cardiovascular complications coincide with these changes. This would allow for the identification of novel therapeutic targets and aid in the prevention and treatment of cardiovascular disease.
journals.physiology.org
June 6, 2025 at 3:19 PM
Reposted by Amanda Mauro, PhD
The first reviews the literature assessing sex-specific mechanisms of how the mineralocorticoid and estrogen receptors contribute to vascular outcomes in aging and obesity www.sciencedirect.com/science/arti... 2/3
Mineralocorticoid and estrogen receptors as sex-dependent modulators of vascular health in aging and obesity
Cardiovascular disease (CVD) is the leading cause of death in both men and women, but there are sex differences in the timing and mechanisms of diseas…
www.sciencedirect.com
June 6, 2025 at 3:19 PM
Reposted by Amanda Mauro, PhD
May 29, 2025 at 8:55 PM
Reposted by Amanda Mauro, PhD
I don't think any single piece of information has ever radicalised me like reading the statistics on how many women have their husbands/boyfriends dump them because they got a terminal illness diagnosis
Among heterosexual couples over age 50, research finds that divorce rates increase significantly when the wife develops a serious illness but the husband does not; however, no such increase is seen when husbands fall ill but wives do not. www.psychologytoday.com/us/blog/soci...
New Research Reveals a Concerning Emerging Divorce Pattern
Divorce trends among middle-aged adults have revealed a shocking new pattern.
www.psychologytoday.com
May 21, 2025 at 2:54 PM