TJ Krzystek
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lakeerieneuro.bsky.social
TJ Krzystek
@lakeerieneuro.bsky.social
PhD in #CellBiology || Senior Scientist 🔬

#Microscopy #Neuroscience #DiseaseModeling #hiPSCs
#Phenomics #TargetBiology #DrugDiscovery #LiveImaging

#BillsMafia || Posts represent only myself
Likely my final #FluorescenceFriday post of 2024! 🔬

Here’s a kinetic showcasing pkMito dynamics and the heterogeneity of axonal mitochondria

I'm looking forward to all of the incredible microscopy from this community in 2025.

Happy Holidays everyone! ☃️❄️
December 20, 2024 at 6:02 PM
Some #MicroscopyMonday to kick off the week! 🔬⛄

I paired #lysosome and #mitochondria kinetics side-by-side to highlight their distinct axonal motility.

I thought this nicely shows the need for organelle-specific metrics when designing high-throughput screening assays.

#Neuroscience #CellBiology
December 16, 2024 at 3:04 PM
It's also #FluorescenceFriday 🔬
so, here's a taste of the lysosomal transport you can find at my poster (HCB-23)

At TDI, we've been integrating #microscopy and #phenomics to identify and validate phenotypes of ALS patient-derived spinal motor neurons for subsequent drug screening.
December 6, 2024 at 11:58 AM
Sharing #FluorescenceFriday early before the food coma hits this weekend! 🦃

Here are longitudinal kinetics showing dose-dependent degeneration from an exogenous stressor: part of an assay developed for drug screening with iPSC-derived neurons. 🔬

#Microscopy #Neuroscience #Bioimaging #CellBiology
November 28, 2024 at 8:50 AM
I feel the science-to-nonsense ratio is much better on this site:

Enjoy these jittery mitochondria sifting through axons of patient-derived motor neurons thanks to the pkMito probe from @spirochrome.com

#neuroscience #science #microscopy #bioimaging #mitochondria
October 19, 2024 at 7:19 PM