@labrullo.bsky.social
Brilliant presentations by @RulloLab @LabRullo group members in the chemical biology division at the nationals #CSC2025 ! Covalent ternary complexes, affinity electrophile mechanisms, reversible covalency , immunotherapy and more !
June 26, 2025 at 2:14 AM
Brilliant presentations by @RulloLab @LabRullo group members in the chemical biology division at the nationals #CSC2025 ! Covalent ternary complexes, affinity electrophile mechanisms, reversible covalency , immunotherapy and more !
Reposted
Down into the details of how compounds and binding sites interact:
Entropy, Enthalpy, and Hydrophobicity
www.science.org
April 15, 2025 at 7:06 PM
Down into the details of how compounds and binding sites interact:
Reposted
Induced proximity at the cell surface - @carolynbertozzi.bskyverified.social @stanfordchemistry.bsky.social go.nature.com/4c9hu6M
Induced proximity at the cell surface - Nature Biotechnology
Technologies to modulate induced proximity at the cell surface advance the manipulation of diverse biological responses.
go.nature.com
March 26, 2025 at 6:10 PM
Induced proximity at the cell surface - @carolynbertozzi.bskyverified.social @stanfordchemistry.bsky.social go.nature.com/4c9hu6M
Here we demonstrate pre-organization of two SuFEx electrophiles on a bifunctional scaffold, enable selective kinetic trapping of ternary complexes to enforce cell-cell induced proximity
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Mimicry of molecular glues using dual covalent chimeras - Nature Communications
The authors report the development of dual covalent proximity inducing molecules capable of selectively cross-linking two non-interacting proteins. Through the selective proximity-based activation of ...
www.nature.com
March 25, 2025 at 1:54 PM
Here we demonstrate pre-organization of two SuFEx electrophiles on a bifunctional scaffold, enable selective kinetic trapping of ternary complexes to enforce cell-cell induced proximity
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted
On this day in 1879, Maud Menten was born in Port Lambton, Ontario.
In her work as a medical researcher, she became a leading expert in histochemistry and enzyme kinetics while fighting against sexism in her field.
Let's learn more about her life!
🧵1/10
In her work as a medical researcher, she became a leading expert in histochemistry and enzyme kinetics while fighting against sexism in her field.
Let's learn more about her life!
🧵1/10
March 20, 2025 at 6:01 PM
On this day in 1879, Maud Menten was born in Port Lambton, Ontario.
In her work as a medical researcher, she became a leading expert in histochemistry and enzyme kinetics while fighting against sexism in her field.
Let's learn more about her life!
🧵1/10
In her work as a medical researcher, she became a leading expert in histochemistry and enzyme kinetics while fighting against sexism in her field.
Let's learn more about her life!
🧵1/10
really impressive art of the deal making happening in real time
here. To end the war in ukraine...simply....give in to all required concessions ! brilliant !
here. To end the war in ukraine...simply....give in to all required concessions ! brilliant !
February 14, 2025 at 2:27 AM
really impressive art of the deal making happening in real time
here. To end the war in ukraine...simply....give in to all required concessions ! brilliant !
here. To end the war in ukraine...simply....give in to all required concessions ! brilliant !
Reposted
ONLY 1️⃣ WEEK remaining until the #CSC2025 abstract submission deadline. Don't delay, submit your abstract by Jan. 30 at 11:59 PM ET. We cannot wait to see you at the Rogers Centre Ottawa (in Ottawa, ON 😌) from Jun. 15 - 19, 2025. buff.ly/3WzQoPB
January 23, 2025 at 10:29 PM
ONLY 1️⃣ WEEK remaining until the #CSC2025 abstract submission deadline. Don't delay, submit your abstract by Jan. 30 at 11:59 PM ET. We cannot wait to see you at the Rogers Centre Ottawa (in Ottawa, ON 😌) from Jun. 15 - 19, 2025. buff.ly/3WzQoPB
Reposted
Hi! I made a compilation doc last year of all the 2023 #mechanismmonday posts, and even though 👀 I def missed some months 👀 I've done one for 2024 as well. If you need mechanism problems for Any Reason this is for you...! xoxoxo shorturl.at/RleIp
MM Compilations - Google Drive
shorturl.at
January 3, 2025 at 8:53 PM
Hi! I made a compilation doc last year of all the 2023 #mechanismmonday posts, and even though 👀 I def missed some months 👀 I've done one for 2024 as well. If you need mechanism problems for Any Reason this is for you...! xoxoxo shorturl.at/RleIp
We really enjoyed putting this accounts paper together , placing our contributions to the covalent stabilization of ternary complexes in the context of induced
proximityhttps://t.co/QaaXS6m9Ci
proximityhttps://t.co/QaaXS6m9Ci
https://pubs.acs.org/doi/abs/10.1021/acschembio.4c00286
t.co
January 6, 2025 at 2:53 AM
We really enjoyed putting this accounts paper together , placing our contributions to the covalent stabilization of ternary complexes in the context of induced
proximityhttps://t.co/QaaXS6m9Ci
proximityhttps://t.co/QaaXS6m9Ci
Reposted
Cool preprint by Dustin and coworkers on how various T cell engager formats, w/varying geometries/rigidities, impact synapse structure and potency
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Solution structure and synaptic analyses reveal determinants of bispecific T cell engager potency
Bispecific T-cell engagers (TcEs) link T cell receptors to tumor-associated antigens on cancer cells, forming cytotoxic immunological synapses (IS). Close membrane-to-membrane contact (≤13 nm) has bee...
www.biorxiv.org
November 27, 2024 at 5:47 PM
Cool preprint by Dustin and coworkers on how various T cell engager formats, w/varying geometries/rigidities, impact synapse structure and potency
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...