Turner Lab
@lab-turner.bsky.social
Account of the Turner lab at the Francis Crick Institute in London. We study sex chromosomes and their impact on health and disease. Rotating curation by lab members.
https://www.crick.ac.uk/research/labs/james-turner
https://www.crick.ac.uk/research/labs/james-turner
Pinned
Turner Lab
@lab-turner.bsky.social
· May 14
Divergent DNA methylation dynamics in marsupial and eutherian embryos - Nature
A study reports on the DNA methylation dynamics during embryogenesis in marsupials, showing that these differ from those occurring during embryogenesis in eutherian mammals.
www.nature.com
We're excited to publish our latest study led by Bryony Leeke @bryonyleeke.bsky.social and Wazeer Varsally, now out in @nature.com 🍾This study focusses on the epigenome of marsupial embryos 🦘 mapping DNA methylation in embryo development to specific embryo events www.nature.com/articles/s41... 🧵
Our latest 📢 We generated isogenic iPSCs with XX, XY, XO and XXY karyotypes to study sex chromosome effects 🧫 While XX and XY transcriptomes are similar, XO cells showed an important effect of the Y and inactive X @crick.ac.uk @stemcellreports.bsky.social www.sciencedirect.com/science/arti...
A human induced pluripotent stem cell toolbox for studying sex chromosome effects
Sex chromosomes shape male (XY)-female (XX) differences in development and disease. These differences can be modeled in vitro by comparing XY and XX h…
www.sciencedirect.com
October 23, 2025 at 11:06 AM
Our latest 📢 We generated isogenic iPSCs with XX, XY, XO and XXY karyotypes to study sex chromosome effects 🧫 While XX and XY transcriptomes are similar, XO cells showed an important effect of the Y and inactive X @crick.ac.uk @stemcellreports.bsky.social www.sciencedirect.com/science/arti...
Reposted by Turner Lab
@pnas.org Front Matter posted a nice summary of our recent work on opossum development @crick.ac.uk Thanks Amy McDermott for the highlight, and @amartinezarias.bsky.social for the comments. It says '6 min read', so now might be a good time
www.pnas.org/post/journal...
www.pnas.org/post/journal...
In opossums, gene expression follows familiar rules but at a strange pace
The arms and heads of opossums (pictured here one day before birth) and other marsupials develop faster than their legs and back bodies. Image credit: Sergio Menchero Fernandez/ Francis Crick Institut...
www.pnas.org
August 11, 2025 at 12:13 PM
@pnas.org Front Matter posted a nice summary of our recent work on opossum development @crick.ac.uk Thanks Amy McDermott for the highlight, and @amartinezarias.bsky.social for the comments. It says '6 min read', so now might be a good time
www.pnas.org/post/journal...
www.pnas.org/post/journal...
Paper alert! 🚨 Something new from us, and this time it's not sex chromosome related 😱 All led by @sermenchero.bsky.social who used the opossum as a model to understand developmental heterochrony. Transcriptional and morphological progression of dev programs are decoupled www.cell.com/developmenta...
Thrilled to share that our latest work on marsupial heterochrony is now online at @cp-devcell.bsky.social @cellpress.bsky.social @lab-turner.bsky.social @crick.ac.uk We used scRNAseq to understand the asynchronous progression of developmental programmes in marsupials www.cell.com/developmenta...
Marsupial single-cell transcriptomics identifies temporal diversity in mammalian developmental programs
Menchero et al. generate a single-cell transcriptomic atlas in the opossum and show
rapid progression of transcriptional programs in specific tissues relative to morphological
landmarks. This shift in...
www.cell.com
July 25, 2025 at 10:45 AM
Paper alert! 🚨 Something new from us, and this time it's not sex chromosome related 😱 All led by @sermenchero.bsky.social who used the opossum as a model to understand developmental heterochrony. Transcriptional and morphological progression of dev programs are decoupled www.cell.com/developmenta...
Reposted by Turner Lab
You can also read a research briefing about the paper here: www.nature.com/articles/d41...
Marsupial embryos lack the epigenetic reset seen in placental mammals
DNA-methylation marks remain stable in early-stage opossum embryos.
www.nature.com
May 15, 2025 at 3:13 PM
You can also read a research briefing about the paper here: www.nature.com/articles/d41...
Reposted by Turner Lab
We are looking to take on an intern at EMBL Rome, for anyone interested in CRISPR and Epigenetics training.
The traineeship is 3-12-months, in Rome (Italy), should start by July, and is supervised by the outstanding @steliostsagkris.bsky.social.
#job #internship; see info below...
The traineeship is 3-12-months, in Rome (Italy), should start by July, and is supervised by the outstanding @steliostsagkris.bsky.social.
#job #internship; see info below...
May 15, 2025 at 7:38 AM
We are looking to take on an intern at EMBL Rome, for anyone interested in CRISPR and Epigenetics training.
The traineeship is 3-12-months, in Rome (Italy), should start by July, and is supervised by the outstanding @steliostsagkris.bsky.social.
#job #internship; see info below...
The traineeship is 3-12-months, in Rome (Italy), should start by July, and is supervised by the outstanding @steliostsagkris.bsky.social.
#job #internship; see info below...
We're excited to publish our latest study led by Bryony Leeke @bryonyleeke.bsky.social and Wazeer Varsally, now out in @nature.com 🍾This study focusses on the epigenome of marsupial embryos 🦘 mapping DNA methylation in embryo development to specific embryo events www.nature.com/articles/s41... 🧵
Divergent DNA methylation dynamics in marsupial and eutherian embryos - Nature
A study reports on the DNA methylation dynamics during embryogenesis in marsupials, showing that these differ from those occurring during embryogenesis in eutherian mammals.
www.nature.com
May 14, 2025 at 4:01 PM
We're excited to publish our latest study led by Bryony Leeke @bryonyleeke.bsky.social and Wazeer Varsally, now out in @nature.com 🍾This study focusses on the epigenome of marsupial embryos 🦘 mapping DNA methylation in embryo development to specific embryo events www.nature.com/articles/s41... 🧵
We are excited to share our latest preprint led by Ruta Meleckyte and Waz Varsally! www.biorxiv.org/content/10.1... We generated a set of human isogenic induced pluripotent stem cells (hiPSCs) that are autosomally identical but differ in sex chromosome composition: XX, XY or monosomic X
A human induced pluripotent stem cell toolbox for studying sex chromosome effects
Sex chromosomes shape male (XY) - female (XX) differences in development and disease. These differences can be modelled in vitro by comparing XY and XX human induced pluripotent stem cells (hiPSCs). H...
www.biorxiv.org
March 7, 2025 at 10:36 AM
We are excited to share our latest preprint led by Ruta Meleckyte and Waz Varsally! www.biorxiv.org/content/10.1... We generated a set of human isogenic induced pluripotent stem cells (hiPSCs) that are autosomally identical but differ in sex chromosome composition: XX, XY or monosomic X
Reposted by Turner Lab
Registration and abstract submission for YEN 2025 is officially open!
We are looking forward to seeing you at the 17th Young Embryologist Network Conference on the 19th May 2025.
Attendence is FREE thanks to our amazing sponsors: @biologists.bsky.social @10xgenomics.bsky.social and Azenta.
We are looking forward to seeing you at the 17th Young Embryologist Network Conference on the 19th May 2025.
Attendence is FREE thanks to our amazing sponsors: @biologists.bsky.social @10xgenomics.bsky.social and Azenta.
January 30, 2025 at 4:36 PM
Registration and abstract submission for YEN 2025 is officially open!
We are looking forward to seeing you at the 17th Young Embryologist Network Conference on the 19th May 2025.
Attendence is FREE thanks to our amazing sponsors: @biologists.bsky.social @10xgenomics.bsky.social and Azenta.
We are looking forward to seeing you at the 17th Young Embryologist Network Conference on the 19th May 2025.
Attendence is FREE thanks to our amazing sponsors: @biologists.bsky.social @10xgenomics.bsky.social and Azenta.
Great summary of our latest paper studying the role of Y genes in spermatogenesis. ⬇️
Researchers at the Crick have uncovered which genes on the Y chromosome regulate the development of sperm and affect fertility in male mice. This could eventually help us to understand male infertility.
www.crick.ac.uk/news-and-rep...
www.crick.ac.uk/news-and-rep...
Uncovering the role of Y chromosome genes in male fertility in mice
Researchers at the Crick have uncovered which genes on the Y chromosome regulate the development of sperm and impact fertility in male mice. This research could help us understand why some men don’t p...
www.crick.ac.uk
January 24, 2025 at 11:12 AM
Great summary of our latest paper studying the role of Y genes in spermatogenesis. ⬇️
We thrilled to see our latest study led by @jeremie-subrini.bsky.social now out in @science.org 🔬
What are the specific functions of each Y-chromosome gene in fertility ? We generated and studied 13 Y-gene KO mouse models to find out! 🧬
www.science.org/doi/full/10....
What are the specific functions of each Y-chromosome gene in fertility ? We generated and studied 13 Y-gene KO mouse models to find out! 🧬
www.science.org/doi/full/10....
www.science.org
January 24, 2025 at 11:02 AM
We thrilled to see our latest study led by @jeremie-subrini.bsky.social now out in @science.org 🔬
What are the specific functions of each Y-chromosome gene in fertility ? We generated and studied 13 Y-gene KO mouse models to find out! 🧬
www.science.org/doi/full/10....
What are the specific functions of each Y-chromosome gene in fertility ? We generated and studied 13 Y-gene KO mouse models to find out! 🧬
www.science.org/doi/full/10....
Reposted by Turner Lab
I am thrilled to share our latest work, released today 🤩
www-nature-com.insb.bib.cnrs.fr/articles/s41...
It results from years of hard work by the team and long-time collaborators, with special thanks to PhD student Clara Roidor and collaborator Laurène Syx.
www-nature-com.insb.bib.cnrs.fr/articles/s41...
It results from years of hard work by the team and long-time collaborators, with special thanks to PhD student Clara Roidor and collaborator Laurène Syx.
January 21, 2025 at 10:34 AM
I am thrilled to share our latest work, released today 🤩
www-nature-com.insb.bib.cnrs.fr/articles/s41...
It results from years of hard work by the team and long-time collaborators, with special thanks to PhD student Clara Roidor and collaborator Laurène Syx.
www-nature-com.insb.bib.cnrs.fr/articles/s41...
It results from years of hard work by the team and long-time collaborators, with special thanks to PhD student Clara Roidor and collaborator Laurène Syx.