Darrell Kotton
@kottond.bsky.social
Director, Center for Regenerative Medicine of Boston University and Boston Medical Center. @CReM-Boston.bsky.social. Pulmonary physician-scientist. #MedSky #stemcells #SciSky
www.kottonlab.com
www.kottonlab.com
Just out @ajrcmb.bsky.social,
our review of how axolotl salamander lung regeneration offers many hints for advancing human lung regeneration research for our patients:
atsjournals.org/doi/abs/10.1...
our review of how axolotl salamander lung regeneration offers many hints for advancing human lung regeneration research for our patients:
atsjournals.org/doi/abs/10.1...
October 17, 2025 at 12:08 AM
Just out @ajrcmb.bsky.social,
our review of how axolotl salamander lung regeneration offers many hints for advancing human lung regeneration research for our patients:
atsjournals.org/doi/abs/10.1...
our review of how axolotl salamander lung regeneration offers many hints for advancing human lung regeneration research for our patients:
atsjournals.org/doi/abs/10.1...
Reposted by Darrell Kotton
Yesterday, October 7, Sir John Gurdon passed away.
Dr. Gurdon was awarded the Nobel Prize in Physiology or Medicine in 2012, together with Shinya Yamanaka.
Through a series of experiments using Xenopus eggs, Gurdon showed that the nucleus of a mature cell can be reprogrammed to a pluripotent state.
Dr. Gurdon was awarded the Nobel Prize in Physiology or Medicine in 2012, together with Shinya Yamanaka.
Through a series of experiments using Xenopus eggs, Gurdon showed that the nucleus of a mature cell can be reprogrammed to a pluripotent state.
October 8, 2025 at 4:39 PM
Yesterday, October 7, Sir John Gurdon passed away.
Dr. Gurdon was awarded the Nobel Prize in Physiology or Medicine in 2012, together with Shinya Yamanaka.
Through a series of experiments using Xenopus eggs, Gurdon showed that the nucleus of a mature cell can be reprogrammed to a pluripotent state.
Dr. Gurdon was awarded the Nobel Prize in Physiology or Medicine in 2012, together with Shinya Yamanaka.
Through a series of experiments using Xenopus eggs, Gurdon showed that the nucleus of a mature cell can be reprogrammed to a pluripotent state.
Reposted by Darrell Kotton
Delighted to give a talk at the Vermont Lung Stem Cell Conference last week.
Also got to visit with @kottond.bsky.social, Finn Hawkins, Joe Kaserman, and Kostas Alysandratos - all legends of the lung regeneration field at the CReM Boston University
@crem-boston.bsky.social
#CureIPF
Also got to visit with @kottond.bsky.social, Finn Hawkins, Joe Kaserman, and Kostas Alysandratos - all legends of the lung regeneration field at the CReM Boston University
@crem-boston.bsky.social
#CureIPF
July 14, 2025 at 5:30 PM
Delighted to give a talk at the Vermont Lung Stem Cell Conference last week.
Also got to visit with @kottond.bsky.social, Finn Hawkins, Joe Kaserman, and Kostas Alysandratos - all legends of the lung regeneration field at the CReM Boston University
@crem-boston.bsky.social
#CureIPF
Also got to visit with @kottond.bsky.social, Finn Hawkins, Joe Kaserman, and Kostas Alysandratos - all legends of the lung regeneration field at the CReM Boston University
@crem-boston.bsky.social
#CureIPF
Thrilled to host Dr. Hao Zhu
@crem-boston.bsky.social
as this year's 10th anniversary Annual Anita Kurmann Memorial Lecturer! Inspiring science from the
@Zhu_Lab
in Anita's honor. #itsthecells
@crem-boston.bsky.social
as this year's 10th anniversary Annual Anita Kurmann Memorial Lecturer! Inspiring science from the
@Zhu_Lab
in Anita's honor. #itsthecells
October 9, 2025 at 2:32 PM
Thrilled to host Dr. Hao Zhu
@crem-boston.bsky.social
as this year's 10th anniversary Annual Anita Kurmann Memorial Lecturer! Inspiring science from the
@Zhu_Lab
in Anita's honor. #itsthecells
@crem-boston.bsky.social
as this year's 10th anniversary Annual Anita Kurmann Memorial Lecturer! Inspiring science from the
@Zhu_Lab
in Anita's honor. #itsthecells
Excited to help spread the word about the latest advances in stem cell research! #itsthecells!
Congratulations to BU's Darrel Kotton, MD, who has joined 12 other distinguished researchers on the editorial board for Stem Cell Reports, the official journal of the International Society for Stem Cell Research.
Stem Cell Reports welcomes new researchers to its Editorial Board. Their appointments reinforce the Board’s commitment to championing the journal, raising its global visibility, and ensuring rigorous, high-quality peer review. Read more: ow.ly/YicL50X5QJF
October 3, 2025 at 6:52 PM
Excited to help spread the word about the latest advances in stem cell research! #itsthecells!
Great research by our own, Dr. Elizabeth Taglauer @The_BMC @CReM_Boston, featured today: "One NICU Doctor Is Finding the Cellular Clues to Preeclampsia’s Impact on Babies" healthcity.bmc.org/one-nicu-doc... #itsthecells #helpisontheway!
One NICU Doctor Is Finding the Cellular Clues to Preeclampsia’s Impact on Babies
Dr. Elizabeth Taglauer uses lung cells to study placental biology and how the placenta can disrupt babies’ development in preeclampsia.
healthcity.bmc.org
September 30, 2025 at 10:43 PM
Great research by our own, Dr. Elizabeth Taglauer @The_BMC @CReM_Boston, featured today: "One NICU Doctor Is Finding the Cellular Clues to Preeclampsia’s Impact on Babies" healthcity.bmc.org/one-nicu-doc... #itsthecells #helpisontheway!
Announcing our latest publication, just out today
@NatureComms, advancing our understanding of interstitial lung disease. Congrats to co-senior authors Drs. Jeremy Katzen and Kostas Alysandratos and their teams @Penn @CReM_Boston. Check it out here: www.nature.com/articles/s41...
@NatureComms, advancing our understanding of interstitial lung disease. Congrats to co-senior authors Drs. Jeremy Katzen and Kostas Alysandratos and their teams @Penn @CReM_Boston. Check it out here: www.nature.com/articles/s41...
Aberrant intermediate alveolar epithelial cells promote pathogenic activation of lung fibroblasts in preclinical fibrosis models - Nature Communications
The direct contribution of aberrant epithelial cells to lung fibrosis is largely unknown. The authors use murine and human systems to identify how these cells activate fibroblasts, and how reciprocal signals cause them to enter a profibrotic state.
www.nature.com
September 30, 2025 at 10:14 PM
Announcing our latest publication, just out today
@NatureComms, advancing our understanding of interstitial lung disease. Congrats to co-senior authors Drs. Jeremy Katzen and Kostas Alysandratos and their teams @Penn @CReM_Boston. Check it out here: www.nature.com/articles/s41...
@NatureComms, advancing our understanding of interstitial lung disease. Congrats to co-senior authors Drs. Jeremy Katzen and Kostas Alysandratos and their teams @Penn @CReM_Boston. Check it out here: www.nature.com/articles/s41...
Reposted by Darrell Kotton
“David Baltimore, a biologist who in 1975 won a Nobel Prize for a startling discovery that seemed to rock the foundations of the fledgling field of molecular biology, died on Saturday at his home in Woods Hole, Mass. He was 87.”🧪🩺
www.nytimes.com
September 7, 2025 at 11:02 PM
“David Baltimore, a biologist who in 1975 won a Nobel Prize for a startling discovery that seemed to rock the foundations of the fledgling field of molecular biology, died on Saturday at his home in Woods Hole, Mass. He was 87.”🧪🩺
An incredible advance in regenerative medicine, published this week: Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes | NEJM: www.nejm.org/doi/full/10....
Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes | NEJM
Zimislecel is an allogeneic stem cell–derived islet-cell therapy. Data on the safety
and efficacy of zimislecel in persons with type 1 diabetes are needed. We conducted
a phase 1–2 study of zimisle...
www.nejm.org
September 8, 2025 at 2:45 AM
An incredible advance in regenerative medicine, published this week: Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes | NEJM: www.nejm.org/doi/full/10....
Another impressive clinical accomplishment thanks to regenerative medicine research, just out @NEJM: #itsthecells! #helpisontheway! Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | www.nejm.org/doi/full/10....
Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | NEJM
The need to suppress a patient’s immune system after the transplantation of allogeneic
cells is associated with wide-ranging side effects. We report the outcomes of transplantation
of genetically m...
www.nejm.org
August 7, 2025 at 11:08 PM
Another impressive clinical accomplishment thanks to regenerative medicine research, just out @NEJM: #itsthecells! #helpisontheway! Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | www.nejm.org/doi/full/10....
So great to be together with so many @CReM_Boston alumni and current members at the #2025LungGRC!
August 5, 2025 at 1:08 AM
So great to be together with so many @CReM_Boston alumni and current members at the #2025LungGRC!
Reposted by Darrell Kotton
The #RespirERA IHU was out in force at the #2025LungGRC in Lucca with Manon Durandy, Laetitia Seguin (IRCAN) and @laure-em.bsky.social #IPMC Great science, wonderful exchanges with old colleagues and new connections and what a gorgeous place ! #LungResearch
August 1, 2025 at 10:05 AM
The #RespirERA IHU was out in force at the #2025LungGRC in Lucca with Manon Durandy, Laetitia Seguin (IRCAN) and @laure-em.bsky.social #IPMC Great science, wonderful exchanges with old colleagues and new connections and what a gorgeous place ! #LungResearch
Farewell #2025LungGRC! Great memories as we say farewell, handing off the ball to our new Chairs. #2025LungGRC. @GordonConf
August 1, 2025 at 7:01 AM
Farewell #2025LungGRC! Great memories as we say farewell, handing off the ball to our new Chairs. #2025LungGRC. @GordonConf
The traditional epithelium vs mesenchyme soccer game, won this year by a new team, Bronchospurs at the 2025 Lung Gordon Research Conference! #2025LungGRC. @GordonConf
August 1, 2025 at 7:00 AM
The traditional epithelium vs mesenchyme soccer game, won this year by a new team, Bronchospurs at the 2025 Lung Gordon Research Conference! #2025LungGRC. @GordonConf
Today we officially hand over our meeting Chair roles to the next Chairs: Drs. Cardoso and Crotty Alexander on Day 5 of the 2025 Lung Gordon Research Conference. Special thanks to Dr. Sue Majka, current Chair!
July 31, 2025 at 5:39 AM
Today we officially hand over our meeting Chair roles to the next Chairs: Drs. Cardoso and Crotty Alexander on Day 5 of the 2025 Lung Gordon Research Conference. Special thanks to Dr. Sue Majka, current Chair!
And we are live at the #grclung2025 in Tuscany!
At 9:45PM, the lecture hall in Tuscany is still full, discussion going strong, although half of the attendees just flew across the Atlantic. That’s the spirit of science I love
Gordon Conference of Lung Development, Injury and Repair.
#GRCLung2025
#ScienceMatters
#LungResearchersAreBest
Gordon Conference of Lung Development, Injury and Repair.
#GRCLung2025
#ScienceMatters
#LungResearchersAreBest
July 28, 2025 at 2:47 AM
And we are live at the #grclung2025 in Tuscany!
Our latest work, just out now at JCI Insight on iPSC modeling of pulmonary fibrosis. The latest chapter in the Kotton-Beers collaboration! Congrats to co-first authors Drs. Rodriguez and Alysandratos for leading the way! insight.jci.org/articles/vie...
JCI Insight -
Impaired AMPK control of alveolar epithelial cell metabolism promotes pulmonary fibrosis
insight.jci.org
July 11, 2025 at 3:44 PM
Our latest work, just out now at JCI Insight on iPSC modeling of pulmonary fibrosis. The latest chapter in the Kotton-Beers collaboration! Congrats to co-first authors Drs. Rodriguez and Alysandratos for leading the way! insight.jci.org/articles/vie...
Congrats @MingxiaGu and all the teams collaborating on this latest advance in stem cell and lung organoid research, just out @CellCellPress! and thanks for including our iPSCs! www.cell.com/cell/fulltex...
Co-development of mesoderm and endoderm enables organotypic vascularization in lung and gut organoids
Recapitulating the concurrent development of germ layers through the co-differentiation
of mesoderm and endoderm within a single spheroid enabled the generation of vascularized
lung and intestinal org...
www.cell.com
June 30, 2025 at 5:40 PM
Congrats @MingxiaGu and all the teams collaborating on this latest advance in stem cell and lung organoid research, just out @CellCellPress! and thanks for including our iPSCs! www.cell.com/cell/fulltex...
Truly amazing pluripotent stem cell clinical trial results for diabetes! “Off-the-shelf stem cell therapy for type 1 diabetes yields more positive results”. Also published in @NEJM this week. #helpisontheway!
www.statnews.com/2025/06/20/s...
www.statnews.com/2025/06/20/s...
Off-the-shelf stem cell therapy for type 1 diabetes continues to show positive results
An off-the-shelf stem cell therapy for type 1 diabetes continues to show positive results, according to a new study.
www.statnews.com
June 21, 2025 at 3:30 AM
Truly amazing pluripotent stem cell clinical trial results for diabetes! “Off-the-shelf stem cell therapy for type 1 diabetes yields more positive results”. Also published in @NEJM this week. #helpisontheway!
www.statnews.com/2025/06/20/s...
www.statnews.com/2025/06/20/s...
Reposted by Darrell Kotton
RFK Jr. plans to bar NIH scientists from top journals like NEJM & JAMA, replacing them with government-run outlets.
This would delegitimize taxpayer-funded research, warns Dr. Adam Gaffney of Harvard Medical School.
www.washingtonpost.com/health/2025/...
This would delegitimize taxpayer-funded research, warns Dr. Adam Gaffney of Harvard Medical School.
www.washingtonpost.com/health/2025/...
RFK Jr. says he may bar scientists from publishing in top medical journals
Health Secretary Robert F. Kennedy Jr. took aim at reputed journals such as the Lancet and said his agency will create “in-house” publications instead.
www.washingtonpost.com
May 28, 2025 at 10:17 PM
RFK Jr. plans to bar NIH scientists from top journals like NEJM & JAMA, replacing them with government-run outlets.
This would delegitimize taxpayer-funded research, warns Dr. Adam Gaffney of Harvard Medical School.
www.washingtonpost.com/health/2025/...
This would delegitimize taxpayer-funded research, warns Dr. Adam Gaffney of Harvard Medical School.
www.washingtonpost.com/health/2025/...
“This is incredibly disappointing,” said Dr. Camille Kotton, an infectious diseases physician who cares for immunocompromised patients, and a former adviser to the CDC
”I don’t know why they would make this restriction; I don’t know of any indication to make this change,”
”I don’t know why they would make this restriction; I don’t know of any indication to make this change,”
F.D.A. Approves Novavax Covid Vaccine With Stricter New Conditions
www.nytimes.com
May 18, 2025 at 3:47 AM
“This is incredibly disappointing,” said Dr. Camille Kotton, an infectious diseases physician who cares for immunocompromised patients, and a former adviser to the CDC
”I don’t know why they would make this restriction; I don’t know of any indication to make this change,”
”I don’t know why they would make this restriction; I don’t know of any indication to make this change,”
An amazing clinical triumph for regenerative medicine! A great example of how federal funding results in patient cures. Let’s keep these stories going, America! “World's First Patient Treated with Personalized CRISPR Therapy” #helpisontheway!
www.pennmedicine.org/news/news-re...
www.pennmedicine.org/news/news-re...
World's First Patient Treated with Personalized CRISPR Therapy
In a historic medical breakthrough, a child diagnosed with a rare genetic disorder has been successfully treated with a customized CRISPR gene editing therapy by a team at Children’s Hospital of Phila...
www.pennmedicine.org
May 15, 2025 at 7:07 PM
An amazing clinical triumph for regenerative medicine! A great example of how federal funding results in patient cures. Let’s keep these stories going, America! “World's First Patient Treated with Personalized CRISPR Therapy” #helpisontheway!
www.pennmedicine.org/news/news-re...
www.pennmedicine.org/news/news-re...
Reposted by Darrell Kotton
The ATS is pleased to recognize Lauren Kearney, MD, as the 2025 Ziskind Clinical Research Scholar Award winner. Dr. Kearney aims to advance early detection of lung cancer, increase access to preventive care and treatment, and reduce health disparities.
Read more: www.thoracic.org/professional...
Read more: www.thoracic.org/professional...
April 16, 2025 at 4:10 PM
The ATS is pleased to recognize Lauren Kearney, MD, as the 2025 Ziskind Clinical Research Scholar Award winner. Dr. Kearney aims to advance early detection of lung cancer, increase access to preventive care and treatment, and reduce health disparities.
Read more: www.thoracic.org/professional...
Read more: www.thoracic.org/professional...
Reposted by Darrell Kotton
"There is perhaps no better demonstration of the folly of human conceits than this distant image of our tiny world. To me, it underscores our responsibility to deal more kindly with one another, and to preserve and cherish the pale blue dot, the only home we've ever known." - Carl Sagan
April 8, 2025 at 4:17 PM
"There is perhaps no better demonstration of the folly of human conceits than this distant image of our tiny world. To me, it underscores our responsibility to deal more kindly with one another, and to preserve and cherish the pale blue dot, the only home we've ever known." - Carl Sagan
Reposted by Darrell Kotton
We are so proud of our director, @kottond.bsky.social, for being awarded BU’s Innovator of the Year!
May 2, 2025 at 9:20 PM
We are so proud of our director, @kottond.bsky.social, for being awarded BU’s Innovator of the Year!