Kishor Sivaraj
@kishorks.bsky.social
Senior Scientist @MPI_Muenster; Interested in Vascular and Bone biology. Opinions are my own
I’m thrilled to announce that I will be giving a talk on Single Cell RNA Sequencing of Bone Stromal Cells at the ECTS 2025 Congress in the beautiful city of Innsbruck, Austria! 🇦🇹 Join me!
www.ects2025.org
@ectssociety.bsky.social
www.ects2025.org
@ectssociety.bsky.social
April 15, 2025 at 4:25 PM
I’m thrilled to announce that I will be giving a talk on Single Cell RNA Sequencing of Bone Stromal Cells at the ECTS 2025 Congress in the beautiful city of Innsbruck, Austria! 🇦🇹 Join me!
www.ects2025.org
@ectssociety.bsky.social
www.ects2025.org
@ectssociety.bsky.social
Reposted by Kishor Sivaraj
Enhancing the Cre-loxP system: Two new genetic tools – roxCre and loxCre – can improve the performance of the Cre-loxP system for making genetic modifications in vivo.
elifesciences.org/reviewed-pre...
elifesciences.org/reviewed-pre...
April 3, 2025 at 3:21 AM
Enhancing the Cre-loxP system: Two new genetic tools – roxCre and loxCre – can improve the performance of the Cre-loxP system for making genetic modifications in vivo.
elifesciences.org/reviewed-pre...
elifesciences.org/reviewed-pre...
Reposted by Kishor Sivaraj
1/Happy to share a new paper reporting a metabolic approach to radiosensitization in lung cancer, from Rachel Chiang, Faith Zhang and colleagues at UT Southwestern Radiation Oncology and @cri-utsw.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Lipoylation inhibition enhances radiation control of lung cancer by suppressing homologous recombination DNA damage repair
Genetic screen finds lipoylation as a target to improve radiation success in lung cancer by blocking DNA damage repair.
www.science.org
March 15, 2025 at 5:27 PM
1/Happy to share a new paper reporting a metabolic approach to radiosensitization in lung cancer, from Rachel Chiang, Faith Zhang and colleagues at UT Southwestern Radiation Oncology and @cri-utsw.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Kishor Sivaraj
"Great news! The ECTS Congress is heading to Innsbruck! 🏔️ Join us for an incredible gathering of ideas, collaboration, and innovation in this stunning alpine city. We can’t wait to see you there! #ECTS2025
March 12, 2025 at 2:34 PM
"Great news! The ECTS Congress is heading to Innsbruck! 🏔️ Join us for an incredible gathering of ideas, collaboration, and innovation in this stunning alpine city. We can’t wait to see you there! #ECTS2025
Reposted by Kishor Sivaraj
ICYMI: New content online: Adrenocortical stem cells in health and disease
Adrenocortical stem cells in health and disease
Nature Reviews Endocrinology, Published online: 10 March 2025; doi:10.1038/s41574-025-01091-2This Review outlines the mechanisms that regulate the establishment and maintenance of the adrenal stem cell niche — comprising capsular stem cells and cortical…
www.nature.com
March 12, 2025 at 9:01 PM
ICYMI: New content online: Adrenocortical stem cells in health and disease
Reposted by Kishor Sivaraj
The 2025 Mini Symposium is only TWO weeks away. To hear talks from @ralfhadams.bsky.social , A/Prof Sanjay Patel, @ianparish.bsky.social and @cgerlachlab.bsky.social - you can register here 👉 www.iseh.org/2025MiniSymposium
March 11, 2025 at 7:30 PM
The 2025 Mini Symposium is only TWO weeks away. To hear talks from @ralfhadams.bsky.social , A/Prof Sanjay Patel, @ianparish.bsky.social and @cgerlachlab.bsky.social - you can register here 👉 www.iseh.org/2025MiniSymposium
Reposted by Kishor Sivaraj
🔥Excited to share our preprint doi: doi.org/10.1101/2025... on the spatiotemporal reprogramming of the bone marrow in myelofibrosis #fibrosis #MPNsmlead in a highly collaborative effort 👇- looking forward to hearing your thoughts and please share 👍
February 19, 2025 at 12:56 PM
🔥Excited to share our preprint doi: doi.org/10.1101/2025... on the spatiotemporal reprogramming of the bone marrow in myelofibrosis #fibrosis #MPNsmlead in a highly collaborative effort 👇- looking forward to hearing your thoughts and please share 👍
Reposted by Kishor Sivaraj
very interesting research and great mentor!!
We are hiring at different levels!
- Lab technician for mouse experiments
- Postdoctoral fellow with experience in mass spectrometry-based metabolomics
For more information:
www.deduveinstitute.be/jobs
&
www.deduveinstitute.be/research-gro...
Come join our team and contribute to exciting science!
- Lab technician for mouse experiments
- Postdoctoral fellow with experience in mass spectrometry-based metabolomics
For more information:
www.deduveinstitute.be/jobs
&
www.deduveinstitute.be/research-gro...
Come join our team and contribute to exciting science!
www.deduveinstitute.be
January 29, 2025 at 2:34 PM
very interesting research and great mentor!!
Reposted by Kishor Sivaraj
Interested in the cell biology of the nucleus? Join us for this unique exciting meeting that covers everything from nuclear biophysics and mechanics to signaling and evolution😍 amazing speaker list and more will be selected from abstracts 🤩
📣 Join us for #EESNucleus 🧬
Explore the dynamic world of the nucleus at the new EMBO | EMBL Symposium. From nuclear mechanics to pathomechanisms, join the conversation shaping modern cell biology.
🗓️ 18 – 21 November 2025
📥 Submit your abstract by 26 August
👉 https://s.embl.org/ees25-07-bl
Explore the dynamic world of the nucleus at the new EMBO | EMBL Symposium. From nuclear mechanics to pathomechanisms, join the conversation shaping modern cell biology.
🗓️ 18 – 21 November 2025
📥 Submit your abstract by 26 August
👉 https://s.embl.org/ees25-07-bl
January 24, 2025 at 12:11 PM
Interested in the cell biology of the nucleus? Join us for this unique exciting meeting that covers everything from nuclear biophysics and mechanics to signaling and evolution😍 amazing speaker list and more will be selected from abstracts 🤩
Reposted by Kishor Sivaraj
#SmoothMuscleCell Mechanobiology
Effects of Pulsatile (not Cyclic) Stretch
(9% physiological strain, heart pressure waveform, 1 Hz, FlexCell) on
10 select genes human aortic SMC for 4/24/72 h
COL1A1
MMP2
LAMA5
FBN1
TGFBR1/2
MLCK
PRKG1
TAGLN
TNFRSF11B
#SciRep 2024
www.nature.com/articles/s41...
Effects of Pulsatile (not Cyclic) Stretch
(9% physiological strain, heart pressure waveform, 1 Hz, FlexCell) on
10 select genes human aortic SMC for 4/24/72 h
COL1A1
MMP2
LAMA5
FBN1
TGFBR1/2
MLCK
PRKG1
TAGLN
TNFRSF11B
#SciRep 2024
www.nature.com/articles/s41...
January 19, 2025 at 8:20 PM
#SmoothMuscleCell Mechanobiology
Effects of Pulsatile (not Cyclic) Stretch
(9% physiological strain, heart pressure waveform, 1 Hz, FlexCell) on
10 select genes human aortic SMC for 4/24/72 h
COL1A1
MMP2
LAMA5
FBN1
TGFBR1/2
MLCK
PRKG1
TAGLN
TNFRSF11B
#SciRep 2024
www.nature.com/articles/s41...
Effects of Pulsatile (not Cyclic) Stretch
(9% physiological strain, heart pressure waveform, 1 Hz, FlexCell) on
10 select genes human aortic SMC for 4/24/72 h
COL1A1
MMP2
LAMA5
FBN1
TGFBR1/2
MLCK
PRKG1
TAGLN
TNFRSF11B
#SciRep 2024
www.nature.com/articles/s41...
Reposted by Kishor Sivaraj
Big congratulations to Shauni Loopmans for her excellent PhD research, now online in @natmetabolism.bsky.social. This study reveals that the pentose phosphate pathway in #chondrocytes is crucial for ER redox homeostasis and cell survival rdcu.be/d5Q65 (1/3)
The pentose phosphate pathway controls oxidative protein folding and prevents ferroptosis in chondrocytes
Nature Metabolism - Loopmans et al. show that the pentose phosphate pathway in chondrocytes provides reducing power to ensure proteostasis necessary for bone lengthening.
rdcu.be
January 13, 2025 at 11:00 AM
Big congratulations to Shauni Loopmans for her excellent PhD research, now online in @natmetabolism.bsky.social. This study reveals that the pentose phosphate pathway in #chondrocytes is crucial for ER redox homeostasis and cell survival rdcu.be/d5Q65 (1/3)
Reposted by Kishor Sivaraj
Reposted by Kishor Sivaraj
Local erythropoiesis directs oxygen availability in bone fracture repair https://www.biorxiv.org/content/10.1101/2025.01.10.632440v1
January 11, 2025 at 9:30 AM
Local erythropoiesis directs oxygen availability in bone fracture repair https://www.biorxiv.org/content/10.1101/2025.01.10.632440v1
View from lab @mpi-muenster.bsky.social
January 9, 2025 at 7:45 PM
View from lab @mpi-muenster.bsky.social
🦴 vessels 🔥 www.nature.com/articles/s44...
Endothelial LATS2 is a suppressor of bone marrow fibrosis - Nature Cardiovascular Research
Sivaraj, Majev et al. demonstrate that the inactivation of Lats2 in endothelial cells triggers the upregulation of serum response factor and endothelial-to-mesenchymal transition, leading to myofibrob...
www.nature.com
January 9, 2025 at 12:03 PM
🦴 vessels 🔥 www.nature.com/articles/s44...