Kimberly Luddy
@kimberly-luddy.bsky.social
Theoretical and experimental immunologist working in cancer research.
Moffitt Cancer Center
Moffitt Cancer Center
Reposted by Kimberly Luddy
The creative process in science has a set of thinking tools that we could do a better job teaching. Here are the 12 articles that Martin and I wrote about them, including "It takes two to think", "A hypothesis is a liability" and "The two languages of science". night-science.org/home/learn/r...
August 11, 2025 at 2:23 AM
The creative process in science has a set of thinking tools that we could do a better job teaching. Here are the 12 articles that Martin and I wrote about them, including "It takes two to think", "A hypothesis is a liability" and "The two languages of science". night-science.org/home/learn/r...
The DNA replication checkpoint targets the kinetochore to reposition DNA structure-induced replication damage to the nuclear periphery
www.cell.com/cell-reports...
www.cell.com/cell-reports...
The DNA replication checkpoint targets the kinetochore to reposition DNA structure-induced replication damage to the nuclear periphery
Expanded CAG repeats, the cause of Huntington’s disease, stall replication and reposition
to the nuclear periphery to effect repair. Maclay et al. report that the DNA replication
checkpoint targets th...
www.cell.com
August 5, 2025 at 12:05 PM
The DNA replication checkpoint targets the kinetochore to reposition DNA structure-induced replication damage to the nuclear periphery
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Reposted by Kimberly Luddy
We're recruiting a postdoc to join my lab at @oncology.ox.ac.uk & @oxcio.bsky.social to understand immune regulation in cancer and develop new approaches for cancer prevention and metastasis.
Deadline: 11 August 2025
my.corehr.com/pls/uoxrecru...
Lab info: www.oncology.ox.ac.uk/team/jie-yang
Deadline: 11 August 2025
my.corehr.com/pls/uoxrecru...
Lab info: www.oncology.ox.ac.uk/team/jie-yang
Job Details
my.corehr.com
July 18, 2025 at 10:19 AM
We're recruiting a postdoc to join my lab at @oncology.ox.ac.uk & @oxcio.bsky.social to understand immune regulation in cancer and develop new approaches for cancer prevention and metastasis.
Deadline: 11 August 2025
my.corehr.com/pls/uoxrecru...
Lab info: www.oncology.ox.ac.uk/team/jie-yang
Deadline: 11 August 2025
my.corehr.com/pls/uoxrecru...
Lab info: www.oncology.ox.ac.uk/team/jie-yang
Reposted by Kimberly Luddy
Nice writeup of our new @cp-cell.bsky.social article on an intuitive, plain language "grammar" to make simulation modeling of complex multicellular systems more accessible. Huge thx to Forest Ray and @genomeweb.bsky.social !
Joint work by @fertiglab.bsky.social, Genevieve Stein-O'Brien & team! 🧪
Joint work by @fertiglab.bsky.social, Genevieve Stein-O'Brien & team! 🧪
Computational Model Predicts Tissue-Specific Cell Activity Over Time
Computational Model Predicts Tissue-Specific Cell Activity Over Time
www.genomeweb.com
July 29, 2025 at 10:43 AM
Nice writeup of our new @cp-cell.bsky.social article on an intuitive, plain language "grammar" to make simulation modeling of complex multicellular systems more accessible. Huge thx to Forest Ray and @genomeweb.bsky.social !
Joint work by @fertiglab.bsky.social, Genevieve Stein-O'Brien & team! 🧪
Joint work by @fertiglab.bsky.social, Genevieve Stein-O'Brien & team! 🧪
Reposted by Kimberly Luddy
Differentiation-associated ISG expression of NK cells in chronic viral infection @cp-iscience.bsky.social
www.cell.com/iscience/ful...
www.cell.com/iscience/ful...
July 28, 2025 at 9:50 PM
Differentiation-associated ISG expression of NK cells in chronic viral infection @cp-iscience.bsky.social
www.cell.com/iscience/ful...
www.cell.com/iscience/ful...
Reposted by Kimberly Luddy
Review of the possible role of Matzinger's "danger theory" of damage-associated molecular patterns in CNS as drivers of increased incidence of major depressive disorder www.science.org/doi/10.1126/...
July 25, 2025 at 8:47 PM
Review of the possible role of Matzinger's "danger theory" of damage-associated molecular patterns in CNS as drivers of increased incidence of major depressive disorder www.science.org/doi/10.1126/...
Reposted by Kimberly Luddy
🧵1/ New in @Cancer_Cell: Our lab discovered that Th17 cells must team up with B cells to eliminate tumors, and prevent it from coming back.
🔗 Read: www.cell.com/cancer-cell/...
🧬This unexpected immune duo sparks tumor immunity.
🖼️Image: See schematic Th17/B cell antitumor action!
🔗 Read: www.cell.com/cancer-cell/...
🧬This unexpected immune duo sparks tumor immunity.
🖼️Image: See schematic Th17/B cell antitumor action!
Adoptively transferred Th17 cells cooperate with host B cells to achieve durable tumor immunity
Cole et al. report that adoptively transferred, tumor-specific Th17 cells engage host
B cells and drive B cell proliferation and differentiation. These Th17 cells require
B cells for sustained immunit...
www.cell.com
July 25, 2025 at 2:51 PM
🧵1/ New in @Cancer_Cell: Our lab discovered that Th17 cells must team up with B cells to eliminate tumors, and prevent it from coming back.
🔗 Read: www.cell.com/cancer-cell/...
🧬This unexpected immune duo sparks tumor immunity.
🖼️Image: See schematic Th17/B cell antitumor action!
🔗 Read: www.cell.com/cancer-cell/...
🧬This unexpected immune duo sparks tumor immunity.
🖼️Image: See schematic Th17/B cell antitumor action!
This announcement from the NIH is fantastic
“NIH will no longer seek proposals exclusively for animal models”
All new proposals should include modern alternatives: e.g. computational modeling and organoid style technologies with human components.
drugdiscoverytrends.com/nih-announces-…
“NIH will no longer seek proposals exclusively for animal models”
All new proposals should include modern alternatives: e.g. computational modeling and organoid style technologies with human components.
drugdiscoverytrends.com/nih-announces-…
July 8, 2025 at 6:47 PM
This announcement from the NIH is fantastic
“NIH will no longer seek proposals exclusively for animal models”
All new proposals should include modern alternatives: e.g. computational modeling and organoid style technologies with human components.
drugdiscoverytrends.com/nih-announces-…
“NIH will no longer seek proposals exclusively for animal models”
All new proposals should include modern alternatives: e.g. computational modeling and organoid style technologies with human components.
drugdiscoverytrends.com/nih-announces-…
Reposted by Kimberly Luddy
A week away from the start of the @smbmathbiology.bsky.social meeting in #Edmonton so it seems like an apt time to share my convo with conference organizer, Jay Newby. You'll also hear me nerding out about potassium channels in neurons 🧠
smb.org/news/13516785
#SciencePodcast #BiologyInNumbers
smb.org/news/13516785
#SciencePodcast #BiologyInNumbers
July 7, 2025 at 11:26 AM
A week away from the start of the @smbmathbiology.bsky.social meeting in #Edmonton so it seems like an apt time to share my convo with conference organizer, Jay Newby. You'll also hear me nerding out about potassium channels in neurons 🧠
smb.org/news/13516785
#SciencePodcast #BiologyInNumbers
smb.org/news/13516785
#SciencePodcast #BiologyInNumbers
Reposted by Kimberly Luddy
Metabolites as agents and targets for cancer immunotherapy www.nature.com/articles/s41...
rdcu.be/etLMD
This new Review discusses the role of metabolic pathways in cancer and immune cells in shaping the tumour microenvironment, and how they can be targeted to improve anticancer immune responses
rdcu.be/etLMD
This new Review discusses the role of metabolic pathways in cancer and immune cells in shaping the tumour microenvironment, and how they can be targeted to improve anticancer immune responses
Metabolites as agents and targets for cancer immunotherapy - Nature Reviews Drug Discovery
Tumour cells undergo profound changes in their metabolism, but targeting these metabolic pathways requires understanding of the impact on immune cells as well as cancer cells. This Review discusses ho...
www.nature.com
June 27, 2025 at 2:54 PM
Metabolites as agents and targets for cancer immunotherapy www.nature.com/articles/s41...
rdcu.be/etLMD
This new Review discusses the role of metabolic pathways in cancer and immune cells in shaping the tumour microenvironment, and how they can be targeted to improve anticancer immune responses
rdcu.be/etLMD
This new Review discusses the role of metabolic pathways in cancer and immune cells in shaping the tumour microenvironment, and how they can be targeted to improve anticancer immune responses
Reposted by Kimberly Luddy
🔥 Dive into the latest on inflammasomes, innate immunity & more at our event with the BSI #Inflammation Affinity Group on 11–12 Sept in Manchester!
Cutting-edge talks, career workshops & networking with experts. Abstract deadline: 15 July!
☑️ Submit your abstract & register: bit.ly/43q9x9r
Cutting-edge talks, career workshops & networking with experts. Abstract deadline: 15 July!
☑️ Submit your abstract & register: bit.ly/43q9x9r
June 26, 2025 at 10:27 AM
🔥 Dive into the latest on inflammasomes, innate immunity & more at our event with the BSI #Inflammation Affinity Group on 11–12 Sept in Manchester!
Cutting-edge talks, career workshops & networking with experts. Abstract deadline: 15 July!
☑️ Submit your abstract & register: bit.ly/43q9x9r
Cutting-edge talks, career workshops & networking with experts. Abstract deadline: 15 July!
☑️ Submit your abstract & register: bit.ly/43q9x9r
Sarah Amend: Describing endocyling in cancer dormancy starts by highlighting the lethality of metastatic + therapy resistant cancer cells.
May 6, 2025 at 10:51 AM
Sarah Amend: Describing endocyling in cancer dormancy starts by highlighting the lethality of metastatic + therapy resistant cancer cells.
Guido Ferlazzo: Hepatic stellate cells facilitate the regrowth of dormant cancer cells by reducing NK cell regulation of dormancy in the liver.
May 6, 2025 at 10:45 AM
Guido Ferlazzo: Hepatic stellate cells facilitate the regrowth of dormant cancer cells by reducing NK cell regulation of dormancy in the liver.
Kenneth Pienta: Detecting prostate cancer metastasis with PSMA has changed his understanding of the metastatic cascade.
May 6, 2025 at 10:29 AM
Kenneth Pienta: Detecting prostate cancer metastasis with PSMA has changed his understanding of the metastatic cascade.
Day 2 of Cancer Dormancy and Therapy Resistance workshop.
May 6, 2025 at 10:21 AM
Day 2 of Cancer Dormancy and Therapy Resistance workshop.
Alessandra Riggio, discussing a rapid autopsy program in metastatic breast cancer. Finding disseminated cells undetectable by imaging.
May 5, 2025 at 2:40 PM
Alessandra Riggio, discussing a rapid autopsy program in metastatic breast cancer. Finding disseminated cells undetectable by imaging.
Simone Baldassarri: Mathematical aspects of Dormancy for non experts.
Dormancy and migration slow gentic drift and enhance diversity
Dormancy and migration slow gentic drift and enhance diversity
May 5, 2025 at 12:34 PM
Simone Baldassarri: Mathematical aspects of Dormancy for non experts.
Dormancy and migration slow gentic drift and enhance diversity
Dormancy and migration slow gentic drift and enhance diversity
Ann Zeuner asks, is Cancer Dormancy a Trojan horse or an Achille's heel?
May 5, 2025 at 12:03 PM
Ann Zeuner asks, is Cancer Dormancy a Trojan horse or an Achille's heel?
Looking forward to a great conference on Cancer Dormancy and Therapy Resistance.
May 5, 2025 at 11:38 AM
Looking forward to a great conference on Cancer Dormancy and Therapy Resistance.
Reposted by Kimberly Luddy
Helper ILCs in the human hematopoietic system #immunology
Helper ILCs in the human hematopoietic system
Helper innate lymphoid cells (ILCs), comprising groups ILC1, ILC2, and ILC3, possess unique advantages in eliciting rapid immune responses and were recently found to exhibit direct tumor-killing capacities comparable with those of cytotoxic ILCs [natural…
dlvr.it
February 26, 2025 at 12:26 AM
Helper ILCs in the human hematopoietic system #immunology
Reposted by Kimberly Luddy
Absolutely delighted to receive this award from
@researchireland.bsky.social
as Highly Commended in the Early Career Researcher of the Year 2024! I'm so grateful to all of my colleagues &the wider research community for their support. Looking forward to continuing our research in 2025 & beyond!
@researchireland.bsky.social
as Highly Commended in the Early Career Researcher of the Year 2024! I'm so grateful to all of my colleagues &the wider research community for their support. Looking forward to continuing our research in 2025 & beyond!
January 17, 2025 at 7:05 PM
Absolutely delighted to receive this award from
@researchireland.bsky.social
as Highly Commended in the Early Career Researcher of the Year 2024! I'm so grateful to all of my colleagues &the wider research community for their support. Looking forward to continuing our research in 2025 & beyond!
@researchireland.bsky.social
as Highly Commended in the Early Career Researcher of the Year 2024! I'm so grateful to all of my colleagues &the wider research community for their support. Looking forward to continuing our research in 2025 & beyond!
An important reminder: Science is really difficult.
It's almost a daily conversation in the lab. Remember, 50% of what we do has never been done before. From the simplest experiments to the most indepth review. This stuff is not easy. Be kind and celebrate the wins!
It's almost a daily conversation in the lab. Remember, 50% of what we do has never been done before. From the simplest experiments to the most indepth review. This stuff is not easy. Be kind and celebrate the wins!
January 21, 2025 at 7:31 PM
An important reminder: Science is really difficult.
It's almost a daily conversation in the lab. Remember, 50% of what we do has never been done before. From the simplest experiments to the most indepth review. This stuff is not easy. Be kind and celebrate the wins!
It's almost a daily conversation in the lab. Remember, 50% of what we do has never been done before. From the simplest experiments to the most indepth review. This stuff is not easy. Be kind and celebrate the wins!
Today's Integrated Mathematical Oncology research in progess talk,
Thomas Veith: Optimizing the Replicator Equation to Model Frequency Dependent Effects in cancer, when Selection favors the rare phenotype. #Oncology
Thomas Veith: Optimizing the Replicator Equation to Model Frequency Dependent Effects in cancer, when Selection favors the rare phenotype. #Oncology
January 21, 2025 at 3:47 PM
Today's Integrated Mathematical Oncology research in progess talk,
Thomas Veith: Optimizing the Replicator Equation to Model Frequency Dependent Effects in cancer, when Selection favors the rare phenotype. #Oncology
Thomas Veith: Optimizing the Replicator Equation to Model Frequency Dependent Effects in cancer, when Selection favors the rare phenotype. #Oncology
Reposted by Kimberly Luddy
"Liquid biopsies" detecting ctDNA have a lot of promise but have had poor sensitivity in early stage disease. Can new ultra-sensitive techniques overcome these challenges? Impressive data from the TRACERx team https://buff.ly/4jfMyF6 Found with researchbriefing.com
Ultrasensitive ctDNA detection for preoperative disease stratification in early-stage lung adenocarcinoma - Nature Medicine
In the TRACERx cohort of 171 patients with lung cancer, the ultrasensitive detection of ctDNA improves preoperative patient stratification, also in early-stage disease.
www.nature.com
January 16, 2025 at 9:00 AM
"Liquid biopsies" detecting ctDNA have a lot of promise but have had poor sensitivity in early stage disease. Can new ultra-sensitive techniques overcome these challenges? Impressive data from the TRACERx team https://buff.ly/4jfMyF6 Found with researchbriefing.com
Reposted by Kimberly Luddy
The single best career advice that I give PhDs is that there are multiple different pathways to success. It is the detours that make your insights unique. This is why @immunolcellbiol.bsky.social made #PathwaysToSuccess - get inspired from different journeys!
onlinelibrary.wiley.com/page/journal...
onlinelibrary.wiley.com/page/journal...
<em>Immunology & Cell Biology</em> | ASI Journal | Wiley Online Library
<em>Immunology & Cell Biology</em> is the flagship journal of the ASI, focusing on the general functioning of the immune system, with particular emphasis on its cell biology.
onlinelibrary.wiley.com
January 12, 2025 at 8:26 PM
The single best career advice that I give PhDs is that there are multiple different pathways to success. It is the detours that make your insights unique. This is why @immunolcellbiol.bsky.social made #PathwaysToSuccess - get inspired from different journeys!
onlinelibrary.wiley.com/page/journal...
onlinelibrary.wiley.com/page/journal...