Seven journals are now accepting submissions through ACS Publishing Center. Together they represent over 25% of the authors who choose ACS journals to publish their best work.

Academic science in the US is being gutted by Trump

Vaccine Integrity Project intends to provide scientific responses to ill-founded vaccine moves

Nearly 2,000 scientists urged that Congress restore funding to federal agencies decimated by recent cuts.

In early 2020, severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) infections leading to COVID-19 disease reached a global level leading to the World Health Organization (WHO) declaration of ...

CCR6 is a chemokine receptor that mediates the migration of pathogenic inflammatory leukocytes to sites of inflammation in response to its ligand, CCL20. Herein we report the design of a potent CCR6 antagonist capable of inhibiting the chemotactic migration of CCR6+ T cells in vitro. Key to this finding was the discovery of a remarkable methyl substituent effect on antagonist potency. A 365-fold improvement in potency was observed for the cis-2-methylcyclohexanamine analogue compared to the unsubstituted cyclohexanamine derivative. Evidence generated through the characterization of conformationally restricted analogues supports the conclusion that the large potency enhancement is the result of the methyl substituent biasing the cyclohexane ring ground state conformation to favor that of the bound ligand and thus decreasing the ligand strain energy.

During his confirmation hearings, President Trump’s nominee to lead the Department of Health and Human Services showed that his dangerous views on vaccines and science haven’t changed.

America’s best scientific minds are scrambling to determine the impact of the disruption.