Joachim Weischenfeldt
@jweischenfeldt.bsky.social
Research group leader and professor at University of Copenhagen and RIgshospitalet. Research in cancer genomics/genetics, structural variants, mutational processes and clonal evolution
Reposted by Joachim Weischenfeldt
Back-to-back: Integrating single-nuclei RNA-seq and whole-genome sequencing, @joachimwei.bsky.social and his team show how prostate cancer metastasis is shaped by plasticity-driven convergence alongside ongoing clonal evolution, with distinct clones adopting shared transcriptional trajectories.
Clonal evolution and transcriptional plasticity shape metastatic dissemination routes in prostate cancer - Nature Communications
The impact of tumour heterogeneity on metastatic potential in prostate cancer remains poorly understood. Here, the analysis of single nuclei RNA sequencing and whole-genome sequencing from samples fro...
www.nature.com
December 23, 2025 at 9:15 PM
Back-to-back: Integrating single-nuclei RNA-seq and whole-genome sequencing, @joachimwei.bsky.social and his team show how prostate cancer metastasis is shaped by plasticity-driven convergence alongside ongoing clonal evolution, with distinct clones adopting shared transcriptional trajectories.
Reposted by Joachim Weischenfeldt
Joachim Weischenfeldt, Ashani Weeraratna, Karuna Ganesh, Elaine Fuchs, Ana Anderson, and Sheetal Hardikar discussed "Endogenous Mechanisms of Early Onset Carcinogenesis" at #AACRearlyonset25. @jweischenfeldt.bsky.social @ashi-w.bsky.social @karunamdphd.bsky.social @thefuchslab.bsky.social
December 12, 2025 at 10:07 PM
Joachim Weischenfeldt, Ashani Weeraratna, Karuna Ganesh, Elaine Fuchs, Ana Anderson, and Sheetal Hardikar discussed "Endogenous Mechanisms of Early Onset Carcinogenesis" at #AACRearlyonset25. @jweischenfeldt.bsky.social @ashi-w.bsky.social @karunamdphd.bsky.social @thefuchslab.bsky.social
Great participation and discussions at our PhD course in Cancer Genomics at @bric-ucph.bsky.social organized together with prof Jesper Andersen. Exciting talks and interactions with external speakers incl @ecuppen.bsky.social and @matlupien.bsky.social 🙏💪👇
October 31, 2025 at 8:26 AM
Great participation and discussions at our PhD course in Cancer Genomics at @bric-ucph.bsky.social organized together with prof Jesper Andersen. Exciting talks and interactions with external speakers incl @ecuppen.bsky.social and @matlupien.bsky.social 🙏💪👇
Reposted by Joachim Weischenfeldt
Heads up: ignore samtools dot org, similarly minimap2 dot com and likely others. It's owned by a known phishing site and while the binaries they offer look valid currently (but note they may be serving us different binaries to others), that could change.
Ie: it's not us (Samtools team)! Be warned
Ie: it's not us (Samtools team)! Be warned
September 15, 2025 at 8:40 AM
Heads up: ignore samtools dot org, similarly minimap2 dot com and likely others. It's owned by a known phishing site and while the binaries they offer look valid currently (but note they may be serving us different binaries to others), that could change.
Ie: it's not us (Samtools team)! Be warned
Ie: it's not us (Samtools team)! Be warned
AACR Conference - Rise in Early-Onset Cancers www.aacr.org/meeting/aacr...
Program
Program details for AACR Special Conference in Cancer Research: The Rise in Early Onset Cancers - Knowledge Gaps and Research Opportunities.
www.aacr.org
September 11, 2025 at 3:43 PM
AACR Conference - Rise in Early-Onset Cancers www.aacr.org/meeting/aacr...
Reposted by Joachim Weischenfeldt
So excited to see it out in @science.org. See details below in the 🧵 from stellar former PhD student @bfurtwa.bsky.social.
Many thanks to all involved, especially Blueskyless Nil Uresin and Sabrina Richer and my co-PIs @fabiantheis.bsky.social and @erwinschoof.bsky.social
Many thanks to all involved, especially Blueskyless Nil Uresin and Sabrina Richer and my co-PIs @fabiantheis.bsky.social and @erwinschoof.bsky.social
We’re excited to present this integrative analysis of single-cell proteomics and transcriptomics of the human HSPC hierarchy. Now published in @science.org together with @fabiantheis.bsky.social, @erwinschoof.bsky.social, @porsebo.bsky.social.
www.science.org/doi/10.1126/...
🧵
www.science.org/doi/10.1126/...
🧵
Mapping early human blood cell differentiation using single-cell proteomics and transcriptomics
Single-cell transcriptomics (scRNA-seq) has facilitated the characterization of cell state heterogeneity and recapitulation of differentiation trajectories. However, the exclusive use of mRNA measurem...
www.science.org
August 22, 2025 at 10:51 AM
So excited to see it out in @science.org. See details below in the 🧵 from stellar former PhD student @bfurtwa.bsky.social.
Many thanks to all involved, especially Blueskyless Nil Uresin and Sabrina Richer and my co-PIs @fabiantheis.bsky.social and @erwinschoof.bsky.social
Many thanks to all involved, especially Blueskyless Nil Uresin and Sabrina Richer and my co-PIs @fabiantheis.bsky.social and @erwinschoof.bsky.social
Reposted by Joachim Weischenfeldt
Almost all grant-review meetings under Trump 2.0 remain suspended at the US National Institutes of Health (NIH), preventing the world’s largest public funder of biomedical research from spending much of its US$47 billion annual budget.
https://go.nature.com/4gM6oW4
https://go.nature.com/4gM6oW4
Revealed: NIH research grants still frozen despite lawsuits challenging Trump order
The Trump administration is exploiting a loophole to keep a funding freeze in place, leaving researchers in limbo.
go.nature.com
February 20, 2025 at 8:04 PM
Almost all grant-review meetings under Trump 2.0 remain suspended at the US National Institutes of Health (NIH), preventing the world’s largest public funder of biomedical research from spending much of its US$47 billion annual budget.
https://go.nature.com/4gM6oW4
https://go.nature.com/4gM6oW4
Reposted by Joachim Weischenfeldt
“I’ve spent over five decades as a scientist in academia & the federal government, including as director of the National Institutes of Health. Never before have I seen my profession so politicized as it is now under the Trump administration”
#AcademicSky 🧪
www.nytimes.com/2025/02/14/o...
#AcademicSky 🧪
www.nytimes.com/2025/02/14/o...
Opinion | American Science is Under Attack (Gift Article)
The Trump administration hobbles research and endangers the public health.
www.nytimes.com
February 15, 2025 at 12:59 AM
“I’ve spent over five decades as a scientist in academia & the federal government, including as director of the National Institutes of Health. Never before have I seen my profession so politicized as it is now under the Trump administration”
#AcademicSky 🧪
www.nytimes.com/2025/02/14/o...
#AcademicSky 🧪
www.nytimes.com/2025/02/14/o...