Joachim Weischenfeldt
@jweischenfeldt.bsky.social
Research group leader and professor at University of Copenhagen and RIgshospitalet. Research in cancer genomics/genetics, structural variants, mutational processes and clonal evolution
Reposted by Joachim Weischenfeldt
Back-to-back: Integrating single-nuclei RNA-seq and whole-genome sequencing, @joachimwei.bsky.social and his team show how prostate cancer metastasis is shaped by plasticity-driven convergence alongside ongoing clonal evolution, with distinct clones adopting shared transcriptional trajectories.
Clonal evolution and transcriptional plasticity shape metastatic dissemination routes in prostate cancer - Nature Communications
The impact of tumour heterogeneity on metastatic potential in prostate cancer remains poorly understood. Here, the analysis of single nuclei RNA sequencing and whole-genome sequencing from samples fro...
www.nature.com
December 23, 2025 at 9:15 PM
Back-to-back: Integrating single-nuclei RNA-seq and whole-genome sequencing, @joachimwei.bsky.social and his team show how prostate cancer metastasis is shaped by plasticity-driven convergence alongside ongoing clonal evolution, with distinct clones adopting shared transcriptional trajectories.