Luca Jovine
@jovinelab.org
Professor of #StructuralBiology @karolinskainst.bsky.social studying #egg-#sperm interaction at #fertilization & #ZonaPellucida (ZP) module proteins
Member of #EMBO & the #NobelAssembly at Karolinska Institutet
More @ http://jovinelab.org
Member of #EMBO & the #NobelAssembly at Karolinska Institutet
More @ http://jovinelab.org
Long-awaited OpenFold3 is out!
OpenFold3-preview (OF3p) is out: a sneak peek of our AF3-based structure prediction model. Our aim for OF3 is full AF3-parity for every modality. We now believe we have a clear path towards this goal and are releasing OF3p to enable building in the OF3 ecosystem. More👇
October 29, 2025 at 7:36 AM
Long-awaited OpenFold3 is out!
Great to get another peek at this story, after hosting @jacob-hanna.bsky.social as keynote speaker of our recent #GRC on Fertilization and Activation of Development!
🧪 From petri dish to embryo model: @jacob-hanna.bsky.social work shows how naïve pluripotent stem cells can self-organize into advanced developmental stages.
The 2025 #HFSPNakasoneAward lecture reveals the science behind synthetic embryo models.
Full lecture 🎥 👉 zurl.co/Tgf4f
#sts
The 2025 #HFSPNakasoneAward lecture reveals the science behind synthetic embryo models.
Full lecture 🎥 👉 zurl.co/Tgf4f
#sts
HFSP Nakasone Award 2025 Lecture – Jacob Hanna on Synthetic Embryo Models
In this official HFSP Nakasone Award lecture, Professor Jacob (Yaqub) Hanna of the Weizmann Institute of Science shares the groundbreaking research that earn...
www.youtube.com
August 14, 2025 at 9:03 AM
Great to get another peek at this story, after hosting @jacob-hanna.bsky.social as keynote speaker of our recent #GRC on Fertilization and Activation of Development!
Excited that the Gordon Research Conference on Fertilization and Activation of Development 2025 (and associated GRS) is just a few days away!
www.grc.org/fertilizatio...
www.grc.org/fertilizatio...
#GRC #GRS #fertilization #development #egg #sperm
www.grc.org/fertilizatio...
www.grc.org/fertilizatio...
#GRC #GRS #fertilization #development #egg #sperm
July 22, 2025 at 9:09 AM
Excited that the Gordon Research Conference on Fertilization and Activation of Development 2025 (and associated GRS) is just a few days away!
www.grc.org/fertilizatio...
www.grc.org/fertilizatio...
#GRC #GRS #fertilization #development #egg #sperm
www.grc.org/fertilizatio...
www.grc.org/fertilizatio...
#GRC #GRS #fertilization #development #egg #sperm
👍🎾🇮🇹
Breaking News from @theathletic.bsky.social: Jannik Sinner defeated Carlos Alcaraz in a 4-set duel to win his first Wimbledon title.
Wimbledon final: Jannik Sinner beats Carlos Alcaraz to win first Wimbledon title
Five weeks after their French Open classic, Sinner outplayed Alcaraz from the baseline to win his first Wimbledon title.
www.nytimes.com
July 13, 2025 at 8:33 PM
👍🎾🇮🇹
Reposted by Luca Jovine
Molecular cat tweezers? 😺
July 12, 2025 at 4:12 AM
Molecular cat tweezers? 😺
Reposted by Luca Jovine
Up on biorxiv! The tour de force protein tagging atlas for the #Celegans cuticle #aECM - from Jordan Ward @gotworms.bsky.social and Andrew Chisholm labs. So many beautiful images of cuticle collagen substructures !! www.biorxiv.org/content/10.1...
Multiscale patterning of a model apical extracellular matrix revealed by systematic endogenous protein tagging
Barrier epithelia are shielded from the external environment by their apical extracellular matrices (aECMs). The molecular complexity of aECMs has challenged understanding of their organization in viv...
www.biorxiv.org
May 17, 2025 at 2:09 PM
Up on biorxiv! The tour de force protein tagging atlas for the #Celegans cuticle #aECM - from Jordan Ward @gotworms.bsky.social and Andrew Chisholm labs. So many beautiful images of cuticle collagen substructures !! www.biorxiv.org/content/10.1...
Thanks @svtnyheter.bsky.social for covering our #ZP2 non-hormonal #contraception story!
www.svt.se/nyheter/inri...
@ki.se
@esrf.fr
@pnas.org
@vetenskapsradet.bsky.social
@kawresearch.bsky.social
www.svt.se/nyheter/inri...
@ki.se
@esrf.fr
@pnas.org
@vetenskapsradet.bsky.social
@kawresearch.bsky.social
Ny forskning kan leda till hormonfritt preventivmedel
Jakten på ett hormonfritt preventivmedel har pågått i många år. Nu har forskare på KI upptäckt ett sätt att stoppa befruktning med hjälp av antikroppar. – Det hade gett kvinnor möjligheten att själva ...
www.svt.se
May 11, 2025 at 8:13 AM
Thanks @svtnyheter.bsky.social for covering our #ZP2 non-hormonal #contraception story!
www.svt.se/nyheter/inri...
@ki.se
@esrf.fr
@pnas.org
@vetenskapsradet.bsky.social
@kawresearch.bsky.social
www.svt.se/nyheter/inri...
@ki.se
@esrf.fr
@pnas.org
@vetenskapsradet.bsky.social
@kawresearch.bsky.social
As an old tRNA aficionado, can't help loving this beautiful tour-de-force cryo-EM work on one of nature's coolest molecules! Congrats @sebastianglatt.bsky.social and colleagues!!!
We are very excited about our latest work, which just came out @embojournal.org – www.embopress.org/doi/full/10..... The work @MCB_UJ was driven by Anna Biela and Ting-Yu Lin 林亭妤 in collaboration with @jmbujnicki.bsky.social…a short🧵
Determining the effects of pseudouridine incorporation on human tRNAs | The EMBO Journal
imageimagetRNAs harbour a complex set of modifications which are important for their function.
Here, single particle cryo-EM, biophysics, and computational analyses of the effects
of pseudouridine inc...
www.embopress.org
April 30, 2025 at 5:15 AM
As an old tRNA aficionado, can't help loving this beautiful tour-de-force cryo-EM work on one of nature's coolest molecules! Congrats @sebastianglatt.bsky.social and colleagues!!!
Fresh off the press in @pnas.org: functional and structural studies of the interaction between #fertilization-blocking mAb IE-3 and mammalian #egg coat protein #ZP2
www.pnas.org/doi/10.1073/...
Thanks to
@vetenskapsradet.bsky.social @erc.europa.eu @embo.org @kawresearch.bsky.social @dfg.de
www.pnas.org/doi/10.1073/...
Thanks to
@vetenskapsradet.bsky.social @erc.europa.eu @embo.org @kawresearch.bsky.social @dfg.de
Structural basis of ZP2-targeted female nonhormonal contraception | PNAS
Monoclonal antibody IE-3 prevents mouse fertilization by binding ZP2, a major component
of the oocyte-specific zona pellucida (ZP). We show that an...
www.pnas.org
April 14, 2025 at 6:43 AM
Fresh off the press in @pnas.org: functional and structural studies of the interaction between #fertilization-blocking mAb IE-3 and mammalian #egg coat protein #ZP2
www.pnas.org/doi/10.1073/...
Thanks to
@vetenskapsradet.bsky.social @erc.europa.eu @embo.org @kawresearch.bsky.social @dfg.de
www.pnas.org/doi/10.1073/...
Thanks to
@vetenskapsradet.bsky.social @erc.europa.eu @embo.org @kawresearch.bsky.social @dfg.de
Just in time for 8 March, we are thrilled to open the way to targeted non-hormonal contraception with the first structure of a fertilization-blocking antibody bound to a key female reproductive protein, #ZP2:
Structural basis of ZP2-targeted immunocontraception
www.biorxiv.org/content/10.1...
Structural basis of ZP2-targeted immunocontraception
www.biorxiv.org/content/10.1...
March 7, 2025 at 6:21 PM
Just in time for 8 March, we are thrilled to open the way to targeted non-hormonal contraception with the first structure of a fertilization-blocking antibody bound to a key female reproductive protein, #ZP2:
Structural basis of ZP2-targeted immunocontraception
www.biorxiv.org/content/10.1...
Structural basis of ZP2-targeted immunocontraception
www.biorxiv.org/content/10.1...
Happy to have played a small part in this nice story on our old friend #endoglin !
Thrombin cleaves membrane-bound endoglin potentially contributing to the heterogeneity of circulating endoglin in preeclampsia
www.nature.com/articles/s42...
#ENG #preeclampsia #HHT
Thrombin cleaves membrane-bound endoglin potentially contributing to the heterogeneity of circulating endoglin in preeclampsia
www.nature.com/articles/s42...
#ENG #preeclampsia #HHT
Thrombin cleaves membrane-bound endoglin potentially contributing to the heterogeneity of circulating endoglin in preeclampsia - Communications Biology
Thrombin cleaves membrane-bound endoglin and soluble endoglin, releasing fragments of varying sizes; these findings emphasize the heterogeneity of sEng in preeclampsia, connecting endothelial dysfunct...
www.nature.com
February 27, 2025 at 10:55 AM
Happy to have played a small part in this nice story on our old friend #endoglin !
Thrombin cleaves membrane-bound endoglin potentially contributing to the heterogeneity of circulating endoglin in preeclampsia
www.nature.com/articles/s42...
#ENG #preeclampsia #HHT
Thrombin cleaves membrane-bound endoglin potentially contributing to the heterogeneity of circulating endoglin in preeclampsia
www.nature.com/articles/s42...
#ENG #preeclampsia #HHT
...they were indeed! 😊
Paper at Cell - ZP2 cleavage blocks polyspermy by modulating the architecture of the egg coat - zurl.co/xw7a - Our MiTeGen Loops zurl.co/Q3vm were used to help determine details of IVF-related mechanisms
February 5, 2025 at 5:34 PM
...they were indeed! 😊
Happy to have contributed (together with @arneelof.bsky.social, @enricabianchi.bsky.social and Gavin Wright) to this @elife.bsky.social special issue on reproductive heath:
elifesciences.org/articles/102...
elifesciences.org/articles/102...
Special Issue: Reproductive health
The articles in this special issue highlight the diversity and complexity of research into reproductive health, including the need for a better understanding of the fundamental biology of reproduction...
elifesciences.org
January 31, 2025 at 8:58 AM
Happy to have contributed (together with @arneelof.bsky.social, @enricabianchi.bsky.social and Gavin Wright) to this @elife.bsky.social special issue on reproductive heath:
elifesciences.org/articles/102...
elifesciences.org/articles/102...
🤦 No comment... (and yes, when you'll translate it you will miss the nuances 😉)
www.tidningencurie.se/debatt/under...
www.tidningencurie.se/debatt/under...
Undervisning på engelska går ut över studenterna | Tidningen Curie
Det finns flera skäl att internationalisera högre utbildning. Men internationalisering är inte detsamma som anglifiering. Att undervisa på ett språk som inte är studenternas förstaspråk går ut över ut...
www.tidningencurie.se
January 30, 2025 at 9:09 AM
🤦 No comment... (and yes, when you'll translate it you will miss the nuances 😉)
www.tidningencurie.se/debatt/under...
www.tidningencurie.se/debatt/under...
What a heartwarming, progressive and - yes - casually illegal way to start the year 😞
edition.cnn.com/2025/01/04/e...
edition.cnn.com/2025/01/04/e...
Sweden allows nearly 10% of wolf population to be killed. The government wants an even more drastic cull | CNN
Sweden began its annual wolf hunt on Thursday, allowing nearly 10% of the endangered species population to be killed, as conservationists raise concerns about the controversial policy.
edition.cnn.com
January 4, 2025 at 1:49 PM
What a heartwarming, progressive and - yes - casually illegal way to start the year 😞
edition.cnn.com/2025/01/04/e...
edition.cnn.com/2025/01/04/e...
Just got out of the supermarket with enough funding for my lab for the next 100 years 🤣
"In return, Sun will receive a banana and a roll of duct tape, as well as a certificate of authenticity and instructions on how to install the work – including how to replace the banana, should they want to"
We will never make it as a species... Never... 🍌😭
We will never make it as a species... Never... 🍌😭
Maurizio Cattelan’s duct-taped banana artwork fetches US$5.2m at New York auction
November 21, 2024 at 6:23 PM
Just got out of the supermarket with enough funding for my lab for the next 100 years 🤣